Oncogene Induced Senescence

No Pathway Network information available for Oncogene Induced Senescence

Pathways in the Oncogene Induced Senescence SuperPath

#	Name	Source	Genes
1	Oncogene Induced Senescence	Reactome	AGO1 AGO3 AGO4 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CDKN2D E2F1 E2F2 E2F3 ERF ETS1 ETS2 ID1 MAPK1 MAPK3 MDM2 MDM4 MOV10 RB1 RPS27A SP1 TFDP1 TFDP2 TNRC6A TNRC6B TNRC6C TP53 UBA52 UBB UBC (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
2	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
4	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
5	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	1
6	CDKN2D	Cyclin Dependent Kinase Inhibitor 2D	Protein Coding	1
7	E2F1	E2F Transcription Factor 1	Protein Coding	1
8	E2F2	E2F Transcription Factor 2	Protein Coding	1
9	E2F3	E2F Transcription Factor 3	Protein Coding	1
10	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
11	AGO4	Argonaute RISC Component 4	Protein Coding	1
12	ERF	ETS2 Repressor Factor	Protein Coding	1
13	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
14	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
15	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
16	AGO1	Argonaute RISC Component 1	Protein Coding	1
17	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	1
18	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
19	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
20	MDM4	MDM4 Regulator Of P53	Protein Coding	1
21	MOV10	Mov10 RNA Helicase	Protein Coding	1
22	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
23	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
24	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
25	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
26	RPS27A	Ribosomal Protein S27a	Protein Coding	1
27	SP1	Sp1 Transcription Factor	Protein Coding	1
28	TFDP1	Transcription Factor Dp-1	Protein Coding	1
29	TFDP2	Transcription Factor Dp-2	Protein Coding	1
30	TP53	Tumor Protein P53	Protein Coding	1
31	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
32	UBB	Ubiquitin B	Protein Coding	1
33	UBC	Ubiquitin C	Protein Coding	1

Disorders associated with Oncogene Induced Senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	6.58
2	Lip and oral cavity carcinoma	Enrichment	CDKN2A, RB1, TP53	5.55
3	Melanoma, cutaneous malignant 1	Enrichment	CDK4, CDKN2A, CDKN2B	5.06
4	Osteogenic sarcoma	Enrichment	RB1, TP53	4.76
5	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	4.76
6	Squamous cell carcinoma	Enrichment	RB1, TP53	4.76
7	Bone osteosarcoma	Enrichment	RB1, TP53	4.76
8	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	4.76
9	Small cell cancer of the lung	Enrichment	RB1, TP53	4.46
10	Bladder cancer	Enrichment	CDKN2A, RB1, TP53	4.34
11	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	4.07
12	Multiple endocrine neoplasia, type i	Enrichment	CDKN2B, CDKN2C	3.92
13	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.92
14	Gastric cancer	Enrichment	CDK4, CDKN2A, TP53	3.82
15	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN2A, RB1, TP53	3.55
16	Myeloma, multiple	Enrichment	CDKN2C, ERF, TP53	3.48
17	Lung cancer susceptibility 3	Enrichment	RB1, TP53	3.29
18	Pancreatic cancer	Enrichment	CDKN2A, TP53	2.78
19	Ovarian cancer	Enrichment	CDKN2A, RB1, TP53	2.73
20	Craniosynostosis 4	Enrichment	ERF	2.61
21	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.61
22	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.61
23	Accelerated tumor formation	Enrichment	MDM2	2.61
24	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.61
25	Noonan syndrome 13	Enrichment	MAPK1	2.61
26	Lessel-kubisch syndrome	Enrichment	MDM2	2.61
27	Bone marrow failure syndrome 6	Enrichment	MDM4	2.61
28	Bone marrow failure syndrome 5	Enrichment	TP53	2.61
29	Papilloma of choroid plexus	Enrichment	TP53	2.61
30	Basal cell carcinoma 7	Enrichment	TP53	2.61
31	Anaplastic thyroid carcinoma	Enrichment	TP53	2.61
32	Ductal carcinoma in situ	Enrichment	TP53	2.61
33	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.61
34	Chitayat syndrome	Enrichment	ERF	2.61
35	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.61
36	Trilateral retinoblastoma	Enrichment	RB1	2.61
37	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.61
38	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.61
39	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.61
40	Choroid plexus cancer	Enrichment	TP53	2.61
41	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.61
42	Lung oat cell carcinoma	Enrichment	RB1	2.61
43	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.31
44	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.31
45	Cervical cancer	Enrichment	TP53	2.31
46	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.31
47	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.31
48	Lymphoma, hodgkin, classic	Enrichment	TP53	2.31
49	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.31
50	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.31
51	Congenital fibrosarcoma	Enrichment	TP53	2.31
52	Li-fraumeni syndrome 1	Enrichment	TP53	2.31
53	Sarcoma	Enrichment	TP53	2.31
54	Cervix carcinoma	Enrichment	TP53	2.31
55	Hodgkin's lymphoma	Enrichment	TP53	2.31
56	Familial retinoblastoma	Enrichment	RB1	2.31
57	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.31
58	Submucosal cleft palate	Enrichment	UBB	2.31
59	Cleft hard palate	Enrichment	UBB	2.31
60	Crouzon syndrome	Enrichment	ERF	2.14
61	Craniosynostosis 1	Enrichment	ERF	2.14
62	Jacobsen syndrome	Enrichment	ETS1	2.14
63	Retinoblastoma	Enrichment	RB1	2.14
64	Uvula, bifid	Enrichment	UBB	2.14
65	Cleft soft palate	Enrichment	UBB	2.14
66	Nasopharyngeal carcinoma	Enrichment	TP53	2.14
67	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.14
68	Hypotrichosis 8	Enrichment	RB1	2.14
69	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.14
70	Anaplastic astrocytoma	Enrichment	TP53	2.14
71	Adenocarcinoma	Enrichment	TP53	2.14
72	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.01
73	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.01
74	Lynch syndrome 4	Enrichment	RB1	2.01
75	Lung sarcomatoid carcinoma	Enrichment	TP53	2.01
76	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.01
77	Rhabdomyosarcoma 2	Enrichment	TP53	1.92
78	Lymphoma	Enrichment	TP53	1.92
79	Acute megakaryocytic leukemia	Enrichment	TP53	1.92
80	Breast cancer	Enrichment	CDKN2B, TP53	1.85
81	Breast adenocarcinoma	Enrichment	TP53	1.84
82	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.84
83	Esophageal cancer	Enrichment	TP53	1.77
84	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.77
85	Essential thrombocythemia	Enrichment	TP53	1.77
86	Gallbladder cancer	Enrichment	TP53	1.77
87	Glioma susceptibility 1	Enrichment	TP53	1.71
88	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.71
89	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.66
90	Adult hepatocellular carcinoma	Enrichment	TP53	1.66
91	Primary hyperaldosteronism	Enrichment	TP53	1.66
92	Leukemia, chronic lymphocytic	Enrichment	TP53	1.62
93	Melanoma	Enrichment	CDKN2A	1.62
94	Familial colorectal cancer	Enrichment	TP53	1.62
95	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.58
96	Myelodysplastic syndrome	Enrichment	TP53	1.58
97	Specific learning disability	Enrichment	MAPK1	1.58
98	Complex neurodevelopmental disorder	Enrichment	AGO1, TNRC6B	1.44
99	Rhabdomyosarcoma	Enrichment	TP53	1.42
100	Gliosarcoma	Enrichment	TP53	1.42
101	Giant cell glioblastoma	Enrichment	TP53	1.39
102	Heart, malformation of	Enrichment	MAPK1	1.37
103	Diffuse large b-cell lymphoma	Enrichment	TP53	1.34
104	Hepatoblastoma	Enrichment	TP53	1.30
105	Hepatocellular carcinoma	Enrichment	TP53	1.28
106	Diamond-blackfan anemia 1	Enrichment	TP53	1.26
107	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	1.26
108	Prostate cancer	Enrichment	TP53	1.17
109	Primary autosomal recessive microcephaly	Enrichment	CDK6	1.12
110	Diamond-blackfan anemia	Enrichment	TP53	1.08
111	Systemic lupus erythematosus	Enrichment	ETS1	1.04
112	Leukemia, acute myeloid	Enrichment	TP53	1.03
113	Hereditary breast carcinoma	Enrichment	TP53	0.99
114	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.90
115	Colorectal cancer	Enrichment	TP53	0.72
116	Autism spectrum disorder	Enrichment	TNRC6B	0.63
117	Microcephaly	Enrichment	MAPK1	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Oncogene Induced Senescence

Pathway Network for Oncogene Induced Senescence

Member Pathways for Oncogene Induced Senescence

Pathways in the Oncogene Induced Senescence SuperPath

Associated Genes for Oncogene Induced Senescence

Associated Disorders for Oncogene Induced Senescence

Disorders associated with Oncogene Induced Senescence SuperPath

STRING Interaction Network for Oncogene Induced Senescence

Sources for Oncogene Induced Senescence