One-carbon metabolism and related pathways

Pathway network for the One-carbon metabolism and related pathways SuperPath

Sources:

WikiPathways
PubChem

Pathways in the One-carbon metabolism and related pathways SuperPath

#	Name	Source	Genes
1	One-carbon metabolism and related pathways	WikiPathways	AGXT2 AHCYL1 BAAT BCAT1 BCAT2 BHMT BHMT2 CDO1 CEPT1 CHDH CHKA CHKB CHPT1 CSAD CTH DHFR2 DMGDH DNM1 DNMT3A ETNK1 ETNK2 GAD1 GAD2 GCLC GCLM GNMT GPX1 GPX2 GPX3 GPX4 GPX5 GPX6 GPX7 GSR GSS LOC102724560 MAT1A MAT2A MTHFR MTR PCYT1A PCYT1B PCYT2 PEMT PLD1 SARDH SHMT1 SHMT2 SOD1 SOD3 TYMS (see all 51) (see less)
2	Trans-sulfuration, one-carbon metabolism and related pathways	WikiPathways	AGXT2 AHCY AHCYL1 AHCYL2 AMT BAAT BCAT1 BCAT2 BHMT BHMT2 CBS CDO1 CEPT1 CHDH CHKA CHKB CHPT1 CSAD CTH DHFR DHFR2 DMGDH DNM1 DNMT3A DNMT3B DNMT3L ETNK1 ETNK2 GAD1 GAD2 GCLC GCLM GNMT GPX1 GPX2 GPX3 GPX4 GPX5 GPX6 GPX7 GSR GSS LOC102724560 MAT1A MAT2A MAT2B MTHFD1 MTHFD1L MTHFD2 MTHFD2L MTHFR MTR PCYT1A PCYT1B PCYT2 PEMT PHGDH PLD1 PSAT1 PSPH SARDH SHMT1 SHMT2 SOD1 SOD3 TYMS (see all 66) (see less)
3	dTMP de novo biosynthesis (mitochondrial)	PubChem	DHFR2 SHMT2 TYMS

Gene overlap in member pathways for One-carbon metabolism and related pathways SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TYMS	Thymidylate Synthetase	Protein Coding	3
2	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	3
3	DHFR2	Dihydrofolate Reductase 2	Protein Coding	3
4	PCYT2	Phosphate Cytidylyltransferase 2, Ethanolamine	Protein Coding	2
5	BAAT	Bile Acid-CoA:Amino Acid N-Acyltransferase	Protein Coding	2
6	ETNK2	Ethanolamine Kinase 2	Protein Coding	2
7	GPX7	Glutathione Peroxidase 7	Protein Coding	2
8	CEPT1	Choline/Ethanolamine Phosphotransferase 1	Protein Coding	2
9	PCYT1B	Phosphate Cytidylyltransferase 1B, Choline	Protein Coding	2
10	SOD3	Superoxide Dismutase 3	Protein Coding	2
11	SOD1	Superoxide Dismutase 1	Protein Coding	2
12	AGXT2	Alanine--Glyoxylate Aminotransferase 2	Protein Coding	2
13	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	2
14	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	2
15	BCAT2	Branched Chain Amino Acid Transaminase 2	Protein Coding	2
16	BCAT1	Branched Chain Amino Acid Transaminase 1	Protein Coding	2
17	CHPT1	Choline Phosphotransferase 1	Protein Coding	2
18	ETNK1	Ethanolamine Kinase 1	Protein Coding	2
19	CHDH	Choline Dehydrogenase	Protein Coding	2
20	PLD1	Phospholipase D1	Protein Coding	2
21	CSAD	Cysteine Sulfinic Acid Decarboxylase	Protein Coding	2
22	PCYT1A	Phosphate Cytidylyltransferase 1A, Choline	Protein Coding	2
23	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	2
24	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	2
25	MAT2A	Methionine Adenosyltransferase 2A	Protein Coding	2
26	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	2
27	DMGDH	Dimethylglycine Dehydrogenase	Protein Coding	2
28	GSS	Glutathione Synthetase	Protein Coding	2
29	GSR	Glutathione-Disulfide Reductase	Protein Coding	2
30	GPX5	Glutathione Peroxidase 5	Protein Coding	2
31	GPX4	Glutathione Peroxidase 4	Protein Coding	2
32	GPX3	Glutathione Peroxidase 3	Protein Coding	2
33	GPX2	Glutathione Peroxidase 2	Protein Coding	2
34	GPX1	Glutathione Peroxidase 1	Protein Coding	2
35	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	2
36	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	2
37	GNMT	Glycine N-Methyltransferase	Protein Coding	2
38	GPX6	Glutathione Peroxidase 6	Protein Coding	2
39	GAD2	Glutamate Decarboxylase 2	Protein Coding	2
40	GAD1	Glutamate Decarboxylase 1	Protein Coding	2
41	BHMT2	Betaine--Homocysteine S-Methyltransferase 2	Protein Coding	2
42	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	2
43	DNM1	Dynamin 1	Protein Coding	2
44	SARDH	Sarcosine Dehydrogenase	Protein Coding	2
45	CTH	Cystathionine Gamma-Lyase	Protein Coding	2
46	CHKB	Choline Kinase Beta	Protein Coding	2
47	CHKA	Choline Kinase Alpha	Protein Coding	2
48	PEMT	Phosphatidylethanolamine N-Methyltransferase	Protein Coding	2
49	CDO1	Cysteine Dioxygenase Type 1	Protein Coding	2
50	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	2
51	LOC102724560	Cystathionine Beta-Synthase Like	Protein Coding	2
52	MTHFD2L	Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2 Like	Protein Coding	1
53	CBS	Cystathionine Beta-Synthase	Protein Coding	1
54	PSPH	Phosphoserine Phosphatase	Protein Coding	1
55	MTHFD1	Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1	Protein Coding	1
56	PSAT1	Phosphoserine Aminotransferase 1	Protein Coding	1
57	AMT	Aminomethyltransferase	Protein Coding	1
58	PHGDH	Phosphoglycerate Dehydrogenase	Protein Coding	1
59	AHCYL2	Adenosylhomocysteinase Like 2	Protein Coding	1
60	AHCY	Adenosylhomocysteinase	Protein Coding	1
61	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	1
62	DHFR	Dihydrofolate Reductase	Protein Coding	1
63	MTHFD2	Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase	Protein Coding	1
64	DNMT3L	DNA Methyltransferase 3 Like	Protein Coding	1
65	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	1
66	MTHFD1L	Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like	Protein Coding	1

Disorders associated with One-carbon metabolism and related pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neural tube defects, folate-sensitive	Enrichment	MTHFD1, MTHFR, MTR	6.36
2	Homocystinuria	Enrichment	CBS, MTR	4.16
3	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	3.66
4	Dyskeratosis congenita, digenic	Enrichment	TYMS	3.35
5	Myocardial infarction	Enrichment	GCLC, GCLM	2.52
6	Cystathioninuria	Enrichment	CTH	2.42
7	Beta-aminoisobutyric aciduria	Enrichment	AGXT2	2.42
8	Glutathione synthetase deficiency	Enrichment	GSS	2.42
9	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.42
10	Anemia, congenital, nonspherocytic hemolytic, 6	Enrichment	GSS	2.42
11	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	2.42
12	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.42
13	Homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity	Enrichment	MTHFR	2.42
14	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	2.42
15	Neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures	Enrichment	CHKA	2.42
16	Proximal myopathy with focal depletion of mitochondria	Enrichment	CHKB	2.42
17	Hypervalinemia and hyperleucine-isoleucinemia	Enrichment	BCAT2	2.42
18	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	2.42
19	Dimethylglycine dehydrogenase deficiency	Enrichment	DMGDH	2.42
20	Sarcosinemia	Enrichment	SARDH	2.42
21	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	2.42
22	Glutathione peroxidase deficiency	Enrichment	GPX1	2.42
23	Hypercholanemia, familial 3	Enrichment	BAAT	2.42
24	Dyskeratosis congenita	Enrichment	TYMS	2.38
25	Neu-laxova syndrome 1	Enrichment	PHGDH	2.31
26	Phosphoglycerate dehydrogenase deficiency	Enrichment	PHGDH	2.31
27	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	2.31
28	Hyperhomocysteinemia	Enrichment	CBS	2.31
29	Phosphoserine aminotransferase deficiency	Enrichment	PSAT1	2.31
30	Phosphoserine phosphatase deficiency	Enrichment	PSPH	2.31
31	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.31
32	Neu-laxova syndrome 2	Enrichment	PSAT1	2.31
33	Neurometabolic disorder due to serine deficiency	Enrichment	PSAT1	2.31
34	Neu-laxova syndrome due to 3-phosphoserine phosphatase deficiency	Enrichment	PSPH	2.31
35	Glycine n-methyltransferase deficiency	Enrichment	GNMT	2.12
36	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.12
37	Spondylometaphyseal dysplasia with cone-rod dystrophy	Enrichment	PCYT1A	2.12
38	Peroxisome biogenesis disorder 4b	Enrichment	GNMT	2.12
39	Spastic paraplegia 82, autosomal recessive	Enrichment	PCYT2	2.12
40	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.12
41	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	2.12
42	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.12
43	Isolated anencephaly	Enrichment	MTHFR	2.12
44	Lipodystrophy, congenital generalized, type 5	Enrichment	PCYT1A	2.12
45	Isolated exencephaly	Enrichment	MTHFR	2.12
46	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.12
47	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	2.01
48	Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia	Enrichment	MTHFD1	2.01
49	Glycine encephalopathy 2	Enrichment	AMT	2.01
50	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	2.01
51	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	1.95
52	Brown-vialetto-van laere syndrome 2	Enrichment	GNMT	1.95
53	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.95
54	West syndrome	Enrichment	DNM1, MTHFR	1.93
55	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	1.84
56	Familial adenomatous polyposis 4	Enrichment	DHFR	1.84
57	Muscular dystrophy, congenital, megaconial type	Enrichment	CHKB	1.83
58	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	1.83
59	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	1.83
60	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.73
61	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.73
62	Myeloproliferative neoplasm	Enrichment	DNMT3A	1.73
63	Glioblastoma	Enrichment	DNMT3A	1.73
64	Atypical glycine encephalopathy	Enrichment	AMT	1.71
65	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS, MAT2A	1.71
66	Familial hypercholanemia	Enrichment	BAAT	1.65
67	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	1.65
68	Thrombophilia due to thrombin defect	Enrichment	MTHFR	1.58
69	Motor neuron disease	Enrichment	SOD1	1.58
70	Facioscapulohumeral muscular dystrophy 1	Enrichment	DNMT3B	1.54
71	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B	1.54
72	Glycine encephalopathy	Enrichment	AMT	1.54
73	Lennox-gastaut syndrome	Enrichment	DNM1	1.53
74	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.43
75	Melanoma	Enrichment	DNMT3A	1.43
76	Glycine encephalopathy 1	Enrichment	AMT	1.42
77	Specific learning disability	Enrichment	DNMT3A	1.39
78	Neural tube defects	Enrichment	MTHFR	1.32
79	Stereotypic movement disorder	Enrichment	DNM1	1.32
80	Rare genetic intellectual disability	Enrichment	DNMT3A	1.26
81	Gliosarcoma	Enrichment	DNMT3A	1.23
82	Giant cell glioblastoma	Enrichment	DNMT3A	1.21
83	Diffuse large b-cell lymphoma	Enrichment	DNMT3A	1.16
84	Muscular dystrophy	Enrichment	CHKB	1.06
85	Endometrial cancer	Enrichment	DHFR	1.01
86	Cystic fibrosis	Enrichment	GCLC	0.94
87	Leukemia, acute myeloid	Enrichment	DNMT3A	0.85
88	Epilepsy	Enrichment	MTR	0.85
89	Connective tissue disease	Enrichment	CBS	0.84
90	Severe combined immunodeficiency	Enrichment	MTHFD1	0.83
91	Body mass index quantitative trait locus 11	Enrichment	DNMT3A	0.76
92	Myeloma, multiple	Enrichment	DNMT3A	0.72
93	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.72
94	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.71
95	Autosomal recessive non-syndromic intellectual disability	Enrichment	CHKA	0.71
96	Schizophrenia	Enrichment	MTHFR	0.70
97	Leber plus disease	Enrichment	PCYT1A	0.52
98	Congenital nervous system abnormality	Enrichment	DNMT3A	0.48
99	Nervous system disease	Enrichment	DNMT3A	0.48
100	Autism spectrum disorder	Enrichment	DNMT3A	0.47
101	Microcephaly	Enrichment	CHKA	0.43
102	Inherited cancer-predisposing syndrome	Enrichment	DHFR	0.32

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

One-carbon metabolism and related pathways

Pathway Network for One-carbon metabolism and related pathways

Pathway network for the One-carbon metabolism and related pathways SuperPath

Member Pathways for One-carbon metabolism and related pathways

Pathways in the One-carbon metabolism and related pathways SuperPath

Gene overlap in member pathways for One-carbon metabolism and related pathways SuperPath

Associated Genes for One-carbon metabolism and related pathways

Associated Disorders for One-carbon metabolism and related pathways

Disorders associated with One-carbon metabolism and related pathways SuperPath

STRING Interaction Network for One-carbon metabolism and related pathways

Sources for One-carbon metabolism and related pathways