Osteopontin-mediated events

No Pathway Network information available for Osteopontin-mediated events

Pathways in the Osteopontin-mediated events SuperPath

#	Name	Source	Genes
1	Osteopontin-mediated events	PubChem	ACTA1 BCAR1 CD44 CDC42 CHUK FOS GSN ILK ITGAV ITGB3 JUN MAP3K1 MAP3K14 MAPK3 MAPK8 MMP2 MMP9 NFKB1 NFKBIA PIK3CA PIK3R1 PIP5K1A PLAU PTK2B RAC1 RELA RHOA ROCK2 SPP1 SYK VAV3 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
2	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
3	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
4	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
5	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
6	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
7	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
8	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
9	GSN	Gelsolin	Protein Coding	1
10	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
11	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
12	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
13	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
14	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
15	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
16	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
17	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
18	ILK	Integrin Linked Kinase	Protein Coding	1
19	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
20	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
21	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
22	CDC42	Cell Division Cycle 42	Protein Coding	1
23	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
24	RHOA	Ras Homolog Family Member A	Protein Coding	1
25	RAC1	Rac Family Small GTPase 1	Protein Coding	1
26	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
27	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
28	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
29	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
30	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
31	MMP9	Matrix Metallopeptidase 9	Protein Coding	1

Disorders associated with Osteopontin-mediated events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.82
2	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.12
3	Macrodactyly	Enrichment	PIK3CA	2.64
4	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.64
5	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.64
6	Amyloidosis, finnish type	Enrichment	GSN	2.64
7	Cowden syndrome 5	Enrichment	PIK3CA	2.64
8	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.64
9	Fetal encasement syndrome	Enrichment	CHUK	2.64
10	46,xy sex reversal 6	Enrichment	MAP3K1	2.64
11	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.64
12	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.64
13	Short syndrome	Enrichment	PIK3R1	2.64
14	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.64
15	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.64
16	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.64
17	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.64
18	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.64
19	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.64
20	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.64
21	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.64
22	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.64
23	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.64
24	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.64
25	Hypospadias	Enrichment	PIK3CA	2.64
26	Colitis	Enrichment	SYK	2.64
27	Immunodeficiency 112	Enrichment	MAP3K14	2.64
28	Rare venous malformation	Enrichment	PIK3CA	2.64
29	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.64
30	Zebra body myopathy	Enrichment	ACTA1	2.64
31	Diaphragmatic eventration	Enrichment	PIK3CA	2.64
32	Nocarh syndrome	Enrichment	CDC42	2.64
33	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.64
34	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.64
35	Rare combined vascular malformation	Enrichment	PIK3CA	2.64
36	Cavernous lymphangioma	Enrichment	PIK3CA	2.64
37	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.64
38	Actin-accumulation myopathy	Enrichment	ACTA1	2.64
39	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.64
40	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.64
41	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.64
42	Macrodactyly of toe	Enrichment	PIK3CA	2.64
43	Nik deficiency	Enrichment	MAP3K14	2.64
44	Quebec platelet disorder	Enrichment	PLAU	2.34
45	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.34
46	Keratosis, seborrheic	Enrichment	PIK3CA	2.34
47	Noonan syndrome 8	Enrichment	PIK3CA	2.34
48	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
49	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.34
50	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.34
51	Rela fusion-positive ependymoma	Enrichment	RELA	2.34
52	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.34
53	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.34
54	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.34
55	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.34
56	Immune system disease	Enrichment	CDC42	2.34
57	Metaphyseal anadysplasia	Enrichment	MMP9	2.34
58	Arthritis	Enrichment	SYK	2.34
59	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
60	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.16
61	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.16
62	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.16
63	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.16
64	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.16
65	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.16
66	Immunodeficiency 14	Enrichment	PIK3R1	2.16
67	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.16
68	Keratoacanthoma	Enrichment	PIK3CA	2.16
69	Nemaline myopathy 2	Enrichment	ACTA1	2.04
70	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.04
71	Congenital generalized lipodystrophy	Enrichment	FOS	2.04
72	Cerebrovascular disease	Enrichment	PIK3CA	2.04
73	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.04
74	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.04
75	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.04
76	Intermediate nemaline myopathy	Enrichment	ACTA1	2.04
77	Capillary malformations, congenital	Enrichment	PIK3CA	1.94
78	Alzheimer disease 2	Enrichment	PLAU	1.94
79	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.94
80	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.94
81	Histiocytoid hemangioma	Enrichment	FOS	1.94
82	Hemimegalencephaly	Enrichment	PIK3CA	1.94
83	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.94
84	Breast cancer	Enrichment	JUN, PIK3CA	1.90
85	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.87
86	Cowden syndrome 1	Enrichment	PIK3CA	1.87
87	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.87
88	Breast adenocarcinoma	Enrichment	PIK3CA	1.87
89	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.87
90	Typical nemaline myopathy	Enrichment	ACTA1	1.87
91	Nevus, epidermal	Enrichment	PIK3CA	1.80
92	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.80
93	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.80
94	Gallbladder cancer	Enrichment	PIK3CA	1.80
95	Common variable immunodeficiency	Enrichment	NFKB1	1.80
96	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.80
97	Overgrowth syndrome	Enrichment	PIK3R1	1.80
98	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.78
99	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.69
100	Arteriovenous malformation	Enrichment	PIK3CA	1.69
101	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.69
102	Cowden syndrome	Enrichment	PIK3CA	1.69
103	Ovarian cancer	Enrichment	MAP3K1, PIK3CA	1.65
104	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.65
105	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
106	Nemaline myopathy	Enrichment	ACTA1	1.65
107	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.65
108	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.65
109	Immune deficiency disease	Enrichment	SYK	1.60
110	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.60
111	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.60
112	Meningioma	Enrichment	PIK3CA	1.57
113	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.57
114	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.50
115	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.47
116	Lynch syndrome	Enrichment	PIK3CA	1.47
117	Gliosarcoma	Enrichment	NFKBIA	1.44
118	Alzheimer disease, familial, 1	Enrichment	PLAU	1.42
119	Giant cell glioblastoma	Enrichment	NFKBIA	1.42
120	Neuromuscular disease	Enrichment	ACTA1	1.39
121	Congenital myopathy	Enrichment	ACTA1	1.37
122	Endometrial cancer	Enrichment	PIK3CA	1.33
123	Centronuclear myopathy	Enrichment	ACTA1	1.33
124	Hepatocellular carcinoma	Enrichment	PIK3CA	1.31
125	Myocardial infarction	Enrichment	ITGB3	1.31
126	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.24
127	Bladder cancer	Enrichment	PIK3CA	1.19
128	Prostate cancer	Enrichment	PIK3CA	1.19
129	Severe covid-19	Enrichment	ITGAV	1.19
130	Non-immune hydrops fetalis	Enrichment	ACTA1	1.16
131	Lung cancer	Enrichment	PIK3CA	1.15
132	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	1.09
133	Systemic lupus erythematosus	Enrichment	SPP1	1.07
134	Myopathy	Enrichment	ACTA1	1.06
135	Distal arthrogryposis	Enrichment	ACTA1	1.04
136	Gastric cancer	Enrichment	PIK3CA	1.03
137	Hereditary breast carcinoma	Enrichment	PIK3CA	1.02
138	Thrombocytopenia	Enrichment	ITGB3	0.98
139	Hypertelorism	Enrichment	PIK3CA	0.95
140	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.93
141	Dilated cardiomyopathy	Enrichment	ACTA1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Osteopontin-mediated events

Pathway Network for Osteopontin-mediated events

Member Pathways for Osteopontin-mediated events

Pathways in the Osteopontin-mediated events SuperPath

Associated Genes for Osteopontin-mediated events

Associated Disorders for Osteopontin-mediated events

Disorders associated with Osteopontin-mediated events SuperPath

STRING Interaction Network for Osteopontin-mediated events

Sources for Osteopontin-mediated events