Osteopontin signaling

No Pathway Network information available for Osteopontin signaling

Pathways in the Osteopontin signaling SuperPath

#	Name	Source	Genes
1	Osteopontin signaling	WikiPathways	CHUK IKBKB ITGAV ITGB3 MAP2K1 MAP3K14 MAPK1 MAPK3 MMP9 NFKB1 PLAU RELA SPP1 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
2	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
3	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
4	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
5	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
6	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
7	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
8	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
9	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
10	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
11	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
12	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
13	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1

Disorders associated with Osteopontin signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melorheostosis, isolated	Enrichment	MAP2K1	3.02
2	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.02
3	Fetal encasement syndrome	Enrichment	CHUK	3.02
4	Immunodeficiency 15b	Enrichment	IKBKB	3.02
5	Noonan syndrome 13	Enrichment	MAPK1	3.02
6	Immunodeficiency 15a	Enrichment	IKBKB	3.02
7	Melorheostosis	Enrichment	MAP2K1	3.02
8	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.02
9	Immunodeficiency 112	Enrichment	MAP3K14	3.02
10	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	3.02
11	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.02
12	Nik deficiency	Enrichment	MAP3K14	3.02
13	Quebec platelet disorder	Enrichment	PLAU	2.72
14	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.72
15	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.72
16	Rela fusion-positive ependymoma	Enrichment	RELA	2.72
17	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.72
18	Metaphyseal anadysplasia	Enrichment	MMP9	2.72
19	Common variable immunodeficiency 12	Enrichment	NFKB1	2.72
20	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.54
21	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.54
22	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.54
23	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.54
24	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.42
25	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.42
26	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.42
27	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.42
28	Alzheimer disease 2	Enrichment	PLAU	2.32
29	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.32
30	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	2.24
31	Glanzmann thrombasthenia 1	Enrichment	ITGB3	2.17
32	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	2.17
33	Common variable immunodeficiency	Enrichment	NFKB1	2.17
34	Arteriovenous malformation	Enrichment	MAP2K1	2.07
35	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	2.02
36	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.02
37	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	2.02
38	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.98
39	Specific learning disability	Enrichment	MAPK1	1.98
40	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1	1.85
41	Alzheimer disease, familial, 1	Enrichment	PLAU	1.79
42	Heart, malformation of	Enrichment	MAPK1	1.77
43	Myocardial infarction	Enrichment	ITGB3	1.68
44	Noonan syndrome 1	Enrichment	MAP2K1	1.66
45	Rasopathy	Enrichment	MAP2K1	1.61
46	Severe covid-19	Enrichment	ITGAV	1.56
47	Severe combined immunodeficiency	Enrichment	IKBKB	1.51
48	Systemic lupus erythematosus	Enrichment	SPP1	1.43
49	Thrombocytopenia	Enrichment	ITGB3	1.35
50	Autism spectrum disorder	Enrichment	MAP2K1	1.00
51	Microcephaly	Enrichment	MAPK1	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Osteopontin signaling

Pathway Network for Osteopontin signaling

Member Pathways for Osteopontin signaling

Pathways in the Osteopontin signaling SuperPath

Associated Genes for Osteopontin signaling

Associated Disorders for Osteopontin signaling

Disorders associated with Osteopontin signaling SuperPath

STRING Interaction Network for Osteopontin signaling

Sources for Osteopontin signaling