Ovarian tumor domain proteases

No Pathway Network information available for Ovarian tumor domain proteases

Pathways in the Ovarian tumor domain proteases SuperPath

#	Name	Source	Genes
1	Ovarian tumor domain proteases	Reactome	APC CDK1 ESR1 IFIH1 IKBKG MAVS NOD1 NOD2 OTUB1 OTUB2 OTUD3 OTUD5 OTUD7A PTEN RHOA RIGI RIPK1 RIPK2 RNF128 RNF135 RPS27A TNFAIP3 TNIP1 TNIP2 TNIP3 TP53 TRAF3 TRAF6 TRIM25 TRIM4 UBA52 UBB UBC UBE2D1 VCP VCPIP1 YOD1 ZRANB1 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNIP1	TNFAIP3 Interacting Protein 1	Protein Coding	1
2	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	1
3	OTUD7A	OTU Deubiquitinase 7A	Protein Coding	1
4	ESR1	Estrogen Receptor 1	Protein Coding	1
5	OTUD3	OTU Deubiquitinase 3	Protein Coding	1
6	RIGI	RNA Sensor RIG-I	Protein Coding	1
7	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
8	RHOA	Ras Homolog Family Member A	Protein Coding	1
9	ZRANB1	Zinc Finger RANBP2-Type Containing 1	Protein Coding	1
10	YOD1	YOD1 Deubiquitinase	Protein Coding	1
11	OTUD5	OTU Deubiquitinase 5	Protein Coding	1
12	OTUB1	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1	Protein Coding	1
13	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
14	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
15	RPS27A	Ribosomal Protein S27a	Protein Coding	1
16	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	1
17	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	1
18	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
19	TP53	Tumor Protein P53	Protein Coding	1
20	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
21	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
22	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
23	UBB	Ubiquitin B	Protein Coding	1
24	UBC	Ubiquitin C	Protein Coding	1
25	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
26	VCP	Valosin Containing Protein	Protein Coding	1
27	TRIM25	Tripartite Motif Containing 25	Protein Coding	1
28	OTUB2	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2	Protein Coding	1
29	TNIP2	TNFAIP3 Interacting Protein 2	Protein Coding	1
30	RNF128	Ring Finger Protein 128	Protein Coding	1
31	TNIP3	TNFAIP3 Interacting Protein 3	Protein Coding	1
32	VCPIP1	Valosin Containing Protein Interacting Protein 1	Protein Coding	1
33	RNF135	Ring Finger Protein 135	Protein Coding	1
34	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
35	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
36	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
37	TRIM4	Tripartite Motif Containing 4	Protein Coding	1
38	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1

Disorders associated with Ovarian tumor domain proteases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary breast carcinoma	Enrichment	APC, ESR1, PTEN, TP53	5.18
2	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	5.12
3	Breast cancer	Enrichment	APC, ESR1, PTEN, TP53	4.26
4	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	4.12
5	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	3.80
6	Gastric cancer	Enrichment	APC, PTEN, TP53	3.64
7	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN, RIPK1, TP53	3.32
8	Rhabdomyosarcoma	Enrichment	PTEN, TP53	3.05
9	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	2.90
10	Hepatoblastoma	Enrichment	APC, TP53	2.81
11	Hepatocellular carcinoma	Enrichment	APC, TP53	2.77
12	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, TRAF3	2.77
13	Ovarian cancer	Enrichment	APC, PTEN, TP53	2.55
14	Vacterl association with hydrocephalus	Enrichment	PTEN	2.55
15	Incontinentia pigmenti	Enrichment	IKBKG	2.55
16	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.55
17	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.55
18	Singleton-merten syndrome 1	Enrichment	IFIH1	2.55
19	Blau syndrome	Enrichment	NOD2	2.55
20	Immunodeficiency 95	Enrichment	IFIH1	2.55
21	Bone marrow failure syndrome 5	Enrichment	TP53	2.55
22	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.55
23	Papilloma of choroid plexus	Enrichment	TP53	2.55
24	Basal cell carcinoma 7	Enrichment	TP53	2.55
25	Immunodeficiency 132a	Enrichment	TRAF3	2.55
26	Type 1 diabetes mellitus 19	Enrichment	IFIH1	2.55
27	Immunodeficiency 132b	Enrichment	TRAF3	2.55
28	Anaplastic thyroid carcinoma	Enrichment	TP53	2.55
29	Multiple congenital anomalies-neurodevelopmental syndrome, x-linked	Enrichment	OTUD5	2.55
30	Papillary tumor of the pineal region	Enrichment	PTEN	2.55
31	Glioma susceptibility 2	Enrichment	PTEN	2.55
32	Ductal carcinoma in situ	Enrichment	TP53	2.55
33	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.55
34	Singleton-merten syndrome 2	Enrichment	RIGI	2.55
35	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.55
36	Neurodevelopmental disorder with hypotonia and seizures	Enrichment	OTUD7A	2.55
37	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.55
38	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.55
39	Multisystem proteinopathy	Enrichment	VCP	2.55
40	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.55
41	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	2.55
42	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.55
43	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.55
44	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.55
45	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.55
46	Choroid plexus cancer	Enrichment	TP53	2.55
47	Familial adenomatous polyposis	Enrichment	APC	2.55
48	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.55
49	Gardner syndrome	Enrichment	APC	2.55
50	5q22 microdeletion syndrome	Enrichment	APC	2.55
51	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.55
52	Attenuated familial adenomatous polyposis	Enrichment	APC	2.55
53	Bladder cancer	Enrichment	PTEN, TP53	2.53
54	Prostate cancer	Enrichment	PTEN, TP53	2.53
55	Systemic lupus erythematosus	Enrichment	TNFAIP3, TNIP1	2.28
56	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.25
57	Cervical cancer	Enrichment	TP53	2.25
58	Immunodeficiency 33	Enrichment	IKBKG	2.25
59	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.25
60	Yao syndrome	Enrichment	NOD2	2.25
61	Lymphoma, hodgkin, classic	Enrichment	TP53	2.25
62	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.25
63	Congenital fibrosarcoma	Enrichment	TP53	2.25
64	Li-fraumeni syndrome 1	Enrichment	TP53	2.25
65	Sarcoma	Enrichment	TP53	2.25
66	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.25
67	Periampullary adenoma	Enrichment	APC	2.25
68	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.25
69	Cervix carcinoma	Enrichment	TP53	2.25
70	Hodgkin's lymphoma	Enrichment	TP53	2.25
71	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.25
72	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.25
73	Basal ganglia disease	Enrichment	IFIH1	2.25
74	Crohn's disease	Enrichment	NOD2	2.25
75	Vacterl with hydrocephalus	Enrichment	PTEN	2.25
76	Juvenile polyposis of infancy	Enrichment	PTEN	2.25
77	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.25
78	Submucosal cleft palate	Enrichment	UBB	2.25
79	Cleft hard palate	Enrichment	UBB	2.25
80	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.25
81	Inherited cancer-predisposing syndrome	Enrichment	APC, PTEN, TP53	2.23
82	Desmoid disease, hereditary	Enrichment	APC	2.08
83	Uvula, bifid	Enrichment	UBB	2.08
84	Neurodegeneration with brain iron accumulation 5	Enrichment	OTUD5	2.08
85	Osteogenic sarcoma	Enrichment	TP53	2.08
86	Cleft soft palate	Enrichment	UBB	2.08
87	Nasopharyngeal carcinoma	Enrichment	TP53	2.08
88	Estrogen resistance	Enrichment	ESR1	2.08
89	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.08
90	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	RNF135	2.08
91	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	2.08
92	Desmoid tumor	Enrichment	APC	2.08
93	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.08
94	Anaplastic astrocytoma	Enrichment	TP53	2.08
95	Squamous cell carcinoma	Enrichment	TP53	2.08
96	Adenocarcinoma	Enrichment	TP53	2.08
97	Migraine without aura	Enrichment	ESR1	2.08
98	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.08
99	Bone osteosarcoma	Enrichment	TP53	2.08
100	Colon adenocarcinoma	Enrichment	APC	2.08
101	Apc-associated polyposis conditions	Enrichment	APC	2.08
102	Small cell cancer of the lung	Enrichment	TP53	1.95
103	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.95
104	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.95
105	Lung sarcomatoid carcinoma	Enrichment	TP53	1.95
106	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.95
107	Craniopharyngioma	Enrichment	APC	1.95
108	Glioma	Enrichment	PTEN	1.95
109	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.86
110	Dementia, lewy body	Enrichment	VCP	1.86
111	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.86
112	Rhabdomyosarcoma 2	Enrichment	TP53	1.86
113	Macrocephaly/autism syndrome	Enrichment	PTEN	1.86
114	Familial adenomatous polyposis 1	Enrichment	APC	1.86
115	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.86
116	Spastic diplegia	Enrichment	IFIH1	1.86
117	Lymphoma	Enrichment	TP53	1.86
118	Hemangioma	Enrichment	PTEN	1.86
119	Hemimegalencephaly	Enrichment	PTEN	1.86
120	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.86
121	Li-fraumeni syndrome	Enrichment	TP53	1.78
122	Cowden syndrome 1	Enrichment	PTEN	1.78
123	Hemihyperplasia, isolated	Enrichment	RHOA	1.78
124	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.78
125	Adrenocortical carcinoma	Enrichment	TP53	1.78
126	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.78
127	Breast adenocarcinoma	Enrichment	TP53	1.78
128	Esophageal cancer	Enrichment	TP53	1.71
129	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.71
130	Essential thrombocythemia	Enrichment	TP53	1.71
131	Gallbladder cancer	Enrichment	TP53	1.71
132	Follicular thyroid carcinoma	Enrichment	PTEN	1.71
133	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.71
134	Glioma susceptibility 1	Enrichment	TP53	1.65
135	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.65
136	Colorectal cancer	Enrichment	APC, TP53	1.61
137	Inflammatory bowel disease 1	Enrichment	NOD2	1.60
138	Coronary heart disease 5	Enrichment	IKBKG	1.60
139	Adult hepatocellular carcinoma	Enrichment	TP53	1.60
140	Progressive non-fluent aphasia	Enrichment	VCP	1.60
141	Primary hyperaldosteronism	Enrichment	TP53	1.60
142	Colonic benign neoplasm	Enrichment	APC	1.60
143	Cowden syndrome	Enrichment	PTEN	1.60
144	Behavioral variant of frontotemporal dementia	Enrichment	VCP	1.60
145	Aicardi-goutiares syndrome	Enrichment	IFIH1	1.60
146	Leukemia, chronic lymphocytic	Enrichment	TP53	1.56
147	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.56
148	Aicardi-goutieres syndrome	Enrichment	IFIH1	1.56
149	Melanoma	Enrichment	PTEN	1.56
150	Familial colorectal cancer	Enrichment	TP53	1.56
151	Migraine with or without aura 1	Enrichment	ESR1	1.52
152	Immune deficiency disease	Enrichment	RIPK1	1.52
153	Meningioma, familial	Enrichment	PTEN	1.52
154	Myelodysplastic syndrome	Enrichment	TP53	1.52
155	Uterine corpus cancer	Enrichment	PTEN	1.52
156	Meningioma	Enrichment	PTEN	1.48
157	Lip and oral cavity carcinoma	Enrichment	TP53	1.48
158	Alzheimer's disease	Enrichment	VCP	1.45
159	Autism spectrum disorder	Enrichment	PTEN, RNF135	1.43
160	Medulloblastoma	Enrichment	APC	1.41
161	Lung cancer susceptibility 3	Enrichment	TP53	1.41
162	Gliosarcoma	Enrichment	TP53	1.36
163	Alzheimer disease, familial, 1	Enrichment	VCP	1.33
164	Giant cell glioblastoma	Enrichment	TP53	1.33
165	Behcet syndrome	Enrichment	NOD2	1.28
166	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.28
167	Endometrial cancer	Enrichment	PTEN	1.24
168	Myocardial infarction	Enrichment	ESR1	1.22
169	Diamond-blackfan anemia 1	Enrichment	TP53	1.20
170	Malaria	Enrichment	IKBKG	1.20
171	Autoinflammatory disease	Enrichment	NOD2	1.19
172	Pancreatic cancer	Enrichment	TP53	1.17
173	Diamond-blackfan anemia	Enrichment	TP53	1.02
174	Leukemia, acute myeloid	Enrichment	TP53	0.97
175	Myeloma, multiple	Enrichment	TP53	0.84
176	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	0.82
177	Congenital nervous system abnormality	Enrichment	PTEN	0.59
178	Nervous system disease	Enrichment	PTEN	0.59
179	Complex neurodevelopmental disorder	Enrichment	OTUD5	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ovarian tumor domain proteases

Pathway Network for Ovarian tumor domain proteases

Member Pathways for Ovarian tumor domain proteases

Pathways in the Ovarian tumor domain proteases SuperPath

Associated Genes for Ovarian tumor domain proteases

Associated Disorders for Ovarian tumor domain proteases

Disorders associated with Ovarian tumor domain proteases SuperPath

STRING Interaction Network for Ovarian tumor domain proteases

Sources for Ovarian tumor domain proteases