Nucleotide metabolism

No Pathway Network information available for Nucleotide metabolism

Pathways in the Nucleotide metabolism SuperPath

#	Name	Source	Genes
1	Nucleotide metabolism	WikiPathways	ADSL ADSS2 DHFR HPRT1 IMPDH1 MTHFD2 NME2 OAZ1 POLA1 POLB POLD1 POLG PRPS1 PRPS2 RRM1 RRM2 RRM2B SAT1 SRM (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PRPS2	Phosphoribosyl Pyrophosphate Synthetase 2	Protein Coding	1
2	SRM	Spermidine Synthase	Protein Coding	1
3	SAT1	Spermidine/Spermine N1-Acetyltransferase 1	Protein Coding	1
4	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	1
5	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	1
6	PRPS1	Phosphoribosyl Pyrophosphate Synthetase 1	Protein Coding	1
7	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	1
8	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	1
9	POLB	DNA Polymerase Beta	Protein Coding	1
10	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	1
11	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	1
12	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	1
13	IMPDH1	Inosine Monophosphate Dehydrogenase 1	Protein Coding	1
14	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	1
15	DHFR	Dihydrofolate Reductase	Protein Coding	1
16	ADSL	Adenylosuccinate Lyase	Protein Coding	1
17	MTHFD2	Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase	Protein Coding	1
18	ADSS2	Adenylosuccinate Synthase 2	Protein Coding	1
19	OAZ1	Ornithine Decarboxylase Antizyme 1	Protein Coding	1

Disorders associated with Nucleotide metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Idiopathic camptocormia	Enrichment	POLG, RRM2B	5.25
2	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	POLG, RRM2B	4.56
3	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	POLG, RRM2B	4.18
4	Charcot-marie-tooth disease, x-linked recessive, 5	Enrichment	PRPS1	2.85
5	Van esch-o'driscoll syndrome	Enrichment	POLA1	2.85
6	Arts syndrome	Enrichment	PRPS1	2.85
7	Colorectal cancer 10	Enrichment	POLD1	2.85
8	Adenylosuccinase deficiency	Enrichment	ADSL	2.85
9	Retinitis pigmentosa 10	Enrichment	IMPDH1	2.85
10	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	2.85
11	Immunodeficiency 120	Enrichment	POLD1	2.85
12	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	2.85
13	Phosphoribosylpyrophosphate synthetase superactivity	Enrichment	PRPS1	2.85
14	Deafness, x-linked 1	Enrichment	PRPS1	2.85
15	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	2.85
16	Leber congenital amaurosis 11	Enrichment	IMPDH1	2.85
17	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.85
18	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.85
19	Childhood myocerebrohepatopathy spectrum	Enrichment	POLG	2.85
20	X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome	Enrichment	PRPS1	2.85
21	Spinocerebellar ataxia with epilepsy	Enrichment	POLG	2.85
22	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	2.85
23	Recessive mitochondrial ataxia syndrome	Enrichment	POLG	2.85
24	Fanconi renotubular syndrome 1	Enrichment	RRM2B	2.55
25	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	2.55
26	Fanconi anemia, complementation group i	Enrichment	POLG	2.55
27	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	2.55
28	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	2.55
29	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	2.55
30	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 1	Enrichment	POLG	2.55
31	Polg-related disorders	Enrichment	POLG	2.55
32	Autosomal recessive progressive external ophthalmoplegia	Enrichment	POLG	2.55
33	Partington syndrome	Enrichment	POLA1	2.38
34	Lesch-nyhan syndrome	Enrichment	HPRT1	2.38
35	Hyperuricemia, hprt-related	Enrichment	HPRT1	2.38
36	Familial adenomatous polyposis 4	Enrichment	DHFR	2.38
37	Keratosis follicularis spinulosa decalvans	Enrichment	SAT1	2.38
38	Polymerase proofreading-related polyposis	Enrichment	POLD1	2.38
39	Generalized epilepsy	Enrichment	POLG	2.25
40	Pediatric systemic lupus erythematosus	Enrichment	SAT1	2.25
41	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	PRPS1	2.25
42	Mitochondrial disease	Enrichment	POLG, RRM2B	2.19
43	Kearns-sayre syndrome	Enrichment	RRM2B	2.16
44	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	Enrichment	POLG	2.16
45	Machado-joseph disease	Enrichment	POLG	2.08
46	Mitochondrial dna depletion syndrome 1	Enrichment	POLG	2.08
47	Mitochondrial dna depletion syndrome	Enrichment	POLG	2.08
48	Early myoclonic encephalopathy	Enrichment	ADSL	2.08
49	Mitochondrial dna depletion syndrome 4a	Enrichment	POLG	2.01
50	Mitochondrial dna depletion syndrome 4b	Enrichment	POLG	1.95
51	Autosomal dominant cerebellar ataxia	Enrichment	POLG	1.90
52	Inherited cancer-predisposing syndrome	Enrichment	DHFR, POLD1	1.84
53	Combined immunodeficiency	Enrichment	POLD1	1.82
54	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.82
55	Familial colorectal cancer type x	Enrichment	POLD1	1.82
56	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.82
57	Endometrial cancer	Enrichment	DHFR	1.54
58	Pancreatic cancer	Enrichment	POLD1	1.46
59	Retinitis pigmentosa	Enrichment	IMPDH1, RRM2B	1.46
60	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	POLG	1.28
61	Hereditary spastic paraplegia	Enrichment	POLG	1.24
62	Hypertrophic cardiomyopathy	Enrichment	POLG	1.23
63	Hereditary retinal dystrophy	Enrichment	IMPDH1, PRPS1	1.21
64	Fundus dystrophy	Enrichment	IMPDH1, PRPS1	1.21
65	Sensorineural hearing loss	Enrichment	RRM2B	1.19
66	Body mass index quantitative trait locus 11	Enrichment	POLG	1.17
67	Primary ovarian insufficiency	Enrichment	POLG	1.10
68	Leigh syndrome, nuclear	Enrichment	POLG	1.03
69	Colorectal cancer	Enrichment	POLD1	0.94
70	Leber plus disease	Enrichment	IMPDH1	0.90
71	Congenital nervous system abnormality	Enrichment	POLG	0.86
72	Nervous system disease	Enrichment	POLG	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nucleotide metabolism

Pathway Network for Nucleotide metabolism

Member Pathways for Nucleotide metabolism

Pathways in the Nucleotide metabolism SuperPath

Associated Genes for Nucleotide metabolism

Associated Disorders for Nucleotide metabolism

Disorders associated with Nucleotide metabolism SuperPath

STRING Interaction Network for Nucleotide metabolism

Sources for Nucleotide metabolism