Ovarian infertility

No Pathway Network information available for Ovarian infertility

Pathways in the Ovarian infertility SuperPath

#	Name	Source	Genes
1	Ovarian infertility	WikiPathways	AKT1 ATM BMPR1B CCND2 CDK4 CDKN1B CEBPB CREB1 CYP19A1 DAZL DMC1 EGR1 ESR2 FIGLA FMR1 FSHR GDF9 GJA4 INHA LHCGR MLH1 MSH5 MTOR NCOR1 NR5A1 NRIP1 PGR PRLR PTGER2 RAD51 SMAD3 SMPD1 SYNE2 VDR ZP2 ZP3 (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
2	CCND2	Cyclin D2	Protein Coding	1
3	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
4	VDR	Vitamin D Receptor	Protein Coding	1
5	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
6	BMPR1B	Bone Morphogenetic Protein Receptor Type 1B	Protein Coding	1
7	RAD51	RAD51 Recombinase	Protein Coding	1
8	PTGER2	Prostaglandin E Receptor 2	Protein Coding	1
9	PRLR	Prolactin Receptor	Protein Coding	1
10	PGR	Progesterone Receptor	Protein Coding	1
11	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
12	MSH5	MutS Homolog 5	Protein Coding	1
13	MLH1	MutL Homolog 1	Protein Coding	1
14	SMAD3	SMAD Family Member 3	Protein Coding	1
15	LHCGR	Luteinizing Hormone/Choriogonadotropin Receptor	Protein Coding	1
16	INHA	Inhibin Subunit Alpha	Protein Coding	1
17	FIGLA	Folliculogenesis Specific BHLH Transcription Factor	Protein Coding	1
18	GJA4	Gap Junction Protein Alpha 4	Protein Coding	1
19	GDF9	Growth Differentiation Factor 9	Protein Coding	1
20	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	1
21	FSHR	Follicle Stimulating Hormone Receptor	Protein Coding	1
22	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
23	FMR1	Fragile X Messenger Ribonucleoprotein 1	Protein Coding	1
24	SYNE2	Spectrin Repeat Containing Nuclear Envelope Protein 2	Protein Coding	1
25	ESR2	Estrogen Receptor 2	Protein Coding	1
26	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
27	EGR1	Early Growth Response 1	Protein Coding	1
28	DAZL	Deleted In Azoospermia Like	Protein Coding	1
29	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	1
30	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
31	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
32	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
33	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
34	DMC1	DNA Meiotic Recombinase 1	Protein Coding	1
35	ZP3	Zona Pellucida Glycoprotein 3	Protein Coding	1
36	ZP2	Zona Pellucida Glycoprotein 2	Protein Coding	1

Disorders associated with Ovarian infertility SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	46 xx gonadal dysgenesis	Enrichment	FIGLA, FSHR, NR5A1	5.43
2	Hereditary breast carcinoma	Enrichment	AKT1, ATM, MLH1, RAD51	5.28
3	Oocyte/zygote/embryo maturation arrest 1	Enrichment	ZP2, ZP3	4.39
4	Breast cancer	Enrichment	AKT1, ATM, MLH1, RAD51	4.35
5	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MTOR	3.85
6	Gastric cancer	Enrichment	ATM, CDK4, MLH1	3.71
7	Colonic benign neoplasm	Enrichment	ATM, MLH1	3.61
8	Lynch syndrome 1	Enrichment	ATM, MLH1	3.52
9	Inherited cancer-predisposing syndrome	Enrichment	ATM, CDK4, CDKN1B, MLH1	3.40
10	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, MLH1, RAD51	3.39
11	Renal cell carcinoma, nonpapillary	Enrichment	ATM, MTOR	3.15
12	Azoospermia	Enrichment	DMC1, MSH5	2.90
13	Endometrial cancer	Enrichment	ATM, MLH1	2.86
14	Colorectal cancer	Enrichment	AKT1, ATM, MLH1	2.81
15	Ovarian cancer	Enrichment	AKT1, ATM, CDKN1B	2.62
16	Proteus syndrome	Enrichment	AKT1	2.58
17	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.58
18	Acromesomelic dysplasia 3	Enrichment	BMPR1B	2.58
19	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.58
20	Mirror movements 2	Enrichment	RAD51	2.58
21	Multiple fibroadenomas of the breast	Enrichment	PRLR	2.58
22	46,xx sex reversal 4	Enrichment	NR5A1	2.58
23	Brachydactyly, type a1, d	Enrichment	BMPR1B	2.58
24	Spermatogenic failure 8	Enrichment	NR5A1	2.58
25	Ovarian dysgenesis 1	Enrichment	FSHR	2.58
26	Fanconi anemia, complementation group r	Enrichment	RAD51	2.58
27	Twinning, dizygotic	Enrichment	FSHR	2.58
28	Progesterone resistance	Enrichment	PGR	2.58
29	Lynch syndrome 2	Enrichment	MLH1	2.58
30	Hyperprolactinemia	Enrichment	PRLR	2.58
31	Premature ovarian failure 6	Enrichment	FIGLA	2.58
32	Ovarian dysgenesis 8	Enrichment	ESR2	2.58
33	Ovarian hyperstimulation syndrome	Enrichment	FSHR	2.58
34	Oocyte/zygote/embryo maturation arrest 6	Enrichment	ZP2	2.58
35	Neuroendocrine tumor	Enrichment	CDKN1B	2.58
36	Emery-dreifuss muscular dystrophy 5, autosomal dominant	Enrichment	SYNE2	2.58
37	Cowden syndrome 6	Enrichment	AKT1	2.58
38	Amenorrhea	Enrichment	FSHR	2.58
39	Premature ovarian failure 7	Enrichment	NR5A1	2.58
40	Endometrial serous adenocarcinoma	Enrichment	ATM	2.58
41	Hemangioma of liver	Enrichment	GJA4	2.58
42	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.58
43	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.58
44	Premature ovarian failure 14	Enrichment	GDF9	2.58
45	Rickets	Enrichment	VDR	2.58
46	Familial hyperprolactinemia	Enrichment	PRLR	2.58
47	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.58
48	Skin hemangioma	Enrichment	GJA4	2.58
49	Xq27.3q28 duplication syndrome	Enrichment	FMR1	2.58
50	Muir-torre syndrome	Enrichment	MLH1	2.28
51	Precocious puberty, male-limited	Enrichment	LHCGR	2.28
52	Leydig cell hypoplasia, type i	Enrichment	LHCGR	2.28
53	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.28
54	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.28
55	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.28
56	Premature ovarian failure 13	Enrichment	MSH5	2.28
57	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.28
58	Oocyte/zygote/embryo maturation arrest 3	Enrichment	ZP3	2.28
59	Cebalid syndrome	Enrichment	MTOR	2.28
60	Spermatogenic failure 74	Enrichment	MSH5	2.28
61	46,xy sex reversal 3	Enrichment	NR5A1	2.28
62	High grade glioma	Enrichment	ATM	2.28
63	T-cell prolymphocytic leukemia	Enrichment	ATM	2.28
64	Smith-kingsmore syndrome	Enrichment	MTOR	2.28
65	Leydig cell hypoplasia type ii	Enrichment	LHCGR	2.28
66	Brachydactyly, type a1	Enrichment	BMPR1B	2.10
67	Brachydactyly, type c	Enrichment	BMPR1B	2.10
68	Thyroid carcinoma, familial medullary	Enrichment	ESR2	2.10
69	Ataxia-telangiectasia	Enrichment	ATM	2.10
70	Acromesomelic dysplasia 2a	Enrichment	BMPR1B	2.10
71	Acromesomelic dysplasia 2c	Enrichment	BMPR1B	2.10
72	Asthma, nasal polyps, and aspirin intolerance	Enrichment	PTGER2	2.10
73	Acromesomelic dysplasia 2b	Enrichment	BMPR1B	2.10
74	Polycythemia vera	Enrichment	ATM	2.10
75	Niemann-pick disease, type a	Enrichment	SMPD1	2.10
76	46,xx sex reversal 1	Enrichment	NR5A1	2.10
77	Niemann-pick disease, type b	Enrichment	SMPD1	2.10
78	Aromatase excess syndrome	Enrichment	CYP19A1	2.10
79	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	2.10
80	Koolen-de vries syndrome	Enrichment	ATM	2.10
81	Dedifferentiated liposarcoma	Enrichment	CDK4	2.10
82	Adenocarcinoma	Enrichment	ATM	2.10
83	Gonadal dysgenesis	Enrichment	FSHR	2.10
84	Aromatase deficiency	Enrichment	CYP19A1	2.10
85	Melanoma of soft tissue	Enrichment	CREB1	2.10
86	Well-differentiated liposarcoma	Enrichment	CDK4	2.10
87	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	MSH5, NR5A1	2.02
88	Mirror movements 1	Enrichment	RAD51	1.98
89	Brachydactyly, type a2	Enrichment	BMPR1B	1.98
90	Mismatch repair cancer syndrome 1	Enrichment	MLH1	1.98
91	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	1.98
92	Fragile x tremor/ataxia syndrome	Enrichment	FMR1	1.98
93	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.98
94	Spermatogenic failure 1	Enrichment	NR5A1	1.98
95	Mantle cell lymphoma	Enrichment	ATM	1.98
96	Fragile x-associated tremor/ataxia syndrome	Enrichment	FMR1	1.98
97	Aortic aneurysm	Enrichment	SMAD3	1.98
98	Primary hyperparathyroidism	Enrichment	CDKN1B	1.98
99	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.98
100	Oculomotor apraxia	Enrichment	ATM	1.98
101	Primary ovarian insufficiency	Enrichment	CYP19A1, PRLR	1.97
102	Niemann-pick disease, type c1	Enrichment	SMPD1	1.88
103	Premature ovarian failure 1	Enrichment	FMR1	1.88
104	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.88
105	Fragile x syndrome	Enrichment	FMR1	1.88
106	Glioblastoma	Enrichment	ATM	1.88
107	Niemann-pick disease	Enrichment	SMPD1	1.88
108	Pseudohermaphroditism	Enrichment	LHCGR	1.88
109	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	NR5A1	1.88
110	Hemimegalencephaly	Enrichment	MTOR	1.88
111	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	SYNE2	1.80
112	Clear cell renal cell carcinoma	Enrichment	ATM	1.80
113	Breast adenocarcinoma	Enrichment	AKT1	1.80
114	46,xy disorder of sex development	Enrichment	NR5A1	1.80
115	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.73
116	Overgrowth syndrome	Enrichment	MTOR	1.73
117	Difference of sex development	Enrichment	NR5A1	1.68
118	Loeys-dietz syndrome	Enrichment	SMAD3	1.63
119	Cowden syndrome	Enrichment	AKT1	1.63
120	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.63
121	Leukemia, chronic lymphocytic	Enrichment	ATM	1.58
122	Familial colorectal cancer	Enrichment	MLH1	1.58
123	Immune deficiency disease	Enrichment	ATM	1.54
124	46,xy complete gonadal dysgenesis	Enrichment	NR5A1	1.54
125	Uterine corpus cancer	Enrichment	ATM	1.54
126	Familial colorectal cancer type x	Enrichment	ATM	1.54
127	Meningioma	Enrichment	AKT1	1.50
128	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.47
129	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.47
130	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.44
131	46,xy partial gonadal dysgenesis	Enrichment	NR5A1	1.44
132	Lynch syndrome	Enrichment	MLH1	1.41
133	Rare genetic intellectual disability	Enrichment	MTOR	1.41
134	Perrault syndrome 1	Enrichment	FSHR	1.38
135	Gliosarcoma	Enrichment	ATM	1.38
136	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.35
137	Giant cell glioblastoma	Enrichment	ATM	1.35
138	Ehlers-danlos syndrome	Enrichment	SMAD3	1.31
139	Hepatocellular carcinoma	Enrichment	VDR	1.25
140	Pancreatic cancer	Enrichment	ATM	1.19
141	Bladder cancer	Enrichment	ATM	1.13
142	Prostate cancer	Enrichment	ATM	1.13
143	Lung cancer	Enrichment	MLH1	1.09
144	Connective tissue disease	Enrichment	SMAD3	1.09
145	Male infertility	Enrichment	NR5A1	1.06
146	Cakut	Enrichment	NRIP1	1.06
147	Fanconi anemia, complementation group a	Enrichment	RAD51	1.05
148	Cerebral palsy	Enrichment	SYNE2	1.01
149	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3	0.96
150	Spastic ataxia	Enrichment	SYNE2	0.88
151	Myeloma, multiple	Enrichment	ATM	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ovarian infertility

Pathway Network for Ovarian infertility

Member Pathways for Ovarian infertility

Pathways in the Ovarian infertility SuperPath

Associated Genes for Ovarian infertility

Associated Disorders for Ovarian infertility

Disorders associated with Ovarian infertility SuperPath

STRING Interaction Network for Ovarian infertility

Sources for Ovarian infertility