p53 Signaling

No Pathway Network information available for p53 Signaling

Pathways in the p53 Signaling SuperPath

#	Name	Source	Genes
1	p53 Signaling	QIAGEN	ABL1 ADGRB1 AKT1 AKT2 AKT3 ATM ATR BAX BCL2 BRCA1 CASP1 CASP10 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CCND1 CCNE1 CDK2 CDK4 CDKN1A CHEK1 CHEK2 CSNK1D DDR1 E2F1 E2F2 E2F3 E2F4 E2F5 EP300 FAS FOS GADD45A GADD45B GADD45G GSK3B HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HIF1A HIPK2 KAT2B MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MDM2 PIAS1 PML PRKDC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PTEN RB1 SFN SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 THBS1 TNFRSF10B TP53 UBB UBC UBD (see all 107) (see less)
2	p53 Pathway	Sino Biological	AKT1 AKT2 AKT3 BAX BCL2 BCL2L1 BRCA1 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CCNE1 CDK2 CDK4 CDKN1A CHEK1 CHEK2 DDR1 E2F2 E2F3 FAS FASLG FOS GADD45A GADD45B GADD45G GSK3B HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC8 HIF1A HIPK2 MAPK1 MAPK14 MAPK6 MAPK7 MDM2 PIAS1 PPIF PTEN RB1 SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 TNFRSF10B TNFSF10 TP53 (see all 62) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
3	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
4	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	2
5	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
6	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	2
7	CASP1	Caspase 1	Protein Coding	2
8	CASP10	Caspase 10	Protein Coding	2
9	CASP2	Caspase 2	Protein Coding	2
10	CASP3	Caspase 3	Protein Coding	2
11	CASP4	Caspase 4	Protein Coding	2
12	CASP5	Caspase 5	Protein Coding	2
13	CASP6	Caspase 6	Protein Coding	2
14	CASP7	Caspase 7	Protein Coding	2
15	CASP8	Caspase 8	Protein Coding	2
16	CASP9	Caspase 9	Protein Coding	2
17	CCNE1	Cyclin E1	Protein Coding	2
18	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
19	CDK4	Cyclin Dependent Kinase 4	Protein Coding	2
20	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
21	CHEK1	Checkpoint Kinase 1	Protein Coding	2
22	CHEK2	Checkpoint Kinase 2	Protein Coding	2
23	DDR1	Discoidin Domain Receptor Tyrosine Kinase 1	Protein Coding	2
24	E2F2	E2F Transcription Factor 2	Protein Coding	2
25	E2F3	E2F Transcription Factor 3	Protein Coding	2
26	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
27	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	2
28	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	2
29	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	2
30	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	2
31	HDAC1	Histone Deacetylase 1	Protein Coding	2
32	HDAC10	Histone Deacetylase 10	Protein Coding	2
33	HDAC11	Histone Deacetylase 11	Protein Coding	2
34	HDAC2	Histone Deacetylase 2	Protein Coding	2
35	HDAC3	Histone Deacetylase 3	Protein Coding	2
36	HDAC8	Histone Deacetylase 8	Protein Coding	2
37	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	2
38	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	2
39	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
40	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
41	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	2
42	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
43	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
44	SIRT1	Sirtuin 1	Protein Coding	2
45	SIRT2	Sirtuin 2	Protein Coding	2
46	SIRT3	Sirtuin 3	Protein Coding	2
47	SIRT4	Sirtuin 4	Protein Coding	2
48	SIRT5	Sirtuin 5	Protein Coding	2
49	SIRT6	Sirtuin 6	Protein Coding	2
50	SIRT7	Sirtuin 7	Protein Coding	2
51	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	2
52	FAS	Fas Cell Surface Death Receptor	Protein Coding	2
53	TP53	Tumor Protein P53	Protein Coding	2
54	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
55	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
56	ATR	ATR Checkpoint Kinase	Protein Coding	1
57	ADGRB1	Adhesion G Protein-Coupled Receptor B1	Protein Coding	1
58	CCND1	Cyclin D1	Protein Coding	1
59	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1
60	E2F1	E2F Transcription Factor 1	Protein Coding	1
61	E2F4	E2F Transcription Factor 4	Protein Coding	1
62	E2F5	E2F Transcription Factor 5	Protein Coding	1
63	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
64	HDAC5	Histone Deacetylase 5	Protein Coding	1
65	HDAC6	Histone Deacetylase 6	Protein Coding	1
66	HDAC7	Histone Deacetylase 7	Protein Coding	1
67	HDAC9	Histone Deacetylase 9	Protein Coding	1
68	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
69	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
70	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
71	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
72	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
73	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
74	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1
75	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
76	PML	PML Nuclear Body Scaffold	Protein Coding	1
77	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
78	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
79	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
80	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
81	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
82	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
83	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
84	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
85	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
86	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
87	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
88	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
89	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
90	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
91	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
92	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
93	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
94	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
95	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
96	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
97	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
98	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
99	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
100	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
101	PSMD4	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4	Protein Coding	1
102	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	1
103	SFN	Stratifin	Protein Coding	1
104	THBS1	Thrombospondin 1	Protein Coding	1
105	UBB	Ubiquitin B	Protein Coding	1
106	UBC	Ubiquitin C	Protein Coding	1
107	UBD	Ubiquitin Like Modifier D	Protein Coding	1
108	BCL2L1	BCL2 Like 1	Protein Coding	1
109	CASP14	Caspase 14	Protein Coding	1
110	FASLG	Fas Ligand	Protein Coding	1
111	HDAC4	Histone Deacetylase 4	Protein Coding	1
112	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
113	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
114	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
115	PPIF	Peptidylprolyl Isomerase F	Protein Coding	1
116	TNFSF10	TNF Superfamily Member 10	Protein Coding	1

Disorders associated with p53 Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gastric cancer	Enrichment	BRCA1, CASP10, CDK4, CHEK2, PTEN, TP53	7.42
2	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, PTEN, RB1, TP53	7.07
3	Osteogenic sarcoma	Enrichment	CHEK2, RB1, TP53	7.04
4	Bone osteosarcoma	Enrichment	CHEK2, RB1, TP53	7.04
5	Lung cancer	Enrichment	BRCA1, CASP8, CHEK2, FAS, FASLG	6.51
6	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	6.44
7	Colorectal cancer	Enrichment	AKT1, ATM, BAX, BRCA1, CCND1, CHEK2, EP300, TP53	6.40
8	Breast cancer	Enrichment	AKT1, BRCA1, CASP8, CHEK2, PTEN, TP53	5.95
9	Uterine corpus cancer	Enrichment	ATM, BRCA1, CHEK2, PTEN	5.94
10	Hereditary breast carcinoma	Enrichment	AKT1, ATM, BRCA1, CHEK2, PTEN, TP53	5.94
11	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	5.74
12	Prostate cancer	Enrichment	ATM, BRCA1, CHEK2, PTEN, TP53	5.55
13	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TNFRSF10B, TP53	5.50
14	Ovarian cancer	Enrichment	AKT1, BRCA1, CHEK2, PTEN, RB1, TP53	5.19
15	Endometrial cancer	Enrichment	ATM, BRCA1, CHEK2, PTEN	4.70
16	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.69
17	Sarcoma	Enrichment	CHEK2, TP53	4.69
18	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, CDK4, CHEK2, PTEN, RB1, TP53	4.53
19	Pancreatic cancer	Enrichment	ATM, BRCA1, CHEK2, TP53	4.39
20	Rhabdomyosarcoma	Enrichment	BRCA1, PTEN, TP53	4.31
21	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	4.26
22	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	4.21
23	Squamous cell carcinoma	Enrichment	RB1, TP53	4.21
24	Laryngeal squamous cell carcinoma	Enrichment	PTEN, TNFRSF10B	4.21
25	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	4.21
26	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, CHEK2, PTEN, TP53	4.15
27	Diffuse large b-cell lymphoma	Enrichment	CHEK2, PTEN, TP53	4.08
28	Lip and oral cavity carcinoma	Enrichment	ABL1, RB1, TP53	4.00
29	Small cell cancer of the lung	Enrichment	RB1, TP53	3.91
30	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, CHEK2	3.89
31	T-cell acute lymphoblastic leukemia	Enrichment	ABL1, BAX	3.74
32	Adenocarcinoma	Enrichment	ATM, TP53	3.74
33	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.69
34	Hemimegalencephaly	Enrichment	AKT3, PTEN	3.69
35	Breast adenocarcinoma	Enrichment	AKT1, TP53	3.52
36	Mantle cell lymphoma	Enrichment	ATM, CCND1	3.44
37	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, TP53	3.25
38	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	3.14
39	Cowden syndrome	Enrichment	AKT1, PTEN	3.14
40	Melanoma	Enrichment	CHEK2, PTEN	3.04
41	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, TP53	2.90
42	Meningioma	Enrichment	AKT1, PTEN	2.88
43	Lung cancer susceptibility 3	Enrichment	RB1, TP53	2.74
44	Colonic benign neoplasm	Enrichment	ATM, CHEK2	2.67
45	Lynch syndrome 1	Enrichment	ATM, CHEK2	2.57
46	Polymicrogyria	Enrichment	AKT3, PSMC3	2.57
47	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	2.49
48	Hepatocellular carcinoma	Enrichment	CASP8, TP53	2.35
49	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.34
50	Proteus syndrome	Enrichment	AKT1	2.34
51	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.34
52	Vacterl association with hydrocephalus	Enrichment	PTEN	2.34
53	Caspase 8 deficiency	Enrichment	CASP8	2.34
54	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.34
55	Accelerated tumor formation	Enrichment	MDM2	2.34
56	Ichthyosis, congenital, autosomal recessive 12	Enrichment	CASP14	2.34
57	Noonan syndrome 13	Enrichment	MAPK1	2.34
58	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.34
59	Lessel-kubisch syndrome	Enrichment	MDM2	2.34
60	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.34
61	Bone marrow failure syndrome 5	Enrichment	TP53	2.34
62	Papilloma of choroid plexus	Enrichment	TP53	2.34
63	Basal cell carcinoma 7	Enrichment	TP53	2.34
64	Anaplastic thyroid carcinoma	Enrichment	TP53	2.34
65	Infant-type hemispheric glioma	Enrichment	BRCA1	2.34
66	Papillary tumor of the pineal region	Enrichment	PTEN	2.34
67	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.34
68	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.34
69	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.34
70	Cowden syndrome 6	Enrichment	AKT1	2.34
71	Glioma susceptibility 2	Enrichment	PTEN	2.34
72	Ductal carcinoma in situ	Enrichment	TP53	2.34
73	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.34
74	Leiomyosarcoma	Enrichment	CHEK2	2.34
75	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.34
76	Trilateral retinoblastoma	Enrichment	RB1	2.34
77	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.34
78	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.34
79	Capillary hemangioma	Enrichment	AKT3	2.34
80	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.34
81	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.34
82	Choroid plexus cancer	Enrichment	TP53	2.34
83	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.34
84	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.34
85	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.34
86	Primary peritoneal carcinoma	Enrichment	BRCA1	2.34
87	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.34
88	Lung oat cell carcinoma	Enrichment	RB1	2.34
89	Gliosarcoma	Enrichment	ATM, TP53	2.16
90	Giant cell glioblastoma	Enrichment	ATM, TP53	2.11
91	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.10
92	Seckel syndrome 1	Enrichment	ATR	2.10
93	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	2.10
94	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.10
95	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.10
96	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.10
97	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.10
98	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.10
99	Endometrial serous adenocarcinoma	Enrichment	ATM	2.10
100	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.10
101	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.10
102	Scoliosis, isolated 1	Enrichment	MAPK7	2.04
103	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.04
104	Cervical cancer	Enrichment	TP53	2.04
105	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.04
106	Lymphoma, hodgkin, classic	Enrichment	TP53	2.04
107	Syndactyly, type iii	Enrichment	HDAC8	2.04
108	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.04
109	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.04
110	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.04
111	Pancreatic cancer 4	Enrichment	BRCA1	2.04
112	Wilson-turner syndrome	Enrichment	HDAC8	2.04
113	Senior-loken syndrome 7	Enrichment	AKT3	2.04
114	Congenital fibrosarcoma	Enrichment	TP53	2.04
115	Cervix carcinoma	Enrichment	TP53	2.04
116	Hodgkin's lymphoma	Enrichment	TP53	2.04
117	Bardet-biedl syndrome 16	Enrichment	AKT3	2.04
118	Inflammatory breast carcinoma	Enrichment	BRCA1	2.04
119	Peritoneum cancer	Enrichment	BRCA1	2.04
120	Bilateral breast cancer	Enrichment	BRCA1	2.04
121	Vacterl with hydrocephalus	Enrichment	PTEN	2.04
122	Familial retinoblastoma	Enrichment	RB1	2.04
123	Juvenile polyposis of infancy	Enrichment	PTEN	2.04
124	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.04
125	Myeloma, multiple	Enrichment	ATM, CCND1, TP53	2.01
126	Primary ovarian insufficiency	Enrichment	CHEK2, SIRT6, THBS1	1.95
127	Retinoblastoma	Enrichment	RB1	1.86
128	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.86
129	Nasopharyngeal carcinoma	Enrichment	TP53	1.86
130	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.86
131	Hypotrichosis 8	Enrichment	RB1	1.86
132	Renu syndrome	Enrichment	SIRT4	1.86
133	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.86
134	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.86
135	Anaplastic astrocytoma	Enrichment	TP53	1.86
136	Enchondromatosis	Enrichment	HIF1A	1.86
137	Vogt-koyanagi-harada disease	Enrichment	FAS	1.86
138	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.80
139	Birk-aharoni syndrome	Enrichment	PSMC1	1.80
140	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.80
141	Menke-hennekam syndrome 2	Enrichment	EP300	1.80
142	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.80
143	High grade glioma	Enrichment	ATM	1.80
144	T-cell prolymphocytic leukemia	Enrichment	ATM	1.80
145	Submucosal cleft palate	Enrichment	UBB	1.80
146	Cleft hard palate	Enrichment	UBB	1.80
147	Microcephaly	Enrichment	ABL1, EP300, HDAC8, PSMC3	1.79
148	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.74
149	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.74
150	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.74
151	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.74
152	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.74
153	Cholangiocarcinoma	Enrichment	BRCA1	1.74
154	Lynch syndrome 4	Enrichment	RB1	1.74
155	Congenital generalized lipodystrophy	Enrichment	FOS	1.74
156	Lung sarcomatoid carcinoma	Enrichment	TP53	1.74
157	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.74
158	Hemoglobin c disease	Enrichment	CHEK2	1.74
159	Glioma	Enrichment	PTEN	1.74
160	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.74
161	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.64
162	Rhabdomyosarcoma 2	Enrichment	TP53	1.64
163	Macrocephaly/autism syndrome	Enrichment	PTEN	1.64
164	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.64
165	Follicular lymphoma	Enrichment	BCL2	1.64
166	Lymphoma	Enrichment	TP53	1.64
167	Hemangioma	Enrichment	PTEN	1.64
168	Histiocytoid hemangioma	Enrichment	FOS	1.64
169	Ataxia-telangiectasia	Enrichment	ATM	1.63
170	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.63
171	Polycythemia vera	Enrichment	ATM	1.63
172	Uvula, bifid	Enrichment	UBB	1.63
173	Cleft soft palate	Enrichment	UBB	1.63
174	Koolen-de vries syndrome	Enrichment	ATM	1.63
175	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.63
176	Advanced sleep phase syndrome	Enrichment	CSNK1D	1.63
177	Thyroid hemiagenesis	Enrichment	PSMD3	1.63
178	Cowden syndrome 1	Enrichment	PTEN	1.57
179	Wilms tumor 5	Enrichment	CHEK2	1.57
180	Adrenocortical carcinoma	Enrichment	TP53	1.57
181	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.51
182	Oculomotor apraxia	Enrichment	ATM	1.51
183	Esophageal cancer	Enrichment	TP53	1.50
184	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.50
185	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.50
186	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.50
187	Essential thrombocythemia	Enrichment	TP53	1.50
188	Gallbladder cancer	Enrichment	TP53	1.50
189	Megacolon	Enrichment	AKT3	1.50
190	Follicular thyroid carcinoma	Enrichment	PTEN	1.50
191	Glioma susceptibility 1	Enrichment	TP53	1.44
192	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.44
193	Von hippel-lindau syndrome	Enrichment	CCND1	1.41
194	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.41
195	Glioblastoma	Enrichment	ATM	1.41
196	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.39
197	Primary hyperaldosteronism	Enrichment	TP53	1.39
198	Cornelia de lange syndrome	Enrichment	HDAC8	1.39
199	Familial colorectal cancer	Enrichment	TP53	1.35
200	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.33
201	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.33
202	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.33
203	Patent ductus arteriosus	Enrichment	PSMC3	1.33
204	Clear cell renal cell carcinoma	Enrichment	ATM	1.33
205	Meningioma, familial	Enrichment	PTEN	1.31
206	Myelodysplastic syndrome	Enrichment	TP53	1.31
207	Atrial heart septal defect	Enrichment	HDAC8	1.31
208	Interatrial communication	Enrichment	HDAC8	1.31
209	Specific learning disability	Enrichment	MAPK1	1.31
210	Leukemia, chronic myeloid	Enrichment	ABL1	1.27
211	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.27
212	Moyamoya angiopathy	Enrichment	ABL1	1.27
213	Nk-cell enteropathy	Enrichment	CHEK2	1.24
214	Lennox-gastaut syndrome	Enrichment	MAPK10	1.21
215	Periventricular nodular heterotopia	Enrichment	BRCA1	1.21
216	Wilms tumor 1	Enrichment	CHEK2	1.18
217	Lynch syndrome	Enrichment	CHEK2	1.18
218	Charge syndrome	Enrichment	EP300	1.16
219	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.13
220	Heart, malformation of	Enrichment	MAPK1	1.10
221	Polycystic kidney disease	Enrichment	HDAC8	1.10
222	Behcet syndrome	Enrichment	FAS	1.08
223	Immune deficiency disease	Enrichment	ATM	1.08
224	Hepatoblastoma	Enrichment	TP53	1.04
225	Acute promyelocytic leukemia	Enrichment	PML	1.01
226	Diamond-blackfan anemia 1	Enrichment	TP53	1.00
227	Seckel syndrome	Enrichment	ATR	0.98
228	Heart disease	Enrichment	ABL1	0.98
229	Renal cell carcinoma, nonpapillary	Enrichment	ATM	0.95
230	Polydactyly, postaxial, type a1	Enrichment	EP300	0.95
231	Rare genetic intellectual disability	Enrichment	EP300	0.95
232	Severe covid-19	Enrichment	CASP10	0.90
233	Patent foramen ovale	Enrichment	PSMC3	0.88
234	Nephronophthisis	Enrichment	PIAS1	0.85
235	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.83
236	Diamond-blackfan anemia	Enrichment	TP53	0.82
237	Myocardial infarction	Enrichment	PSMA6	0.80
238	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	0.78
239	Leukemia, acute myeloid	Enrichment	TP53	0.78
240	Type 2 diabetes mellitus	Enrichment	AKT2	0.76
241	Congenital nervous system abnormality	Enrichment	PTEN	0.41
242	Nervous system disease	Enrichment	PTEN	0.41
243	Autism spectrum disorder	Enrichment	PTEN	0.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

p53 Signaling

Pathway Network for p53 Signaling

Member Pathways for p53 Signaling

Pathways in the p53 Signaling SuperPath

Associated Genes for p53 Signaling

Associated Disorders for p53 Signaling

Disorders associated with p53 Signaling SuperPath

STRING Interaction Network for p53 Signaling

Sources for p53 Signaling