Nucleotide-binding oligomerization domain (NOD) pathway

No Pathway Network information available for Nucleotide-binding oligomerization domain (NOD) pathway

Pathways in the Nucleotide-binding oligomerization domain (NOD) pathway SuperPath

#	Name	Source	Genes
1	Nucleotide-binding oligomerization domain (NOD) pathway	WikiPathways	AAMP ACAP1 AIM2 CARD6 CARD8 CARD9 CASP1 CASP5 CASP7 CASP8 CASP9 CHUK COPS6 DUOX2 ERBIN HSP90AA1 IKBKB IKBKG IL18 IL1B MEFV NAIP NDUFA13 NFKBIA NLRC4 NLRP1 NLRP10 NLRP12 NLRP2 NLRP3 NLRP4 NLRP7 NOD1 NOD2 PRDM1 PYCARD RAC1 RELA RIPK2 SUGT1 XIAP (see all 41) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AAMP	Angio Associated Migratory Cell Protein	Protein Coding	1
2	AIM2	Absent In Melanoma 2	Protein Coding	1
3	NLRP12	NLR Family Pyrin Domain Containing 12	Protein Coding	1
4	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
5	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
6	CASP9	Caspase 9	Protein Coding	1
7	CASP8	Caspase 8	Protein Coding	1
8	CASP7	Caspase 7	Protein Coding	1
9	CASP1	Caspase 1	Protein Coding	1
10	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	1
11	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	1
12	PRDM1	PR/SET Domain 1	Protein Coding	1
13	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
14	RAC1	Rac Family Small GTPase 1	Protein Coding	1
15	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	1
16	ERBIN	Erbb2 Interacting Protein	Protein Coding	1
17	NDUFA13	NADH:Ubiquinone Oxidoreductase Subunit A13	Protein Coding	1
18	DUOX2	Dual Oxidase 2	Protein Coding	1
19	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
20	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	1
21	IL18	Interleukin 18	Protein Coding	1
22	IL1B	Interleukin 1 Beta	Protein Coding	1
23	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
24	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
25	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
26	PYCARD	PYD And CARD Domain Containing	Protein Coding	1
27	CARD8	Caspase Recruitment Domain Family Member 8	Protein Coding	1
28	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	1
29	NLRP7	NLR Family Pyrin Domain Containing 7	Protein Coding	1
30	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
31	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
32	COPS6	COP9 Signalosome Subunit 6	Protein Coding	1
33	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	1
34	NLRP4	NLR Family Pyrin Domain Containing 4	Protein Coding	1
35	ACAP1	ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 1	Protein Coding	1
36	CARD6	Caspase Recruitment Domain Family Member 6	Protein Coding	1
37	SUGT1	SGT1 Assembly Cochaperone Of MIS12 Kinetochore Complex	Protein Coding	1
38	CASP5	Caspase 5	Protein Coding	1
39	NLRP2	NLR Family Pyrin Domain Containing 2	Protein Coding	1
40	NAIP	NLR Family Apoptosis Inhibitory Protein	Protein Coding	1
41	NLRP10	NLR Family Pyrin Domain Containing 10	Protein Coding	1

Disorders associated with Nucleotide-binding oligomerization domain (NOD) pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoinflammatory disease	Enrichment	MEFV, NLRC4, NLRP12, NLRP3, NOD2, XIAP	10.08
2	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.05
3	Behcet syndrome	Enrichment	MEFV, NOD2	2.83
4	Multisystem inflammatory syndrome in children	Enrichment	NLRP12, NLRP2	2.70
5	Immunodeficiency 103 fungal infections	Enrichment	CARD9	2.52
6	Incontinentia pigmenti	Enrichment	IKBKG	2.52
7	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.52
8	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.52
9	Cinca syndrome	Enrichment	NLRP3	2.52
10	Caspase 8 deficiency	Enrichment	CASP8	2.52
11	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.52
12	Vitiligo-associated multiple autoimmune disease susceptibility 1	Enrichment	NLRP1	2.52
13	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.52
14	Thyroid dyshormonogenesis 6	Enrichment	DUOX2	2.52
15	Fetal encasement syndrome	Enrichment	CHUK	2.52
16	Blau syndrome	Enrichment	NOD2	2.52
17	Muckle-wells syndrome	Enrichment	NLRP3	2.52
18	Immunodeficiency 15b	Enrichment	IKBKB	2.52
19	Inflammatory bowel disease 30	Enrichment	CARD8	2.52
20	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.52
21	Immunodeficiency 15a	Enrichment	IKBKB	2.52
22	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.52
23	Respiratory papillomatosis, juvenile recurrent, congenital	Enrichment	NLRP1	2.52
24	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	2.52
25	Familial cold autoinflammatory syndrome 2	Enrichment	NLRP12	2.52
26	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	2.52
27	Palmoplantar carcinoma, multiple self-healing	Enrichment	NLRP1	2.52
28	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.52
29	Oocyte/zygote/embryo maturation arrest 18	Enrichment	NLRP2	2.52
30	Autoinflammation with arthritis and dyskeratosis	Enrichment	NLRP1	2.52
31	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.52
32	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.52
33	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.52
34	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.52
35	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	2.52
36	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	2.52
37	Recurrent hydatidiform mole	Enrichment	NLRP7	2.52
38	Familial mediterranean fever, autosomal dominant	Enrichment	MEFV	2.22
39	Immunodeficiency 33	Enrichment	IKBKG	2.22
40	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.22
41	Thyroid carcinoma, hurthle cell	Enrichment	NDUFA13	2.22
42	Yao syndrome	Enrichment	NOD2	2.22
43	Familial mediterranean fever	Enrichment	MEFV	2.22
44	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.22
45	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.22
46	Rela fusion-positive ependymoma	Enrichment	RELA	2.22
47	Pericardial effusion	Enrichment	NLRP3	2.22
48	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.22
49	Intermittent hydrarthrosis	Enrichment	MEFV	2.22
50	Crohn's disease	Enrichment	NOD2	2.22
51	Partial hydatidiform mole	Enrichment	NLRP7	2.22
52	Spinal muscular atrophy, type iii	Enrichment	NAIP	2.04
53	Spinal muscular atrophy, type i	Enrichment	NAIP	2.04
54	Spinal muscular atrophy, type ii	Enrichment	NAIP	2.04
55	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.04
56	Neutrophilic dermatosis, acute febrile	Enrichment	MEFV	2.04
57	Mitochondrial complex i deficiency, nuclear type 28	Enrichment	NDUFA13	2.04
58	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.92
59	Hydatidiform mole, recurrent, 1	Enrichment	NLRP7	1.82
60	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.82
61	Familial thyroid dyshormonogenesis	Enrichment	DUOX2	1.74
62	Inflammatory bowel disease 1	Enrichment	NOD2	1.57
63	Coronary heart disease 5	Enrichment	IKBKG	1.57
64	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.57
65	Adult hepatocellular carcinoma	Enrichment	CASP8	1.57
66	Congenital hypothyroidism	Enrichment	DUOX2	1.45
67	Lactic acidosis	Enrichment	NDUFA13	1.45
68	Neuronal ceroid lipofuscinosis	Enrichment	MEFV	1.35
69	Kidney disease	Enrichment	MEFV	1.35
70	Gliosarcoma	Enrichment	NFKBIA	1.33
71	Giant cell glioblastoma	Enrichment	NFKBIA	1.30
72	Arteriovenous malformations of the brain	Enrichment	NLRP3	1.25
73	Hepatocellular carcinoma	Enrichment	CASP8	1.19
74	Malaria	Enrichment	IKBKG	1.17
75	Differentiated thyroid carcinoma	Enrichment	NDUFA13	1.08
76	Lung cancer	Enrichment	CASP8	1.03
77	Severe combined immunodeficiency	Enrichment	IKBKB	1.02
78	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NDUFA13	0.96
79	Gastric cancer	Enrichment	IL1B	0.91
80	Hypertrophic cardiomyopathy	Enrichment	NDUFA13	0.91
81	Leigh syndrome, nuclear	Enrichment	NDUFA13	0.72
82	Breast cancer	Enrichment	CASP8	0.69
83	Leigh disease	Enrichment	NDUFA13	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nucleotide-binding oligomerization domain (NOD) pathway

Pathway Network for Nucleotide-binding oligomerization domain (NOD) pathway

Member Pathways for Nucleotide-binding oligomerization domain (NOD) pathway

Pathways in the Nucleotide-binding oligomerization domain (NOD) pathway SuperPath

Associated Genes for Nucleotide-binding oligomerization domain (NOD) pathway

Associated Disorders for Nucleotide-binding oligomerization domain (NOD) pathway

Disorders associated with Nucleotide-binding oligomerization domain (NOD) pathway SuperPath

STRING Interaction Network for Nucleotide-binding oligomerization domain (NOD) pathway

Sources for Nucleotide-binding oligomerization domain (NOD) pathway