Oligomerization of connexins into connexons

No Pathway Network information available for Oligomerization of connexins into connexons

Pathways in the Oligomerization of connexins into connexons SuperPath

#	Name	Source	Genes
1	Oligomerization of connexins into connexons	Reactome	GJA1 GJB1 GJB2
2	Transport of connexins along the secretory pathway	Reactome	GJA1 GJB1 GJB2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GJA1	Gap Junction Protein Alpha 1	Protein Coding	2
2	GJB1	Gap Junction Protein Beta 1	Protein Coding	2
3	GJB2	Gap Junction Protein Beta 2	Protein Coding	2

Disorders associated with Oligomerization of connexins into connexons SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1, GJB2	3.90
2	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	3.66
3	Bart-pumphrey syndrome	Enrichment	GJB2	3.66
4	Vohwinkel syndrome	Enrichment	GJB2	3.66
5	Hypoplastic left heart syndrome 1	Enrichment	GJA1	3.66
6	Deafness, autosomal dominant 3a	Enrichment	GJB2	3.66
7	Keratitis-ichthyosis-deafness syndrome, autosomal dominant	Enrichment	GJB2	3.66
8	Oculodentodigital dysplasia	Enrichment	GJA1	3.66
9	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	3.66
10	Ichthyosis, hystrix-like, with deafness	Enrichment	GJB2	3.66
11	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	3.66
12	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	3.66
13	Porokeratotic eccrine ostial and dermal duct nevus	Enrichment	GJB2	3.66
14	Autosomal dominant nonsyndromic hearing loss 3a	Enrichment	GJB2	3.66
15	Spinocerebellar ataxia, x-linked 1	Enrichment	GJB1	3.35
16	Hallermann-streiff syndrome	Enrichment	GJA1	3.35
17	Syndactyly, type iii	Enrichment	GJA1	3.35
18	Syndactyly, type v	Enrichment	GJA1	3.35
19	Deafness, autosomal recessive 104	Enrichment	GJB2	3.35
20	Craniometaphyseal dysplasia	Enrichment	GJA1	3.35
21	Deafness, autosomal recessive 1b	Enrichment	GJB2	3.35
22	Keratitis ichthyosis and deafness syndrome	Enrichment	GJB2	3.35
23	Hereditary palmoplantar keratoderma	Enrichment	GJB2	3.35
24	Keratoderma, palmoplantar, with deafness	Enrichment	GJB2	3.18
25	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	GJB2	3.18
26	Charcot-marie-tooth disease, x-linked dominant, 1	Enrichment	GJB1	3.18
27	Deafness, x-linked 2	Enrichment	GJB2	3.18
28	X-linked mixed hearing loss with perilymphatic gusher	Enrichment	GJB2	3.18
29	Deafness, autosomal recessive 1a	Enrichment	GJB2	3.05
30	Gjb2-related autosomal recessive nonsyndromic hearing loss	Enrichment	GJB2	3.05
31	Hypertrophic neuropathy of dejerine-sottas	Enrichment	GJB1	2.96
32	Cleft upper lip	Enrichment	GJA1	2.96
33	Sensory peripheral neuropathy	Enrichment	GJB1	2.96
34	Deafness, autosomal recessive 12	Enrichment	GJB2	2.88
35	Pain disorder	Enrichment	GJB1	2.88
36	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	2.75
37	Hypoplastic left heart syndrome	Enrichment	GJA1	2.75
38	Noonan syndrome 1	Enrichment	GJB2	2.29
39	Ear malformation	Enrichment	GJB2	2.28
40	Peripheral nervous system disease	Enrichment	GJB1	2.15
41	Neuropathy	Enrichment	GJB1	2.15
42	Non-syndromic genetic deafness	Enrichment	GJB2	2.10
43	Charcot-marie-tooth disease	Enrichment	GJB1	2.04
44	Nonsyndromic hearing loss	Enrichment	GJB2	2.03
45	Sensorineural hearing loss	Enrichment	GJB2	1.98
46	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GJB2	1.94
47	Deafness, autosomal recessive	Enrichment	GJB2	1.86
48	Autosomal recessive nonsyndromic deafness	Enrichment	GJB2	1.85
49	Rare genetic deafness	Enrichment	GJB2	1.76
50	Autism spectrum disorder	Enrichment	GJB2	1.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Oligomerization of connexins into connexons

Pathway Network for Oligomerization of connexins into connexons

Member Pathways for Oligomerization of connexins into connexons

Pathways in the Oligomerization of connexins into connexons SuperPath

Associated Genes for Oligomerization of connexins into connexons

Associated Disorders for Oligomerization of connexins into connexons

Disorders associated with Oligomerization of connexins into connexons SuperPath

STRING Interaction Network for Oligomerization of connexins into connexons

Sources for Oligomerization of connexins into connexons