p75 NTR receptor-mediated signalling

Pathway network for the p75 NTR receptor-mediated signalling SuperPath

Sources:

Reactome

Pathways in the p75 NTR receptor-mediated signalling SuperPath

#	Name	Source	Genes
1	p75 NTR receptor-mediated signalling	Reactome	AATF ABR ADAM17 AKAP13 APH1A APH1B ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 BEX3 CASP2 ECT2 FGD1 FGD2 FGD3 FGD4 GNA13 HDAC1 HDAC2 HDAC3 IKBKB IRAK1 ITGB3BP ITSN1 KALRN LINGO1 MAG MAGED1 MAPK8 MCF2 MCF2L MYD88 NCSTN NET1 NFKB1 NFKBIA NGEF NGF OMG PLEKHG2 PLEKHG5 PRDM4 PREX1 PRKCI PSEN1 PSEN2 PSENEN RAC1 RASGRF2 RELA RHOA RIPK2 RPS27A RTN4 RTN4R SMPD2 SOS1 SOS2 SQSTM1 TIAM1 TIAM2 TRAF6 TRIO UBA52 UBB UBC VAV1 VAV2 VAV3 YWHAE (see all 94) (see less)
2	Death Receptor Signaling	Reactome	AATF ABR ADAM17 AKAP13 APH1A APH1B ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 BEX3 BIRC2 BIRC3 CASP10 CASP2 CASP8 CHUK CLIP3 CYLD ECT2 FADD FGD1 FGD2 FGD3 FGD4 GNA13 HDAC1 HDAC2 HDAC3 IKBKB IKBKE IKBKG IRAK1 ITGB3BP ITSN1 KALRN LINGO1 MADD MAG MAGED1 MAP3K7 MAPK8 MAPKAPK2 MCF2 MCF2L MIB2 MYD88 NCSTN NET1 NFKB1 NFKBIA NGEF NGF NSMAF OMG OPTN OTULIN PLEKHG2 PLEKHG5 PRDM4 PREX1 PRKCI PSEN1 PSEN2 PSENEN RAC1 RACK1 RASGRF2 RBCK1 RELA RHOA RIPK1 RIPK2 RPS27A RTN4 RTN4R SMPD2 SMPD3 SOS1 SOS2 SPPL2A SPPL2B SQSTM1 STUB1 TAB1 TAB2 TAB3 TAX1BP1 TBK1 TIAM1 TIAM2 TNFAIP3 TNFRSF10D TRAF1 TRAF2 TRAF6 TRIO UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 ULK1 VAV1 VAV2 VAV3 YWHAE (see all 132) (see less)
3	G alpha (12/13) signalling events	Reactome	ABR ADRA1A ADRA1B ADRA1D AKAP13 ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BTK ECT2 FGD1 FGD2 FGD3 FGD4 GNA12 GNA13 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITSN1 KALRN MCF2 MCF2L NET1 NGEF PLEKHG2 PLEKHG5 PLXNB1 PREX1 RASGRF2 RHOA RHOB RHOC ROCK1 ROCK2 SOS1 SOS2 TBXA2R TIAM1 TIAM2 TRIO VAV1 VAV2 VAV3 (see all 79) (see less)
4	Cell death signalling via NRAGE, NRIF and NADE	Reactome	AATF ABR AKAP13 APH1A APH1B ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 BEX3 CASP2 ECT2 FGD1 FGD2 FGD3 FGD4 GNA13 ITGB3BP ITSN1 KALRN MAGED1 MAPK8 MCF2 MCF2L NCSTN NET1 NGEF NGF PLEKHG2 PLEKHG5 PREX1 PSEN1 PSEN2 PSENEN RAC1 RASGRF2 RPS27A SOS1 SOS2 SQSTM1 TIAM1 TIAM2 TRAF6 TRIO UBA52 UBB UBC VAV1 VAV2 VAV3 YWHAE (see all 73) (see less)
5	NRAGE signals death through JNK	Reactome	AATF ABR AKAP13 ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BAD BCL2L11 ECT2 FGD1 FGD2 FGD3 FGD4 GNA13 ITSN1 KALRN MAGED1 MAPK8 MCF2 MCF2L NET1 NGEF NGF PLEKHG2 PLEKHG5 PREX1 RAC1 RASGRF2 SOS1 SOS2 TIAM1 TIAM2 TRIO VAV1 VAV2 VAV3 (see all 57) (see less)
6	NRIF signals cell death from the nucleus	Reactome	APH1A APH1B ITGB3BP MAPK8 NCSTN NGF PSEN1 PSEN2 PSENEN RPS27A SQSTM1 TRAF6 UBA52 UBB UBC (see all 15) (see less)
7	p75NTR signals via NF-kB	Reactome	IKBKB IRAK1 MYD88 NFKB1 NFKBIA NGF PRKCI RELA RIPK2 RPS27A SQSTM1 TRAF6 UBA52 UBB UBC (see all 15) (see less)
8	NF-kB is activated and signals survival	Reactome	IKBKB IRAK1 NFKB1 NFKBIA NGF RELA RPS27A SQSTM1 TRAF6 UBA52 UBB UBC (see all 12) (see less)
9	p75NTR recruits signalling complexes	Reactome	IKBKB IRAK1 MYD88 NGF PRKCI RIPK2 RPS27A SQSTM1 TRAF6 UBA52 UBB UBC (see all 12) (see less)
10	p75NTR regulates axonogenesis	Reactome	ARHGDIA LINGO1 MAG MCF2 NGF OMG RHOA RTN4 RTN4R (see all 9) (see less)
11	Axonal growth inhibition (RHOA activation)	Reactome	ARHGDIA LINGO1 MAG MCF2 OMG RHOA RTN4 RTN4R (see all 8) (see less)
12	p75NTR negatively regulates cell cycle via SC1	Reactome	HDAC1 HDAC2 HDAC3 NGF PRDM4
13	NADE modulates death signalling	Reactome	BEX3 CASP2 NGF YWHAE
14	Axonal growth stimulation	Reactome	ARHGDIA NGF RHOA

Gene overlap in member pathways for p75 NTR receptor-mediated signalling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NGF	Nerve Growth Factor	Protein Coding	12
2	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	7
3	RPS27A	Ribosomal Protein S27a	Protein Coding	7
4	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	7
5	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	7
6	UBB	Ubiquitin B	Protein Coding	7
7	UBC	Ubiquitin C	Protein Coding	7
8	SQSTM1	Sequestosome 1	Protein Coding	7
9	RHOA	Ras Homolog Family Member A	Protein Coding	6
10	ARHGEF33	Rho Guanine Nucleotide Exchange Factor 33	Protein Coding	5
11	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	5
12	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	5
13	GNA13	G Protein Subunit Alpha 13	Protein Coding	5
14	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	5
15	FGD4	FYVE, RhoGEF And PH Domain Containing 4	Protein Coding	5
16	ARHGEF19	Rho Guanine Nucleotide Exchange Factor 19	Protein Coding	5
17	ECT2	Epithelial Cell Transforming 2	Protein Coding	5
18	FGD2	FYVE, RhoGEF And PH Domain Containing 2	Protein Coding	5
19	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	5
20	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	5
21	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	5
22	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	5
23	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	5
24	ARHGEF18	Rho/Rac Guanine Nucleotide Exchange Factor 18	Protein Coding	5
25	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	5
26	ARHGEF26	Rho Guanine Nucleotide Exchange Factor 26	Protein Coding	5
27	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	5
28	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	5
29	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	5
30	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	5
31	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	5
32	ARHGEF37	Rho Guanine Nucleotide Exchange Factor 37	Protein Coding	5
33	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	5
34	ARHGEF35	Rho Guanine Nucleotide Exchange Factor 35	Protein Coding	5
35	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	5
36	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	5
37	ARHGEF38	Rho Guanine Nucleotide Exchange Factor 38	Protein Coding	5
38	ARHGEF10L	Rho Guanine Nucleotide Exchange Factor 10 Like	Protein Coding	5
39	ARHGEF40	Rho Guanine Nucleotide Exchange Factor 40	Protein Coding	5
40	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	5
41	PLEKHG5	Pleckstrin Homology And RhoGEF Domain Containing G5	Protein Coding	5
42	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	5
43	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	5
44	ITSN1	Intersectin 1	Protein Coding	5
45	PLEKHG2	Pleckstrin Homology And RhoGEF Domain Containing G2	Protein Coding	5
46	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	5
47	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	5
48	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	5
49	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	5
50	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	5
51	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	5
52	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	5
53	ARHGEF39	Rho Guanine Nucleotide Exchange Factor 39	Protein Coding	5
54	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	5
55	FGD3	FYVE, RhoGEF And PH Domain Containing 3	Protein Coding	5
56	KALRN	Kalirin RhoGEF Kinase	Protein Coding	5
57	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	5
58	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	5
59	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	5
60	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	5
61	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	5
62	ARHGEF17	Rho Guanine Nucleotide Exchange Factor 17	Protein Coding	5
63	BCL2L11	BCL2 Like 11	Protein Coding	4
64	NCSTN	Nicastrin	Protein Coding	4
65	ITGB3BP	Integrin Subunit Beta 3 Binding Protein	Protein Coding	4
66	AATF	Apoptosis Antagonizing Transcription Factor	Protein Coding	4
67	BEX3	Brain Expressed X-Linked 3	Protein Coding	4
68	MAG	Myelin Associated Glycoprotein	Protein Coding	4
69	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	4
70	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	4
71	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	4
72	OMG	Oligodendrocyte Myelin Glycoprotein	Protein Coding	4
73	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	4
74	PRKCI	Protein Kinase C Iota	Protein Coding	4
75	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	4
76	PSEN1	Presenilin 1	Protein Coding	4
77	PSEN2	Presenilin 2	Protein Coding	4
78	RTN4	Reticulon 4	Protein Coding	4
79	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	4
80	RAC1	Rac Family Small GTPase 1	Protein Coding	4
81	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	4
82	RTN4R	Reticulon 4 Receptor	Protein Coding	4
83	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	4
84	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	4
85	CASP2	Caspase 2	Protein Coding	4
86	LINGO1	Leucine Rich Repeat And Ig Domain Containing 1	Protein Coding	4
87	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	4
88	MAGED1	MAGE Family Member D1	Protein Coding	4
89	PRDM4	PR/SET Domain 4	Protein Coding	3
90	HDAC1	Histone Deacetylase 1	Protein Coding	3
91	HDAC2	Histone Deacetylase 2	Protein Coding	3
92	HDAC3	Histone Deacetylase 3	Protein Coding	3
93	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	2
94	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	2
95	OPTN	Optineurin	Protein Coding	1
96	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
97	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
98	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
99	RBCK1	RANBP2-Type And C3HC4-Type Zinc Finger Containing 1	Protein Coding	1
100	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
101	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	1
102	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
103	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	1
104	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	1
105	CLIP3	CAP-Gly Domain Containing Linker Protein 3	Protein Coding	1
106	TBK1	TANK Binding Kinase 1	Protein Coding	1
107	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
108	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
109	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
110	SPPL2B	Signal Peptide Peptidase Like 2B	Protein Coding	1
111	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
112	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
113	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
114	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
115	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
116	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	1
117	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
118	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	1
119	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
120	CASP8	Caspase 8	Protein Coding	1
121	CASP10	Caspase 10	Protein Coding	1
122	NSMAF	Neutral Sphingomyelinase Activation Associated Factor	Protein Coding	1
123	SPPL2A	Signal Peptide Peptidase Like 2A	Protein Coding	1
124	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
125	MADD	MAP Kinase Activating Death Domain	Protein Coding	1
126	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
127	FADD	Fas Associated Via Death Domain	Protein Coding	1
128	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
129	TAX1BP1	Tax1 Binding Protein 1	Protein Coding	1
130	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	1
131	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
132	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
133	GNB5	G Protein Subunit Beta 5	Protein Coding	1
134	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	1
135	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	1
136	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	1
137	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
138	GNB1	G Protein Subunit Beta 1	Protein Coding	1
139	GNB2	G Protein Subunit Beta 2	Protein Coding	1
140	GNB3	G Protein Subunit Beta 3	Protein Coding	1
141	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
142	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
143	GNG5	G Protein Subunit Gamma 5	Protein Coding	1
144	GNG7	G Protein Subunit Gamma 7	Protein Coding	1
145	GNG10	G Protein Subunit Gamma 10	Protein Coding	1
146	GNG11	G Protein Subunit Gamma 11	Protein Coding	1
147	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
148	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	1
149	RHOB	Ras Homolog Family Member B	Protein Coding	1
150	RHOC	Ras Homolog Family Member C	Protein Coding	1
151	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
152	PLXNB1	Plexin B1	Protein Coding	1
153	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
154	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
155	GNB4	G Protein Subunit Beta 4	Protein Coding	1
156	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
157	TBXA2R	Thromboxane A2 Receptor	Protein Coding	1
158	BTK	Bruton Tyrosine Kinase	Protein Coding	1
159	GNG8	G Protein Subunit Gamma 8	Protein Coding	1
160	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1

Disorders associated with p75 NTR receptor-mediated signalling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	5.47
2	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	4.62
3	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1, SQSTM1	4.39
4	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.03
5	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	3.66
6	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	3.66
7	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	3.66
8	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	3.53
9	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	3.53
10	Intellectual developmental disorder, autosomal recessive 64	Enrichment	LINGO1	3.23
11	Spastic paraplegia 75, autosomal recessive	Enrichment	MAG	3.23
12	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	3.05
13	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	3.05
14	Paget disease of bone 3	Enrichment	SQSTM1	3.05
15	Immunodeficiency 15b	Enrichment	IKBKB	3.05
16	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	3.05
17	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	3.05
18	Immunodeficiency 15a	Enrichment	IKBKB	3.05
19	Immunodeficiency 68	Enrichment	MYD88	3.05
20	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	3.05
21	Waldenstram macroglobulinemia	Enrichment	MYD88	3.05
22	Acne inversa, familial, 1	Enrichment	NCSTN	2.96
23	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.96
24	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.96
25	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.96
26	Acne inversa, familial, 3	Enrichment	PSEN1	2.96
27	Pash syndrome	Enrichment	NCSTN	2.96
28	Huntington's disease-like	Enrichment	PSEN2	2.96
29	Hemihyperplasia, isolated	Enrichment	RHOA	2.88
30	Endometrial stromal sarcoma	Enrichment	YWHAE	2.83
31	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	2.82
32	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF	2.81
33	Kidney clear cell sarcoma	Enrichment	YWHAE	2.75
34	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.75
35	Welander distal myopathy	Enrichment	SQSTM1	2.75
36	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.75
37	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.75
38	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.75
39	Rela fusion-positive ependymoma	Enrichment	RELA	2.75
40	Paget's disease of bone	Enrichment	SQSTM1	2.75
41	Common variable immunodeficiency 12	Enrichment	NFKB1	2.75
42	Submucosal cleft palate	Enrichment	UBB	2.75
43	Cleft hard palate	Enrichment	UBB	2.75
44	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.75
45	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	2.75
46	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1, SQSTM1	2.74
47	Motor neuron disease	Enrichment	OPTN, TBK1	2.72
48	Alzheimer disease 3	Enrichment	PSEN1	2.66
49	Pick disease of brain	Enrichment	PSEN1	2.66
50	Uvula, bifid	Enrichment	UBB	2.58
51	Cleft soft palate	Enrichment	UBB	2.58
52	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.58
53	Coronary heart disease 5	Enrichment	IKBKG, KALRN	2.49
54	Progressive non-fluent aphasia	Enrichment	PSEN1, TBK1	2.49
55	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.45
56	Paget's disease of bone 2	Enrichment	SQSTM1	2.45
57	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.45
58	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1, TBK1	2.40
59	Noonan syndrome 1	Enrichment	SOS1, SOS2	2.38
60	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.38
61	Noonan syndrome 4	Enrichment	SOS1	2.38
62	Noonan syndrome 9	Enrichment	SOS2	2.38
63	Charcot-marie-tooth disease, demyelinating, type 4h	Enrichment	FGD4	2.38
64	Spinal muscular atrophy, facioscapulohumeral type	Enrichment	PLEKHG5	2.38
65	Immunodeficiency 62	Enrichment	ARHGEF1	2.38
66	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.38
67	Retinitis pigmentosa 78	Enrichment	ARHGEF18	2.38
68	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.38
69	Charcot-marie-tooth disease type 4h	Enrichment	FGD4	2.38
70	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.38
71	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.38
72	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.38
73	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.38
74	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.38
75	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.35
76	Dowling-degos disease	Enrichment	PSENEN	2.35
77	Rasopathy	Enrichment	SOS1, SOS2	2.28
78	Dementia	Enrichment	PSEN1	2.26
79	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.23
80	Bleeding disorder, platelet-type, 13	Enrichment	TBXA2R	2.23
81	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.23
82	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.23
83	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.23
84	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.23
85	Sick sinus syndrome 4	Enrichment	GNB2	2.23
86	Bleeding diathesis due to thromboxane synthesis deficiency	Enrichment	TBXA2R	2.23
87	Common variable immunodeficiency	Enrichment	NFKB1	2.21
88	Systemic lupus erythematosus	Enrichment	IRAK1, TNFAIP3, UBE2L3	2.20
89	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	2.18
90	Aortic valve disease 1	Enrichment	SOS1, TAB2	2.17
91	Peripheral nervous system disease	Enrichment	NGF	2.15
92	Neuropathy	Enrichment	NGF	2.15
93	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	2.12
94	Semantic dementia	Enrichment	PSEN1	2.11
95	Fibromatosis, gingival, 1	Enrichment	SOS1	2.08
96	Pulmonic stenosis	Enrichment	SOS1	2.08
97	Deafness, autosomal recessive 28	Enrichment	TRIO	2.08
98	Neuronopathy, distal hereditary motor, autosomal recessive 4	Enrichment	PLEKHG5	2.08
99	Charcot-marie-tooth disease, recessive intermediate c	Enrichment	PLEKHG5	2.08
100	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.08
101	Aarskog syndrome	Enrichment	FGD1	2.08
102	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.05
103	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.01
104	Incontinentia pigmenti	Enrichment	IKBKG	2.01
105	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.01
106	Caspase 8 deficiency	Enrichment	CASP8	2.01
107	Polyglucosan body myopathy 1 with or without immunodeficiency	Enrichment	RBCK1	2.01
108	Fetal encasement syndrome	Enrichment	CHUK	2.01
109	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.01
110	Immunodeficiency 107 invasive staphylococcus aureus infection	Enrichment	OTULIN	2.01
111	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.01
112	Deeah syndrome	Enrichment	MADD	2.01
113	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.01
114	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.01
115	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.01
116	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	Enrichment	OTULIN	2.01
117	Corticobasal syndrome	Enrichment	TBK1	2.01
118	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.01
119	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.01
120	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.01
121	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.01
122	Immunodeficiency 86	Enrichment	SPPL2A	2.01
123	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.01
124	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	Enrichment	OTULIN	2.01
125	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.01
126	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.01
127	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.94
128	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.94
129	Agammaglobulinemia, x-linked	Enrichment	BTK	1.94
130	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.94
131	Cerebral visual impairment	Enrichment	GNB1	1.94
132	Frontotemporal dementia 1	Enrichment	PSEN1	1.92
133	Aarskog-scott syndrome	Enrichment	FGD1	1.90
134	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	1.90
135	Nuchal bleb, familial	Enrichment	SOS1	1.90
136	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.90
137	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	PLEKHG2	1.90
138	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	1.90
139	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	1.86
140	Gliosarcoma	Enrichment	NFKBIA	1.85
141	Alzheimer's disease	Enrichment	PSEN1	1.85
142	Giant cell glioblastoma	Enrichment	NFKBIA	1.83
143	Diffuse large b-cell lymphoma	Enrichment	MYD88	1.78
144	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	1.78
145	Gingival fibromatosis	Enrichment	SOS1	1.78
146	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.78
147	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.76
148	Agammaglobulinemia 1	Enrichment	BTK	1.76
149	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.73
150	Cylindromatosis, familial	Enrichment	CYLD	1.71
151	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	1.71
152	Immunodeficiency 33	Enrichment	IKBKG	1.71
153	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	1.71
154	Spinocerebellar ataxia 48	Enrichment	STUB1	1.71
155	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	1.71
156	Brooke-spiegler syndrome	Enrichment	CYLD	1.71
157	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	1.71
158	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	1.71
159	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.71
160	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	1.71
161	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.71
162	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.71
163	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.71
164	Oculootodental syndrome	Enrichment	FADD	1.71
165	Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Enrichment	RBCK1	1.71
166	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	1.69
167	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.64
168	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.64
169	Familial sick sinus syndrome	Enrichment	GNB2	1.64
170	Skin disease	Enrichment	NCSTN	1.62
171	Severe combined immunodeficiency	Enrichment	IKBKB	1.54
172	Craniometaphyseal dysplasia, autosomal dominant	Enrichment	OTULIN	1.54
173	Pelvic organ prolapse	Enrichment	TAB2	1.54
174	Glycogen storage disease iv	Enrichment	RBCK1	1.54
175	Glaucoma, normal tension	Enrichment	OPTN	1.54
176	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.54
177	Noonan syndrome 3	Enrichment	SOS1	1.54
178	Severe covid-19	Enrichment	CASP10, RBCK1	1.49
179	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	PLEKHG2	1.48
180	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, ITSN1	1.47
181	Schizophrenia	Enrichment	RTN4R	1.46
182	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.43
183	Juvenile amyotrophic lateral sclerosis	Enrichment	PLEKHG5	1.43
184	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	1.42
185	Chondrocalcinosis 2	Enrichment	OTULIN	1.42
186	Hypothyroidism	Enrichment	GNB1	1.34
187	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.32
188	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.32
189	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	1.32
190	Herpes simplex virus encephalitis	Enrichment	TBK1	1.32
191	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.32
192	Glaucoma, primary open angle	Enrichment	OPTN	1.24
193	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.24
194	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.24
195	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.24
196	Cleft lip/palate	Enrichment	ARHGEF38	1.24
197	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.24
198	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.21
199	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.21
200	Myelodysplastic syndrome	Enrichment	GNB1	1.21
201	Syndromic intellectual disability	Enrichment	TRIO	1.16
202	Charcot-marie-tooth disease type 4	Enrichment	FGD4	1.14
203	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	1.12
204	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.11
205	Adult hepatocellular carcinoma	Enrichment	CASP8	1.07
206	Hypertension, essential	Enrichment	GNB3	1.02
207	Cleft palate, isolated	Enrichment	GNB1	1.02
208	Migraine with or without aura 1	Enrichment	TAB2	0.99
209	Immune deficiency disease	Enrichment	RIPK1	0.99
210	Congenital nervous system abnormality	Enrichment	PSEN1	0.95
211	Nervous system disease	Enrichment	PSEN1	0.95
212	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.92
213	Congenital stationary night blindness	Enrichment	GNB3	0.90
214	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.85
215	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.85
216	Strabismus	Enrichment	GNB1	0.84
217	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.80
218	Microcephaly	Enrichment	GNB1, TRIO	0.79
219	Patent foramen ovale	Enrichment	TAB2	0.79
220	Hereditary spastic paraplegia	Enrichment	PLEKHG5	0.79
221	Complex neurodevelopmental disorder	Enrichment	GNB2, TIAM1	0.79
222	Dystonia	Enrichment	GNB1	0.73
223	Hepatocellular carcinoma	Enrichment	CASP8	0.71
224	Malaria	Enrichment	IKBKG	0.70
225	Cerebral palsy	Enrichment	GNB1	0.69
226	Lung cancer	Enrichment	CASP8	0.57
227	Left ventricular noncompaction	Enrichment	MIB2	0.54
228	Gastric cancer	Enrichment	CASP10	0.46
229	Breast cancer	Enrichment	GNG3	0.45
230	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.38
231	Myeloma, multiple	Enrichment	CYLD	0.37
232	Autism spectrum disorder	Enrichment	GNB1	0.33
233	Dilated cardiomyopathy	Enrichment	TAB2	0.26
234	Retinitis pigmentosa	Enrichment	ARHGEF18	0.23
235	Hereditary retinal dystrophy	Enrichment	ARHGEF18	0.15
236	Fundus dystrophy	Enrichment	ARHGEF18	0.15
237	Inherited cancer-predisposing syndrome	Enrichment	CYLD	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

p75 NTR receptor-mediated signalling

Pathway Network for p75 NTR receptor-mediated signalling

Pathway network for the p75 NTR receptor-mediated signalling SuperPath

Member Pathways for p75 NTR receptor-mediated signalling

Pathways in the p75 NTR receptor-mediated signalling SuperPath

Gene overlap in member pathways for p75 NTR receptor-mediated signalling SuperPath

Associated Genes for p75 NTR receptor-mediated signalling

Associated Disorders for p75 NTR receptor-mediated signalling

Disorders associated with p75 NTR receptor-mediated signalling SuperPath

STRING Interaction Network for p75 NTR receptor-mediated signalling

Sources for p75 NTR receptor-mediated signalling