p38 MAPK signaling pathway (WikiPathways)

No Pathway Network information available for p38 MAPK signaling pathway (WikiPathways)

Pathways in the p38 MAPK signaling pathway (WikiPathways) SuperPath

#	Name	Source	Genes
1	p38 MAPK signaling pathway	WikiPathways	ATF2 CDC42 CREB1 DAXX DDIT3 ELK1 GRB2 HMGN1 HRAS HSPB1 MAP2K4 MAP2K6 MAP3K1 MAP3K5 MAP3K7 MAP3K9 MAPK14 MAPKAPK2 MAPKAPK5 MAX MEF2D MKNK1 MYC PLA2G4A RAC1 RASGRF1 RIPK1 RPS6KA5 SHC1 STAT1 TGFB2 TGFBR1 TRADD TRAF2 (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDC42	Cell Division Cycle 42	Protein Coding	1
2	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
3	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
4	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
5	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
6	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
7	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
8	SHC1	SHC Adaptor Protein 1	Protein Coding	1
9	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
10	RAC1	Rac Family Small GTPase 1	Protein Coding	1
11	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
12	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
14	MAP3K9	Mitogen-Activated Protein Kinase Kinase Kinase 9	Protein Coding	1
15	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
16	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
17	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
18	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
19	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
20	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
21	HMGN1	High Mobility Group Nucleosome Binding Domain 1	Protein Coding	1
22	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
23	DAXX	Death Domain Associated Protein	Protein Coding	1
24	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
25	ATF2	Activating Transcription Factor 2	Protein Coding	1
26	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
27	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
28	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
29	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	1
30	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
31	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
32	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
33	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
34	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with p38 MAPK signaling pathway (WikiPathways) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	TGFB2, TGFBR1	3.66
2	Marfan syndrome	Enrichment	TGFB2, TGFBR1	3.57
3	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.60
4	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.60
5	46,xy sex reversal 6	Enrichment	MAP3K1	2.60
6	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.60
7	Camurati-engelmann disease 2	Enrichment	TGFB2	2.60
8	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.60
9	Immunodeficiency 31a	Enrichment	STAT1	2.60
10	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.60
11	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.60
12	Immunodeficiency 31b	Enrichment	STAT1	2.60
13	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.60
14	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.60
15	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.60
16	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.60
17	Nocarh syndrome	Enrichment	CDC42	2.60
18	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.60
19	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.60
20	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.60
21	Burkitt lymphoma	Enrichment	MYC	2.30
22	Costello syndrome	Enrichment	HRAS	2.30
23	Loeys-dietz syndrome 2	Enrichment	TGFBR1	2.30
24	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.30
25	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.30
26	Immunodeficiency 31c	Enrichment	STAT1	2.30
27	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.30
28	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.30
29	Immune system disease	Enrichment	CDC42	2.30
30	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.30
31	Wooly hair nevus	Enrichment	HRAS	2.30
32	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2, TGFBR1	2.27
33	Large congenital melanocytic nevus	Enrichment	HRAS	2.12
34	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.12
35	Loeys-dietz syndrome 1	Enrichment	TGFBR1	2.12
36	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.12
37	Myxoid liposarcoma	Enrichment	DDIT3	2.12
38	Spermatocytoma	Enrichment	HRAS	2.12
39	Melanoma of soft tissue	Enrichment	CREB1	2.12
40	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.00
41	Aortic aneurysm	Enrichment	TGFBR1	2.00
42	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.00
43	Epidermolytic nevus	Enrichment	HRAS	2.00
44	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.90
45	Atrial septal defect 1	Enrichment	TGFB2	1.83
46	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.83
47	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.83
48	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.83
49	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.83
50	Nevus, epidermal	Enrichment	HRAS	1.76
51	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.76
52	Noonan syndrome 3	Enrichment	HRAS	1.76
53	Follicular thyroid carcinoma	Enrichment	HRAS	1.76
54	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.70
55	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.65
56	Arteriovenous malformation	Enrichment	HRAS	1.65
57	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.61
58	Pectus excavatum	Enrichment	TGFBR1	1.56
59	Immune deficiency disease	Enrichment	RIPK1	1.56
60	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.56
61	Lung non-small cell carcinoma	Enrichment	HRAS	1.56
62	Lip and oral cavity carcinoma	Enrichment	HRAS	1.53
63	Pheochromocytoma	Enrichment	MAX	1.46
64	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.46
65	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.43
66	Rhabdomyosarcoma	Enrichment	HRAS	1.40
67	Ehlers-danlos syndrome	Enrichment	TGFB2	1.33
68	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	1.29
69	Noonan syndrome 1	Enrichment	HRAS	1.25
70	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.25
71	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.20
72	Rasopathy	Enrichment	HRAS	1.20
73	Bladder cancer	Enrichment	HRAS	1.15
74	Differentiated thyroid carcinoma	Enrichment	HRAS	1.15
75	Non-immune hydrops fetalis	Enrichment	HRAS	1.13
76	Charcot-marie-tooth disease	Enrichment	HSPB1	1.01
77	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.89
78	Breast cancer	Enrichment	SHC1	0.76
79	Ovarian cancer	Enrichment	MAP3K1	0.65
80	Inherited cancer-predisposing syndrome	Enrichment	MAX	0.55

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

p38 MAPK signaling pathway (WikiPathways)

Pathway Network for p38 MAPK signaling pathway (WikiPathways)

Member Pathways for p38 MAPK signaling pathway (WikiPathways)

Pathways in the p38 MAPK signaling pathway (WikiPathways) SuperPath

Associated Genes for p38 MAPK signaling pathway (WikiPathways)

Associated Disorders for p38 MAPK signaling pathway (WikiPathways)

Disorders associated with p38 MAPK signaling pathway (WikiPathways) SuperPath

STRING Interaction Network for p38 MAPK signaling pathway (WikiPathways)

Sources for p38 MAPK signaling pathway (WikiPathways)