Nuclear receptors in lipid metabolism and toxicity

No Pathway Network information available for Nuclear receptors in lipid metabolism and toxicity

Pathways in the Nuclear receptors in lipid metabolism and toxicity SuperPath

#	Name	Source	Genes
1	Nuclear receptors in lipid metabolism and toxicity	WikiPathways	ABCA1 ABCB1 ABCB11 ABCB4 ABCC2 ABCC3 ABCD2 ABCD3 ABCG1 ABCG5 CYP1A2 CYP24A1 CYP26A1 CYP27B1 CYP2B6 CYP2C9 CYP2E1 CYP3A4 CYP4A11 CYP4B1 CYP7A1 CYP8B1 MIR33A MIR33B NR1H3 NR1H4 NR1I2 NR1I3 PPARA PPARD PPARG RARA RARB RARG VDR (see all 35) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	1
2	NR1I3	Nuclear Receptor Subfamily 1 Group I Member 3	Protein Coding	1
3	ABCG1	ATP Binding Cassette Subfamily G Member 1	Protein Coding	1
4	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
5	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	1
6	ABCB11	ATP Binding Cassette Subfamily B Member 11	Protein Coding	1
7	VDR	Vitamin D Receptor	Protein Coding	1
8	MIR33B	MicroRNA 33b	RNA Gene	1
9	ABCG5	ATP Binding Cassette Subfamily G Member 5	Protein Coding	1
10	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
11	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
12	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
13	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	1
14	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
15	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
16	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
17	ABCB4	ATP Binding Cassette Subfamily B Member 4	Protein Coding	1
18	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
19	ABCD2	ATP Binding Cassette Subfamily D Member 2	Protein Coding	1
20	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	1
21	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	1
22	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	1
23	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	1
24	CYP8B1	Cytochrome P450 Family 8 Subfamily B Member 1	Protein Coding	1
25	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	1
26	CYP4B1	Cytochrome P450 Family 4 Subfamily B Member 1	Protein Coding	1
27	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	1
28	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
29	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
30	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
31	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	1
32	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
33	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
34	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
35	MIR33A	MicroRNA 33a	RNA Gene	1

Disorders associated with Nuclear receptors in lipid metabolism and toxicity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Intrahepatic cholestasis of pregnancy	Enrichment	ABCB11, ABCB4, NR1H4	7.20
2	Cholestasis, progressive familial intrahepatic, 3	Enrichment	ABCB11, ABCB4	5.19
3	Cholestasis, intrahepatic, of pregnancy 3	Enrichment	ABCB11, ABCB4	5.19
4	Intrahepatic cholestasis	Enrichment	ABCB11, ABCB4	5.19
5	Cholestasis, progressive familial intrahepatic, 1	Enrichment	ABCB4, NR1H4	4.02
6	Progressive familial intrahepatic cholestasis	Enrichment	ABCB11, ABCB4	3.87
7	Coronary heart disease 5	Enrichment	ABCA1, ABCG5	3.64
8	Multiple sclerosis	Enrichment	CYP27B1, NR1H3	3.24
9	Colchicine resistance	Enrichment	ABCB1	2.59
10	Gallbladder disease 1	Enrichment	ABCB4	2.59
11	Encephalopathy, acute transient	Enrichment	ABCB1	2.59
12	Inflammatory bowel disease 13	Enrichment	ABCB1	2.59
13	Efavirenz, poor metabolism of	Enrichment	CYP2B6	2.59
14	Microphthalmia, syndromic 12	Enrichment	RARB	2.59
15	Cholestasis, progressive familial intrahepatic, 5	Enrichment	NR1H4	2.59
16	Bile acid synthesis defect, congenital, 5	Enrichment	ABCD3	2.59
17	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.59
18	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	2.59
19	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.59
20	Rickets	Enrichment	VDR	2.59
21	Hypoalphalipoproteinemia	Enrichment	ABCA1	2.59
22	Tangier disease	Enrichment	ABCA1	2.29
23	Carotid intimal medial thickness 1	Enrichment	PPARG	2.29
24	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	2.29
25	Cholestasis, benign recurrent intrahepatic, 2	Enrichment	ABCB11	2.29
26	Gallbladder disease 4	Enrichment	ABCG5	2.29
27	Cholestasis, progressive familial intrahepatic, 4	Enrichment	ABCB11	2.29
28	Cholestasis, progressive familial intrahepatic, 2	Enrichment	ABCB11	2.29
29	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.29
30	Sitosterolemia 2	Enrichment	ABCG5	2.29
31	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	ABCG5	2.29
32	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1	2.29
33	Familial partial lipodystrophy	Enrichment	PPARG	2.29
34	Dubin-johnson syndrome	Enrichment	ABCC2	2.11
35	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	CYP27B1	2.11
36	Coumarin resistance	Enrichment	CYP2C9	2.11
37	Sitosterolemia 1	Enrichment	ABCG5	2.11
38	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1	2.11
39	Sitosterolemia	Enrichment	ABCG5	2.11
40	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1	1.99
41	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.99
42	Leptin deficiency or dysfunction	Enrichment	PPARG	1.99
43	Congenital generalized lipodystrophy	Enrichment	PPARG	1.99
44	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.89
45	Pseudoxanthoma elasticum	Enrichment	ABCC2	1.81
46	Lipid metabolism disorder	Enrichment	ABCG5	1.81
47	Oculopharyngodistal myopathy 1	Enrichment	ABCD3	1.75
48	Homozygous familial hypercholesterolemia	Enrichment	ABCG5	1.69
49	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.55
50	Microphthalmia/coloboma 12	Enrichment	RARB	1.48
51	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.48
52	Acute promyelocytic leukemia	Enrichment	RARA	1.48
53	Coloboma of macula	Enrichment	RARB	1.42
54	Gliosarcoma	Enrichment	PPARG	1.39
55	Giant cell glioblastoma	Enrichment	PPARG	1.37
56	Hepatocellular carcinoma	Enrichment	VDR	1.26
57	Microphthalmia	Enrichment	RARB	1.26
58	Differentiated thyroid carcinoma	Enrichment	PPARG	1.14
59	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	ABCG5	1.09
60	Type 2 diabetes mellitus	Enrichment	PPARG	0.99
61	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.92
62	Breast cancer	Enrichment	ABCA1	0.75
63	Colorectal cancer	Enrichment	PPARG	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nuclear receptors in lipid metabolism and toxicity

Pathway Network for Nuclear receptors in lipid metabolism and toxicity

Member Pathways for Nuclear receptors in lipid metabolism and toxicity

Pathways in the Nuclear receptors in lipid metabolism and toxicity SuperPath

Associated Genes for Nuclear receptors in lipid metabolism and toxicity

Associated Disorders for Nuclear receptors in lipid metabolism and toxicity

Disorders associated with Nuclear receptors in lipid metabolism and toxicity SuperPath

STRING Interaction Network for Nuclear receptors in lipid metabolism and toxicity

Sources for Nuclear receptors in lipid metabolism and toxicity