OX40 Pathway

No Pathway Network information available for OX40 Pathway

Pathways in the OX40 Pathway SuperPath

#	Name	Source	Genes
1	OX40 Pathway	QIAGEN	BCL2 BCL2L1 CD247 CD3E IFNG IL10 IL13 IL2 IL4 IL5 IL9 JUN LTA LTB MAPK10 MAPK8 MAPK9 NFKB1 NFKBIA NFKBIB NFKBIE TNFRSF4 TNFSF4 TRAF2 TRAF3 TRAF5 (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
2	BCL2L1	BCL2 Like 1	Protein Coding	1
3	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
4	CD247	CD247 Molecule	Protein Coding	1
5	IFNG	Interferon Gamma	Protein Coding	1
6	IL10	Interleukin 10	Protein Coding	1
7	IL13	Interleukin 13	Protein Coding	1
8	IL2	Interleukin 2	Protein Coding	1
9	IL4	Interleukin 4	Protein Coding	1
10	IL5	Interleukin 5	Protein Coding	1
11	IL9	Interleukin 9	Protein Coding	1
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
13	LTA	Lymphotoxin Alpha	Protein Coding	1
14	LTB	Lymphotoxin Beta	Protein Coding	1
15	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
16	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
17	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
18	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
19	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
20	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
21	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
22	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	1
23	TNFSF4	TNF Superfamily Member 4	Protein Coding	1
24	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
25	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
26	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	1

Disorders associated with OX40 Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3E	4.98
2	Human immunodeficiency virus type 1	Enrichment	IFNG, IL10	3.28
3	Myocardial infarction	Enrichment	LTA, TNFSF4	3.10
4	Severe combined immunodeficiency	Enrichment	CD247, CD3E	2.75
5	Leprosy 4	Enrichment	LTA	2.72
6	Immunodeficiency 16	Enrichment	TNFRSF4	2.72
7	Immunodeficiency 69	Enrichment	IFNG	2.72
8	Graft-versus-host disease	Enrichment	IL10	2.72
9	Immunodeficiency 132a	Enrichment	TRAF3	2.72
10	Immunodeficiency 132b	Enrichment	TRAF3	2.72
11	Immunodeficiency 18	Enrichment	CD3E	2.72
12	Allergic rhinitis	Enrichment	IL13	2.72
13	Immunodeficiency 25	Enrichment	CD247	2.72
14	Systemic lupus erythematosus	Enrichment	IL10, TNFSF4	2.60
15	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.42
16	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.42
17	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.42
18	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.42
19	Common variable immunodeficiency 12	Enrichment	NFKB1	2.42
20	Tuberous sclerosis 1	Enrichment	IFNG	2.24
21	Psoriatic arthritis	Enrichment	LTA	2.24
22	Hepatitis c virus	Enrichment	IFNG	2.24
23	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.24
24	Tuberous sclerosis 2	Enrichment	IFNG	2.24
25	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.24
26	Breast cancer	Enrichment	IL2, JUN	2.05
27	Follicular lymphoma	Enrichment	BCL2	2.02
28	Herpes simplex virus encephalitis	Enrichment	TRAF3	2.02
29	Idiopathic aplastic anemia	Enrichment	IFNG	2.02
30	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.94
31	Common variable immunodeficiency	Enrichment	NFKB1	1.87
32	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.87
33	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.87
34	Narcolepsy 1	Enrichment	TNFSF4	1.82
35	Lennox-gastaut syndrome	Enrichment	MAPK10	1.82
36	Rheumatoid arthritis	Enrichment	IL10	1.77
37	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.72
38	Aplastic anemia	Enrichment	IFNG	1.72
39	Asthma	Enrichment	IL13	1.68
40	Gliosarcoma	Enrichment	NFKBIA	1.52
41	Giant cell glioblastoma	Enrichment	NFKBIA	1.49
42	Behcet syndrome	Enrichment	IL10	1.45
43	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.38
44	Myeloma, multiple	Enrichment	TRAF5	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for OX40 Pathway

Member Pathways for OX40 Pathway

Pathways in the OX40 Pathway SuperPath

Associated Genes for OX40 Pathway

Associated Disorders for OX40 Pathway

Disorders associated with OX40 Pathway SuperPath

STRING Interaction Network for OX40 Pathway

Sources for OX40 Pathway