P38 MAPK Signaling Pathway (sino)

No Pathway Network information available for P38 MAPK Signaling Pathway (sino)

Pathways in the P38 MAPK Signaling Pathway (sino) SuperPath

#	Name	Source	Genes
1	P38 MAPK Signaling Pathway	Sino Biological	ATF1 ATF2 BORCS8 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L4 DDIT3 DLK1 DLK2 EEF2K ELK1 ETS1 ETV1 FZD1 FZD10 FZD2 FZD4 FZD5 FZD9 H3C1 HMGN1 HSPB1 MAP2K3 MAP2K4 MAP2K6 MAP3K11 MAP3K2 MAP3K3 MAP3K7 MAPK14 MAPKAPK3 MAPKAPK5 MAPT MAX MEF2A MEF2C MEF2D MKNK1 MYC NR2C2 PAX6 PLA2G4A RARA RELA RIPK1 RIPK2 RIPK3 RPS6KA5 STAT1 TANK TAOK3 TGFB1 TGFB2 TGFB3 TP53AIP1 TP53I3 TP53RK TP53TG5 TRADD (see all 61) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATF1	Activating Transcription Factor 1	Protein Coding	1
2	ATF2	Activating Transcription Factor 2	Protein Coding	1
3	BORCS8	BLOC-1 Related Complex Subunit 8	Protein Coding	1
4	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
5	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
6	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
7	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	1
8	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
9	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
10	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
11	DLK2	Delta Like Non-Canonical Notch Ligand 2	Protein Coding	1
12	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	1
13	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
14	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
15	ETV1	ETS Variant Transcription Factor 1	Protein Coding	1
16	FZD1	Frizzled Class Receptor 1	Protein Coding	1
17	FZD10	Frizzled Class Receptor 10	Protein Coding	1
18	FZD2	Frizzled Class Receptor 2	Protein Coding	1
19	FZD4	Frizzled Class Receptor 4	Protein Coding	1
20	FZD5	Frizzled Class Receptor 5	Protein Coding	1
21	FZD9	Frizzled Class Receptor 9	Protein Coding	1
22	H3C1	H3 Clustered Histone 1	Protein Coding	1
23	HMGN1	High Mobility Group Nucleosome Binding Domain 1	Protein Coding	1
24	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
25	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
26	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
27	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
28	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
29	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
30	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
31	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
32	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
33	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
34	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	1
35	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
36	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
37	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
38	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
39	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
40	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
41	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
42	NR2C2	Nuclear Receptor Subfamily 2 Group C Member 2	Protein Coding	1
43	PAX6	Paired Box 6	Protein Coding	1
44	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
45	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
46	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
47	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
48	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
49	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
50	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
51	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
52	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
53	TAOK3	TAO Kinase 3	Protein Coding	1
54	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
55	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
56	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
57	TP53AIP1	Tumor Protein P53 Regulated Apoptosis Inducing Protein 1	Protein Coding	1
58	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	1
59	TP53RK	TP53 Regulating Kinase	Protein Coding	1
60	TP53TG5	TP53 Target 5	Protein Coding	1
61	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1

Disorders associated with P38 MAPK Signaling Pathway (sino) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.70
2	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	4.23
3	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.23
4	Eyelid coloboma	Enrichment	FZD5, PAX6	3.93
5	Lens coloboma	Enrichment	FZD5, PAX6	3.93
6	Coloboma of choroid and retina	Enrichment	FZD5, PAX6	3.71
7	Coloboma of optic nerve	Enrichment	FZD5, PAX6	3.53
8	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1, TGFB1	3.53
9	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1, TGFB1	3.53
10	Loeys-dietz syndrome	Enrichment	TGFB2, TGFB3	3.15
11	Cat eye syndrome	Enrichment	FZD5, PAX6	3.06
12	Microphthalmia/coloboma 12	Enrichment	FZD5, PAX6	2.82
13	Coloboma of macula	Enrichment	FZD5, PAX6	2.70
14	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.35
15	Omodysplasia 2	Enrichment	FZD2	2.35
16	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	2.35
17	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.35
18	Parkinson-dementia syndrome	Enrichment	MAPT	2.35
19	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.35
20	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.35
21	Camurati-engelmann disease 2	Enrichment	TGFB2	2.35
22	Progressive supranuclear palsy	Enrichment	MAPT	2.35
23	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.35
24	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.35
25	Immunodeficiency 31a	Enrichment	STAT1	2.35
26	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.35
27	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.35
28	Microphthalmia/coloboma 11	Enrichment	FZD5	2.35
29	Immunodeficiency 31b	Enrichment	STAT1	2.35
30	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.35
31	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.35
32	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.35
33	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.35
34	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.35
35	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.35
36	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.35
37	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.35
38	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.35
39	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.35
40	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.35
41	Mef2c-related disorder	Enrichment	MEF2C	2.35
42	Verrucous hemangioma	Enrichment	MAP3K3	2.35
43	Keratitis, hereditary	Enrichment	PAX6	2.05
44	Burkitt lymphoma	Enrichment	MYC	2.05
45	Foveal hypoplasia 1	Enrichment	PAX6	2.05
46	Camurati-engelmann disease 1	Enrichment	TGFB1	2.05
47	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.05
48	Pick disease of brain	Enrichment	MAPT	2.05
49	Optic nerve hypoplasia, bilateral	Enrichment	PAX6	2.05
50	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.05
51	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	2.05
52	Immunodeficiency 31c	Enrichment	STAT1	2.05
53	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.05
54	Neurodegeneration, infantile-onset, with optic atrophy and brain abnormalities	Enrichment	BORCS8	2.05
55	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.05
56	Rela fusion-positive ependymoma	Enrichment	RELA	2.05
57	Central precocious puberty	Enrichment	DLK1	2.05
58	Camurati-engelmann disease	Enrichment	TGFB1	2.05
59	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.05
60	Jacobsen syndrome	Enrichment	ETS1	1.87
61	Gillespie syndrome	Enrichment	PAX6	1.87
62	Galloway-mowat syndrome 4	Enrichment	TP53RK	1.87
63	Bacteremia 2	Enrichment	MAPKAPK3	1.87
64	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.87
65	Precocious puberty, central, 2	Enrichment	DLK1	1.87
66	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.87
67	Myxoid liposarcoma	Enrichment	DDIT3	1.87
68	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2, TGFB3	1.78
69	Aniridia 1	Enrichment	PAX6	1.75
70	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2	1.75
71	Kagami-ogata syndrome	Enrichment	DLK1	1.75
72	Temple syndrome	Enrichment	DLK1	1.75
73	Retinopathy of prematurity	Enrichment	FZD4	1.75
74	Tuberculosis	Enrichment	MAPKAPK3	1.75
75	Autosomal dominant robinow syndrome	Enrichment	FZD2	1.75
76	Genetic central precocious puberty in male	Enrichment	DLK1	1.75
77	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.65
78	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.65
79	Exudative vitreoretinopathy 1	Enrichment	FZD4	1.65
80	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2	1.65
81	Norrie disease	Enrichment	FZD4	1.65
82	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.65
83	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.65
84	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.65
85	Dementia	Enrichment	MAPT	1.65
86	Aniridia	Enrichment	PAX6	1.65
87	Atrial septal defect 1	Enrichment	TGFB2	1.57
88	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	PAX6	1.57
89	Anterior segment dysgenesis 5	Enrichment	PAX6	1.57
90	Autosomal recessive robinow syndrome	Enrichment	FZD2	1.57
91	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.57
92	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT, MEF2C	1.55
93	Coats disease	Enrichment	FZD4	1.51
94	Semantic dementia	Enrichment	MAPT	1.51
95	Glioma susceptibility 1	Enrichment	H3C1	1.45
96	Ewing sarcoma	Enrichment	ETV1	1.45
97	Exudative vitreoretinopathy	Enrichment	FZD4	1.45
98	Progressive non-fluent aphasia	Enrichment	MAPT	1.40
99	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.40
100	Marfan syndrome	Enrichment	TGFB2	1.36
101	Peters-plus syndrome	Enrichment	PAX6	1.36
102	Galloway-mowat syndrome	Enrichment	TP53RK	1.36
103	Immune deficiency disease	Enrichment	RIPK1	1.32
104	Frontotemporal dementia 1	Enrichment	MAPT	1.32
105	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.28
106	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.28
107	Acute promyelocytic leukemia	Enrichment	RARA	1.24
108	Alzheimer's disease	Enrichment	MAPT	1.24
109	Pheochromocytoma	Enrichment	MAX	1.21
110	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.21
111	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	1.18
112	Anterior segment dysgenesis	Enrichment	PAX6	1.18
113	Alzheimer disease, familial, 1	Enrichment	MAPT	1.13
114	Ehlers-danlos syndrome	Enrichment	TGFB2	1.09
115	Macs syndrome	Enrichment	PAX6	1.06
116	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	1.04
117	Microphthalmia	Enrichment	PAX6	1.02
118	Brittle bone disorder	Enrichment	CREB3L1	1.01
119	Malaria	Enrichment	MAPKAPK3	1.01
120	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.01
121	Parkinson disease, late-onset	Enrichment	MAPT	0.99
122	Cystic fibrosis	Enrichment	TGFB1	0.87
123	Systemic lupus erythematosus	Enrichment	ETS1	0.79
124	Charcot-marie-tooth disease	Enrichment	HSPB1	0.77
125	Hypertelorism	Enrichment	PAX6	0.68
126	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.66
127	Myeloma, multiple	Enrichment	H3C1	0.65
128	Autism spectrum disorder	Enrichment	MEF2C	0.41
129	Inherited cancer-predisposing syndrome	Enrichment	MAX	0.35
130	Hereditary retinal dystrophy	Enrichment	FZD4	0.13
131	Fundus dystrophy	Enrichment	FZD4	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

P38 MAPK Signaling Pathway (sino)

Pathway Network for P38 MAPK Signaling Pathway (sino)

Member Pathways for P38 MAPK Signaling Pathway (sino)

Pathways in the P38 MAPK Signaling Pathway (sino) SuperPath

Associated Genes for P38 MAPK Signaling Pathway (sino)

Associated Disorders for P38 MAPK Signaling Pathway (sino)

Disorders associated with P38 MAPK Signaling Pathway (sino) SuperPath

STRING Interaction Network for P38 MAPK Signaling Pathway (sino)

Sources for P38 MAPK Signaling Pathway (sino)