Overview of interferons-mediated signaling pathway

Pathway network for the Overview of interferons-mediated signaling pathway SuperPath

Sources:

WikiPathways
Reactome
R&D Systems
QIAGEN
GeneGo (Thomson Reuters)

Pathways in the Overview of interferons-mediated signaling pathway SuperPath

#	Name	Source	Genes
1	Overview of interferons-mediated signaling pathway	WikiPathways	IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNE IFNG IFNGR1 IFNGR2 IFNK IFNL1 IFNL2 IFNL3 IFNL4 IFNLR1 IFNW1 IL10RB IRF9 JAK1 JAK2 PIK3CA PIK3R1 PRKCA STAT1 STAT2 TYK2 (see all 37) (see less)
2	Interferon alpha/beta signaling	Reactome	ABCE1 ADAR BST2 EGR1 EIF2AK2 GBP2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G IFI27 IFI35 IFI6 IFIT1 IFIT2 IFIT3 IFIT5 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 JAK1 KPNA1 KPNB1 MX1 MX2 OAS1 OAS2 OAS3 OASL PSMB8 PTPN1 PTPN11 PTPN6 RNASEL RPS27A RSAD2 SAMHD1 SOCS1 SOCS3 STAT1 STAT2 TYK2 UBA52 UBB UBC USP18 XAF1 (see all 76) (see less)
3	Jak/STAT Signaling Pathway	R&D Systems	AGTR1 CSF2RB CXCL12 CXCR4 EGF EGFR EPO EPOR IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IFNK IL10 IL10RA IL10RB IL12A IL12B IL12RB1 IL12RB2 IL2 IL2RA IL2RB IL3 IL3RA IL6 IL6R IL6ST IRF9 JAK1 JAK2 JAK3 PLCB1 PLCB3 PLCB4 PRKCD PTK2B PTPN11 SRC STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TYK2 (see all 61) (see less)
4	all-trans-Retinoic Acid Mediated Apoptosis	QIAGEN	APAF1 BID CASP3 CASP8 CASP9 CFLAR CRABP2 CYCS DAP3 FADD IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IFNGR1 IFNGR2 IFNL1 IFNL2 IFNL3 IFNW1 IL6 PARP10 PARP11 PARP14 PARP15 PARP16 PARP3 PARP4 PARP8 RARA RARB RARG RBP5 TNFRSF10A TNFRSF10B TNFSF10 (see all 46) (see less)
5	Cytokine Network	QIAGEN	CXCL8 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IFNG IL10 IL12A IL12B IL13 IL15 IL16 IL17A IL18 IL1A IL1B IL2 IL3 IL4 IL5 IL6 IL9 LTA TNF (see all 34) (see less)
6	Immune response IFN alpha/beta signaling pathway	GeneGo (Thomson Reuters)	IFI6 IFIT2 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IRF1 IRF2 IRF9 ISG15 JAK1 PML PRMT1 PTPN1 PTPN11 PTPN6 SOCS1 STAT1 STAT2 TYK2 USP18 (see all 33) (see less)
7	Regulation of IFNA/IFNB signaling	Reactome	IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 JAK1 PTPN1 PTPN11 PTPN6 SOCS1 SOCS3 STAT1 STAT2 TYK2 USP18 (see all 26) (see less)
8	Type III interferon signaling	WikiPathways	IFNL1 IFNL2 IFNL3 IFNLR1 IL10RB IRF9 JAK1 STAT1 STAT2 TYK2 (see all 10) (see less)

Gene overlap in member pathways for Overview of interferons-mediated signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IFNB1	Interferon Beta 1	Protein Coding	7
2	IFNA10	Interferon Alpha 10	Protein Coding	7
3	IFNA5	Interferon Alpha 5	Protein Coding	7
4	IFNA2	Interferon Alpha 2	Protein Coding	7
5	IFNA1	Interferon Alpha 1	Protein Coding	7
6	IFNA21	Interferon Alpha 21	Protein Coding	7
7	IFNA17	Interferon Alpha 17	Protein Coding	7
8	IFNA16	Interferon Alpha 16	Protein Coding	7
9	IFNA14	Interferon Alpha 14	Protein Coding	7
10	IFNA13	Interferon Alpha 13	Protein Coding	7
11	IFNA8	Interferon Alpha 8	Protein Coding	7
12	IFNA7	Interferon Alpha 7	Protein Coding	7
13	IFNA4	Interferon Alpha 4	Protein Coding	7
14	TYK2	Tyrosine Kinase 2	Protein Coding	6
15	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	6
16	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	6
17	JAK1	Janus Kinase 1	Protein Coding	6
18	IFNA6	Interferon Alpha 6	Protein Coding	6
19	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	5
20	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	5
21	IRF9	Interferon Regulatory Factor 9	Protein Coding	5
22	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	4
23	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	3
24	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	3
25	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	3
26	IFNG	Interferon Gamma	Protein Coding	3
27	IFNL3	Interferon Lambda 3	Protein Coding	3
28	IFNL1	Interferon Lambda 1	Protein Coding	3
29	IFNL2	Interferon Lambda 2	Protein Coding	3
30	USP18	Ubiquitin Specific Peptidase 18	Protein Coding	3
31	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	3
32	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	3
33	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	3
34	IL6	Interleukin 6	Protein Coding	3
35	JAK2	Janus Kinase 2	Protein Coding	2
36	IFNLR1	Interferon Lambda Receptor 1	Protein Coding	2
37	IFNK	Interferon Kappa	Protein Coding	2
38	IFNW1	Interferon Omega 1	Protein Coding	2
39	IFI6	Interferon Alpha Inducible Protein 6	Protein Coding	2
40	IFIT2	Interferon Induced Protein With Tetratricopeptide Repeats 2	Protein Coding	2
41	IRF1	Interferon Regulatory Factor 1	Protein Coding	2
42	IRF2	Interferon Regulatory Factor 2	Protein Coding	2
43	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	2
44	ISG15	ISG15 Ubiquitin Like Modifier	Protein Coding	2
45	IL2	Interleukin 2	Protein Coding	2
46	IL3	Interleukin 3	Protein Coding	2
47	IL10	Interleukin 10	Protein Coding	2
48	IL12A	Interleukin 12A	Protein Coding	2
49	IL12B	Interleukin 12B	Protein Coding	2
50	PRKCA	Protein Kinase C Alpha	Protein Coding	1
51	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
52	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
53	IFNL4	Interferon Lambda 4 (Gene/Pseudogene)	Protein Coding	1
54	IFNE	Interferon Epsilon	Protein Coding	1
55	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
56	IFITM3	Interferon Induced Transmembrane Protein 3	Protein Coding	1
57	IFITM2	Interferon Induced Transmembrane Protein 2	Protein Coding	1
58	EGR1	Early Growth Response 1	Protein Coding	1
59	IFIT5	Interferon Induced Protein With Tetratricopeptide Repeats 5	Protein Coding	1
60	SAMHD1	SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1	Protein Coding	1
61	GBP2	Guanylate Binding Protein 2	Protein Coding	1
62	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
63	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
64	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	1
65	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	1
66	HLA-F	Major Histocompatibility Complex, Class I, F	Protein Coding	1
67	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	1
68	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
69	IFI27	Interferon Alpha Inducible Protein 27	Protein Coding	1
70	IFI35	Interferon Induced Protein 35	Protein Coding	1
71	IFIT1	Interferon Induced Protein With Tetratricopeptide Repeats 1	Protein Coding	1
72	IFIT3	Interferon Induced Protein With Tetratricopeptide Repeats 3	Protein Coding	1
73	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
74	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
75	IRF5	Interferon Regulatory Factor 5	Protein Coding	1
76	IRF6	Interferon Regulatory Factor 6	Protein Coding	1
77	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
78	ISG20	Interferon Stimulated Exonuclease Gene 20	Protein Coding	1
79	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
80	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
81	MX1	MX Dynamin Like GTPase 1	Protein Coding	1
82	MX2	MX Dynamin Like GTPase 2	Protein Coding	1
83	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	1
84	OAS2	2''-5''-Oligoadenylate Synthetase 2	Protein Coding	1
85	OAS3	2''-5''-Oligoadenylate Synthetase 3	Protein Coding	1
86	XAF1	XIAP Associated Factor 1	Protein Coding	1
87	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
88	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	1
89	RNASEL	Ribonuclease L	Protein Coding	1
90	ABCE1	ATP Binding Cassette Subfamily E Member 1	Protein Coding	1
91	RPS27A	Ribosomal Protein S27a	Protein Coding	1
92	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	1
93	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
94	UBB	Ubiquitin B	Protein Coding	1
95	UBC	Ubiquitin C	Protein Coding	1
96	IFITM1	Interferon Induced Transmembrane Protein 1	Protein Coding	1
97	OASL	2''-5''-Oligoadenylate Synthetase Like	Protein Coding	1
98	RSAD2	Radical S-Adenosyl Methionine Domain Containing 2	Protein Coding	1
99	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
100	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
101	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
102	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
103	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
104	EGF	Epidermal Growth Factor	Protein Coding	1
105	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
106	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
107	EPO	Erythropoietin	Protein Coding	1
108	EPOR	Erythropoietin Receptor	Protein Coding	1
109	JAK3	Janus Kinase 3	Protein Coding	1
110	IL6R	Interleukin 6 Receptor	Protein Coding	1
111	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
112	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
113	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
114	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	1
115	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	1
116	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
117	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
118	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
119	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	1
120	PLCB1	Phospholipase C Beta 1	Protein Coding	1
121	PLCB3	Phospholipase C Beta 3	Protein Coding	1
122	PLCB4	Phospholipase C Beta 4	Protein Coding	1
123	PRKCD	Protein Kinase C Delta	Protein Coding	1
124	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
125	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
126	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
127	PARP4	Poly(ADP-Ribose) Polymerase Family Member 4	Protein Coding	1
128	PARP3	Poly(ADP-Ribose) Polymerase Family Member 3	Protein Coding	1
129	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
130	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
131	PARP11	Poly(ADP-Ribose) Polymerase Family Member 11	Protein Coding	1
132	CASP3	Caspase 3	Protein Coding	1
133	CASP8	Caspase 8	Protein Coding	1
134	CASP9	Caspase 9	Protein Coding	1
135	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	1
136	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	1
137	CYCS	Cytochrome C, Somatic	Protein Coding	1
138	DAP3	Death Associated Protein 3	Protein Coding	1
139	FADD	Fas Associated Via Death Domain	Protein Coding	1
140	PARP10	Poly(ADP-Ribose) Polymerase Family Member 10	Protein Coding	1
141	PARP16	Poly(ADP-Ribose) Polymerase Family Member 16	Protein Coding	1
142	PARP8	Poly(ADP-Ribose) Polymerase Family Member 8	Protein Coding	1
143	PARP15	Poly(ADP-Ribose) Polymerase Family Member 15	Protein Coding	1
144	PARP14	Poly(ADP-Ribose) Polymerase Family Member 14	Protein Coding	1
145	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
146	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
147	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
148	RBP5	Retinol Binding Protein 5	Protein Coding	1
149	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	1
150	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
151	TNFSF10	TNF Superfamily Member 10	Protein Coding	1
152	IL13	Interleukin 13	Protein Coding	1
153	IL15	Interleukin 15	Protein Coding	1
154	IL16	Interleukin 16	Protein Coding	1
155	IL17A	Interleukin 17A	Protein Coding	1
156	IL18	Interleukin 18	Protein Coding	1
157	IL1A	Interleukin 1 Alpha	Protein Coding	1
158	IL1B	Interleukin 1 Beta	Protein Coding	1
159	IL4	Interleukin 4	Protein Coding	1
160	IL5	Interleukin 5	Protein Coding	1
161	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
162	IL9	Interleukin 9	Protein Coding	1
163	LTA	Lymphotoxin Alpha	Protein Coding	1
164	TNF	Tumor Necrosis Factor	Protein Coding	1
165	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	1
166	PML	PML Nuclear Body Scaffold	Protein Coding	1

Disorders associated with Overview of interferons-mediated signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multisystem inflammatory syndrome in children	Enrichment	IFNA21, IFNA4, IFNA6, IFNAR2, IFNB1	9.34
2	Hepatitis b	Enrichment	IFNAR2, IFNGR1, IL10RB	7.13
3	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.06
4	Behcet syndrome	Enrichment	IFNGR1, IL10, IL12A, STAT4	5.87
5	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA, IL10RB	5.77
6	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.52
7	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.52
8	Immunodeficiency 44	Enrichment	IFNAR2, STAT2	4.98
9	Psoriatic arthritis	Enrichment	LTA, TNF	4.74
10	Hepatitis c virus	Enrichment	IFNG, IFNL3	4.66
11	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.66
12	Severe cutaneous adverse reaction	Enrichment	HLA-A, HLA-B	4.51
13	Human immunodeficiency virus type 1	Enrichment	CXCL12, IFNG, IL10	4.17
14	Erythrocytosis, familial, 1	Enrichment	EPOR, JAK2	3.93
15	Asthma	Enrichment	IL13, TNF	3.48
16	Myelofibrosis	Enrichment	JAK2, SRC	3.39
17	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.15
18	Immunodeficiency 35	Enrichment	TYK2	3.13
19	Pseudo-torch syndrome 3	Enrichment	STAT2	3.13
20	Immunodeficiency 31a	Enrichment	STAT1	3.13
21	Immunodeficiency 31b	Enrichment	STAT1	3.13
22	Immunodeficiency 65 viral infections	Enrichment	IRF9	3.13
23	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.13
24	Aicardi-goutiares syndrome	Enrichment	ADAR, SAMHD1	2.96
25	Aicardi-goutieres syndrome	Enrichment	ADAR, SAMHD1	2.87
26	Immunodeficiency 31c	Enrichment	STAT1	2.83
27	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.83
28	Lymphomatoid papulosis	Enrichment	TYK2	2.83
29	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.83
30	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	2.82
31	Metachondromatosis	Enrichment	PTPN11	2.72
32	Dermatitis, atopic, 4	Enrichment	SOCS3	2.72
33	Leopard syndrome 1	Enrichment	PTPN11	2.72
34	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.72
35	Pseudo-torch syndrome 2	Enrichment	USP18	2.72
36	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.72
37	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.72
38	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.72
39	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.72
40	Malignant astrocytoma	Enrichment	PTPN11	2.72
41	Inflammatory bowel disease 25	Enrichment	IL10RB	2.66
42	Immunodeficiency 38 with basal ganglia calcification	Enrichment	ISG15	2.61
43	Leprosy 4	Enrichment	LTA	2.60
44	Immunodeficiency 69	Enrichment	IFNG	2.60
45	Graft-versus-host disease	Enrichment	IL10	2.60
46	Allergic rhinitis	Enrichment	IL13	2.60
47	Immunodeficiency 29	Enrichment	IL12B	2.60
48	Macrodactyly	Enrichment	PIK3CA	2.56
49	Helicobacter pylori infection	Enrichment	IFNGR1	2.56
50	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.56
51	Cowden syndrome 5	Enrichment	PIK3CA	2.56
52	Immunodeficiency 27a	Enrichment	IFNGR1	2.56
53	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.56
54	Short syndrome	Enrichment	PIK3R1	2.56
55	Immunodeficiency 27b	Enrichment	IFNGR1	2.56
56	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.56
57	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.56
58	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.56
59	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.56
60	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.56
61	Hypospadias	Enrichment	PIK3CA	2.56
62	Rare venous malformation	Enrichment	PIK3CA	2.56
63	Diaphragmatic eventration	Enrichment	PIK3CA	2.56
64	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.56
65	Rare combined vascular malformation	Enrichment	PIK3CA	2.56
66	Cavernous lymphangioma	Enrichment	PIK3CA	2.56
67	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.56
68	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.56
69	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.56
70	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.56
71	Macrodactyly of toe	Enrichment	PIK3CA	2.56
72	Arteriovenous malformations of the brain	Enrichment	EGFR, IL6	2.49
73	Caspase 8 deficiency	Enrichment	CASP8	2.47
74	Thrombocytopenia 4	Enrichment	CYCS	2.47
75	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.47
76	Microphthalmia, syndromic 12	Enrichment	RARB	2.47
77	Perrault syndrome 7	Enrichment	DAP3	2.47
78	Immunodeficiency 45	Enrichment	IFNAR2	2.42
79	Werner syndrome	Enrichment	PTPN11	2.42
80	Systemic lupus erythematosus	Enrichment	IL10, TNF	2.37
81	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	2.35
82	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.35
83	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.35
84	Hypomagnesemia 4, renal	Enrichment	EGF	2.35
85	Immunodeficiency 30	Enrichment	IL12RB1	2.35
86	Microvascular complications of diabetes 2	Enrichment	EPO	2.35
87	Whim syndrome 1	Enrichment	CXCR4	2.35
88	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.35
89	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.35
90	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.35
91	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.35
92	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.35
93	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.35
94	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.35
95	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.35
96	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.35
97	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.35
98	Systemic lupus erythematosus 11	Enrichment	STAT4	2.35
99	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.35
100	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	2.35
101	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.35
102	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.35
103	Erythrocytosis, familial, 5	Enrichment	EPO	2.35
104	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.35
105	Thrombocytopenia 6	Enrichment	SRC	2.35
106	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.35
107	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.35
108	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.35
109	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.35
110	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.35
111	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.35
112	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.35
113	Immunodeficiency 117	Enrichment	IRF1	2.31
114	Immunodeficiency 127	Enrichment	TNF	2.30
115	Keratosis, seborrheic	Enrichment	PIK3CA	2.26
116	Noonan syndrome 8	Enrichment	PIK3CA	2.26
117	Thrombocythemia 3	Enrichment	JAK2	2.26
118	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.26
119	Polycythemia	Enrichment	JAK2	2.26
120	Hypereosinophilic syndrome	Enrichment	JAK2	2.26
121	Spondyloarthropathy 1	Enrichment	HLA-B	2.25
122	Prostate cancer, hereditary, 1	Enrichment	RNASEL	2.25
123	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.25
124	Orofacial cleft 6	Enrichment	IRF6	2.25
125	Psoriasis 1	Enrichment	HLA-C	2.25
126	Popliteal pterygium syndrome	Enrichment	IRF6	2.25
127	Chilblain lupus 2	Enrichment	SAMHD1	2.25
128	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.25
129	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.25
130	Immunodeficiency 32a	Enrichment	IRF8	2.25
131	Immunodeficiency 131	Enrichment	IRF4	2.25
132	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.25
133	Aicardi-goutieres syndrome 5	Enrichment	SAMHD1	2.25
134	Immunodeficiency 39	Enrichment	IRF7	2.25
135	Ankylosing spondylitis 1	Enrichment	HLA-B	2.25
136	Systemic lupus erythematosus 10	Enrichment	IRF5	2.25
137	Birdshot chorioretinopathy	Enrichment	HLA-A	2.25
138	Influenza, severe	Enrichment	IFITM3	2.25
139	Inflammatory bowel disease 14	Enrichment	IRF5	2.25
140	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	2.25
141	Reactive arthritis	Enrichment	HLA-B	2.25
142	Irf6-related disorders	Enrichment	IRF6	2.25
143	Autosomal dominant popliteal pterygium syndrome	Enrichment	IRF6	2.25
144	Dystonia 33	Enrichment	EIF2AK2	2.25
145	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.25
146	Whipple disease	Enrichment	IRF4	2.25
147	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	2.25
148	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	2.25
149	Immune thrombocytopenia	Enrichment	SOCS1	2.24
150	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.24
151	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.24
152	Tricuspid valve insufficiency	Enrichment	PTPN11	2.24
153	Grange syndrome	Enrichment	DAP3	2.17
154	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.17
155	Oculootodental syndrome	Enrichment	FADD	2.17
156	Severe covid-19	Enrichment	IL10RB, JAK3	2.13
157	Takayasu arteritis	Enrichment	IL12B	2.12
158	Tuberous sclerosis 1	Enrichment	IFNG	2.12
159	Tuberous sclerosis 2	Enrichment	IFNG	2.12
160	Migraine without aura	Enrichment	TNF	2.12
161	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.12
162	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.12
163	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.12
164	Polycythemia vera	Enrichment	JAK2	2.09
165	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.09
166	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.09
167	Immunodeficiency 28	Enrichment	IFNGR2	2.09
168	Immunodeficiency 14	Enrichment	PIK3R1	2.09
169	Keratoacanthoma	Enrichment	PIK3CA	2.09
170	Hemangiopericytoma, malignant	Enrichment	STAT6	2.05
171	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.05
172	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.05
173	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.05
174	Diamond-blackfan anemia-like	Enrichment	EPO	2.05
175	Inflammatory bowel disease 28	Enrichment	IL10RA	2.05
176	Ocular melanoma	Enrichment	PLCB4	2.05
177	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.05
178	Lymphoma	Enrichment	PTPN11	2.02
179	Kaposi sarcoma	Enrichment	IL6	2.00
180	Cerebral malaria	Enrichment	TNF	2.00
181	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.00
182	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	1.99
183	Budd-chiari syndrome	Enrichment	JAK2	1.96
184	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.96
185	Cerebrovascular disease	Enrichment	PIK3CA	1.96
186	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.96
187	Immunodeficiency 32b	Enrichment	IRF8	1.95
188	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	1.95
189	Aicardi-goutieres syndrome 6	Enrichment	ADAR	1.95
190	Stevens-johnson syndrome	Enrichment	HLA-B	1.95
191	Van der woude syndrome	Enrichment	IRF6	1.95
192	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	1.95
193	Submucosal cleft palate	Enrichment	UBB	1.95
194	Cleft hard palate	Enrichment	UBB	1.95
195	Patent ductus arteriosus	Enrichment	PTPN11	1.94
196	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.90
197	Vascular dementia	Enrichment	TNF	1.90
198	Idiopathic aplastic anemia	Enrichment	IFNG	1.90
199	Noonan syndrome 3	Enrichment	PTPN11	1.87
200	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.87
201	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.87
202	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.87
203	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.87
204	Primary polycythemia	Enrichment	EPOR	1.87
205	Hyper ige syndrome	Enrichment	STAT3	1.87
206	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.87
207	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.87
208	Capillary malformations, congenital	Enrichment	PIK3CA	1.87
209	Myeloproliferative neoplasm	Enrichment	JAK2	1.87
210	Hemimegalencephaly	Enrichment	PIK3CA	1.87
211	Type 1 diabetes mellitus	Enrichment	IL6	1.83
212	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.79
213	Cowden syndrome 1	Enrichment	PIK3CA	1.79
214	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.79
215	Breast adenocarcinoma	Enrichment	PIK3CA	1.79
216	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.79
217	Van der woude syndrome 1	Enrichment	IRF6	1.78
218	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB8	1.78
219	Uvula, bifid	Enrichment	UBB	1.78
220	Cleft soft palate	Enrichment	UBB	1.78
221	Torsion dystonia 1	Enrichment	EIF2AK2	1.78
222	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB8	1.78
223	Familial chilblain lupus	Enrichment	SAMHD1	1.78
224	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.77
225	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.75
226	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.75
227	Adenosine deaminase deficiency	Enrichment	JAK3	1.75
228	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.75
229	Nevus, epidermal	Enrichment	PIK3CA	1.72
230	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.72
231	Essential thrombocythemia	Enrichment	JAK2	1.72
232	Gallbladder cancer	Enrichment	PIK3CA	1.72
233	Overgrowth syndrome	Enrichment	PIK3R1	1.72
234	Thrombocytopenia	Enrichment	PTPN11, SRC	1.71
235	Pectus excavatum	Enrichment	PTPN11	1.68
236	Specific learning disability	Enrichment	PTPN11	1.68
237	Temporal arteritis	Enrichment	HLA-B	1.65
238	Cleft lip and alveolus	Enrichment	IRF6	1.65
239	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	1.65
240	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.65
241	Hereditary pulmonary alveolar proteinosis	Enrichment	CSF2RB	1.65
242	Rheumatoid arthritis	Enrichment	IL10	1.65
243	Inflammatory bowel disease 1	Enrichment	IL6	1.65
244	Epicanthus	Enrichment	PTPN11	1.64
245	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.64
246	Congenital long qt syndrome	Enrichment	PTPN11	1.64
247	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.63
248	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B	1.63
249	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.61
250	Arteriovenous malformation	Enrichment	PIK3CA	1.61
251	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.61
252	Cowden syndrome	Enrichment	PIK3CA	1.61
253	Aplastic anemia	Enrichment	IFNG	1.61
254	Lung non-small cell carcinoma	Enrichment	IRF1	1.58
255	Melanoma, uveal	Enrichment	PLCB4	1.57
256	Renal tubular dysgenesis	Enrichment	AGTR1	1.57
257	Autosomal dominant secondary polycythemia	Enrichment	EPO	1.57
258	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.57
259	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.57
260	Cleft upper lip	Enrichment	IRF6	1.56
261	Diffuse cutaneous systemic sclerosis	Enrichment	IRF5	1.56
262	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.55
263	Alzheimer's disease	Enrichment	TNF	1.49
264	Meningioma	Enrichment	PIK3CA	1.49
265	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.49
266	Limited scleroderma	Enrichment	IRF5	1.48
267	Patent foramen ovale	Enrichment	PTPN11	1.47
268	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.45
269	Diffuse large b-cell lymphoma	Enrichment	SOCS1	1.45
270	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	HLA-C	1.41
271	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.40
272	Lynch syndrome	Enrichment	PIK3CA	1.40
273	Noonan syndrome 1	Enrichment	PTPN11	1.36
274	Microphthalmia/coloboma 12	Enrichment	RARB	1.36
275	Scoliosis	Enrichment	PTPN11	1.35
276	Ichthyosis	Enrichment	IL2RB	1.32
277	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.31
278	Rasopathy	Enrichment	PTPN11	1.31
279	Coloboma of macula	Enrichment	RARB	1.30
280	Strabismus	Enrichment	PTPN11	1.30
281	Perrault syndrome 1	Enrichment	DAP3	1.28
282	Myocardial infarction	Enrichment	LTA	1.27
283	Endometrial cancer	Enrichment	PIK3CA	1.25
284	Long qt syndrome 1	Enrichment	PTPN11	1.25
285	Malaria	Enrichment	TNF	1.25
286	Nk-cell enteropathy	Enrichment	JAK3	1.24
287	Non-immune hydrops fetalis	Enrichment	PTPN11	1.24
288	Hepatocellular carcinoma	Enrichment	PIK3CA	1.23
289	Osteoporosis	Enrichment	SRC	1.21
290	Lung cancer susceptibility 3	Enrichment	EGFR	1.21
291	Gliosarcoma	Enrichment	EGFR	1.16
292	Microphthalmia	Enrichment	RARB	1.14
293	Hypertension, essential	Enrichment	AGTR1	1.13
294	Giant cell glioblastoma	Enrichment	EGFR	1.13
295	Lung cancer	Enrichment	IRF1	1.12
296	Cleft lip/palate	Enrichment	IRF6	1.12
297	Bladder cancer	Enrichment	PIK3CA	1.12
298	Prostate cancer	Enrichment	PIK3CA	1.12
299	Type 2 diabetes mellitus	Enrichment	PTPN1	1.11
300	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.10
301	Cleft palate, isolated	Enrichment	IRF6	1.04
302	Gastric cancer	Enrichment	IRF1	1.00
303	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	0.99
304	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.99
305	Leukemia, acute myeloid	Enrichment	JAK2	0.98
306	Hereditary breast carcinoma	Enrichment	PIK3CA	0.95
307	Tooth agenesis	Enrichment	IRF6	0.93
308	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PTPN11	0.93
309	Autoinflammatory disease	Enrichment	PSMB8	0.90
310	Hypertelorism	Enrichment	PIK3CA	0.88
311	Severe combined immunodeficiency	Enrichment	JAK3	0.86
312	Primary ovarian insufficiency	Enrichment	JAK2	0.83
313	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.77
314	Breast cancer	Enrichment	IL2	0.76
315	Centralopathic epilepsy	Enrichment	PLCB1	0.75
316	West syndrome	Enrichment	PLCB1	0.74
317	Autism spectrum disorder	Enrichment	PTPN11	0.72
318	Cerebral palsy	Enrichment	SAMHD1	0.71
319	Microcephaly	Enrichment	PTPN11	0.68
320	Ovarian cancer	Enrichment	PIK3CA	0.62
321	Myeloma, multiple	Enrichment	SAMHD1	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Overview of interferons-mediated signaling pathway

Pathway Network for Overview of interferons-mediated signaling pathway

Pathway network for the Overview of interferons-mediated signaling pathway SuperPath

Member Pathways for Overview of interferons-mediated signaling pathway

Pathways in the Overview of interferons-mediated signaling pathway SuperPath

Gene overlap in member pathways for Overview of interferons-mediated signaling pathway SuperPath

Associated Genes for Overview of interferons-mediated signaling pathway

Associated Disorders for Overview of interferons-mediated signaling pathway

Disorders associated with Overview of interferons-mediated signaling pathway SuperPath

STRING Interaction Network for Overview of interferons-mediated signaling pathway

Sources for Overview of interferons-mediated signaling pathway