p75(NTR)-mediated signaling

No Pathway Network information available for p75(NTR)-mediated signaling

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with p75(NTR)-mediated signaling SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Breast adenocarcinomaEnrichmentAKT1, PIK3CA, TP535.77
2Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentPIK3CA, PIK3R14.23
3Hemihyperplasia, isolatedEnrichmentPIK3CA, RHOA3.53
4Breast cancerEnrichmentAKT1, PIK3CA, SHC1, TP533.45
5Neuropathy, hereditary sensory and autonomic, type vEnrichmentNGF, NTRK13.39
6Gallbladder cancerEnrichmentPIK3CA, TP533.39
7Early-onset autosomal dominant alzheimer diseaseEnrichmentAPP, PSEN13.39
8Colorectal cancerEnrichmentAKT1, PIK3CA, PIK3R1, TP533.21
9Adult hepatocellular carcinomaEnrichmentPIK3CA, TP533.15
10Cowden syndromeEnrichmentAKT1, PIK3CA3.15
11Behavioral variant of frontotemporal dementiaEnrichmentPSEN1, SQSTM13.15
12Hereditary breast carcinomaEnrichmentAKT1, PIK3CA, TP533.00
13Ovarian cancerEnrichmentAKT1, NTRK1, PIK3CA, TP532.96
14MeningiomaEnrichmentAKT1, PIK3CA2.89
15Lip and oral cavity carcinomaEnrichmentPIK3CA, TP532.89
16Alzheimer's diseaseEnrichmentAPP, PSEN12.82
17Alzheimer disease, familial, 1EnrichmentAPP, PSEN12.59
18Diffuse large b-cell lymphomaEnrichmentMYD88, TP532.49
19Hepatocellular carcinomaEnrichmentPIK3CA, TP532.36
20MacrodactylyEnrichmentPIK3CA2.35
21Proteus syndromeEnrichmentAKT12.35
22Paget disease of bone 3EnrichmentSQSTM12.35
23Incontinentia pigmentiEnrichmentIKBKG2.35
24Autoinflammatory disease, systemic, x-linkedEnrichmentIKBKG2.35
25Immunodeficiency 68EnrichmentMYD882.35
26Macroglobulinemia, waldenstrom 1EnrichmentMYD882.35
27Megalencephaly, autosomal dominantEnrichmentPIK3CA2.35
28White blood cell count quantitative trait locus 1EnrichmentACKR12.35
29Acne inversa, familial, 1EnrichmentNCSTN2.35
30Cowden syndrome 5EnrichmentPIK3CA2.35
31Scheuermann diseaseEnrichmentGNPTAB2.35
32Mucolipidosis iii alpha/betaEnrichmentGNPTAB2.35
33Nephrotic syndrome, type 8EnrichmentARHGDIA2.35
34Fetal encasement syndromeEnrichmentCHUK2.35
35Low density lipoprotein cholesterol level quantitative trait locus 6EnrichmentSORT12.35
36Mucolipidosis ii alpha/betaEnrichmentGNPTAB2.35
37Angioedema, hereditary, 4EnrichmentPLG2.35
38Cerebral cavernous malformations 4EnrichmentPIK3CA2.35
39Immunodeficiency 15bEnrichmentIKBKB2.35
40Myopathy, distal, with rimmed vacuolesEnrichmentSQSTM12.35
41Frontotemporal dementia and/or amyotrophic lateral sclerosis 3EnrichmentSQSTM12.35
42Immunodeficiency 15aEnrichmentIKBKB2.35
43Short syndromeEnrichmentPIK3R12.35
44Bone marrow failure syndrome 5EnrichmentTP532.35
45Ectodermal dysplasia and immunodeficiency 1EnrichmentIKBKG2.35
46Papilloma of choroid plexusEnrichmentTP532.35
47Basal cell carcinoma 7EnrichmentTP532.35
48Anaplastic thyroid carcinomaEnrichmentTP532.35
49Cardioacrofacial dysplasia 2EnrichmentPRKACB2.35
50Thrombocytopenia 4EnrichmentCYCS2.35
51Hemifacial myohyperplasiaEnrichmentPIK3CA2.35
52Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowthEnrichmentPIK3CA2.35
53Cerebral amyloid angiopathy, app-relatedEnrichmentAPP2.35
54Cardiomyopathy, dilated, 1uEnrichmentPSEN12.35
55Coronary heart disease 6EnrichmentMMP32.35
56Glaucoma 1, open angle, oEnrichmentNTF42.35
57Immunodeficiency 36 with lymphoproliferationEnrichmentPIK3R12.35
58Cowden syndrome 6EnrichmentAKT12.35
59Agammaglobulinemia 7, autosomal recessiveEnrichmentPIK3R12.35
60Acne inversa, familial, 2, with or without dowling-degos diseaseEnrichmentPSENEN2.35
61Acne inversa, familial, 3EnrichmentPSEN12.35
62Ductal carcinoma in situEnrichmentTP532.35
63Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomaliesEnrichmentRHOA2.35
64Bartsocas-papas syndrome 2EnrichmentCHUK2.35
65Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomaliesEnrichmentRHOA2.35
66Segmental progressive overgrowth syndrome with fibroadipose hyperplasiaEnrichmentPIK3CA2.35
67Thyroid gland undifferentiated carcinomaEnrichmentTP532.35
68Small-cell carcinoma of the ovary of hypercalcemic typeEnrichmentTP532.35
69HypospadiasEnrichmentPIK3CA2.35
70Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtypeEnrichmentTP532.35
71Gnptab-related disordersEnrichmentGNPTAB2.35
72Choroid plexus cancerEnrichmentTP532.35
73Rare venous malformationEnrichmentPIK3CA2.35
74Diaphragmatic eventrationEnrichmentPIK3CA2.35
75Waldenstram macroglobulinemiaEnrichmentMYD882.35
76Pik3ca-related overgrowth spectrumEnrichmentPIK3CA2.35
77Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiencyEnrichmentCHUK2.35
78Pleomorphic xanthoastrocytomaEnrichmentTP532.35
79Rare combined vascular malformationEnrichmentPIK3CA2.35
80Cavernous lymphangiomaEnrichmentPIK3CA2.35
81Pik3ca-related overgrowth syndromeEnrichmentPIK3CA2.35
82Pash syndromeEnrichmentNCSTN2.35
83Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndromEnrichmentRAC12.35
84Hemihyperplasia-multiple lipomatosis syndromeEnrichmentPIK3CA2.35
85Eccrine angiomatous hamartomaEnrichmentPIK3CA2.35
86Distal 17p13.3 microdeletion syndromeEnrichmentYWHAE2.35
87Macrodactyly of toeEnrichmentPIK3CA2.35
88Peripheral nervous system diseaseEnrichmentNGF2.33
89NeuropathyEnrichmentNGF2.33
90MalariaEnrichmentACKR1, IKBKG2.32
91Bladder cancerEnrichmentPIK3CA, TP532.13
92Prostate cancerEnrichmentPIK3CA, TP532.13
93Cerebral amyloid angiopathy, cst3-relatedEnrichmentAPP2.05
94Adrenocortical carcinoma, hereditaryEnrichmentTP532.05
95Insensitivity to pain, congenital, with anhidrosisEnrichmentNTRK12.05
96Plasminogen deficiency, type iEnrichmentPLG2.05
97Alzheimer disease 3EnrichmentPSEN12.05
98Cervical cancerEnrichmentTP532.05
99Immunodeficiency 33EnrichmentIKBKG2.05
100Pick disease of brainEnrichmentPSEN12.05
101Welander distal myopathyEnrichmentSQSTM12.05
102Legg-calve-perthes diseaseEnrichmentGNPTAB2.05
103Keratosis, seborrheicEnrichmentPIK3CA2.05
104Noonan syndrome 8EnrichmentPIK3CA2.05
105Lymphoma, hodgkin, classicEnrichmentTP532.05
106Deafness, autosomal dominant 64EnrichmentDIABLO2.05
107Pain sensitivity quantitative trait locus 1EnrichmentNTRK12.05
108Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onsetEnrichmentSQSTM12.05
109Lung disease, immunodeficiency, and chromosome breakage syndromeEnrichmentNSMCE32.05
110Intellectual developmental disorder, autosomal dominant 48EnrichmentRAC12.05
111Rosette-forming glioneuronal tumorEnrichmentPIK3CA2.05
112Congenital fibrosarcomaEnrichmentTP532.05
113Li-fraumeni syndrome 1EnrichmentTP532.05
114SarcomaEnrichmentTP532.05
115Inflammatory skin and bowel disease, neonatal, 1EnrichmentADAM172.05
116Ectodermal dysplasia and immune deficiencyEnrichmentIKBKG2.05
117Hereditary angioedemaEnrichmentPLG2.05
118Cervix carcinomaEnrichmentTP532.05
119Hodgkin's lymphomaEnrichmentTP532.05
120Paget's disease of boneEnrichmentSQSTM12.05
121Glucosephosphate dehydrogenase deficiencyEnrichmentIKBKG2.05
122Transient predisposition to invasive pyogenic bacterial infectionEnrichmentMYD882.05
123Pleomorphic rhabdomyosarcomaEnrichmentTP532.05
124Spastic paraplegia-paget disease of bone syndromeEnrichmentSQSTM12.05
125Angioedema, hereditary, 1EnrichmentPLG1.87
126Thyroid carcinoma, familial medullaryEnrichmentNTRK11.87
127Pompe disease, infantile-onsetEnrichmentPIK3CA1.87
128Osteogenic sarcomaEnrichmentTP531.87
129Alzheimer disease 4EnrichmentPSEN11.87
130Nasopharyngeal carcinomaEnrichmentTP531.87
131Immunodeficiency 14a with lymphoproliferation, autosomal dominantEnrichmentPIK3R11.87
132Miller-dieker lissencephaly syndromeEnrichmentYWHAE1.87
133Chromosome 17p13.3, centromeric, duplication syndromeEnrichmentYWHAE1.87
134MucolipidosisEnrichmentGNPTAB1.87
135Atypical teratoid rhabdoid tumorEnrichmentTP531.87
136Anaplastic astrocytomaEnrichmentTP531.87
137Immunodeficiency 14EnrichmentPIK3R11.87
138Squamous cell carcinomaEnrichmentTP531.87
139AdenocarcinomaEnrichmentTP531.87
140Bone osteosarcomaEnrichmentTP531.87
141Neonatal inflammatory skin and bowel diseaseEnrichmentADAM171.87
142KeratoacanthomaEnrichmentPIK3CA1.87
143Gastric cancerEnrichmentPIK3CA, TP531.80
144Small cell cancer of the lungEnrichmentTP531.75
145Thyroid cancer, nonmedullary, 1EnrichmentTP531.75
146Paget disease of bone 2, early-onsetEnrichmentSQSTM11.75
147Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentPIK3CA1.75
148Schaaf-yang syndromeEnrichmentNDN1.75
149Dowling-degos diseaseEnrichmentPSENEN1.75
150Lung sarcomatoid carcinomaEnrichmentTP531.75
151Cerebrovascular diseaseEnrichmentPIK3CA1.75
152Embryonal rhabdomyosarcomaEnrichmentTP531.75
153Familial cerebral cavernous malformationsEnrichmentPIK3CA1.75
154Paget's disease of bone 2EnrichmentSQSTM11.75
155Pediatric systemic lupus erythematosusEnrichmentIRAK11.75
156Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominantEnrichmentTRAF61.65
157Capillary malformations, congenitalEnrichmentPIK3CA1.65
158Anemia, congenital, nonspherocytic hemolytic, 1EnrichmentIKBKG1.65
159Rhabdomyosarcoma 2EnrichmentTP531.65
160LymphomaEnrichmentTP531.65
161Acute megakaryocytic leukemiaEnrichmentTP531.65
162Autosomal thrombocytopenia with normal plateletsEnrichmentCYCS1.65
163HemimegalencephalyEnrichmentPIK3CA1.65
164DementiaEnrichmentPSEN11.65
165Endometrial stromal sarcomaEnrichmentYWHAE1.65
166Klippel-trenaunay-weber syndromeEnrichmentPIK3CA1.57
167Li-fraumeni syndromeEnrichmentTP531.57
168Cowden syndrome 1EnrichmentPIK3CA1.57
169Telangiectasia, hereditary hemorrhagic, type 1EnrichmentPSEN11.57
170Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentBDNF1.57
171Mucopolysaccharidosis, type iiiaEnrichmentGNPTAB1.57
172Adrenocortical carcinomaEnrichmentTP531.57
173Lung squamous cell carcinomaEnrichmentPIK3CA1.57
174Kidney clear cell sarcomaEnrichmentYWHAE1.57
175Frontotemporal dementia and/or amyotrophic lateral sclerosis 7EnrichmentPSEN1, SQSTM11.55
176Esophageal cancerEnrichmentTP531.51
177Nevus, epidermalEnrichmentPIK3CA1.51
178Prader-willi syndromeEnrichmentNDN1.51
179Squamous cell carcinoma, head and neckEnrichmentTP531.51
180Capillary malformation-arteriovenous malformation 1EnrichmentPIK3CA1.51
181Semantic dementiaEnrichmentPSEN11.51
182Alzheimer's disease 1EnrichmentAPP1.51
183Essential thrombocythemiaEnrichmentTP531.51
184Overgrowth syndromeEnrichmentPIK3R11.51
185B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentTP531.51
186Glioma susceptibility 1EnrichmentTP531.45
187Lymphoma, non-hodgkin, familialEnrichmentTP531.45
188Ellis-van creveld syndromeEnrichmentPRKACB1.40
189Coronary heart disease 5EnrichmentIKBKG1.40
190Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentRAC11.40
191Arteriovenous malformationEnrichmentPIK3CA1.40
192Congenital central hypoventilation syndromeEnrichmentBDNF1.40
193Progressive non-fluent aphasiaEnrichmentPSEN11.40
194Primary hyperaldosteronismEnrichmentTP531.40
195Leukemia, chronic lymphocyticEnrichmentTP531.36
196Frontotemporal dementia and/or amyotrophic lateral sclerosis 1EnrichmentSQSTM11.36
197Myopathy, x-linked, with excessive autophagyEnrichmentPIK3CA1.36
198Familial colorectal cancerEnrichmentTP531.36
199Autosomal non-syndromic agammaglobulinemiaEnrichmentPIK3R11.36
200Frontotemporal dementia 1EnrichmentPSEN11.32
201Myelodysplastic syndromeEnrichmentTP531.32
202Lung non-small cell carcinomaEnrichmentPIK3CA1.32
203Lung cancer susceptibility 3EnrichmentTP531.21
204Lynch syndromeEnrichmentPIK3CA1.18
205RhabdomyosarcomaEnrichmentTP531.16
206GliosarcomaEnrichmentTP531.16
207Giant cell glioblastomaEnrichmentTP531.13
208Endometrial cancerEnrichmentPIK3CA1.04
209HepatoblastomaEnrichmentTP531.04
210Skin diseaseEnrichmentNCSTN1.02
211Diamond-blackfan anemia 1EnrichmentTP531.01
212Pancreatic cancerEnrichmentTP530.97
213Differentiated thyroid carcinomaEnrichmentNTRK10.91
214Lung cancerEnrichmentPIK3CA0.87
215Cystic fibrosisEnrichmentPLG0.87
216Severe combined immunodeficiencyEnrichmentIKBKB0.86
217Genetic steroid-resistant nephrotic syndromeEnrichmentARHGDIA0.85
218Diamond-blackfan anemiaEnrichmentTP530.82
219Systemic lupus erythematosusEnrichmentIRAK10.79
220Leukemia, acute myeloidEnrichmentTP530.78
221ThrombocytopeniaEnrichmentCYCS0.71
222Body mass index quantitative trait locus 11EnrichmentBDNF0.69
223HypertelorismEnrichmentPIK3CA0.68
224Rare autosomal dominant non-syndromic sensorineural deafness type dfnaEnrichmentDIABLO0.68
225Familial isolated dilated cardiomyopathyEnrichmentPSEN10.67
226Hereditary breast ovarian cancer syndromeEnrichmentTP530.66
227Myeloma, multipleEnrichmentTP530.65
228SchizophreniaEnrichmentRTN4R0.63
229Primary ovarian insufficiencyEnrichmentNTRK10.63
230Congenital nervous system abnormalityEnrichmentPSEN10.42
231Nervous system diseaseEnrichmentPSEN10.42
232Inherited cancer-predisposing syndromeEnrichmentTP530.35

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