Oncogenic MAPK signaling

No Pathway Network information available for Oncogenic MAPK signaling

Pathways in the Oncogenic MAPK signaling SuperPath

#	Name	Source	Genes
1	Oncogenic MAPK signaling	Reactome	ACTB ACTG1 AGGF1 AGK AGTRAP AKAP9 AP3B1 APBB1IP ARAF ARRB1 ARRB2 ATG7 BCL2L11 BRAF BRAP CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CLCN6 CNKSR1 CNKSR2 CSK DUSP10 DUSP16 DUSP6 DUSP7 DUSP8 DUSP9 ESRP1 FAM114A2 FAM131B FGA FGB FGG FN1 FXR1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KDM7A KIAA1549 KRAS KSR1 KSR2 LMNA MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MPRIP MRAS NF1 NRAS PAPSS1 PEBP1 PHB1 PPP1CB PPP1CC QKI RAF1 RAP1A RAP1B SHOC2 SND1 SPRED1 SPRED2 SPRED3 SRC TENT4A TLN1 TRAK1 TRIM24 VCL VWF YWHAB ZC3HAV1 (see all 84) (see less)
2	Signaling by BRAF and RAF1 fusions	Reactome	ACTB ACTG1 AGGF1 AGK AGTRAP AKAP9 AP3B1 APBB1IP ARAF ARRB1 ARRB2 ATG7 BCL2L11 BRAF CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CLCN6 CNKSR1 CNKSR2 CSK ESRP1 FAM114A2 FAM131B FGA FGB FGG FN1 FXR1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KDM7A KIAA1549 KRAS KSR1 KSR2 LMNA MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MPRIP NRAS PAPSS1 PEBP1 QKI RAF1 RAP1A RAP1B SND1 SRC TENT4A TLN1 TRAK1 TRIM24 VCL VWF YWHAB ZC3HAV1 (see all 67) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL2L11	BCL2 Like 11	Protein Coding	2
2	AKAP9	A-Kinase Anchoring Protein 9	Protein Coding	2
3	CNKSR1	Connector Enhancer Of Kinase Suppressor Of Ras 1	Protein Coding	2
4	ATG7	Autophagy Related 7	Protein Coding	2
5	FAM114A2	Family With Sequence Similarity 114 Member A2	Protein Coding	2
6	TENT4A	Terminal Nucleotidyltransferase 4A	Protein Coding	2
7	CLCN6	Chloride Voltage-Gated Channel 6	Protein Coding	2
8	CSK	C-Terminal Src Kinase	Protein Coding	2
9	FGA	Fibrinogen Alpha Chain	Protein Coding	2
10	FGB	Fibrinogen Beta Chain	Protein Coding	2
11	FGG	Fibrinogen Gamma Chain	Protein Coding	2
12	CNKSR2	Connector Enhancer Of Kinase Suppressor Of Ras 2	Protein Coding	2
13	TRAK1	Trafficking Kinesin Protein 1	Protein Coding	2
14	MPRIP	Myosin Phosphatase Rho Interacting Protein	Protein Coding	2
15	FN1	Fibronectin 1	Protein Coding	2
16	SND1	Staphylococcal Nuclease And Tudor Domain Containing 1	Protein Coding	2
17	KSR2	Kinase Suppressor Of Ras 2	Protein Coding	2
18	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
19	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	2
20	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
21	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
22	JAK2	Janus Kinase 2	Protein Coding	2
23	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
24	LMNA	Lamin A/C	Protein Coding	2
25	ARRB1	Arrestin Beta 1	Protein Coding	2
26	ARRB2	Arrestin Beta 2	Protein Coding	2
27	MARK3	Microtubule Affinity Regulating Kinase 3	Protein Coding	2
28	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
29	PEBP1	Phosphatidylethanolamine Binding Protein 1	Protein Coding	2
30	APBB1IP	Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein	Protein Coding	2
31	ESRP1	Epithelial Splicing Regulatory Protein 1	Protein Coding	2
32	AGGF1	Angiogenic Factor With G-Patch And FHA Domains 1	Protein Coding	2
33	AGK	Acylglycerol Kinase	Protein Coding	2
34	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
35	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
36	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
37	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
38	ZC3HAV1	Zinc Finger CCCH-Type Containing, Antiviral 1	Protein Coding	2
39	AGTRAP	Angiotensin II Receptor Associated Protein	Protein Coding	2
40	KIAA1549	KIAA1549	Protein Coding	2
41	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
42	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
43	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	2
44	ACTB	Actin Beta	Protein Coding	2
45	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
46	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
47	TLN1	Talin 1	Protein Coding	2
48	ACTG1	Actin Gamma 1	Protein Coding	2
49	VCL	Vinculin	Protein Coding	2
50	VWF	Von Willebrand Factor	Protein Coding	2
51	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
52	CALM1	Calmodulin 1	Protein Coding	2
53	CALM2	Calmodulin 2	Protein Coding	2
54	CALM3	Calmodulin 3	Protein Coding	2
55	KDM7A	Lysine Demethylase 7A	Protein Coding	2
56	FXR1	FMR1 Autosomal Homolog 1	Protein Coding	2
57	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	2
58	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	2
59	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	2
60	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	2
61	AP3B1	Adaptor Related Protein Complex 3 Subunit Beta 1	Protein Coding	2
62	TRIM24	Tripartite Motif Containing 24	Protein Coding	2
63	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	2
64	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	2
65	PAPSS1	3''-Phosphoadenosine 5''-Phosphosulfate Synthase 1	Protein Coding	2
66	QKI	QKI, KH Domain Containing RNA Binding	Protein Coding	2
67	FAM131B	Family With Sequence Similarity 131 Member B	Protein Coding	2
68	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	1
69	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	1
70	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
71	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	1
72	DUSP8	Dual Specificity Phosphatase 8	Protein Coding	1
73	DUSP9	Dual Specificity Phosphatase 9	Protein Coding	1
74	SPRED2	Sprouty Related EVH1 Domain Containing 2	Protein Coding	1
75	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
76	SPRED3	Sprouty Related EVH1 Domain Containing 3	Protein Coding	1
77	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
78	NF1	Neurofibromin 1	Protein Coding	1
79	PHB1	Prohibitin 1	Protein Coding	1
80	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
81	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
82	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	1
83	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1
84	BRAP	BRCA1 Associated Protein	Protein Coding	1

Disorders associated with Oncogenic MAPK signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, PPP1CB, RAF1, SHOC2, SPRED2	16.00
2	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NF1, NRAS, PPP1CB, RAF1, SHOC2	16.00
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.88
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.24
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.24
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	8.94
7	Pilomyxoid astrocytoma	Enrichment	BRAF, KIAA1549, KRAS, RAF1	7.72
8	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	7.43
9	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.94
10	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.94
11	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	6.94
12	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	6.94
13	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, TRIM24	6.56
14	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.34
15	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.34
16	Thrombocytopenia	Enrichment	FGG, ITGA2B, ITGB3, SRC, VWF	5.44
17	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.40
18	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	5.40
19	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	5.40
20	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	5.40
21	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.20
22	Long qt syndrome 1	Enrichment	AKAP9, CALM1, CALM2, CALM3	4.87
23	Long qt syndrome	Enrichment	AKAP9, CALM1, CALM2, LMNA	4.81
24	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.62
25	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.62
26	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB, SHOC2	4.42
27	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NF1, NRAS	4.32
28	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.14
29	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.14
30	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.84
31	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.84
32	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	3.65
33	Pilocytic astrocytoma	Enrichment	KRAS, NF1	3.65
34	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	3.45
35	Myelofibrosis	Enrichment	JAK2, SRC	3.30
36	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.30
37	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.30
38	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.30
39	Gallbladder cancer	Enrichment	BRAF, KRAS	3.30
40	Dilated cardiomyopathy	Enrichment	BRAF, LMNA, RAF1, VCL	3.19
41	Bladder cancer	Enrichment	HRAS, KRAS, NF1	3.13
42	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.07
43	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	3.00
44	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.98
45	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	2.98
46	Neurofibromatosis, type i	Enrichment	NF1, SPRED1	2.88
47	Leukemia, acute lymphoblastic 3	Enrichment	JAK2, NF1	2.88
48	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	2.81
49	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.68
50	Familial isolated dilated cardiomyopathy	Enrichment	LMNA, RAF1, VCL	2.65
51	Microcephaly	Enrichment	ACTB, ACTG1, CAMK2B, MAPK1	2.50
52	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.41
53	Rhabdomyosarcoma	Enrichment	HRAS, NF1	2.37
54	Dandy-walker syndrome	Enrichment	BRAF, PPP1CB	2.31
55	Von willebrand disease, type 1	Enrichment	VWF	2.31
56	Baraitser-winter syndrome 1	Enrichment	ACTB	2.31
57	Oculoectodermal syndrome	Enrichment	KRAS	2.31
58	Pallister-killian syndrome	Enrichment	ARAF	2.31
59	Noonan syndrome 5	Enrichment	RAF1	2.31
60	Melorheostosis, isolated	Enrichment	MAP2K1	2.31
61	Noonan syndrome 7	Enrichment	BRAF	2.31
62	Leopard syndrome 3	Enrichment	BRAF	2.31
63	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.31
64	Von willebrand disease, type 2	Enrichment	VWF	2.31
65	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.31
66	Melanosis, neurocutaneous	Enrichment	NRAS	2.31
67	Noonan syndrome 6	Enrichment	NRAS	2.31
68	Noonan syndrome 13	Enrichment	MAPK1	2.31
69	Intellectual developmental disorder, x-linked, syndromic, houge type	Enrichment	CNKSR2	2.31
70	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.31
71	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.31
72	Von willebrand disease, type 3	Enrichment	VWF	2.31
73	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.31
74	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.31
75	Cataract 38	Enrichment	AGK	2.31
76	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.31
77	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.31
78	Lymphangioma	Enrichment	BRAF	2.31
79	Long qt syndrome 11	Enrichment	AKAP9	2.31
80	Phace association	Enrichment	BRAF	2.31
81	Becker nevus syndrome	Enrichment	ACTB	2.31
82	Melorheostosis	Enrichment	MAP2K1	2.31
83	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.31
84	Leopard syndrome 2	Enrichment	RAF1	2.31
85	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.31
86	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.31
87	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.31
88	Long qt syndrome 16	Enrichment	CALM3	2.31
89	Visual impairment and progressive phthisis bulbi	Enrichment	MARK3	2.31
90	Thrombocytopenia 6	Enrichment	SRC	2.31
91	Atypical werner syndrome	Enrichment	LMNA	2.31
92	Retinitis pigmentosa 86	Enrichment	KIAA1549	2.31
93	Von willebrand's disease	Enrichment	VWF	2.31
94	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.31
95	Developmental and epileptic encephalopathy 68	Enrichment	TRAK1	2.31
96	Congenital myopathy 9b, proximal, with minicore lesions	Enrichment	FXR1	2.31
97	Congenital myopathy 9a	Enrichment	FXR1	2.31
98	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.31
99	Ceroid lipofuscinosis, neuronal, 15	Enrichment	CLCN6	2.31
100	Trigonitis	Enrichment	RAF1	2.31
101	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.31
102	Hermansky-pudlak syndrome due to ap3b1 deficiency	Enrichment	AP3B1	2.31
103	Long qt syndrome 15	Enrichment	CALM2	2.31
104	Baraitser-winter syndrome	Enrichment	ACTB	2.31
105	Mandibuloacral dysplasia	Enrichment	LMNA	2.31
106	Atrioventricular block	Enrichment	LMNA	2.31
107	Congenital fibrinogen deficiency	Enrichment	FGG	2.31
108	Congenital pulmonary airway malformation	Enrichment	KRAS	2.31
109	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.31
110	Capillary leak syndrome	Enrichment	TLN1	2.31
111	Syringocystadenoma papilliferum	Enrichment	BRAF	2.31
112	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.31
113	Ganglioglioma	Enrichment	BRAF	2.31
114	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.31
115	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.31
116	Phace syndrome	Enrichment	BRAF	2.31
117	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.31
118	Classic hairy cell leukemia	Enrichment	BRAF	2.31
119	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.31
120	Neurocutaneous melanocytosis	Enrichment	NRAS	2.31
121	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.31
122	Laminopathy	Enrichment	LMNA	2.31
123	Myeloma, multiple	Enrichment	BRAF, KRAS, NF1	2.30
124	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA, RAF1	2.21
125	Legius syndrome	Enrichment	SPRED1	2.21
126	Noonan syndrome 11	Enrichment	MRAS	2.21
127	Noonan syndrome 14	Enrichment	SPRED2	2.21
128	Noonan syndrome-like disorder with loose anagen hair 1	Enrichment	SHOC2	2.21
129	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.21
130	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.21
131	Plexiform neurofibroma	Enrichment	NF1	2.21
132	Neurofibroma	Enrichment	NF1	2.21
133	Neurofibromatosis	Enrichment	NF1	2.21
134	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.21
135	Optic nerve glioma	Enrichment	NF1	2.21
136	Brugada syndrome	Enrichment	AKAP9, LMNA	2.14
137	Skin disease	Enrichment	CLCN6, NF1	2.09
138	Colorectal cancer	Enrichment	BRAF, NRAS, SRC	2.04
139	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.01
140	Costello syndrome	Enrichment	HRAS	2.01
141	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.01
142	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.01
143	Pulmonic stenosis	Enrichment	BRAF	2.01
144	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.01
145	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.01
146	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.01
147	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.01
148	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.01
149	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.01
150	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.01
151	Fatty liver disease 1	Enrichment	ATG7	2.01
152	Thrombocythemia 3	Enrichment	JAK2	2.01
153	Long qt syndrome 14	Enrichment	CALM1	2.01
154	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.01
155	Restrictive dermopathy 2	Enrichment	LMNA	2.01
156	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.01
157	Deafness, autosomal recessive 109	Enrichment	ESRP1	2.01
158	Hermansky-pudlak syndrome 2	Enrichment	AP3B1	2.01
159	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.01
160	Spinocerebellar ataxia, autosomal recessive 31	Enrichment	ATG7	2.01
161	Neurogenic bladder	Enrichment	CLCN6	2.01
162	Respiratory system disease	Enrichment	CLCN6	2.01
163	Angiocentric glioma	Enrichment	QKI	2.01
164	Polycythemia	Enrichment	JAK2	2.01
165	Familial partial lipodystrophy	Enrichment	LMNA	2.01
166	Hypereosinophilic syndrome	Enrichment	JAK2	2.01
167	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.01
168	Non-syndromic syndactyly	Enrichment	AGGF1	2.01
169	Tafro syndrome	Enrichment	MAP2K2	2.01
170	Wooly hair nevus	Enrichment	HRAS	2.01
171	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.99
172	Lung cancer	Enrichment	BRAF, KRAS	1.97
173	Cafe-au-lait spots, multiple	Enrichment	NF1	1.91
174	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	1.91
175	Bardet-biedl syndrome 9	Enrichment	NF1	1.91
176	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	1.91
177	Left ventricular noncompaction	Enrichment	LMNA, RAF1	1.89
178	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.83
179	Myotonia congenita, autosomal dominant	Enrichment	FAM131B	1.83
180	Ataxia-telangiectasia	Enrichment	BRAF	1.83
181	Myotonia congenita, autosomal recessive	Enrichment	FAM131B	1.83
182	Sengers syndrome	Enrichment	AGK	1.83
183	Polycythemia vera	Enrichment	JAK2	1.83
184	Periventricular nodular heterotopia 1	Enrichment	VWF	1.83
185	Restrictive dermopathy 1	Enrichment	LMNA	1.83
186	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.83
187	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.83
188	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.83
189	Tethered spinal cord syndrome	Enrichment	BRAF	1.83
190	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.83
191	Restrictive dermopathy	Enrichment	LMNA	1.83
192	Spermatocytoma	Enrichment	HRAS	1.83
193	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.83
194	Watson syndrome	Enrichment	NF1	1.73
195	Neurofibromatosis, familial spinal	Enrichment	NF1	1.73
196	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.73
197	Polycystic kidney disease 4	Enrichment	SHOC2	1.73
198	Brain cancer	Enrichment	NF1	1.73
199	Erythrocytosis, familial, 1	Enrichment	JAK2	1.71
200	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.71
201	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.71
202	Trichohepatoenteric syndrome 1	Enrichment	AGK	1.71
203	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.71
204	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.71
205	Budd-chiari syndrome	Enrichment	JAK2	1.71
206	Microtia-anotia	Enrichment	LMNA	1.71
207	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.71
208	Aminoacylase 1 deficiency	Enrichment	ACTB	1.71
209	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.71
210	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.71
211	Craniopharyngioma	Enrichment	BRAF	1.71
212	Newborn respiratory distress syndrome	Enrichment	BRAF	1.71
213	Epidermolytic nevus	Enrichment	HRAS	1.71
214	Sick sinus syndrome	Enrichment	LMNA	1.71
215	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.71
216	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.61
217	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.61
218	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.61
219	Myeloproliferative neoplasm	Enrichment	JAK2	1.61
220	Histiocytoid hemangioma	Enrichment	LMNA	1.61
221	Coloboma of choroid and retina	Enrichment	ACTG1	1.61
222	Embryonal rhabdomyosarcoma	Enrichment	NF1	1.61
223	Middle aortic syndrome	Enrichment	NF1	1.61
224	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B	1.60
225	Gastric cancer	Enrichment	KRAS, NF1	1.54
226	Klippel-trenaunay-weber syndrome	Enrichment	AGGF1	1.53
227	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.53
228	Wilms tumor 5	Enrichment	BRAF	1.53
229	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.53
230	Breast adenocarcinoma	Enrichment	KRAS	1.53
231	Lung squamous cell carcinoma	Enrichment	KRAS	1.53
232	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	SHOC2	1.51
233	Rhabdomyosarcoma 2	Enrichment	NF1	1.51
234	Undetermined early-onset epileptic encephalopathy	Enrichment	CNKSR2, TRAK1	1.51
235	Bethlem myopathy 1a	Enrichment	LMNA	1.47
236	Thrombophilia due to thrombin defect	Enrichment	FGA	1.47
237	Essential thrombocythemia	Enrichment	JAK2	1.47
238	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.41
239	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.41
240	Congenital muscular dystrophy	Enrichment	LMNA	1.41
241	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.41
242	Myocarditis	Enrichment	LMNA	1.41
243	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.36
244	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.36
245	Primary hyperaldosteronism	Enrichment	BRAF	1.36
246	Ventricular septal defect	Enrichment	BRAF	1.36
247	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, NF1	1.34
248	Cat eye syndrome	Enrichment	ACTG1	1.32
249	Melanoma	Enrichment	BRAF	1.32
250	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	SHOC2	1.31
251	Ewing sarcoma	Enrichment	NF1	1.31
252	Movement disease	Enrichment	CLCN6	1.28
253	Specific learning disability	Enrichment	MAPK1	1.28
254	Cardiac conduction defect	Enrichment	LMNA	1.24
255	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.24
256	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.24
257	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.24
258	Protein-deficiency anemia	Enrichment	NRAS	1.21
259	Pectus excavatum	Enrichment	SHOC2	1.18
260	Osteoporosis	Enrichment	SRC	1.17
261	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.17
262	Wilms tumor 1	Enrichment	BRAF	1.14
263	Hermansky-pudlak syndrome	Enrichment	AP3B1	1.14
264	Lynch syndrome	Enrichment	KRAS	1.14
265	Hermansky-pudlak syndrome 1	Enrichment	AP3B1	1.12
266	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.12
267	Breast cancer	Enrichment	KRAS, PHB1	1.10
268	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.09
269	Sudden infant death syndrome	Enrichment	CALM2	1.09
270	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.09
271	Cataract 44	Enrichment	AGK	1.09
272	Pheochromocytoma	Enrichment	NF1	1.08
273	Heart, malformation of	Enrichment	MAPK1	1.07
274	Neuromuscular disease	Enrichment	LMNA	1.07
275	Ovarian cancer	Enrichment	KRAS, TRIM24	1.05
276	Male infertility with spermatogenesis disorder	Enrichment	SPRED1	1.05
277	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.05
278	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.05
279	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.01
280	Lissencephaly	Enrichment	ACTG1	1.01
281	Myocardial infarction	Enrichment	ITGB3	0.99
282	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	0.98
283	Autoinflammatory disease	Enrichment	AP3B1	0.95
284	Muscular dystrophy	Enrichment	LMNA	0.95
285	Pancreatic cancer	Enrichment	KRAS	0.93
286	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.92
287	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	0.91
288	Kallmann syndrome	Enrichment	DUSP6	0.88
289	Autism spectrum disorder	Enrichment	MAP2K1, NF1	0.83
290	Peripheral nervous system disease	Enrichment	LMNA	0.83
291	Neuropathy	Enrichment	LMNA	0.83
292	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.82
293	Cakut	Enrichment	ACTG1	0.81
294	Dystonia	Enrichment	CAMK2B	0.80
295	Non-syndromic x-linked intellectual disability	Enrichment	CNKSR2	0.79
296	Non-syndromic genetic deafness	Enrichment	ACTG1	0.79
297	Charcot-marie-tooth disease	Enrichment	LMNA	0.74
298	Nonsyndromic hearing loss	Enrichment	ACTG1	0.73
299	Nephrotic syndrome	Enrichment	FN1	0.72
300	Hereditary breast carcinoma	Enrichment	KRAS	0.71
301	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.64
302	Primary ovarian insufficiency	Enrichment	JAK2	0.60
303	Autism	Enrichment	CAMK2G	0.52
304	Rare genetic deafness	Enrichment	ACTG1	0.49
305	Mitochondrial disease	Enrichment	AGK	0.45
306	Congenital nervous system abnormality	Enrichment	CAMK2B	0.39
307	Nervous system disease	Enrichment	CAMK2B	0.39
308	Inherited cancer-predisposing syndrome	Enrichment	NF1	0.25
309	Retinitis pigmentosa	Enrichment	KIAA1549	0.19
310	Hereditary retinal dystrophy	Enrichment	KIAA1549	0.12
311	Fundus dystrophy	Enrichment	KIAA1549	0.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Oncogenic MAPK signaling

Pathway Network for Oncogenic MAPK signaling

Member Pathways for Oncogenic MAPK signaling

Pathways in the Oncogenic MAPK signaling SuperPath

Associated Genes for Oncogenic MAPK signaling

Associated Disorders for Oncogenic MAPK signaling

Disorders associated with Oncogenic MAPK signaling SuperPath

STRING Interaction Network for Oncogenic MAPK signaling

Sources for Oncogenic MAPK signaling