p53 pathway

No Pathway Network information available for p53 pathway

Pathways in the p53 pathway SuperPath

#	Name	Source	Genes
1	p53 pathway	PubChem	ABL1 AKT1 ATM ATR CCNA2 CCNG1 CDK2 CDKN2A CHEK1 CHEK2 COP1 CSE1L DAXX DYRK2 E4F1 FBXO11 GSK3B HIPK2 HUWE1 KAT2B KAT5 KAT8 KMT5A MAPK14 MAPK8 MDM2 MDM4 NEDD8 PIN1 PPM1D PPP1R13L PPP2CA PRKCD PRMT5 PTPA RASSF1 RCHY1 RPL11 RPL23 RPL5 SETD7 SKP2 SMYD2 TP53 TP53AIP1 TRIM28 TTC5 UBE2D1 USP7 YY1 (see all 50) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	E4F1	E4F Transcription Factor 1	Protein Coding	1
2	HUWE1	HECT, UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
3	FBXO11	F-Box Protein 11	Protein Coding	1
4	CSE1L	Chromosome Segregation 1 Like	Protein Coding	1
5	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
6	RASSF1	Ras Association Domain Family Member 1	Protein Coding	1
7	SETD7	SET Domain Containing 7, Histone Lysine Methyltransferase	Protein Coding	1
8	PPP1R13L	Protein Phosphatase 1 Regulatory Subunit 13 Like	Protein Coding	1
9	TP53AIP1	Tumor Protein P53 Regulated Apoptosis Inducing Protein 1	Protein Coding	1
10	TTC5	Tetratricopeptide Repeat Domain 5	Protein Coding	1
11	CCNG1	Cyclin G1	Protein Coding	1
12	SMYD2	SET And MYND Domain Containing 2	Protein Coding	1
13	PPM1D	Protein Phosphatase, Mg2+/Mn2+ Dependent 1D	Protein Coding	1
14	DYRK2	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2	Protein Coding	1
15	KAT8	Lysine Acetyltransferase 8	Protein Coding	1
16	PRMT5	Protein Arginine Methyltransferase 5	Protein Coding	1
17	DAXX	Death Domain Associated Protein	Protein Coding	1
18	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	1
19	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
20	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
21	CCNA2	Cyclin A2	Protein Coding	1
22	COP1	COP1 E3 Ubiquitin Ligase	Protein Coding	1
23	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
24	MDM4	MDM4 Regulator Of P53	Protein Coding	1
25	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
26	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	1
27	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
28	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
29	CHEK2	Checkpoint Kinase 2	Protein Coding	1
30	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
31	RCHY1	Ring Finger And CHY Zinc Finger Domain Containing 1	Protein Coding	1
32	PRKCD	Protein Kinase C Delta	Protein Coding	1
33	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
34	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
35	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
36	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
37	KMT5A	Lysine Methyltransferase 5A	Protein Coding	1
38	YY1	YY1 Transcription Factor	Protein Coding	1
39	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
40	RPL11	Ribosomal Protein L11	Protein Coding	1
41	RPL23	Ribosomal Protein L23	Protein Coding	1
42	RPL5	Ribosomal Protein L5	Protein Coding	1
43	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
44	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	1
45	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
46	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
47	ATR	ATR Checkpoint Kinase	Protein Coding	1
48	CHEK1	Checkpoint Kinase 1	Protein Coding	1
49	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
50	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with p53 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Li-fraumeni syndrome	Enrichment	CDKN2A, CHEK2, MDM2, TP53	8.61
2	Hereditary breast carcinoma	Enrichment	AKT1, ATM, CHEK2, PPM1D, TP53	6.27
3	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A, TP53	5.79
4	Ovarian cancer	Enrichment	AKT1, ATM, CDKN2A, CHEK2, PPM1D, TP53	5.75
5	Pancreatic cancer	Enrichment	ATM, CDKN2A, CHEK2, TP53	5.71
6	Breast cancer	Enrichment	AKT1, ATM, CHEK2, PPM1D, TP53	5.10
7	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A, TP53	4.99
8	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.88
9	Sarcoma	Enrichment	CHEK2, TP53	4.88
10	Gastric cancer	Enrichment	ATM, CDKN2A, CHEK2, TP53	4.74
11	Osteogenic sarcoma	Enrichment	CHEK2, TP53	4.40
12	Adenocarcinoma	Enrichment	ATM, TP53	4.40
13	Bone osteosarcoma	Enrichment	CHEK2, TP53	4.40
14	Diamond-blackfan anemia 1	Enrichment	RPL11, RPL5, TP53	4.10
15	Bladder cancer	Enrichment	ATM, CDKN2A, TP53	3.79
16	Prostate cancer	Enrichment	ATM, CHEK2, TP53	3.79
17	Wilms tumor 5	Enrichment	CHEK2, TRIM28	3.70
18	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.70
19	Breast adenocarcinoma	Enrichment	AKT1, TP53	3.70
20	Colorectal cancer	Enrichment	AKT1, ATM, CHEK2, TP53	3.54
21	Diamond-blackfan anemia	Enrichment	RPL11, RPL5, TP53	3.51
22	Colonic benign neoplasm	Enrichment	ATM, CHEK2	3.33
23	Lynch syndrome 1	Enrichment	ATM, CHEK2	3.23
24	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	3.23
25	Melanoma	Enrichment	CDKN2A, CHEK2	3.23
26	Uterine corpus cancer	Enrichment	ATM, CHEK2	3.14
27	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.14
28	Breast-ovarian cancer, familial 1	Enrichment	ATM, CHEK2	2.99
29	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, CHEK2, TP53	2.97
30	Complex neurodevelopmental disorder	Enrichment	FBXO11, HUWE1, KAT8, PPP2CA	2.96
31	Wilms tumor 1	Enrichment	CHEK2, TRIM28	2.87
32	Inherited cancer-predisposing syndrome	Enrichment	ATM, CDKN2A, CHEK2, TP53	2.86
33	Gliosarcoma	Enrichment	ATM, TP53	2.81
34	Giant cell glioblastoma	Enrichment	ATM, TP53	2.76
35	Diffuse large b-cell lymphoma	Enrichment	CHEK2, TP53	2.66
36	Endometrial cancer	Enrichment	ATM, CHEK2	2.57
37	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A	2.49
38	Proteus syndrome	Enrichment	AKT1	2.43
39	Seckel syndrome 1	Enrichment	ATR	2.43
40	Accelerated tumor formation	Enrichment	MDM2	2.43
41	Diamond-blackfan anemia 7	Enrichment	RPL11	2.43
42	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.43
43	Li-ghorbani-weisz-hubshman syndrome	Enrichment	KAT8	2.43
44	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.43
45	Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities	Enrichment	PPP1R13L	2.43
46	Trigonocephaly with short stature and developmental delay	Enrichment	HUWE1	2.43
47	Lessel-kubisch syndrome	Enrichment	MDM2	2.43
48	Bone marrow failure syndrome 6	Enrichment	MDM4	2.43
49	Bone marrow failure syndrome 5	Enrichment	TP53	2.43
50	Papilloma of choroid plexus	Enrichment	TP53	2.43
51	Basal cell carcinoma 7	Enrichment	TP53	2.43
52	Anaplastic thyroid carcinoma	Enrichment	TP53	2.43
53	Intellectual developmental disorder, x-linked, syndromic, turner type	Enrichment	HUWE1	2.43
54	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.43
55	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.43
56	Cowden syndrome 6	Enrichment	AKT1	2.43
57	Syndromic x-linked intellectual disability turner type	Enrichment	HUWE1	2.43
58	Endometrial serous adenocarcinoma	Enrichment	ATM	2.43
59	Ductal carcinoma in situ	Enrichment	TP53	2.43
60	Jansen-de vries syndrome	Enrichment	PPM1D	2.43
61	Leiomyosarcoma	Enrichment	CHEK2	2.43
62	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.43
63	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.43
64	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.43
65	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.43
66	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.43
67	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.43
68	Choroid plexus cancer	Enrichment	TP53	2.43
69	Wilms tumor 7	Enrichment	TRIM28	2.43
70	Multiple congenital anomalies/dysmorphic syndrome	Enrichment	PPP1R13L	2.43
71	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.43
72	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.43
73	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.13
74	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.13
75	Autism x-linked 2	Enrichment	HUWE1	2.13
76	Cervical cancer	Enrichment	TP53	2.13
77	Diamond-blackfan anemia 6	Enrichment	RPL5	2.13
78	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.13
79	Lymphoma, hodgkin, classic	Enrichment	TP53	2.13
80	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.13
81	Gabriele-de vries syndrome	Enrichment	YY1	2.13
82	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.13
83	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.13
84	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.13
85	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.13
86	Congenital fibrosarcoma	Enrichment	TP53	2.13
87	High grade glioma	Enrichment	ATM	2.13
88	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.13
89	Cervix carcinoma	Enrichment	TP53	2.13
90	Hodgkin's lymphoma	Enrichment	TP53	2.13
91	Insulinoma	Enrichment	YY1	2.13
92	T-cell prolymphocytic leukemia	Enrichment	ATM	2.13
93	Hao-fountain syndrome	Enrichment	USP7	2.13
94	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.13
95	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.13
96	Ataxia-telangiectasia	Enrichment	ATM	1.96
97	Polycythemia vera	Enrichment	ATM	1.96
98	Nasopharyngeal carcinoma	Enrichment	TP53	1.96
99	Neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism	Enrichment	TTC5	1.96
100	Koolen-de vries syndrome	Enrichment	ATM	1.96
101	Dedifferentiated liposarcoma	Enrichment	MDM2	1.96
102	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.96
103	Anaplastic astrocytoma	Enrichment	TP53	1.96
104	Squamous cell carcinoma	Enrichment	TP53	1.96
105	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.96
106	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	FBXO11	1.96
107	Well-differentiated liposarcoma	Enrichment	MDM2	1.96
108	Small cell cancer of the lung	Enrichment	TP53	1.83
109	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	E4F1	1.83
110	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.83
111	Mantle cell lymphoma	Enrichment	ATM	1.83
112	Lung sarcomatoid carcinoma	Enrichment	TP53	1.83
113	Orofacial cleft	Enrichment	PPP1R13L	1.83
114	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.83
115	Ciliary dyskinesia, primary, 22	Enrichment	RASSF1	1.83
116	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.83
117	Noonan syndrome with multiple lentigines	Enrichment	PPP1R13L	1.83
118	Hemoglobin c disease	Enrichment	CHEK2	1.83
119	Orofacial clefting syndrome	Enrichment	PPP1R13L	1.83
120	Oculomotor apraxia	Enrichment	ATM	1.83
121	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.83
122	Myeloma, multiple	Enrichment	ATM, TP53	1.74
123	Rhabdomyosarcoma 2	Enrichment	TP53	1.74
124	Lymphoma	Enrichment	TP53	1.74
125	Glioblastoma	Enrichment	ATM	1.74
126	Hemangioma	Enrichment	RPL5	1.74
127	Acute megakaryocytic leukemia	Enrichment	TP53	1.74
128	Clear cell renal cell carcinoma	Enrichment	ATM	1.66
129	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.66
130	Esophageal cancer	Enrichment	TP53	1.59
131	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.59
132	Leukemia, chronic myeloid	Enrichment	ABL1	1.59
133	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.59
134	Essential thrombocythemia	Enrichment	TP53	1.59
135	Gallbladder cancer	Enrichment	TP53	1.59
136	Moyamoya angiopathy	Enrichment	ABL1	1.59
137	Glioma susceptibility 1	Enrichment	TP53	1.54
138	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.54
139	Adult hepatocellular carcinoma	Enrichment	TP53	1.49
140	Primary hyperaldosteronism	Enrichment	TP53	1.49
141	Cowden syndrome	Enrichment	AKT1	1.49
142	Aplastic anemia	Enrichment	RPL5	1.44
143	Familial colorectal cancer	Enrichment	TP53	1.44
144	Immune deficiency disease	Enrichment	ATM	1.40
145	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.40
146	Myelodysplastic syndrome	Enrichment	TP53	1.40
147	Atrial heart septal defect	Enrichment	RPL5	1.40
148	Interatrial communication	Enrichment	RPL5	1.40
149	Meningioma	Enrichment	AKT1	1.36
150	Pulmonary hypertension, primary, 1	Enrichment	RPL5	1.33
151	Protein-deficiency anemia	Enrichment	RPL11	1.33
152	Nk-cell enteropathy	Enrichment	CHEK2	1.33
153	Lung cancer susceptibility 3	Enrichment	TP53	1.30
154	Seckel syndrome	Enrichment	ATR	1.30
155	Heart disease	Enrichment	ABL1	1.30
156	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.27
157	Lynch syndrome	Enrichment	CHEK2	1.27
158	Rhabdomyosarcoma	Enrichment	TP53	1.24
159	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.22
160	Hepatoblastoma	Enrichment	TP53	1.13
161	Hepatocellular carcinoma	Enrichment	TP53	1.11
162	Lung cancer	Enrichment	CHEK2	0.95
163	Non-syndromic x-linked intellectual disability	Enrichment	HUWE1	0.90
164	Leukemia, acute myeloid	Enrichment	TP53	0.86
165	Body mass index quantitative trait locus 11	Enrichment	FBXO11	0.77
166	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPM1D	0.77
167	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	HUWE1	0.73
168	Autosomal recessive non-syndromic intellectual disability	Enrichment	TTC5	0.71
169	Primary ovarian insufficiency	Enrichment	CHEK2	0.71
170	Dilated cardiomyopathy	Enrichment	PPP1R13L	0.59
171	Microcephaly	Enrichment	ABL1	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

p53 pathway

Pathway Network for p53 pathway

Member Pathways for p53 pathway

Pathways in the p53 pathway SuperPath

Associated Genes for p53 pathway

Associated Disorders for p53 pathway

Disorders associated with p53 pathway SuperPath

STRING Interaction Network for p53 pathway

Sources for p53 pathway