Oligodendrocyte specification and differentiation, leading to myelin components for CNS

No Pathway Network information available for Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Pathways in the Oligodendrocyte specification and differentiation, leading to myelin components for CNS SuperPath

#	Name	Source	Genes
1	Oligodendrocyte specification and differentiation, leading to myelin components for CNS	WikiPathways	ASCL1 BMP2 BMP4 CNP CNTF CXCL1 FGF2 GLI2 IGF1 IL1B LIF MAG MOG MYT1 NKX2-2 NKX2-6 OLIG1 OLIG2 OMG PDGFB PLP1 SHH SOX10 SOX5 SOX6 SOX8 SOX9 TNF (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	OLIG1	Oligodendrocyte Transcription Factor 1	Protein Coding	1
2	SOX6	SRY-Box Transcription Factor 6	Protein Coding	1
3	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	1
4	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	1
5	PLP1	Proteolipid Protein 1	Protein Coding	1
6	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
7	NKX2-6	NK2 Homeobox 6	Protein Coding	1
8	SOX8	SRY-Box Transcription Factor 8	Protein Coding	1
9	SOX5	SRY-Box Transcription Factor 5	Protein Coding	1
10	CNP	2'''',3''''-Cyclic Nucleotide 3'''' Phosphodiesterase	Protein Coding	1
11	OMG	Oligodendrocyte Myelin Glycoprotein	Protein Coding	1
12	MYT1	Myelin Transcription Factor 1	Protein Coding	1
13	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
14	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
15	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	1
16	MAG	Myelin Associated Glycoprotein	Protein Coding	1
17	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	1
18	CNTF	Ciliary Neurotrophic Factor	Protein Coding	1
19	IL1B	Interleukin 1 Beta	Protein Coding	1
20	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
21	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
22	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
23	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
24	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
25	SOX10	SRY-Box Transcription Factor 10	Protein Coding	1
26	TNF	Tumor Necrosis Factor	Protein Coding	1
27	NKX2-2	NK2 Homeobox 2	Protein Coding	1
28	FGF2	Fibroblast Growth Factor 2	Protein Coding	1

Disorders associated with Oligodendrocyte specification and differentiation, leading to myelin components for CNS SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Septopreoptic holoprosencephaly	Enrichment	GLI2, SHH	3.37
2	Midline interhemispheric variant of holoprosencephaly	Enrichment	GLI2, SHH	3.37
3	Microform holoprosencephaly	Enrichment	GLI2, SHH	3.31
4	Lobar holoprosencephaly	Enrichment	GLI2, SHH	3.31
5	Alobar holoprosencephaly	Enrichment	GLI2, SHH	3.26
6	Semilobar holoprosencephaly	Enrichment	GLI2, SHH	3.21
7	Holoprosencephaly 3	Enrichment	SHH	2.69
8	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.69
9	Microphthalmia/coloboma 5	Enrichment	SHH	2.69
10	Lamb-shaffer syndrome	Enrichment	SOX5	2.69
11	Culler-jones syndrome	Enrichment	GLI2	2.69
12	46,xy sex reversal 10	Enrichment	SOX9	2.69
13	Tolchin-le caignec syndrome	Enrichment	SOX6	2.69
14	46,xx sex reversal 2	Enrichment	SOX9	2.69
15	Leukodystrophy, hypomyelinating, 20	Enrichment	CNP	2.69
16	Microphthalmia, syndromic 6	Enrichment	BMP4	2.69
17	Orofacial cleft 11	Enrichment	BMP4	2.69
18	Holoprosencephaly 9	Enrichment	GLI2	2.69
19	Narcolepsy 7	Enrichment	MOG	2.69
20	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.69
21	Spastic paraplegia 75, autosomal recessive	Enrichment	MAG	2.69
22	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.69
23	Hypomyelination of early myelinating structures	Enrichment	PLP1	2.69
24	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.69
25	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.69
26	Campomelic dysplasia	Enrichment	SOX9	2.38
27	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.38
28	Waardenburg syndrome, type 4c	Enrichment	SOX10	2.38
29	Solitary median maxillary central incisor	Enrichment	SHH	2.38
30	White-sutton syndrome	Enrichment	GLI2	2.38
31	Immunodeficiency 127	Enrichment	TNF	2.38
32	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	SOX10	2.38
33	Craniosynostosis 7	Enrichment	BMP2	2.38
34	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.38
35	Isolated radial hemimelia	Enrichment	SHH	2.38
36	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.38
37	Waardenburg syndrome, type 2a	Enrichment	SOX10	2.21
38	Myopia 2, autosomal dominant	Enrichment	CNP	2.21
39	Syndactyly, type iv	Enrichment	SHH	2.21
40	Pelizaeus-merzbacher disease	Enrichment	PLP1	2.21
41	46,xx sex reversal 1	Enrichment	SOX9	2.21
42	Spastic paraplegia 2, x-linked	Enrichment	PLP1	2.21
43	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	2.21
44	Psoriatic arthritis	Enrichment	TNF	2.21
45	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.21
46	Migraine without aura	Enrichment	TNF	2.21
47	Pelizeaus-merzbacher spectrum disorder	Enrichment	PLP1	2.21
48	Brachydactyly, type a2	Enrichment	BMP2	2.08
49	Polydactyly, preaxial ii	Enrichment	SHH	2.08
50	Schizencephaly	Enrichment	SHH	2.08
51	Cerebral malaria	Enrichment	TNF	2.08
52	Haddad syndrome	Enrichment	ASCL1	2.08
53	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	SOX10	1.99
54	Insulin-like growth factor i	Enrichment	IGF1	1.99
55	Ventricular septal defect 1	Enrichment	BMP2	1.99
56	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9	1.99
57	Vascular dementia	Enrichment	TNF	1.99
58	Persistent truncus arteriosus	Enrichment	NKX2-6	1.99
59	Atrial septal defect 1	Enrichment	BMP2	1.91
60	Conotruncal heart malformations	Enrichment	NKX2-6	1.91
61	Pierre robin syndrome	Enrichment	SOX9	1.91
62	Waardenburg syndrome, type 4a	Enrichment	SOX10	1.91
63	Anterior segment dysgenesis 5	Enrichment	BMP4	1.91
64	Waardenburg syndrome	Enrichment	SOX10	1.91
65	Waardenburg syndrome, type 1	Enrichment	SOX10	1.84
66	Waardenburg syndrome, type 2e	Enrichment	SOX10	1.84
67	Melanocytic nevus syndrome, congenital	Enrichment	SOX5	1.79
68	Narcolepsy 1	Enrichment	MOG	1.79
69	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB	1.79
70	Hemochromatosis, type 1	Enrichment	BMP2	1.79
71	Combined pituitary hormone deficiency	Enrichment	GLI2	1.79
72	Peters-plus syndrome	Enrichment	BMP4	1.69
73	Stickler syndrome	Enrichment	BMP4	1.69
74	Asthma	Enrichment	TNF	1.65
75	Meningioma, familial	Enrichment	PDGFB	1.65
76	46,xy complete gonadal dysgenesis	Enrichment	SOX9	1.65
77	Septooptic dysplasia	Enrichment	SHH	1.61
78	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.61
79	Meningioma	Enrichment	PDGFB	1.61
80	Alzheimer's disease	Enrichment	TNF	1.58
81	Cleft lip/palate	Enrichment	BMP4	1.54
82	46,xy partial gonadal dysgenesis	Enrichment	SOX9	1.54
83	Macs syndrome	Enrichment	SHH	1.39
84	Craniosynostosis	Enrichment	GLI2	1.39
85	Malaria	Enrichment	TNF	1.33
86	Kallmann syndrome	Enrichment	SOX10	1.33
87	Familial atrial fibrillation	Enrichment	NKX2-6	1.31
88	Tetralogy of fallot	Enrichment	NKX2-6	1.28
89	Auditory neuropathy	Enrichment	PLP1	1.28
90	Strabismus	Enrichment	SOX5	1.27
91	Hirschsprung disease 1	Enrichment	SOX10	1.23
92	Connective tissue disease	Enrichment	SOX9	1.19
93	Systemic lupus erythematosus	Enrichment	TNF	1.11
94	Cerebral palsy	Enrichment	NKX2-6	1.11
95	Hereditary spastic paraplegia	Enrichment	PLP1	1.08
96	Gastric cancer	Enrichment	IL1B	1.07
97	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.96
98	Autism	Enrichment	SHH	0.86
99	Rare genetic deafness	Enrichment	SOX10	0.82
100	Colorectal cancer	Enrichment	SOX9	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Pathway Network for Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Member Pathways for Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Pathways in the Oligodendrocyte specification and differentiation, leading to myelin components for CNS SuperPath

Associated Genes for Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Associated Disorders for Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Disorders associated with Oligodendrocyte specification and differentiation, leading to myelin components for CNS SuperPath

STRING Interaction Network for Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Sources for Oligodendrocyte specification and differentiation, leading to myelin components for CNS