p38 MAPK signaling pathway (Pathway Interaction Database)

No Pathway Network information available for p38 MAPK signaling pathway (Pathway Interaction Database)

Pathways in the p38 MAPK signaling pathway (Pathway Interaction Database) SuperPath

#	Name	Source	Genes
1	p38 MAPK signaling pathway	PubChem	ATM CAMK2B CCM2 MAP2K3 MAP2K6 MAP3K1 MAP3K10 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAPK14 RAC1 TAB2 TAOK1 TRAF2 TRAF6 TXN (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CCM2	CCM2 Scaffold Protein	Protein Coding	1
2	MAP3K10	Mitogen-Activated Protein Kinase Kinase Kinase 10	Protein Coding	1
3	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
4	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
5	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
6	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
7	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
8	TAOK1	TAO Kinase 1	Protein Coding	1
9	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
10	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
11	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
12	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	1
13	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
14	TXN	Thioredoxin	Protein Coding	1
15	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
16	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
17	RAC1	Rac Family Small GTPase 1	Protein Coding	1
18	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
19	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1

Disorders associated with p38 MAPK signaling pathway (Pathway Interaction Database) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.85
2	46,xy sex reversal 6	Enrichment	MAP3K1	2.85
3	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.85
4	Developmental delay with or without intellectual impairment or behavioral abnormalities	Enrichment	TAOK1	2.85
5	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.85
6	Endometrial serous adenocarcinoma	Enrichment	ATM	2.85
7	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.85
8	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.85
9	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.85
10	Verrucous hemangioma	Enrichment	MAP3K3	2.85
11	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.85
12	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2B, TAOK1	2.66
13	Macroglossia	Enrichment	TAOK1	2.55
14	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.55
15	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.55
16	Neurodevelopmental disorder with developmental delay and with or without motor or speech delay	Enrichment	TAOK1	2.55
17	Cerebral cavernous malformations 2	Enrichment	CCM2	2.55
18	High grade glioma	Enrichment	ATM	2.55
19	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.55
20	T-cell prolymphocytic leukemia	Enrichment	ATM	2.55
21	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.55
22	Cerebral cavernous malformations	Enrichment	CCM2	2.38
23	Pelvic organ prolapse	Enrichment	TAB2	2.38
24	Ataxia-telangiectasia	Enrichment	ATM	2.38
25	Polycythemia vera	Enrichment	ATM	2.38
26	Koolen-de vries syndrome	Enrichment	ATM	2.38
27	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.38
28	Adenocarcinoma	Enrichment	ATM	2.38
29	Cavernous hemangioma	Enrichment	CCM2	2.38
30	Diffuse gastric and lobular breast cancer syndrome	Enrichment	MAP3K6	2.25
31	Mantle cell lymphoma	Enrichment	ATM	2.25
32	Familial cerebral cavernous malformations	Enrichment	CCM2	2.25
33	Oculomotor apraxia	Enrichment	ATM	2.25
34	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.16
35	Glioblastoma	Enrichment	ATM	2.16
36	Clear cell renal cell carcinoma	Enrichment	ATM	2.08
37	Ovarian cancer	Enrichment	ATM, MAP3K1	2.06
38	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.01
39	Fanconi anemia, complementation group c	Enrichment	TAOK1	1.95
40	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.90
41	Colonic benign neoplasm	Enrichment	ATM	1.90
42	Lynch syndrome 1	Enrichment	ATM	1.86
43	Leukemia, chronic lymphocytic	Enrichment	ATM	1.86
44	Migraine with or without aura 1	Enrichment	TAB2	1.82
45	Immune deficiency disease	Enrichment	ATM	1.82
46	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.82
47	Uterine corpus cancer	Enrichment	ATM	1.82
48	Familial colorectal cancer type x	Enrichment	ATM	1.82
49	Aortic valve disease 1	Enrichment	TAB2	1.74
50	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.74
51	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.71
52	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.68
53	Gliosarcoma	Enrichment	ATM	1.65
54	Giant cell glioblastoma	Enrichment	ATM	1.63
55	Patent foramen ovale	Enrichment	TAB2	1.60
56	Endometrial cancer	Enrichment	ATM	1.54
57	Pancreatic cancer	Enrichment	ATM	1.46
58	Bladder cancer	Enrichment	ATM	1.40
59	Prostate cancer	Enrichment	ATM	1.40
60	Dystonia	Enrichment	CAMK2B	1.32
61	Gastric cancer	Enrichment	ATM	1.23
62	Hereditary breast carcinoma	Enrichment	ATM	1.22
63	Hereditary breast ovarian cancer syndrome	Enrichment	ATM	1.13
64	Myeloma, multiple	Enrichment	ATM	1.12
65	Breast cancer	Enrichment	ATM	1.00
66	Dilated cardiomyopathy	Enrichment	TAB2	0.97
67	Colorectal cancer	Enrichment	ATM	0.94
68	Congenital nervous system abnormality	Enrichment	CAMK2B	0.86
69	Nervous system disease	Enrichment	CAMK2B	0.86
70	Microcephaly	Enrichment	CAMK2B	0.80
71	Inherited cancer-predisposing syndrome	Enrichment	ATM	0.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

p38 MAPK signaling pathway (Pathway Interaction Database)

Pathway Network for p38 MAPK signaling pathway (Pathway Interaction Database)

Member Pathways for p38 MAPK signaling pathway (Pathway Interaction Database)

Pathways in the p38 MAPK signaling pathway (Pathway Interaction Database) SuperPath

Associated Genes for p38 MAPK signaling pathway (Pathway Interaction Database)

Associated Disorders for p38 MAPK signaling pathway (Pathway Interaction Database)

Disorders associated with p38 MAPK signaling pathway (Pathway Interaction Database) SuperPath

STRING Interaction Network for p38 MAPK signaling pathway (Pathway Interaction Database)

Sources for p38 MAPK signaling pathway (Pathway Interaction Database)