Orexin receptor pathway

No Pathway Network information available for Orexin receptor pathway

Pathways in the Orexin receptor pathway SuperPath

#	Name	Source	Genes
1	Orexin receptor pathway	WikiPathways	ARRB1 ARRB2 BGLAP CASP3 CASP9 CREB1 DYNLT1 EIF4B EIF4EBP1 FOXO1 GNAQ HCRTR1 HCRTR2 HIF1A MAP2K1 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 PDK1 PDPK1 PIK3R1 PIK3R2 PRKCA PRKD1 PTPN11 RPS6 RPS6KA1 SLC1A2 SLC2A1 SMAD1 SMAD5 STAT3 TH VHL (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARRB1	Arrestin Beta 1	Protein Coding	1
2	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
3	PRKD1	Protein Kinase D1	Protein Coding	1
4	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
5	DYNLT1	Dynein Light Chain Tctex-Type 1	Protein Coding	1
6	SMAD1	SMAD Family Member 1	Protein Coding	1
7	SMAD5	SMAD Family Member 5	Protein Coding	1
8	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
9	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
10	TH	Tyrosine Hydroxylase	Protein Coding	1
11	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1
12	RPS6	Ribosomal Protein S6	Protein Coding	1
13	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
14	ARRB2	Arrestin Beta 2	Protein Coding	1
15	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
16	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
17	CASP9	Caspase 9	Protein Coding	1
18	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
19	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
20	FOXO1	Forkhead Box O1	Protein Coding	1
21	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
22	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
23	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
24	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
25	CASP3	Caspase 3	Protein Coding	1
26	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
27	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
28	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	1
29	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
30	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
31	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
32	PRKCA	Protein Kinase C Alpha	Protein Coding	1
33	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
34	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
35	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
36	HCRTR2	Hypocretin Receptor 2	Protein Coding	1
37	HCRTR1	Hypocretin Receptor 1	Protein Coding	1

Disorders associated with Orexin receptor pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A, VHL	3.82
2	Specific learning disability	Enrichment	MAPK1, PTPN11	3.41
3	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11	3.13
4	Diffuse large b-cell lymphoma	Enrichment	FOXO1, STAT3	2.92
5	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11	2.75
6	Rasopathy	Enrichment	MAP2K1, PTPN11	2.65
7	Strabismus	Enrichment	PTPN11, SLC2A1	2.61
8	Metachondromatosis	Enrichment	PTPN11	2.56
9	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.56
10	Melorheostosis, isolated	Enrichment	MAP2K1	2.56
11	Leopard syndrome 1	Enrichment	PTPN11	2.56
12	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.56
13	Developmental and epileptic encephalopathy 41	Enrichment	SLC1A2	2.56
14	Sturge-weber syndrome	Enrichment	GNAQ	2.56
15	Noonan syndrome 13	Enrichment	MAPK1	2.56
16	Short syndrome	Enrichment	PIK3R1	2.56
17	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.56
18	Melorheostosis	Enrichment	MAP2K1	2.56
19	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.56
20	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.56
21	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.56
22	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.56
23	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.56
24	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.56
25	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.56
26	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.56
27	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.56
28	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.56
29	Malignant astrocytoma	Enrichment	PTPN11	2.56
30	Retinal hemangioblastoma	Enrichment	VHL	2.56
31	Microcephaly	Enrichment	MAPK1, PTPN11, SLC2A1	2.35
32	Scoliosis, isolated 1	Enrichment	MAPK7	2.26
33	Dystonia 9	Enrichment	SLC2A1	2.26
34	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.26
35	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.26
36	Segawa syndrome, autosomal recessive	Enrichment	TH	2.26
37	Werner syndrome	Enrichment	PTPN11	2.26
38	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.26
39	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.26
40	Phakomatosis cesioflammea	Enrichment	GNAQ	2.26
41	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.09
42	Dystonia, dopa-responsive	Enrichment	TH	2.09
43	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	2.09
44	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.09
45	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.09
46	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.09
47	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.09
48	Primary polycythemia	Enrichment	VHL	2.09
49	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.09
50	Hyper ige syndrome	Enrichment	STAT3	2.09
51	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.09
52	Immunodeficiency 14	Enrichment	PIK3R1	2.09
53	Melanoma of soft tissue	Enrichment	CREB1	2.09
54	Tricuspid valve insufficiency	Enrichment	PTPN11	2.09
55	Anastomosing haemangioma	Enrichment	GNAQ	2.09
56	Enchondromatosis	Enrichment	HIF1A	2.09
57	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.96
58	Erythrocytosis, familial, 2	Enrichment	VHL	1.96
59	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.96
60	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.96
61	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.96
62	Au-kline syndrome	Enrichment	VHL	1.96
63	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.96
64	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.96
65	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.96
66	Capillary malformations, congenital	Enrichment	GNAQ	1.87
67	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.87
68	Fanconi anemia, complementation group d2	Enrichment	VHL	1.87
69	Von hippel-lindau syndrome	Enrichment	VHL	1.87
70	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.87
71	Lymphoma	Enrichment	PTPN11	1.87
72	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.79
73	Melanoma, uveal	Enrichment	GNAQ	1.79
74	Patent ductus arteriosus	Enrichment	PTPN11	1.79
75	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	VHL	1.79
76	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.72
77	Renal cell carcinoma, papillary, 1	Enrichment	VHL	1.72
78	Noonan syndrome 3	Enrichment	PTPN11	1.72
79	Paroxysmal dystonia	Enrichment	SLC2A1	1.72
80	Overgrowth syndrome	Enrichment	PIK3R1	1.72
81	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.67
82	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.67
83	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.61
84	Arteriovenous malformation	Enrichment	MAP2K1	1.61
85	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.57
86	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.57
87	Pectus excavatum	Enrichment	PTPN11	1.53
88	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.53
89	Epicanthus	Enrichment	PTPN11	1.49
90	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.49
91	Congenital long qt syndrome	Enrichment	PTPN11	1.49
92	Acute promyelocytic leukemia	Enrichment	STAT3	1.46
93	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.45
94	Pheochromocytoma	Enrichment	VHL	1.43
95	Renal cell carcinoma, nonpapillary	Enrichment	VHL	1.40
96	Heart, malformation of	Enrichment	MAPK1	1.32
97	Patent foramen ovale	Enrichment	PTPN11	1.32
98	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, VHL	1.30
99	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.25
100	Scoliosis	Enrichment	PTPN11	1.20
101	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.18
102	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.16
103	Long qt syndrome 1	Enrichment	PTPN11	1.10
104	Non-immune hydrops fetalis	Enrichment	PTPN11	1.09
105	Fanconi anemia, complementation group a	Enrichment	VHL	1.04
106	Dystonia	Enrichment	TH	1.04
107	Epilepsy	Enrichment	SLC2A1	0.98
108	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	0.97
109	Centralopathic epilepsy	Enrichment	SLC2A1	0.95
110	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.95
111	West syndrome	Enrichment	SLC2A1	0.95
112	Thrombocytopenia	Enrichment	PTPN11	0.91
113	Myeloma, multiple	Enrichment	PIK3R2	0.85
114	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.85
115	Undetermined early-onset epileptic encephalopathy	Enrichment	SLC1A2	0.85
116	Colorectal cancer	Enrichment	PIK3R1	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Orexin receptor pathway

Pathway Network for Orexin receptor pathway

Member Pathways for Orexin receptor pathway

Pathways in the Orexin receptor pathway SuperPath

Associated Genes for Orexin receptor pathway

Associated Disorders for Orexin receptor pathway

Disorders associated with Orexin receptor pathway SuperPath

STRING Interaction Network for Orexin receptor pathway

Sources for Orexin receptor pathway