Osteoblast differentiation and related diseases

No Pathway Network information available for Osteoblast differentiation and related diseases

Pathways in the Osteoblast differentiation and related diseases SuperPath

#	Name	Source	Genes
1	Osteoblast differentiation and related diseases	WikiPathways	BMP2 BMP4 BMPR1A BMPR1B BMPR2 CTNNB1 DLL1 DLL3 DLL4 FGF18 FGF3 FGF6 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FZD10 FZD2 FZD4 FZD8 FZD9 GLI2 GLI3 HES2 HES3 HES6 HEY1 HEY2 IHH JAG1 JAG2 LRP5 LRP6 MYOD1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIK3C2G PIK3CA PPARG PRKCD PRKCZ PTCH1 RBPJ RUNX2 SMAD1 SMAD4 SMAD5 SMAD9 SMO SOX9 STAT1 WNT1 WNT10B WNT11 WNT2 WNT3 WNT5A WNT6 WNT7A WNT9B (see all 63) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	1
2	FGF18	Fibroblast Growth Factor 18	Protein Coding	1
3	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
4	FZD8	Frizzled Class Receptor 8	Protein Coding	1
5	FZD4	Frizzled Class Receptor 4	Protein Coding	1
6	WNT11	Wnt Family Member 11	Protein Coding	1
7	WNT10B	Wnt Family Member 10B	Protein Coding	1
8	WNT7A	Wnt Family Member 7A	Protein Coding	1
9	WNT5A	Wnt Family Member 5A	Protein Coding	1
10	WNT3	Wnt Family Member 3	Protein Coding	1
11	WNT2	Wnt Family Member 2	Protein Coding	1
12	WNT1	Wnt Family Member 1	Protein Coding	1
13	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
14	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
15	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
16	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	1
17	BMPR1B	Bone Morphogenetic Protein Receptor Type 1B	Protein Coding	1
18	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	1
19	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
20	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
21	PTCH1	Patched 1	Protein Coding	1
22	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
23	PRKCD	Protein Kinase C Delta	Protein Coding	1
24	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
25	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
26	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
27	NOTCH4	Notch Receptor 4	Protein Coding	1
28	NOTCH3	Notch Receptor 3	Protein Coding	1
29	NOTCH2	Notch Receptor 2	Protein Coding	1
30	NOTCH1	Notch Receptor 1	Protein Coding	1
31	MYOD1	Myogenic Differentiation 1	Protein Coding	1
32	SMAD9	SMAD Family Member 9	Protein Coding	1
33	SMAD5	SMAD Family Member 5	Protein Coding	1
34	SMAD4	SMAD Family Member 4	Protein Coding	1
35	SMAD1	SMAD Family Member 1	Protein Coding	1
36	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
37	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
38	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
39	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	1
40	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
41	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
42	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
43	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
44	FZD2	Frizzled Class Receptor 2	Protein Coding	1
45	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	1
46	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
47	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
48	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
49	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
50	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
51	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
52	FGF6	Fibroblast Growth Factor 6	Protein Coding	1
53	FGF3	Fibroblast Growth Factor 3	Protein Coding	1
54	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
55	CTNNB1	Catenin Beta 1	Protein Coding	1
56	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
57	FZD10	Frizzled Class Receptor 10	Protein Coding	1
58	FZD9	Frizzled Class Receptor 9	Protein Coding	1
59	WNT9B	Wnt Family Member 9B	Protein Coding	1
60	WNT6	Wnt Family Member 6	Protein Coding	1
61	HES6	Hes Family BHLH Transcription Factor 6	Protein Coding	1
62	HES2	Hes Family BHLH Transcription Factor 2	Protein Coding	1
63	HES3	Hes Family BHLH Transcription Factor 3	Protein Coding	1

Disorders associated with Osteoblast differentiation and related diseases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2, PIK3CA	7.02
2	Colorectal cancer	Enrichment	CTNNB1, FGFR2, FGFR3, PIK3CA, PPARG, SMAD4, SOX9	6.84
3	Microform holoprosencephaly	Enrichment	DLL1, FGFR1, GLI2, PTCH1	6.13
4	Lobar holoprosencephaly	Enrichment	DLL1, FGFR1, GLI2, PTCH1	6.13
5	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	6.02
6	Semilobar holoprosencephaly	Enrichment	DLL1, FGFR1, GLI2, PTCH1	5.91
7	Craniosynostosis	Enrichment	FGFR2, FGFR3, GLI2, GLI3	5.71
8	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	5.48
9	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA, SMAD4	5.48
10	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	5.28
11	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.67
12	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.67
13	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.67
14	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.67
15	Septopreoptic holoprosencephaly	Enrichment	DLL1, GLI2, PTCH1	4.38
16	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1, GLI2, PTCH1	4.38
17	Gliosarcoma	Enrichment	FGFR1, FGFR3, PPARG	4.29
18	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	4.21
19	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3, PPARG	4.21
20	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	4.21
21	Alobar holoprosencephaly	Enrichment	DLL1, GLI2, PTCH1	4.21
22	Brachydactyly, type a1	Enrichment	BMPR1B, IHH	4.20
23	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.20
24	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.20
25	Juvenile polyposis syndrome	Enrichment	BMPR1A, SMAD4	4.20
26	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2, SMAD9	4.20
27	Hepatoblastoma	Enrichment	CTNNB1, FGFR3, JAG1	3.92
28	Brachydactyly, type a2	Enrichment	BMP2, BMPR1B	3.90
29	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2, WNT5A	3.90
30	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.90
31	Retinopathy of prematurity	Enrichment	FZD4, LRP5	3.90
32	Cerebrovascular disease	Enrichment	NOTCH3, PIK3CA	3.90
33	Autosomal dominant robinow syndrome	Enrichment	FZD2, WNT5A	3.90
34	Tooth agenesis	Enrichment	FGFR1, LRP6, WNT10B	3.86
35	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.68
36	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2, WNT5A	3.68
37	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A, SMAD4	3.68
38	Tetralogy of fallot	Enrichment	HEY2, JAG1, NOTCH1	3.64
39	Autosomal recessive robinow syndrome	Enrichment	FZD2, WNT5A	3.50
40	Lung squamous cell carcinoma	Enrichment	FGFR3, PIK3CA	3.50
41	Bladder cancer	Enrichment	CTNNB1, FGFR3, PIK3CA	3.49
42	Hirschsprung disease 1	Enrichment	GLI3, IHH, SMO	3.49
43	Connective tissue disease	Enrichment	FGFR3, NOTCH1, SOX9	3.37
44	Nevus, epidermal	Enrichment	FGFR3, PIK3CA	3.36
45	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.13
46	Gastric cancer	Enrichment	FGFR2, PIK3CA, SMAD4	2.99
47	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	HEY2, NOTCH1, SMAD4	2.96
48	Heritable pulmonary arterial hypertension	Enrichment	BMPR2, SMAD9	2.94
49	Ovarian cancer	Enrichment	BMPR1A, CTNNB1, PIK3CA, PTCH1	2.91
50	Renal hypodysplasia/aplasia 3	Enrichment	BMP4, FGFR3	2.87
51	Meningioma	Enrichment	PIK3CA, SMO	2.87
52	Osteoporosis	Enrichment	LRP5, WNT1	2.73
53	Medulloblastoma	Enrichment	CTNNB1, PTCH1	2.73
54	Polydactyly, postaxial, type a1	Enrichment	GLI3, PTCH1	2.67
55	Endometrial cancer	Enrichment	FGFR2, PIK3CA	2.38
56	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.34
57	Pallister-hall syndrome	Enrichment	GLI3	2.33
58	Hypochondroplasia	Enrichment	FGFR3	2.33
59	Macrodactyly	Enrichment	PIK3CA	2.33
60	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.33
61	Osteoglophonic dysplasia	Enrichment	FGFR1	2.33
62	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.33
63	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.33
64	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.33
65	Trigonocephaly 1	Enrichment	FGFR1	2.33
66	Muenke syndrome	Enrichment	FGFR3	2.33
67	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.33
68	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.33
69	Curry-jones syndrome	Enrichment	SMO	2.33
70	Schilbach-rott syndrome	Enrichment	PTCH1	2.33
71	Polydactyly, preaxial iv	Enrichment	GLI3	2.33
72	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.33
73	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	2.33
74	Acromesomelic dysplasia 3	Enrichment	BMPR1B	2.33
75	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.33
76	Omodysplasia 2	Enrichment	FZD2	2.33
77	Apert syndrome	Enrichment	FGFR2	2.33
78	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.33
79	Alagille syndrome 2	Enrichment	NOTCH2	2.33
80	Lateral meningocele syndrome	Enrichment	NOTCH3	2.33
81	Cowden syndrome 5	Enrichment	PIK3CA	2.33
82	Split-hand/foot malformation 6	Enrichment	WNT10B	2.33
83	Tooth agenesis, selective, 7	Enrichment	LRP6	2.33
84	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.33
85	Tooth agenesis, selective, 8	Enrichment	WNT10B	2.33
86	Brachydactyly, type a1, d	Enrichment	BMPR1B	2.33
87	Culler-jones syndrome	Enrichment	GLI2	2.33
88	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.33
89	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.33
90	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.33
91	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.33
92	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.33
93	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.33
94	46,xy sex reversal 10	Enrichment	SOX9	2.33
95	Adams-oliver syndrome 6	Enrichment	DLL4	2.33
96	46,xx sex reversal 2	Enrichment	SOX9	2.33
97	Microphthalmia, syndromic 6	Enrichment	BMP4	2.33
98	Orofacial cleft 11	Enrichment	BMP4	2.33
99	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.33
100	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.33
101	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.33
102	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.33
103	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.33
104	Acrocapitofemoral dysplasia	Enrichment	IHH	2.33
105	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.33
106	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.33
107	Santos syndrome	Enrichment	WNT7A	2.33
108	Holoprosencephaly 9	Enrichment	GLI2	2.33
109	Multiple synostoses syndrome 3	Enrichment	FGF9	2.33
110	Immunodeficiency 31a	Enrichment	STAT1	2.33
111	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.33
112	Congenital myopathy 17	Enrichment	MYOD1	2.33
113	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.33
114	Immunodeficiency 31b	Enrichment	STAT1	2.33
115	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.33
116	Hartsfield syndrome	Enrichment	FGFR1	2.33
117	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.33
118	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.33
119	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.33
120	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.33
121	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.33
122	Adenoid ameloblastoma	Enrichment	CTNNB1	2.33
123	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.33
124	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.33
125	Heritable thoracic aortic disease	Enrichment	SMAD4	2.33
126	Hypospadias	Enrichment	PIK3CA	2.33
127	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.33
128	Transient cerebral ischemia	Enrichment	NOTCH3	2.33
129	Primary pulmonary hypertension	Enrichment	BMPR2	2.33
130	Rare venous malformation	Enrichment	PIK3CA	2.33
131	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.33
132	Pulmonary hypertension	Enrichment	BMPR2	2.33
133	Turner syndrome	Enrichment	PTCH1	2.33
134	Diaphragmatic eventration	Enrichment	PIK3CA	2.33
135	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.33
136	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	2.33
137	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.33
138	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.33
139	Rare combined vascular malformation	Enrichment	PIK3CA	2.33
140	Cavernous lymphangioma	Enrichment	PIK3CA	2.33
141	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.33
142	Monosomy 9q22.3	Enrichment	PTCH1	2.33
143	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.33
144	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.33
145	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.33
146	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.33
147	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.33
148	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.33
149	Macrodactyly of toe	Enrichment	PIK3CA	2.33
150	Microcystic stromal tumor	Enrichment	CTNNB1	2.33
151	Brittle bone disorder	Enrichment	LRP5, WNT1	2.30
152	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.03
153	Myhre syndrome	Enrichment	SMAD4	2.03
154	Campomelic dysplasia	Enrichment	SOX9	2.03
155	Otodental dysplasia	Enrichment	FGF3	2.03
156	Van buchem disease	Enrichment	LRP5	2.03
157	Pallister-hall-like syndrome	Enrichment	SMO	2.03
158	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	2.03
159	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	2.03
160	Bladder exstrophy and epispadias complex	Enrichment	WNT3	2.03
161	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.03
162	Carotid intimal medial thickness 1	Enrichment	PPARG	2.03
163	Cervical cancer	Enrichment	FGFR3	2.03
164	Tetraamelia syndrome 1	Enrichment	WNT3	2.03
165	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.03
166	Aural atresia, congenital	Enrichment	FGFR2	2.03
167	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.03
168	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	2.03
169	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.03
170	Fibrodysplasia ossificans progressiva	Enrichment	BMPR2	2.03
171	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.03
172	White-sutton syndrome	Enrichment	GLI2	2.03
173	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	2.03
174	Noonan syndrome 8	Enrichment	PIK3CA	2.03
175	Spermatogenic failure 17	Enrichment	PIK3C2G	2.03
176	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	2.03
177	Adams-oliver syndrome 3	Enrichment	RBPJ	2.03
178	Immunodeficiency 31c	Enrichment	STAT1	2.03
179	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.03
180	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.03
181	Infantile myofibromatosis	Enrichment	NOTCH3	2.03
182	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	2.03
183	Tibial hemimelia	Enrichment	GLI3	2.03
184	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.03
185	Split hand-foot malformation	Enrichment	FGFR2	2.03
186	Synpolydactyly	Enrichment	GLI3	2.03
187	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.03
188	Depressive disorder	Enrichment	NOTCH3	2.03
189	Cervix carcinoma	Enrichment	FGFR3	2.03
190	Craniosynostosis 7	Enrichment	BMP2	2.03
191	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A	2.03
192	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.03
193	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.03
194	Postaxial polydactyly type b	Enrichment	GLI3	2.03
195	Familial partial lipodystrophy	Enrichment	PPARG	2.03
196	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.03
197	Pulmonary venoocclusive disease	Enrichment	BMPR2	2.03
198	Teratoma	Enrichment	CTNNB1	2.03
199	Osteosclerosis	Enrichment	LRP5	2.03
200	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	2.03
201	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.03
202	Oculootodental syndrome	Enrichment	FGF3	2.03
203	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.03
204	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.03
205	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.86
206	Desmoid disease, hereditary	Enrichment	CTNNB1	1.86
207	Achondroplasia	Enrichment	FGFR3	1.86
208	Brachydactyly, type c	Enrichment	BMPR1B	1.86
209	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.86
210	Larsen syndrome	Enrichment	FGFR3	1.86
211	Alagille syndrome 1	Enrichment	JAG1	1.86
212	Acromesomelic dysplasia 2a	Enrichment	BMPR1B	1.86
213	Acromesomelic dysplasia 2c	Enrichment	BMPR1B	1.86
214	Acromesomelic dysplasia 2b	Enrichment	BMPR1B	1.86
215	Acrocallosal syndrome	Enrichment	GLI3	1.86
216	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.86
217	Aarskog-scott syndrome	Enrichment	GLI3	1.86
218	46,xx sex reversal 1	Enrichment	SOX9	1.86
219	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	1.86
220	Osteoporosis, juvenile	Enrichment	WNT1	1.86
221	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.86
222	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.86
223	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.86
224	Holoprosencephaly 7	Enrichment	PTCH1	1.86
225	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.86
226	Anus, imperforate	Enrichment	CTNNB1	1.86
227	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.86
228	Umbilical hernia	Enrichment	GLI3	1.86
229	Desmoid tumor	Enrichment	CTNNB1	1.86
230	Hamartoma	Enrichment	FGFR3	1.86
231	Testicular germ cell cancer	Enrichment	FGFR3	1.86
232	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	1.86
233	Cleidocranial dysplasia	Enrichment	RUNX2	1.86
234	Migraine without aura	Enrichment	NOTCH3	1.86
235	Spermatocytoma	Enrichment	FGFR3	1.86
236	Tetraamelia syndrome	Enrichment	WNT3	1.86
237	Testicular cancer	Enrichment	FGFR3	1.86
238	Type 2 diabetes mellitus	Enrichment	PPARG, RBPJ	1.79
239	Polydactyly, preaxial ii	Enrichment	PTCH1	1.73
240	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.73
241	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.73
242	Pilomatrixoma	Enrichment	CTNNB1	1.73
243	Leptin deficiency or dysfunction	Enrichment	PPARG	1.73
244	Alazami syndrome	Enrichment	CTNNB1	1.73
245	Congenital generalized lipodystrophy	Enrichment	PPARG	1.73
246	Multiple synostoses syndrome	Enrichment	FGF9	1.73
247	Orofacial cleft	Enrichment	LRP6	1.73
248	Craniopharyngioma	Enrichment	CTNNB1	1.73
249	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.73
250	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.73
251	Glioma	Enrichment	FGFR2	1.73
252	Vitreoretinopathy	Enrichment	LRP5	1.73
253	Orofacial clefting syndrome	Enrichment	LRP6	1.73
254	Middle aortic syndrome	Enrichment	JAG1	1.73
255	Capillary malformations, congenital	Enrichment	PIK3CA	1.64
256	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.64
257	Norrie disease	Enrichment	FZD4	1.64
258	Ventricular septal defect 1	Enrichment	BMP2	1.64
259	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.64
260	Holoprosencephaly	Enrichment	FGFR1	1.64
261	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.64
262	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9	1.64
263	Aplasia cutis congenita	Enrichment	DLL4	1.64
264	Vascular dementia	Enrichment	NOTCH3	1.64
265	Hemimegalencephaly	Enrichment	PIK3CA	1.64
266	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.64
267	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A, PTCH1, SMAD4	1.63
268	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.62
269	Atrial septal defect 1	Enrichment	BMP2	1.56
270	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.56
271	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.56
272	Cowden syndrome 1	Enrichment	PIK3CA	1.56
273	Basal cell nevus syndrome 1	Enrichment	PTCH1	1.56
274	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.56
275	Split-hand/foot malformation 1	Enrichment	FGFR2	1.56
276	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.56
277	Pierre robin syndrome	Enrichment	SOX9	1.56
278	Holoprosencephaly 1	Enrichment	FGFR1	1.56
279	Testicular germ cell tumor	Enrichment	FGFR3	1.56
280	Anterior segment dysgenesis 5	Enrichment	BMP4	1.56
281	Renal dysplasia, cystic	Enrichment	WNT9B	1.56
282	Basal cell carcinoma 1	Enrichment	PTCH1	1.56
283	Renal hypoplasia	Enrichment	WNT9B	1.56
284	Adrenocortical carcinoma	Enrichment	CTNNB1	1.56
285	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.56
286	Breast adenocarcinoma	Enrichment	PIK3CA	1.56
287	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3	1.56
288	46,xy disorder of sex development	Enrichment	FGFR3	1.56
289	Coats disease	Enrichment	FZD4	1.49
290	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.49
291	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.49
292	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.49
293	Congenital hydrocephalus	Enrichment	PTCH1	1.49
294	Overgrowth syndrome	Enrichment	PTCH1	1.49
295	Hemochromatosis, type 1	Enrichment	BMP2	1.44
296	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	1.44
297	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.44
298	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.44
299	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.44
300	Combined pituitary hormone deficiency	Enrichment	GLI2	1.44
301	Tooth agenesis, selective, 1	Enrichment	BMPR2	1.39
302	Arteriovenous malformation	Enrichment	PIK3CA	1.39
303	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.39
304	Cowden syndrome	Enrichment	PIK3CA	1.39
305	Renal agenesis, bilateral	Enrichment	WNT9B	1.39
306	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.34
307	Peters-plus syndrome	Enrichment	BMP4	1.34
308	Stroke, ischemic	Enrichment	NOTCH3	1.34
309	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.34
310	Stickler syndrome	Enrichment	BMP4	1.34
311	Primary bone dysplasia	Enrichment	FGFR3	1.34
312	Migraine with or without aura 1	Enrichment	NOTCH3	1.30
313	46,xy complete gonadal dysgenesis	Enrichment	SOX9	1.30
314	Osteochondrodysplasia	Enrichment	FGFR3	1.30
315	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.30
316	Familial colorectal cancer type x	Enrichment	BMPR1A	1.30
317	Septooptic dysplasia	Enrichment	FGFR1	1.26
318	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.26
319	Aortic valve disease 1	Enrichment	NOTCH1	1.23
320	Diaphragmatic hernia, congenital	Enrichment	GLI3	1.23
321	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.23
322	Pulmonary hypertension, primary, 1	Enrichment	BMPR2	1.23
323	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.23
324	Chronic kidney disease	Enrichment	WNT9B	1.23
325	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.20
326	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.20
327	Cleft lip/palate	Enrichment	BMP4	1.20
328	46,xy partial gonadal dysgenesis	Enrichment	SOX9	1.20
329	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.17
330	Hydrocephalus	Enrichment	FGFR2	1.17
331	Lynch syndrome	Enrichment	PIK3CA	1.17
332	Rhabdomyosarcoma	Enrichment	PTCH1	1.14
333	Heart, malformation of	Enrichment	JAG1	1.09
334	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.09
335	Congenital nervous system abnormality	Enrichment	CTNNB1, FGFR3	1.06
336	Nervous system disease	Enrichment	CTNNB1, FGFR3	1.06
337	Macs syndrome	Enrichment	PTCH1	1.05
338	Microphthalmia	Enrichment	PTCH1	1.01
339	Kallmann syndrome	Enrichment	FGFR1	0.99
340	Pancreatic cancer	Enrichment	SMAD4	0.96
341	Auditory neuropathy	Enrichment	NOTCH3	0.94
342	Prostate cancer	Enrichment	PIK3CA	0.90
343	Differentiated thyroid carcinoma	Enrichment	PPARG	0.90
344	Lung cancer	Enrichment	PIK3CA	0.86
345	Hereditary retinal dystrophy	Enrichment	FZD4, JAG1, LRP5	0.82
346	Fundus dystrophy	Enrichment	FZD4, JAG1, LRP5	0.82
347	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	0.80
348	Distal arthrogryposis	Enrichment	MYOD1	0.75
349	Nephrotic syndrome	Enrichment	RUNX2	0.74
350	Hereditary breast carcinoma	Enrichment	PIK3CA	0.73
351	Thrombocytopenia	Enrichment	SMAD4	0.70
352	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.68
353	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.68
354	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	0.65
355	Myeloma, multiple	Enrichment	FGFR3	0.64
356	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.64
357	Primary ovarian insufficiency	Enrichment	NOTCH2	0.62
358	Breast cancer	Enrichment	PIK3CA	0.53
359	Microcephaly	Enrichment	CTNNB1	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Osteoblast differentiation and related diseases

Pathway Network for Osteoblast differentiation and related diseases

Member Pathways for Osteoblast differentiation and related diseases

Pathways in the Osteoblast differentiation and related diseases SuperPath

Associated Genes for Osteoblast differentiation and related diseases

Associated Disorders for Osteoblast differentiation and related diseases

Disorders associated with Osteoblast differentiation and related diseases SuperPath

STRING Interaction Network for Osteoblast differentiation and related diseases

Sources for Osteoblast differentiation and related diseases