Nucleotide salvage

Pathway network for the Nucleotide salvage SuperPath

Sources:

Reactome
PubChem

Pathways in the Nucleotide salvage SuperPath

#	Name	Source	Genes
1	Nucleotide salvage	Reactome	ADA ADK AMPD1 AMPD2 AMPD3 APRT CDA DCK DGUOK GMPR GMPR2 HPRT1 MAPDA PNP PUDP TK1 TK2 TYMP UCK1 UCK2 UCKL1 UPP1 UPP2 (see all 23) (see less)
2	Purine salvage	Reactome	ADA ADK AMPD1 AMPD2 AMPD3 APRT DCK DGUOK GMPR GMPR2 HPRT1 MAPDA PNP (see all 13) (see less)
3	Pyrimidine salvage	Reactome	CDA DCK PUDP TK1 TK2 TYMP UCK1 UCK2 UCKL1 UPP1 UPP2 (see all 11) (see less)
4	Diseases of nucleotide metabolism	Reactome	ADA APRT HPRT1 PNP
5	adenine and adenosine salvage III	PubChem	ADA HPRT1 PNP
6	Nucleotide salvage defects	Reactome	ADA APRT HPRT1
7	pyrimidine ribonucleosides salvage I	PubChem	CDA UCK1 UCK2
8	pyrimidine deoxyribonucleosides degradation	PubChem	CDA TYMP UPP1
9	guanine and guanosine salvage	PubChem	HPRT1 PNP
10	pyrimidine ribonucleosides degradation	PubChem	CDA UPP1
11	Defective HPRT1 disrupts guanine and hypoxanthine salvage	Reactome	HPRT1
12	Defective APRT disrupts adenine salvage	Reactome	APRT

Gene overlap in member pathways for Nucleotide salvage SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	7
2	ADA	Adenosine Deaminase	Protein Coding	5
3	APRT	Adenine Phosphoribosyltransferase	Protein Coding	5
4	PNP	Purine Nucleoside Phosphorylase	Protein Coding	5
5	CDA	Cytidine Deaminase	Protein Coding	5
6	UPP1	Uridine Phosphorylase 1	Protein Coding	4
7	DCK	Deoxycytidine Kinase	Protein Coding	3
8	TYMP	Thymidine Phosphorylase	Protein Coding	3
9	UCK2	Uridine-Cytidine Kinase 2	Protein Coding	3
10	UCK1	Uridine-Cytidine Kinase 1	Protein Coding	3
11	ADK	Adenosine Kinase	Protein Coding	2
12	UPP2	Uridine Phosphorylase 2	Protein Coding	2
13	MAPDA	N6-Methyl-AMP Deaminase	Protein Coding	2
14	DGUOK	Deoxyguanosine Kinase	Protein Coding	2
15	AMPD1	Adenosine Monophosphate Deaminase 1	Protein Coding	2
16	AMPD2	Adenosine Monophosphate Deaminase 2	Protein Coding	2
17	AMPD3	Adenosine Monophosphate Deaminase 3	Protein Coding	2
18	GMPR	Guanosine Monophosphate Reductase	Protein Coding	2
19	GMPR2	Guanosine Monophosphate Reductase 2	Protein Coding	2
20	UCKL1	Uridine-Cytidine Kinase 1 Like 1	Protein Coding	2
21	TK1	Thymidine Kinase 1	Protein Coding	2
22	TK2	Thymidine Kinase 2	Protein Coding	2
23	PUDP	Pseudouridine 5''-Phosphatase	Protein Coding	2

Disorders associated with Nucleotide salvage SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Purine-pyrimidine metabolic disorder	Direct
2	Lesch-nyhan syndrome	Direct
3	Adenine phosphoribosyltransferase deficiency	Direct
4	Adenosine monophosphate deaminase deficiency	Enrichment	AMPD1, AMPD3	6.07
5	Severe combined immunodeficiency	Enrichment	ADA, PNP	4.76
6	Purine nucleoside phosphorylase deficiency	Enrichment	PNP	3.83
7	Hyperuricemia, hprt-related	Enrichment	HPRT1	3.35
8	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	3.18
9	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 3	Enrichment	TK2	3.09
10	Adenosine deaminase deficiency	Enrichment	ADA	3.05
11	Erythrocyte amp deaminase deficiency	Enrichment	AMPD3	3.02
12	Hypermethioninemia due to adenosine kinase deficiency	Enrichment	ADK	3.02
13	Myopathy due to myoadenylate deaminase deficiency	Enrichment	AMPD1	3.02
14	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	2.96
15	Mitochondrial dna depletion syndrome 1	Enrichment	TYMP	2.88
16	Mitochondrial dna depletion syndrome 2	Enrichment	TK2	2.79
17	Autosomal recessive progressive external ophthalmoplegia	Enrichment	TK2	2.79
18	Mitochondrial dna depletion syndrome 4b	Enrichment	TYMP	2.75
19	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	TYMP	2.70
20	Omenn syndrome	Enrichment	ADA	2.66
21	Pontocerebellar hypoplasia, type 9	Enrichment	AMPD2	2.54
22	Mitochondrial dna depletion syndrome 3	Enrichment	DGUOK	2.54
23	Portal hypertension, noncirrhotic, 1	Enrichment	DGUOK	2.54
24	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 4	Enrichment	DGUOK	2.54
25	Spastic paraplegia 63, autosomal recessive	Enrichment	AMPD2	2.54
26	Portal hypertension	Enrichment	DGUOK	2.42
27	Mitochondrial dna depletion syndrome	Enrichment	TK2	2.31
28	Pontocerebellar hypoplasia	Enrichment	AMPD2	1.77
29	Myopathy	Enrichment	TK2	1.50
30	Spastic ataxia	Enrichment	AMPD2	1.30
31	Mitochondrial disease	Enrichment	TK2	1.17
32	Congenital nervous system abnormality	Enrichment	AMPD2	1.01
33	Nervous system disease	Enrichment	AMPD2	1.01

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nucleotide salvage

Pathway Network for Nucleotide salvage

Pathway network for the Nucleotide salvage SuperPath

Member Pathways for Nucleotide salvage

Pathways in the Nucleotide salvage SuperPath

Gene overlap in member pathways for Nucleotide salvage SuperPath

Associated Genes for Nucleotide salvage

Associated Disorders for Nucleotide salvage

Disorders associated with Nucleotide salvage SuperPath

STRING Interaction Network for Nucleotide salvage

Sources for Nucleotide salvage