Oct4 in Mammalian ESC Pluripotency

No Pathway Network information available for Oct4 in Mammalian ESC Pluripotency

#	Name	Source	Genes
1	Oct4 in Mammalian ESC Pluripotency	QIAGEN	CDX2 ETS2 FBXO15 FGF4 FOXD3 LEFTY1 NANOG NR2F1 NR2F2 NR5A2 NR6A1 POU5F1 RXRB SF1 SOX2 SPP1 UTF1 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDX2	Caudal Type Homeobox 2	Protein Coding	1
2	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
3	FBXO15	F-Box Protein 15	Protein Coding	1
4	FGF4	Fibroblast Growth Factor 4	Protein Coding	1
5	FOXD3	Forkhead Box D3	Protein Coding	1
6	LEFTY1	Left-Right Determination Factor 1	Protein Coding	1
7	NANOG	Nanog Homeobox	Protein Coding	1
8	NR2F1	Nuclear Receptor Subfamily 2 Group F Member 1	Protein Coding	1
9	NR2F2	Nuclear Receptor Subfamily 2 Group F Member 2	Protein Coding	1
10	NR5A2	Nuclear Receptor Subfamily 5 Group A Member 2	Protein Coding	1
11	NR6A1	Nuclear Receptor Subfamily 6 Group A Member 1	Protein Coding	1
12	POU5F1	POU Class 5 Homeobox 1	Protein Coding	1
13	RXRB	Retinoid X Receptor Beta	Protein Coding	1
14	SF1	Splicing Factor 1	Protein Coding	1
15	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
16	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
17	UTF1	Undifferentiated Embryonic Cell Transcription Factor 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	46,xx sex reversal 5	Enrichment	NR2F2	2.90
2	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	2.90
3	Sirenomelia	Enrichment	CDX2	2.90
4	Oculovertebral syndrome	Enrichment	NR6A1	2.90
5	Anorectal malformation	Enrichment	CDX2	2.90
6	Bosch-boonstra-schaaf optic atrophy syndrome	Enrichment	NR2F1	2.60
7	Autoimmune disease 1	Enrichment	FOXD3	2.43
8	Microphthalmia, syndromic 3	Enrichment	SOX2	2.30
9	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.30
10	Congenital heart defects, multiple types, 4	Enrichment	NR2F2	2.20
11	46,xy disorder of sex development	Enrichment	NR2F2	2.13
12	Nanophthalmos	Enrichment	SOX2	1.86
13	Septooptic dysplasia	Enrichment	SOX2	1.83
14	Heart disease	Enrichment	NR2F2	1.76
15	Macs syndrome	Enrichment	SOX2	1.61
16	Microphthalmia	Enrichment	SOX2	1.56
17	Systemic lupus erythematosus	Enrichment	SPP1	1.32
18	Optic atrophy plus syndrome	Enrichment	NR2F1	1.27
19	Primary ovarian insufficiency	Enrichment	NR5A2	1.15
20	Autism spectrum disorder	Enrichment	NR2F1	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Oct4 in Mammalian ESC Pluripotency