Overlap between signal transduction pathways contributing to LMNA laminopathies

No Pathway Network information available for Overlap between signal transduction pathways contributing to LMNA laminopathies

Pathways in the Overlap between signal transduction pathways contributing to LMNA laminopathies SuperPath

#	Name	Source	Genes
1	Overlap between signal transduction pathways contributing to LMNA laminopathies	WikiPathways	ACTB AGO2 APC AXIN1 BMP2 CDK4 CDKN1A CEBPA CEBPB CEBPD CREBBP CSNK1A1 CSNK1A1L CTNNB1 CTSK DICER1 E2F1 FNTA GSK3B HDAC1 HES1 HES5 HMGA2 ICMT JUNB KAT2B LEF1 LEMD3 LMNA MAOA MAOB MIR33B MIRLET7B MSTN MYOD1 NAP1L1 NOTCH1 PPARG RB1 RUNX2 SMAD2 SMAD3 SPP1 SREBF1 TARBP2 TCF7 TCF7L1 TCF7L2 TGFB1 TGFB2 TLE1 TMPO TNFRSF11B WNT10B WNT7B ZMPSTE24 (see all 56) (see less)
2	Influence of laminopathies on Wnt signaling	WikiPathways	ADIPOQ AGO2 APC AXIN1 CCND1 CDK6 CEBPA CEBPB CEBPD CSNK1A1 CSNK1A1L CTNNB1 DICER1 EMD FNTA GSK3B HES1 HES5 HMGA2 ICMT LEF1 LMNA MIR33B MIRLET7B PPARG RUNX2 SLC2A4 SPP1 SREBF1 TARBP2 TCF7 TCF7L1 TCF7L2 TLE1 TOR1AIP1 WNT10B ZMPSTE24 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	2
2	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	2
3	AXIN1	Axin 1	Protein Coding	2
4	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	2
5	WNT10B	Wnt Family Member 10B	Protein Coding	2
6	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	2
7	TCF7	Transcription Factor 7	Protein Coding	2
8	MIR33B	MicroRNA 33b	RNA Gene	2
9	TARBP2	TARBP2 Subunit Of RISC Loading Complex	Protein Coding	2
10	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	2
11	SPP1	Secreted Phosphoprotein 1	Protein Coding	2
12	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	2
13	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	2
14	MIRLET7B	MicroRNA Let-7b	RNA Gene	2
15	LMNA	Lamin A/C	Protein Coding	2
16	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	2
17	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	2
18	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	2
19	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	2
20	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	2
21	DICER1	Dicer 1, Ribonuclease III	Protein Coding	2
22	CTNNB1	Catenin Beta 1	Protein Coding	2
23	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	2
24	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	2
25	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	2
26	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	2
27	ZMPSTE24	Zinc Metallopeptidase STE24	Protein Coding	2
28	CSNK1A1L	Casein Kinase 1 Alpha 1 Like	Protein Coding	2
29	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	2
30	ICMT	Isoprenylcysteine Carboxyl Methyltransferase	Protein Coding	2
31	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	2
32	LEMD3	LEM Domain Containing 3	Protein Coding	1
33	CTSK	Cathepsin K	Protein Coding	1
34	TMPO	Thymopoietin	Protein Coding	1
35	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
36	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
37	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
38	ACTB	Actin Beta	Protein Coding	1
39	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
40	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	1
41	NOTCH1	Notch Receptor 1	Protein Coding	1
42	MYOD1	Myogenic Differentiation 1	Protein Coding	1
43	MAOB	Monoamine Oxidase B	Protein Coding	1
44	MAOA	Monoamine Oxidase A	Protein Coding	1
45	SMAD3	SMAD Family Member 3	Protein Coding	1
46	SMAD2	SMAD Family Member 2	Protein Coding	1
47	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
48	HDAC1	Histone Deacetylase 1	Protein Coding	1
49	MSTN	Myostatin	Protein Coding	1
50	E2F1	E2F Transcription Factor 1	Protein Coding	1
51	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
52	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
53	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
54	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
55	WNT7B	Wnt Family Member 7B	Protein Coding	1
56	NAP1L1	Nucleosome Assembly Protein 1 Like 1	Protein Coding	1
57	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	1
58	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
59	CCND1	Cyclin D1	Protein Coding	1
60	TOR1AIP1	Torsin 1A Interacting Protein 1	Protein Coding	1
61	EMD	Emerin	Protein Coding	1
62	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1

Disorders associated with Overlap between signal transduction pathways contributing to LMNA laminopathies SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2	5.26
2	Familial partial lipodystrophy	Enrichment	LMNA, PPARG	5.14
3	12q14 microdeletion syndrome	Enrichment	HMGA2, LEMD3	4.78
4	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	4.66
5	Restrictive dermopathy 1	Enrichment	LMNA, ZMPSTE24	4.66
6	Desmoid tumor	Enrichment	APC, CTNNB1	4.66
7	Restrictive dermopathy	Enrichment	LMNA, ZMPSTE24	4.66
8	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	4.56
9	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1, SMAD2, SMAD3, TGFB2	4.50
10	Hutchinson-gilford progeria syndrome	Enrichment	LMNA, ZMPSTE24	4.36
11	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD, LMNA	4.36
12	Emery-dreifuss muscular dystrophy	Enrichment	EMD, LMNA	4.36
13	Craniopharyngioma	Enrichment	APC, CTNNB1	4.36
14	Dedifferentiated liposarcoma	Enrichment	CDK4, HMGA2	4.30
15	Well-differentiated liposarcoma	Enrichment	CDK4, HMGA2	4.30
16	Colorectal cancer	Enrichment	APC, CCND1, CTNNB1, PPARG	4.05
17	Type 2 diabetes mellitus	Enrichment	PPARG, SLC2A4, TCF7L2	3.70
18	Inherited cancer-predisposing syndrome	Enrichment	APC, CDK4, CEBPA, DICER1, RB1	3.68
19	Bladder cancer	Enrichment	CDKN1A, CTNNB1, RB1	3.65
20	Atrial septal defect 1	Enrichment	BMP2, TGFB2	3.60
21	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	3.59
22	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA, TOR1AIP1	3.33
23	Medulloblastoma	Enrichment	APC, CTNNB1	3.19
24	Ovarian cancer	Enrichment	APC, CTNNB1, DICER1, RB1	3.10
25	Neuromuscular disease	Enrichment	EMD, LMNA	2.97
26	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD, LMNA	2.92
27	Hepatoblastoma	Enrichment	APC, CTNNB1	2.83
28	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1, SMAD3	2.83
29	Rhabdomyosarcoma, embryonal, 2	Enrichment	DICER1	2.56
30	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.56
31	Split-hand/foot malformation 6	Enrichment	WNT10B	2.56
32	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.56
33	Caudal duplication anomaly	Enrichment	AXIN1	2.56
34	Tooth agenesis, selective, 8	Enrichment	WNT10B	2.56
35	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.56
36	Silver-russell syndrome 5	Enrichment	HMGA2	2.56
37	Ifap syndrome 2	Enrichment	SREBF1	2.56
38	Dicer1 syndrome	Enrichment	DICER1	2.56
39	Pleuropulmonary blastoma	Enrichment	DICER1	2.56
40	Global developmental delay, lung cysts, overgrowth, and wilms tumor	Enrichment	DICER1	2.56
41	Stature quantitative trait locus 9	Enrichment	HMGA2	2.56
42	Atypical werner syndrome	Enrichment	LMNA	2.56
43	Malignant sertoli-leydig cell tumor of ovary	Enrichment	DICER1	2.56
44	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.56
45	Adenoid ameloblastoma	Enrichment	CTNNB1	2.56
46	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.56
47	Mandibuloacral dysplasia	Enrichment	LMNA	2.56
48	Atrioventricular block	Enrichment	LMNA	2.56
49	Supratentorial primitive neuroectodermal tumor	Enrichment	DICER1	2.56
50	Familial adenomatous polyposis	Enrichment	APC	2.56
51	Gynandroblastoma	Enrichment	DICER1	2.56
52	Dicer1 tumor predisposition	Enrichment	DICER1	2.56
53	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.56
54	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.56
55	Gardner syndrome	Enrichment	APC	2.56
56	5q22 microdeletion syndrome	Enrichment	APC	2.56
57	Attenuated familial adenomatous polyposis	Enrichment	APC	2.56
58	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.56
59	Microcystic stromal tumor	Enrichment	CTNNB1	2.56
60	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.56
61	Laminopathy	Enrichment	LMNA	2.56
62	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2	2.56
63	Buschke-ollendorff syndrome	Enrichment	LEMD3	2.38
64	Baraitser-winter syndrome 1	Enrichment	ACTB	2.38
65	Pycnodysostosis	Enrichment	CTSK	2.38
66	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.38
67	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.38
68	Brunner syndrome	Enrichment	MAOA	2.38
69	Camurati-engelmann disease 2	Enrichment	TGFB2	2.38
70	Becker nevus syndrome	Enrichment	ACTB	2.38
71	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.38
72	Congenital myopathy 17	Enrichment	MYOD1	2.38
73	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.38
74	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.38
75	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.38
76	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.38
77	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.38
78	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	2.38
79	Trilateral retinoblastoma	Enrichment	RB1	2.38
80	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.38
81	Baraitser-winter syndrome	Enrichment	ACTB	2.38
82	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.38
83	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.38
84	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.38
85	Menke-hennekam syndrome	Enrichment	CREBBP	2.38
86	Isolated osteopoikilosis	Enrichment	LEMD3	2.38
87	Lung oat cell carcinoma	Enrichment	RB1	2.38
88	Scoliosis	Enrichment	CREBBP, CTSK	2.36
89	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.26
90	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.26
91	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.26
92	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.26
93	Carotid intimal medial thickness 1	Enrichment	PPARG	2.26
94	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	2.26
95	Premature ovarian failure 3	Enrichment	AGO2	2.26
96	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.26
97	Salivary gland adenoma, pleomorphic	Enrichment	HMGA2	2.26
98	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.26
99	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	DICER1	2.26
100	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.26
101	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.26
102	Restrictive dermopathy 2	Enrichment	LMNA	2.26
103	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.26
104	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	DICER1	2.26
105	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.26
106	Split hand-foot malformation	Enrichment	LEF1	2.26
107	Mandibuloacral dysplasia with type b lipodystrophy	Enrichment	ZMPSTE24	2.26
108	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.26
109	Pineoblastoma	Enrichment	DICER1	2.26
110	Periampullary adenoma	Enrichment	APC	2.26
111	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.26
112	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.26
113	Teratoma	Enrichment	CTNNB1	2.26
114	Malignant granulosa cell tumor of the ovary	Enrichment	DICER1	2.26
115	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.26
116	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	2.26
117	Connective tissue disease	Enrichment	NOTCH1, SMAD3	2.12
118	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.09
119	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.09
120	Adiponectin deficiency	Enrichment	ADIPOQ	2.09
121	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.09
122	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	2.09
123	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.09
124	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	2.09
125	Anus, imperforate	Enrichment	CTNNB1	2.09
126	Myopathy, autosomal recessive, with rigid spine and distal joint contractures	Enrichment	TOR1AIP1	2.09
127	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.09
128	Cleidocranial dysplasia	Enrichment	RUNX2	2.09
129	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.09
130	Colon adenocarcinoma	Enrichment	APC	2.09
131	Apc-associated polyposis conditions	Enrichment	APC	2.09
132	Camurati-engelmann disease 1	Enrichment	TGFB1	2.08
133	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11B	2.08
134	Thumb deformity	Enrichment	CREBBP	2.08
135	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.08
136	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.08
137	Muscle hypertrophy	Enrichment	MSTN	2.08
138	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.08
139	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.08
140	Myostatin-related muscle hypertrophy	Enrichment	MSTN	2.08
141	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.08
142	Camurati-engelmann disease	Enrichment	TGFB1	2.08
143	Osteopoikilosis	Enrichment	LEMD3	2.08
144	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.08
145	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	2.08
146	Craniosynostosis 7	Enrichment	BMP2	2.08
147	Familial retinoblastoma	Enrichment	RB1	2.08
148	Microtia-anotia	Enrichment	LMNA	1.96
149	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.96
150	Pilomatrixoma	Enrichment	CTNNB1	1.96
151	Leptin deficiency or dysfunction	Enrichment	PPARG	1.96
152	Alazami syndrome	Enrichment	CTNNB1	1.96
153	Congenital generalized lipodystrophy	Enrichment	PPARG	1.96
154	Mantle cell lymphoma	Enrichment	CCND1	1.96
155	Embryonal rhabdomyosarcoma	Enrichment	DICER1	1.96
156	Sick sinus syndrome	Enrichment	LMNA	1.96
157	Silver-russell syndrome due to a point mutation	Enrichment	HMGA2	1.96
158	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.96
159	Retinoblastoma	Enrichment	RB1	1.91
160	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.91
161	Osteogenic sarcoma	Enrichment	RB1	1.91
162	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.91
163	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.91
164	Hypotrichosis 8	Enrichment	RB1	1.91
165	Tethered spinal cord syndrome	Enrichment	CREBBP	1.91
166	Nail disorder, nonsyndromic congenital, 9	Enrichment	CTSK	1.91
167	Loeys-dietz syndrome 1	Enrichment	SMAD2	1.91
168	Squamous cell carcinoma	Enrichment	RB1	1.91
169	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.91
170	Bone osteosarcoma	Enrichment	RB1	1.91
171	Keratoacanthoma	Enrichment	NOTCH1	1.91
172	Gastric cancer	Enrichment	APC, CDK4	1.87
173	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.87
174	Von hippel-lindau syndrome	Enrichment	CCND1	1.87
175	Familial adenomatous polyposis 1	Enrichment	APC	1.87
176	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.87
177	Histiocytoid hemangioma	Enrichment	LMNA	1.87
178	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.87
179	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.87
180	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.79
181	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.79
182	Muscular dystrophy, limb-girdle, autosomal recessive 1	Enrichment	TOR1AIP1	1.79
183	Split-hand/foot malformation 1	Enrichment	LEF1	1.79
184	Adrenocortical carcinoma	Enrichment	CTNNB1	1.79
185	Brachydactyly, type a2	Enrichment	BMP2	1.78
186	Small cell cancer of the lung	Enrichment	RB1	1.78
187	Chondrocalcinosis 2	Enrichment	TNFRSF11B	1.78
188	Aminoacylase 1 deficiency	Enrichment	ACTB	1.78
189	Lynch syndrome 4	Enrichment	RB1	1.78
190	Aortic aneurysm	Enrichment	SMAD3	1.78
191	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.78
192	Bethlem myopathy 1a	Enrichment	LMNA	1.72
193	Silver-russell syndrome 1	Enrichment	HMGA2	1.72
194	Gallbladder cancer	Enrichment	CTNNB1	1.72
195	Dilated cardiomyopathy	Enrichment	EMD, LMNA	1.70
196	Familial isolated dilated cardiomyopathy	Enrichment	LMNA, TMPO	1.70
197	Ventricular septal defect 1	Enrichment	BMP2	1.69
198	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.67
199	Congenital muscular dystrophy	Enrichment	LMNA	1.67
200	Myocarditis	Enrichment	LMNA	1.67
201	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.67
202	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.61
203	Colonic benign neoplasm	Enrichment	APC	1.61
204	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.61
205	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.61
206	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.61
207	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.61
208	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.61
209	Hypertrichosis	Enrichment	CREBBP	1.61
210	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.57
211	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.54
212	Adams-oliver syndrome	Enrichment	NOTCH1	1.54
213	Cardiac conduction defect	Enrichment	LMNA	1.49
214	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.49
215	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.49
216	Hemochromatosis, type 1	Enrichment	BMP2	1.49
217	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.49
218	Autism	Enrichment	CREBBP, TCF7L2	1.45
219	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.44
220	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.43
221	Marfan syndrome	Enrichment	TGFB2	1.39
222	Primary bone dysplasia	Enrichment	CTSK	1.39
223	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.37
224	Rhabdomyosarcoma	Enrichment	DICER1	1.37
225	Gliosarcoma	Enrichment	PPARG	1.37
226	Osteochondrodysplasia	Enrichment	CTSK	1.35
227	Complex neurodevelopmental disorder	Enrichment	AGO2, TCF7L2	1.35
228	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.34
229	Polycystic liver disease	Enrichment	CTNNB1	1.34
230	Giant cell glioblastoma	Enrichment	PPARG	1.34
231	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.34
232	Lip and oral cavity carcinoma	Enrichment	RB1	1.31
233	Aortic valve disease 1	Enrichment	NOTCH1	1.28
234	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.25
235	Centronuclear myopathy	Enrichment	TOR1AIP1	1.25
236	Lung cancer susceptibility 3	Enrichment	RB1	1.25
237	Heart disease	Enrichment	CREBBP	1.25
238	Tooth agenesis	Enrichment	WNT10B	1.23
239	Corpus callosum, agenesis of	Enrichment	CREBBP	1.22
240	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.22
241	Rare genetic intellectual disability	Enrichment	CREBBP	1.22
242	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.22
243	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	1.20
244	Muscular dystrophy	Enrichment	LMNA	1.20
245	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.17
246	Brugada syndrome	Enrichment	LMNA	1.16
247	Congenital nervous system abnormality	Enrichment	CREBBP, CTNNB1	1.15
248	Nervous system disease	Enrichment	CREBBP, CTNNB1	1.15
249	Arteriovenous malformations of the brain	Enrichment	LEMD3	1.12
250	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.12
251	Hirschsprung disease 1	Enrichment	SREBF1	1.12
252	Differentiated thyroid carcinoma	Enrichment	PPARG	1.12
253	Macs syndrome	Enrichment	WNT7B	1.10
254	Long qt syndrome	Enrichment	LMNA	1.09
255	Primary autosomal recessive microcephaly	Enrichment	CDK6	1.08
256	Peripheral nervous system disease	Enrichment	LMNA	1.08
257	Neuropathy	Enrichment	LMNA	1.08
258	Microphthalmia	Enrichment	WNT7B	1.06
259	Left ventricular noncompaction	Enrichment	LMNA	1.04
260	Microcephaly	Enrichment	ACTB, CTNNB1	1.04
261	Systemic lupus erythematosus	Enrichment	SPP1	0.99
262	Tetralogy of fallot	Enrichment	NOTCH1	0.99
263	Leukemia, acute myeloid	Enrichment	CEBPA	0.98
264	Myopathy	Enrichment	EMD	0.98
265	Charcot-marie-tooth disease	Enrichment	LMNA	0.97
266	Nephrotic syndrome	Enrichment	RUNX2	0.95
267	Hereditary breast carcinoma	Enrichment	APC	0.95
268	Cystic fibrosis	Enrichment	TGFB1	0.91
269	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.89
270	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	0.85
271	Myeloma, multiple	Enrichment	CCND1	0.85
272	Distal arthrogryposis	Enrichment	MYOD1	0.80
273	Breast cancer	Enrichment	APC	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Overlap between signal transduction pathways contributing to LMNA laminopathies

Pathway Network for Overlap between signal transduction pathways contributing to LMNA laminopathies

Member Pathways for Overlap between signal transduction pathways contributing to LMNA laminopathies

Pathways in the Overlap between signal transduction pathways contributing to LMNA laminopathies SuperPath

Associated Genes for Overlap between signal transduction pathways contributing to LMNA laminopathies

Associated Disorders for Overlap between signal transduction pathways contributing to LMNA laminopathies

Disorders associated with Overlap between signal transduction pathways contributing to LMNA laminopathies SuperPath

STRING Interaction Network for Overlap between signal transduction pathways contributing to LMNA laminopathies

Sources for Overlap between signal transduction pathways contributing to LMNA laminopathies