Oxidative damage response

No Pathway Network information available for Oxidative damage response

Pathways in the Oxidative damage response SuperPath

#	Name	Source	Genes
1	Oxidative damage response	WikiPathways	APAF1 BAD BAG4 BAK1 BCL2 C1QA C1QB C1QC C1R C1S C2 C3AR1 C4B C5 C5AR1 CASP3 CASP9 CDC42 CDKN1A CDKN1B CDKN1C CR2 CYCS GADD45A MAP2K4 MAP3K1 MAP3K9 MAPK10 MAPK13 NFKB1 NFKBIE PCNA TDP2 TNF TNFRSF1B TNK2 TRAF1 TRAF2 TRAF3 TRAF6 (see all 40) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDC42	Cell Division Cycle 42	Protein Coding	1
2	CASP9	Caspase 9	Protein Coding	1
3	CASP3	Caspase 3	Protein Coding	1
4	C5AR1	Complement C5a Receptor 1	Protein Coding	1
5	C5	Complement C5	Protein Coding	1
6	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	1
7	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
8	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
9	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
10	C2	Complement C2	Protein Coding	1
11	C1S	Complement C1s	Protein Coding	1
12	C1R	Complement C1r	Protein Coding	1
13	C1QC	Complement C1q C Chain	Protein Coding	1
14	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
15	C1QB	Complement C1q B Chain	Protein Coding	1
16	TNF	Tumor Necrosis Factor	Protein Coding	1
17	C1QA	Complement C1q A Chain	Protein Coding	1
18	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
19	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
20	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
21	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
22	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
23	CYCS	Cytochrome C, Somatic	Protein Coding	1
24	TDP2	Tyrosyl-DNA Phosphodiesterase 2	Protein Coding	1
25	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
26	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
27	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
28	MAP3K9	Mitogen-Activated Protein Kinase Kinase Kinase 9	Protein Coding	1
29	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
30	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
31	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
32	CR2	Complement C3d Receptor 2	Protein Coding	1
33	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	1
34	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
35	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
36	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
37	BAG4	BAG Cochaperone 4	Protein Coding	1
38	C3AR1	Complement C3a Receptor 1	Protein Coding	1
39	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
40	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1

Disorders associated with Oxidative damage response SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1QA, C1QB, C1QC, C1R, C1S, C2, C4B	10.62
2	C1q deficiency 1	Enrichment	C1QA, C1QB, C1QC	7.62
3	Periodontal ehlers-danlos syndrome	Enrichment	C1R, C1S	5.07
4	Ehlers-danlos syndrome, periodontal type, 1	Enrichment	C1R, C1S	4.60
5	Ehlers-danlos syndrome, periodontal type, 2	Enrichment	C1R, C1S	4.60
6	Systemic lupus erythematosus 16	Enrichment	C1QA, C1R	4.07
7	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	3.75
8	Systemic lupus erythematosus	Enrichment	C4B, CR2, TNF	3.70
9	Complement component 2 deficiency	Enrichment	C2	2.53
10	Complement component 5 deficiency	Enrichment	C5	2.53
11	Spinocerebellar ataxia, autosomal recessive 23	Enrichment	TDP2	2.53
12	Eculizumab, poor response to	Enrichment	C5	2.53
13	46,xy sex reversal 6	Enrichment	MAP3K1	2.53
14	C1q deficiency 3	Enrichment	C1QC	2.53
15	Immunodeficiency 132a	Enrichment	TRAF3	2.53
16	Immunodeficiency 132b	Enrichment	TRAF3	2.53
17	Thrombocytopenia 4	Enrichment	CYCS	2.53
18	Neuroendocrine tumor	Enrichment	CDKN1B	2.53
19	Complement component 4b deficiency	Enrichment	C4B	2.53
20	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.53
21	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.53
22	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	2.53
23	C1q deficiency 2	Enrichment	C1QB	2.53
24	Nocarh syndrome	Enrichment	CDC42	2.53
25	Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome	Enrichment	CDKN1C	2.53
26	Immunodeficiency, common variable, 2	Enrichment	CR2	2.23
27	Complement component c1s deficiency	Enrichment	C1S	2.23
28	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	CDKN1C	2.23
29	Lathosterolosis	Enrichment	C5	2.23
30	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.23
31	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.23
32	Macular degeneration, age-related, 14	Enrichment	C2	2.23
33	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.23
34	Immunodeficiency, common variable, 7	Enrichment	CR2	2.23
35	Immunodeficiency 127	Enrichment	TNF	2.23
36	Immune system disease	Enrichment	CDC42	2.23
37	Common variable immunodeficiency 12	Enrichment	NFKB1	2.23
38	Mycosis fungoides	Enrichment	TNFRSF1B	2.05
39	Systemic lupus erythematosus 9	Enrichment	CR2	2.05
40	Psoriatic arthritis	Enrichment	TNF	2.05
41	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.05
42	Migraine without aura	Enrichment	TNF	2.05
43	Saczary syndrome	Enrichment	TNFRSF1B	2.05
44	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.93
45	Cerebral malaria	Enrichment	TNF	1.93
46	Silver-russell syndrome due to a point mutation	Enrichment	CDKN1C	1.93
47	Primary hyperparathyroidism	Enrichment	CDKN1B	1.93
48	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.83
49	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1	1.83
50	Follicular lymphoma	Enrichment	BCL2	1.83
51	Vascular dementia	Enrichment	TNF	1.83
52	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.83
53	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.83
54	Common variable immunodeficiency	Enrichment	NFKB1	1.69
55	Immunodeficiency due to a late component of complement deficiency	Enrichment	C5	1.69
56	Lennox-gastaut syndrome	Enrichment	MAPK10	1.63
57	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.54
58	Asthma	Enrichment	TNF	1.50
59	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.50
60	Ovarian cancer	Enrichment	CDKN1B, MAP3K1	1.45
61	Alzheimer's disease	Enrichment	TNF	1.42
62	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.39
63	Beckwith-wiedemann syndrome	Enrichment	CDKN1C	1.29
64	Ehlers-danlos syndrome	Enrichment	C1R	1.26
65	Parkinson's disease	Enrichment	TNK2	1.26
66	Williams-beuren syndrome	Enrichment	CDKN1C	1.24
67	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.20
68	Malaria	Enrichment	TNF	1.18
69	Bladder cancer	Enrichment	CDKN1A	1.09
70	Thrombocytopenia	Enrichment	CYCS	0.88
71	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Oxidative damage response

Pathway Network for Oxidative damage response

Member Pathways for Oxidative damage response

Pathways in the Oxidative damage response SuperPath

Associated Genes for Oxidative damage response

Associated Disorders for Oxidative damage response

Disorders associated with Oxidative damage response SuperPath

STRING Interaction Network for Oxidative damage response

Sources for Oxidative damage response