Oxidative stress response

No Pathway Network information available for Oxidative stress response

Pathways in the Oxidative stress response SuperPath

#	Name	Source	Genes
1	Oxidative stress response	WikiPathways	CAT CYBB CYP1A1 FOS GCLC GPX1 GPX3 GSR GSTT2 HMOX1 JUNB MAOA MAPK10 MAPK14 MGST1 MT1X NFE2L2 NFIX NFKB1 NOX1 NOX3 NOX4 NQO1 SOD1 SOD2 SOD3 SP1 TXN2 TXNRD1 TXNRD2 UGT1A6 XDH (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CAT	Catalase	Protein Coding	1
2	XDH	Xanthine Dehydrogenase	Protein Coding	1
3	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
4	SP1	Sp1 Transcription Factor	Protein Coding	1
5	SOD3	Superoxide Dismutase 3	Protein Coding	1
6	SOD2	Superoxide Dismutase 2	Protein Coding	1
7	SOD1	Superoxide Dismutase 1	Protein Coding	1
8	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
9	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	1
10	NOX3	NADPH Oxidase 3	Protein Coding	1
11	NOX4	NADPH Oxidase 4	Protein Coding	1
12	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
13	NFIX	Nuclear Factor I X	Protein Coding	1
14	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
15	MGST1	Microsomal Glutathione S-Transferase 1	Protein Coding	1
16	MAOA	Monoamine Oxidase A	Protein Coding	1
17	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
18	HMOX1	Heme Oxygenase 1	Protein Coding	1
19	GSTT2	Glutathione S-Transferase Theta 2 (Gene/Pseudogene)	Protein Coding	1
20	GSR	Glutathione-Disulfide Reductase	Protein Coding	1
21	GPX3	Glutathione Peroxidase 3	Protein Coding	1
22	GPX1	Glutathione Peroxidase 1	Protein Coding	1
23	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	1
24	NOX1	NADPH Oxidase 1	Protein Coding	1
25	TXN2	Thioredoxin 2	Protein Coding	1
26	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
27	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
28	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
29	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
30	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
31	TXNRD2	Thioredoxin Reductase 2	Protein Coding	1
32	MT1X	Metallothionein 1X	Protein Coding	1

Disorders associated with Oxidative stress response SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pulmonary disease, chronic obstructive	Enrichment	HMOX1, MGST1	3.38
2	Immunodeficiency 34	Enrichment	CYBB	2.63
3	Microvascular complications of diabetes 6	Enrichment	SOD2	2.63
4	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.63
5	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	2.63
6	Combined oxidative phosphorylation deficiency 29	Enrichment	TXN2	2.63
7	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.63
8	Brunner syndrome	Enrichment	MAOA	2.63
9	Marshall-smith syndrome	Enrichment	NFIX	2.63
10	Glucocorticoid deficiency 5	Enrichment	TXNRD2	2.63
11	Acatalasemia	Enrichment	CAT	2.63
12	Glutathione peroxidase deficiency	Enrichment	GPX1	2.63
13	Malan syndrome	Enrichment	NFIX	2.63
14	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.63
15	19p13.3 microduplication syndrome	Enrichment	NFIX	2.63
16	Sotos syndrome 2	Enrichment	NFIX	2.63
17	Cystic fibrosis	Enrichment	GCLC, HMOX1	2.59
18	Xanthinuria, type i	Enrichment	XDH	2.33
19	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.33
20	Albinism, oculocutaneous, type ia	Enrichment	NOX4	2.33
21	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.33
22	Common variable immunodeficiency 12	Enrichment	NFKB1	2.33
23	Laryngomalacia	Enrichment	NFIX	2.15
24	Megalocornea	Enrichment	NFIX	2.15
25	Xanthinuria, type ii	Enrichment	XDH	2.15
26	Granulomatous disease, chronic, x-linked	Enrichment	CYBB	2.03
27	Congenital generalized lipodystrophy	Enrichment	FOS	2.03
28	Megalencephalic leukoencephalopathy with subcortical cysts 1	Enrichment	GSTT2	1.93
29	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.93
30	Histiocytoid hemangioma	Enrichment	FOS	1.93
31	Familial glucocorticoid deficiency	Enrichment	TXNRD2	1.93
32	Motor neuron disease	Enrichment	SOD1	1.79
33	Common variable immunodeficiency	Enrichment	NFKB1	1.79
34	Lennox-gastaut syndrome	Enrichment	MAPK10	1.73
35	Chronic granulomatous disease	Enrichment	CYBB	1.68
36	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.63
37	Crigler-najjar syndrome, type i	Enrichment	UGT1A6	1.63
38	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A6	1.63
39	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A6	1.63
40	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.63
41	Crigler-najjar syndrome, type ii	Enrichment	UGT1A6	1.63
42	Gilbert syndrome	Enrichment	UGT1A6	1.59
43	Bilirubin metabolic disorder	Enrichment	UGT1A6	1.59
44	Myocardial infarction	Enrichment	GCLC	1.30
45	Strabismus	Enrichment	NFIX	1.21
46	Lung cancer	Enrichment	NFE2L2	1.14
47	Familial isolated dilated cardiomyopathy	Enrichment	TXNRD2	0.93
48	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.89
49	Colorectal cancer	Enrichment	NFE2L2	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Oxidative stress response

Pathway Network for Oxidative stress response

Member Pathways for Oxidative stress response

Pathways in the Oxidative stress response SuperPath

Associated Genes for Oxidative stress response

Associated Disorders for Oxidative stress response

Disorders associated with Oxidative stress response SuperPath

STRING Interaction Network for Oxidative stress response

Sources for Oxidative stress response