Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

No Pathway Network information available for Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Pathways in the Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways SuperPath

#	Name	Source	Genes
1	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Reactome	AAMP AIM2 APP BCL2 BCL2L1 BIRC2 BIRC3 CARD9 CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CYLD HMOX1 HSP90AB1 IKBKB IKBKG IRAK1 IRAK2 ITCH MAP2K6 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 MEFV NFKB1 NFKB2 NLRC4 NLRP1 NLRP3 NOD1 NOD2 P2RX7 PANX1 PSTPIP1 PYCARD RELA RIPK2 RPS27A SUGT1 TAB1 TAB2 TAB3 TNFAIP3 TRAF6 TXN TXNIP UBA52 UBB UBC UBE2N UBE2V1 (see all 56) (see less)
2	NOD1/2 Signaling Pathway	Reactome	AAMP BIRC2 BIRC3 CARD9 CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CYLD IKBKB IKBKG IRAK1 IRAK2 ITCH MAP2K6 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 NOD1 NOD2 RIPK2 RPS27A TAB1 TAB2 TAB3 TNFAIP3 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	2
2	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
3	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
4	AAMP	Angio Associated Migratory Cell Protein	Protein Coding	2
5	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
6	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	2
7	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
8	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	2
9	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	2
10	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	2
11	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
12	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
13	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	2
14	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
15	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
16	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
17	RPS27A	Ribosomal Protein S27a	Protein Coding	2
18	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
19	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	2
20	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	2
21	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
22	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	2
23	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
24	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
25	UBB	Ubiquitin B	Protein Coding	2
26	UBC	Ubiquitin C	Protein Coding	2
27	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
28	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	2
29	CASP1	Caspase 1	Protein Coding	2
30	CASP2	Caspase 2	Protein Coding	2
31	CASP4	Caspase 4	Protein Coding	2
32	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	2
33	CASP8	Caspase 8	Protein Coding	2
34	CASP9	Caspase 9	Protein Coding	2
35	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
36	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
37	TXNIP	Thioredoxin Interacting Protein	Protein Coding	1
38	SUGT1	SGT1 Assembly Cochaperone Of MIS12 Kinetochore Complex	Protein Coding	1
39	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
40	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	1
41	PANX1	Pannexin 1	Protein Coding	1
42	PYCARD	PYD And CARD Domain Containing	Protein Coding	1
43	HMOX1	Heme Oxygenase 1	Protein Coding	1
44	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
45	APP	Amyloid Beta Precursor Protein	Protein Coding	1
46	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	1
47	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
48	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
49	P2RX7	Purinergic Receptor P2X 7	Protein Coding	1
50	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	1
51	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
52	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
53	BCL2L1	BCL2 Like 1	Protein Coding	1
54	TXN	Thioredoxin	Protein Coding	1
55	PSTPIP1	Proline-Serine-Threonine Phosphatase Interacting Protein 1	Protein Coding	1
56	AIM2	Absent In Melanoma 2	Protein Coding	1

Disorders associated with Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoinflammatory disease	Enrichment	MEFV, NLRC4, NLRP3, NOD2	5.58
2	Behcet syndrome	Enrichment	MEFV, NOD2, PSTPIP1	4.21
3	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.46
4	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.58
5	Immunodeficiency 103 fungal infections	Enrichment	CARD9	2.58
6	Incontinentia pigmenti	Enrichment	IKBKG	2.58
7	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.58
8	Caspase 8 deficiency	Enrichment	CASP8	2.58
9	Fetal encasement syndrome	Enrichment	CHUK	2.58
10	Blau syndrome	Enrichment	NOD2	2.58
11	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.58
12	Immunodeficiency 15b	Enrichment	IKBKB	2.58
13	Immunodeficiency 15a	Enrichment	IKBKB	2.58
14	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.58
15	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.58
16	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.58
17	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.58
18	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.58
19	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.58
20	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.58
21	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.58
22	Cinca syndrome	Enrichment	NLRP3	2.38
23	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.38
24	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne	Enrichment	PSTPIP1	2.38
25	Vitiligo-associated multiple autoimmune disease susceptibility 1	Enrichment	NLRP1	2.38
26	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.38
27	Muckle-wells syndrome	Enrichment	NLRP3	2.38
28	Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia	Enrichment	PSTPIP1	2.38
29	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.38
30	Respiratory papillomatosis, juvenile recurrent, congenital	Enrichment	NLRP1	2.38
31	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	2.38
32	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	2.38
33	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.38
34	Palmoplantar carcinoma, multiple self-healing	Enrichment	NLRP1	2.38
35	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.38
36	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.38
37	Autoinflammation with arthritis and dyskeratosis	Enrichment	NLRP1	2.38
38	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.38
39	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.38
40	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	2.38
41	Systemic lupus erythematosus	Enrichment	IRAK1, TNFAIP3	2.32
42	Cylindromatosis, familial	Enrichment	CYLD	2.28
43	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	2.28
44	Immunodeficiency 33	Enrichment	IKBKG	2.28
45	Yao syndrome	Enrichment	NOD2	2.28
46	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.28
47	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	2.28
48	Brooke-spiegler syndrome	Enrichment	CYLD	2.28
49	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.28
50	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.28
51	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.28
52	Crohn's disease	Enrichment	NOD2	2.28
53	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.28
54	Submucosal cleft palate	Enrichment	UBB	2.28
55	Cleft hard palate	Enrichment	UBB	2.28
56	Pelvic organ prolapse	Enrichment	TAB2	2.10
57	Uvula, bifid	Enrichment	UBB	2.10
58	Cleft soft palate	Enrichment	UBB	2.10
59	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.10
60	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.08
61	Familial mediterranean fever, autosomal dominant	Enrichment	MEFV	2.08
62	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.08
63	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.08
64	Familial mediterranean fever	Enrichment	MEFV	2.08
65	Oocyte/zygote/embryo maturation arrest 7	Enrichment	PANX1	2.08
66	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.08
67	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.08
68	Rela fusion-positive ependymoma	Enrichment	RELA	2.08
69	Pericardial effusion	Enrichment	NLRP3	2.08
70	Intermittent hydrarthrosis	Enrichment	MEFV	2.08
71	Common variable immunodeficiency 12	Enrichment	NFKB1	2.08
72	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.98
73	Neutrophilic dermatosis, acute febrile	Enrichment	MEFV	1.91
74	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.91
75	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.88
76	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.88
77	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.88
78	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.78
79	Follicular lymphoma	Enrichment	BCL2	1.69
80	Female infertility due to oocyte meiotic arrest	Enrichment	PANX1	1.69
81	Inflammatory bowel disease 1	Enrichment	NOD2	1.63
82	Coronary heart disease 5	Enrichment	IKBKG	1.63
83	Adult hepatocellular carcinoma	Enrichment	CASP8	1.63
84	Alzheimer's disease 1	Enrichment	APP	1.54
85	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.54
86	Migraine with or without aura 1	Enrichment	TAB2	1.54
87	Aortic valve disease 1	Enrichment	TAB2	1.47
88	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.39
89	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.39
90	Patent foramen ovale	Enrichment	TAB2	1.33
91	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.28
92	Alzheimer's disease	Enrichment	APP	1.28
93	Hepatocellular carcinoma	Enrichment	CASP8	1.25
94	Malaria	Enrichment	IKBKG	1.23
95	Neuronal ceroid lipofuscinosis	Enrichment	MEFV	1.22
96	Kidney disease	Enrichment	MEFV	1.22
97	Alzheimer disease, familial, 1	Enrichment	APP	1.17
98	Arteriovenous malformations of the brain	Enrichment	NLRP3	1.12
99	Lung cancer	Enrichment	CASP8	1.09
100	Severe combined immunodeficiency	Enrichment	IKBKB	1.08
101	Cystic fibrosis	Enrichment	HMOX1	0.91
102	Myeloma, multiple	Enrichment	CYLD	0.86
103	Breast cancer	Enrichment	CASP8	0.74
104	Dilated cardiomyopathy	Enrichment	TAB2	0.72
105	Inherited cancer-predisposing syndrome	Enrichment	CYLD	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Pathway Network for Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Member Pathways for Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Pathways in the Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways SuperPath

Associated Genes for Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Associated Disorders for Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Disorders associated with Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways SuperPath

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