Packaging Of Telomere Ends

Pathway network for the Packaging Of Telomere Ends SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the Packaging Of Telomere Ends SuperPath

#	Name	Source	Genes
1	Packaging Of Telomere Ends	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 POT1 TERF1 TERF2 TERF2IP TINF2 (see all 51) (see less)
2	Base Excision Repair	Reactome	ACD ADPRS APEX1 FEN1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 LIG1 LIG3 MBD4 MPG MUTYH NEIL1 NEIL2 NEIL3 NTHL1 OGG1 PARG PARP1 PARP2 PCNA PNKP POLB POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POT1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 SMUG1 TDG TERF1 TERF2 TERF2IP TINF2 UNG XRCC1 (see all 90) (see less)
3	Signal transduction Activin A signaling regulation	GeneGo (Thomson Reuters)	ACVR1B ACVR2A ACVR2B BAMBI CREBBP DLX1 EP300 FKBP1A FOXG1 FOXH1 FST FSTL3 H2AC11 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC20 H2AC6 H2AC7 H2AX H2AZ1 H2BC10 H2BC11 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 IGSF1 INHA INHBA INHBB LEMD3 MECOM MED15 NCOR1 SIN3A SKI SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 TGFBR3 UBA52 UBB UBC (see all 75) (see less)
4	DNA Damage/Telomere Stress Induced Senescence	Reactome	ACD ASF1A ATM CABIN1 CCNA1 CCNA2 CCNE1 CCNE2 CDK2 CDKN1A CDKN1B EP400 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HMGA1 HMGA2 KAT5 LMNB1 MRE11 NBN POT1 RAD50 RB1 TERF1 TERF2 TERF2IP TINF2 TP53 UBN1 (see all 73) (see less)
5	Nucleosome assembly	Reactome	CENPA CENPC CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CENPW CENPX H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HJURP ITGB3BP KNL1 MIS18A MIS18BP1 NPM1 OIP5 RBBP4 RBBP7 RSF1 RUVBL1 SMARCA5 (see all 73) (see less)
6	Deposition of new CENPA-containing nucleosomes at the centromere	Reactome	CENPA CENPC CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CENPW CENPX H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HJURP ITGB3BP KNL1 MIS18A MIS18BP1 NPM1 OIP5 RBBP4 RBBP7 RSF1 RUVBL1 SMARCA5 (see all 73) (see less)
7	Inhibition of DNA recombination at telomere	Reactome	ACD ATRX DAXX H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POT1 TERF1 TERF2 TERF2IP TINF2 (see all 67) (see less)
8	Base-Excision Repair, AP Site Formation	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MBD4 MPG MUTYH NEIL1 NEIL2 NEIL3 NTHL1 OGG1 POT1 SMUG1 TDG TERF1 TERF2 TERF2IP TINF2 UNG (see all 62) (see less)
9	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MBD4 NEIL1 NEIL2 NEIL3 NTHL1 OGG1 POT1 SMUG1 TDG TERF1 TERF2 TERF2IP TINF2 UNG (see all 60) (see less)
10	Depyrimidination	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MBD4 NEIL1 NEIL2 NEIL3 NTHL1 OGG1 POT1 SMUG1 TDG TERF1 TERF2 TERF2IP TINF2 UNG (see all 60) (see less)
11	Cleavage of the damaged pyrimidine	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MBD4 NEIL1 NEIL2 NEIL3 NTHL1 OGG1 POT1 SMUG1 TDG TERF1 TERF2 TERF2IP TINF2 UNG (see all 60) (see less)
12	Recognition and association of DNA glycosylase with site containing an affected purine	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MPG MUTYH NEIL3 OGG1 POT1 TERF1 TERF2 TERF2IP TINF2 (see all 55) (see less)
13	Cleavage of the damaged purine	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MPG MUTYH NEIL3 OGG1 POT1 TERF1 TERF2 TERF2IP TINF2 (see all 55) (see less)
14	Depurination	Reactome	ACD H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MPG MUTYH NEIL3 OGG1 POT1 TERF1 TERF2 TERF2IP TINF2 (see all 55) (see less)
15	Replacement of protamines by nucleosomes in the male pronucleus	Reactome	H1-8 H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA METTL23 NPM2 PRM1 PRM2 SRPK1 (see all 42) (see less)
16	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Reactome	ASF1A CABIN1 EP400 HIRA HMGA1 HMGA2 LMNB1 RB1 TP53 UBN1 (see all 10) (see less)

Gene overlap in member pathways for Packaging Of Telomere Ends SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	H4C16	H4 Histone 16	Protein Coding	15
2	H2AX	H2A.X Variant Histone	Protein Coding	15
3	H2BC5	H2B Clustered Histone 5	Protein Coding	15
4	H2BC3	H2B Clustered Histone 3	Protein Coding	15
5	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	15
6	H4C15	H4 Clustered Histone 15	Protein Coding	15
7	H4C9	H4 Clustered Histone 9	Protein Coding	15
8	H2BC8	H2B Clustered Histone 8	Protein Coding	15
9	H2BC13	H2B Clustered Histone 13	Protein Coding	15
10	H2BC15	H2B Clustered Histone 15	Protein Coding	15
11	H2BC14	H2B Clustered Histone 14	Protein Coding	15
12	H2BC7	H2B Clustered Histone 7	Protein Coding	15
13	H2BC6	H2B Clustered Histone 6	Protein Coding	15
14	H2BC9	H2B Clustered Histone 9	Protein Coding	15
15	H2BC10	H2B Clustered Histone 10	Protein Coding	15
16	H2BC4	H2B Clustered Histone 4	Protein Coding	15
17	H2BC17	H2B Clustered Histone 17	Protein Coding	15
18	H2BC21	H2B Clustered Histone 21	Protein Coding	15
19	H4C1	H4 Clustered Histone 1	Protein Coding	15
20	H4C4	H4 Clustered Histone 4	Protein Coding	15
21	H4C6	H4 Clustered Histone 6	Protein Coding	15
22	H4C12	H4 Clustered Histone 12	Protein Coding	15
23	H4C11	H4 Clustered Histone 11	Protein Coding	15
24	H4C3	H4 Clustered Histone 3	Protein Coding	15
25	H4C8	H4 Clustered Histone 8	Protein Coding	15
26	H4C2	H4 Clustered Histone 2	Protein Coding	15
27	H4C5	H4 Clustered Histone 5	Protein Coding	15
28	H4C13	H4 Clustered Histone 13	Protein Coding	15
29	H4C14	H4 Clustered Histone 14	Protein Coding	15
30	H2BC11	H2B Clustered Histone 11	Protein Coding	15
31	H2BC26	H2B Clustered Histone 26	Protein Coding	14
32	H2BC1	H2B Clustered Histone 1	Protein Coding	14
33	H2AC7	H2A Clustered Histone 7	Protein Coding	14
34	H2AC14	H2A Clustered Histone 14	Protein Coding	14
35	H2AC6	H2A Clustered Histone 6	Protein Coding	14
36	H2AC20	H2A Clustered Histone 20	Protein Coding	14
37	H2BC12	H2B Clustered Histone 12	Protein Coding	14
38	H2AC8	H2A Clustered Histone 8	Protein Coding	13
39	H2AB1	H2A.B Variant Histone 1	Protein Coding	13
40	H2AJ	H2A.J Histone	Protein Coding	13
41	H2AC19	H2A Clustered Histone 19	Protein Coding	13
42	H2AC4	H2A Clustered Histone 4	Protein Coding	13
43	H2AC18	H2A Clustered Histone 18	Protein Coding	13
44	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	13
45	H3-4	H3.4 Histone, Cluster Member	Protein Coding	12
46	POT1	Protection Of Telomeres 1	Protein Coding	11
47	TINF2	TERF1 Interacting Nuclear Factor 2	Protein Coding	11
48	TERF2IP	TERF2 Interacting Protein	Protein Coding	11
49	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	11
50	TERF1	Telomeric Repeat Binding Factor 1	Protein Coding	11
51	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	11
52	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	8
53	NEIL3	Nei Like DNA Glycosylase 3	Protein Coding	8
54	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	5
55	NEIL2	Nei Like DNA Glycosylase 2	Protein Coding	5
56	MPG	N-Methylpurine DNA Glycosylase	Protein Coding	5
57	MUTYH	MutY DNA Glycosylase	Protein Coding	5
58	NTHL1	Nth Like DNA Glycosylase 1	Protein Coding	5
59	TDG	Thymine DNA Glycosylase	Protein Coding	5
60	UNG	Uracil DNA Glycosylase	Protein Coding	5
61	NEIL1	Nei Like DNA Glycosylase 1	Protein Coding	5
62	MBD4	Methyl-CpG Binding Domain 4, DNA Glycosylase	Protein Coding	5
63	H3-3A	H3.3 Histone A	Protein Coding	3
64	H3-3B	H3.3 Histone B	Protein Coding	3
65	HIRA	Histone Cell Cycle Regulator	Protein Coding	3
66	CABIN1	Calcineurin Binding Protein 1	Protein Coding	2
67	ASF1A	Anti-Silencing Function 1A Histone Chaperone	Protein Coding	2
68	UBN1	Ubinuclein 1	Protein Coding	2
69	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	2
70	LMNB1	Lamin B1	Protein Coding	2
71	EP400	E1A Binding Protein P400	Protein Coding	2
72	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
73	TP53	Tumor Protein P53	Protein Coding	2
74	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	2
75	CENPS-CORT	CENPS-CORT Readthrough	Protein Coding	2
76	CENPA	Centromere Protein A	Protein Coding	2
77	CENPC	Centromere Protein C	Protein Coding	2
78	OIP5	Opa Interacting Protein 5	Protein Coding	2
79	CENPX	Centromere Protein X	Protein Coding	2
80	ITGB3BP	Integrin Subunit Beta 3 Binding Protein	Protein Coding	2
81	CENPI	Centromere Protein I	Protein Coding	2
82	CENPS	Centromere Protein S	Protein Coding	2
83	CENPW	Centromere Protein W	Protein Coding	2
84	CENPP	Centromere Protein P	Protein Coding	2
85	NPM1	Nucleophosmin 1	Protein Coding	2
86	RSF1	Remodeling And Spacing Factor 1	Protein Coding	2
87	MIS18A	MIS18 Kinetochore Protein A	Protein Coding	2
88	CENPQ	Centromere Protein Q	Protein Coding	2
89	MIS18BP1	MIS18 Binding Protein 1	Protein Coding	2
90	HJURP	Holliday Junction Recognition Protein	Protein Coding	2
91	CENPN	Centromere Protein N	Protein Coding	2
92	KNL1	Kinetochore Scaffold 1	Protein Coding	2
93	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
94	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
95	CENPK	Centromere Protein K	Protein Coding	2
96	CENPH	Centromere Protein H	Protein Coding	2
97	CENPM	Centromere Protein M	Protein Coding	2
98	CENPO	Centromere Protein O	Protein Coding	2
99	CENPU	Centromere Protein U	Protein Coding	2
100	CENPT	Centromere Protein T	Protein Coding	2
101	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	2
102	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	2
103	CENPL	Centromere Protein L	Protein Coding	2
104	PARP2	Poly(ADP-Ribose) Polymerase 2	Protein Coding	1
105	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	1
106	PNKP	Polynucleotide Kinase 3''-Phosphatase	Protein Coding	1
107	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
108	FEN1	Flap Structure-Specific Endonuclease 1	Protein Coding	1
109	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
110	LIG1	DNA Ligase 1	Protein Coding	1
111	LIG3	DNA Ligase 3	Protein Coding	1
112	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
113	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	1
114	POLB	DNA Polymerase Beta	Protein Coding	1
115	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	1
116	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	1
117	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	1
118	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	1
119	ADPRS	ADP-Ribosylserine Hydrolase	Protein Coding	1
120	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	1
121	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	1
122	RFC1	Replication Factor C Subunit 1	Protein Coding	1
123	RFC2	Replication Factor C Subunit 2	Protein Coding	1
124	RFC3	Replication Factor C Subunit 3	Protein Coding	1
125	RFC4	Replication Factor C Subunit 4	Protein Coding	1
126	RFC5	Replication Factor C Subunit 5	Protein Coding	1
127	RPA1	Replication Protein A1	Protein Coding	1
128	RPA2	Replication Protein A2	Protein Coding	1
129	RPA3	Replication Protein A3	Protein Coding	1
130	XRCC1	X-Ray Repair Cross Complementing 1	Protein Coding	1
131	PARG	Poly(ADP-Ribose) Glycohydrolase	Protein Coding	1
132	ACVR1B	Activin A Receptor Type 1B	Protein Coding	1
133	ACVR2A	Activin A Receptor Type 2A	Protein Coding	1
134	ACVR2B	Activin A Receptor Type 2B	Protein Coding	1
135	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
136	DLX1	Distal-Less Homeobox 1	Protein Coding	1
137	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
138	MECOM	MDS1 And EVI1 Complex Locus	Protein Coding	1
139	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
140	FOXG1	Forkhead Box G1	Protein Coding	1
141	H2AZ1	H2A.Z Variant Histone 1	Protein Coding	1
142	HDAC1	Histone Deacetylase 1	Protein Coding	1
143	IGSF1	Immunoglobulin Superfamily Member 1	Protein Coding	1
144	INHA	Inhibin Subunit Alpha	Protein Coding	1
145	INHBA	Inhibin Subunit Beta A	Protein Coding	1
146	INHBB	Inhibin Subunit Beta B	Protein Coding	1
147	SMAD2	SMAD Family Member 2	Protein Coding	1
148	SMAD3	SMAD Family Member 3	Protein Coding	1
149	SMAD4	SMAD Family Member 4	Protein Coding	1
150	SMAD7	SMAD Family Member 7	Protein Coding	1
151	SKI	SKI Proto-Oncogene	Protein Coding	1
152	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
153	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
154	UBB	Ubiquitin B	Protein Coding	1
155	UBC	Ubiquitin C	Protein Coding	1
156	H2AC13	H2A Clustered Histone 13	Protein Coding	1
157	H2AC15	H2A Clustered Histone 15	Protein Coding	1
158	H2AC16	H2A Clustered Histone 16	Protein Coding	1
159	H2AC17	H2A Clustered Histone 17	Protein Coding	1
160	FOXH1	Forkhead Box H1	Protein Coding	1
161	H2AC11	H2A Clustered Histone 11	Protein Coding	1
162	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
163	FSTL3	Follistatin Like 3	Protein Coding	1
164	FST	Follistatin	Protein Coding	1
165	LEMD3	LEM Domain Containing 3	Protein Coding	1
166	BAMBI	BMP And Activin Membrane Bound Inhibitor	Protein Coding	1
167	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
168	MED15	Mediator Complex Subunit 15	Protein Coding	1
169	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
170	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
171	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
172	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
173	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
174	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
175	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
176	NBN	Nibrin	Protein Coding	1
177	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
178	CCNA2	Cyclin A2	Protein Coding	1
179	CCNA1	Cyclin A1	Protein Coding	1
180	CCNE1	Cyclin E1	Protein Coding	1
181	CCNE2	Cyclin E2	Protein Coding	1
182	DAXX	Death Domain Associated Protein	Protein Coding	1
183	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
184	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
185	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
186	POLR2D	RNA Polymerase II Subunit D	Protein Coding	1
187	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	1
188	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	1
189	POLR2G	RNA Polymerase II Subunit G	Protein Coding	1
190	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	1
191	POLR2I	RNA Polymerase II Subunit I	Protein Coding	1
192	POLR2J	RNA Polymerase II Subunit J	Protein Coding	1
193	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	1
194	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	1
195	ATRX	ATRX Chromatin Remodeler	Protein Coding	1
196	NPM2	Nucleophosmin/Nucleoplasmin 2	Protein Coding	1
197	METTL23	Methyltransferase 23, Arginine	Protein Coding	1
198	H1-8	H1.8 Linker Histone	Protein Coding	1
199	PRM1	Protamine 1	Protein Coding	1
200	PRM2	Protamine 2	Protein Coding	1
201	SRPK1	SRSF Protein Kinase 1	Protein Coding	1

Disorders associated with Packaging Of Telomere Ends SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	7.56
2	Inherited cancer-predisposing syndrome	Enrichment	ATM, CDKN1B, MRE11, NBN, POT1, RAD50, RB1, TP53	6.29
3	Ovarian cancer	Enrichment	ATM, CDKN1B, MRE11, NBN, RAD50, RB1, TP53	5.95
4	Osteogenic sarcoma	Enrichment	RB1, TP53	5.83
5	Squamous cell carcinoma	Enrichment	RB1, TP53	5.83
6	Bone osteosarcoma	Enrichment	RB1, TP53	5.83
7	Small cell cancer of the lung	Enrichment	RB1, TP53	5.53
8	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	5.03
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	5.03
10	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	5.03
11	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, MRE11, NBN, RAD50, TP53	4.96
12	Bladder cancer	Enrichment	ATM, CDKN1A, RB1, TP53	4.78
13	Leukemia, chronic lymphocytic	Enrichment	ATM, POT1, TP53	4.76
14	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.55
15	Lip and oral cavity carcinoma	Enrichment	RB1, TP53	4.49
16	Melanoma, cutaneous malignant 1	Enrichment	ACD, POT1, TERF2IP	4.48
17	Lung cancer susceptibility 3	Enrichment	RB1, TP53	4.35
18	Familial colorectal cancer type x	Enrichment	MUTYH, POLD1, POLE	4.35
19	Breast cancer	Enrichment	ATM, MRE11, NBN, RAD50, TP53	4.30
20	Adenocarcinoma	Enrichment	ATM, TP53	4.07
21	Hereditary breast carcinoma	Enrichment	ATM, NBN, RAD50, TP53	4.05
22	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SKI, SMAD2, SMAD3, SMAD4	4.00
23	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	3.89
24	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	3.77
25	Hoyeraal-hreidarsson syndrome	Enrichment	ACD, TINF2	3.69
26	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	3.67
27	Pancreatic cancer	Enrichment	ATM, NBN, TP53	3.50
28	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.35
29	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.35
30	Prostate cancer	Enrichment	ATM, NBN, TP53	3.31
31	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	3.23
32	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	3.13
33	Silver-russell syndrome 5	Enrichment	HMGA2	3.13
34	Bone marrow failure syndrome 5	Enrichment	TP53	3.13
35	Papilloma of choroid plexus	Enrichment	TP53	3.13
36	Basal cell carcinoma 7	Enrichment	TP53	3.13
37	Anaplastic thyroid carcinoma	Enrichment	TP53	3.13
38	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	3.13
39	Stature quantitative trait locus 9	Enrichment	HMGA2	3.13
40	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	3.13
41	Ductal carcinoma in situ	Enrichment	TP53	3.13
42	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.13
43	Trilateral retinoblastoma	Enrichment	RB1	3.13
44	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.13
45	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.13
46	Choroid plexus cancer	Enrichment	TP53	3.13
47	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.13
48	Lung oat cell carcinoma	Enrichment	RB1	3.13
49	Colonic benign neoplasm	Enrichment	ATM, MRE11	3.00
50	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	2.98
51	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.83
52	Cervical cancer	Enrichment	TP53	2.83
53	Salivary gland adenoma, pleomorphic	Enrichment	HMGA2	2.83
54	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.83
55	Lymphoma, hodgkin, classic	Enrichment	TP53	2.83
56	Congenital fibrosarcoma	Enrichment	TP53	2.83
57	Li-fraumeni syndrome 1	Enrichment	TP53	2.83
58	Sarcoma	Enrichment	TP53	2.83
59	Cervix carcinoma	Enrichment	TP53	2.83
60	Hodgkin's lymphoma	Enrichment	TP53	2.83
61	Autosomal dominant primary microcephaly	Enrichment	LMNB1	2.83
62	12q14 microdeletion syndrome	Enrichment	HMGA2	2.83
63	Familial retinoblastoma	Enrichment	RB1	2.83
64	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.83
65	Gastric cancer	Enrichment	ATM, NBN, TP53	2.80
66	Breast-ovarian cancer, familial 1	Enrichment	ATM, NBN	2.67
67	Retinoblastoma	Enrichment	RB1	2.66
68	Nasopharyngeal carcinoma	Enrichment	TP53	2.66
69	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.66
70	Hypotrichosis 8	Enrichment	RB1	2.66
71	Dedifferentiated liposarcoma	Enrichment	HMGA2	2.66
72	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.66
73	Anaplastic astrocytoma	Enrichment	TP53	2.66
74	Well-differentiated liposarcoma	Enrichment	HMGA2	2.66
75	Dyskeratosis congenita	Enrichment	POT1, TINF2	2.64
76	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.53
77	Lynch syndrome 4	Enrichment	RB1	2.53
78	Lung sarcomatoid carcinoma	Enrichment	TP53	2.53
79	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.53
80	Silver-russell syndrome due to a point mutation	Enrichment	HMGA2	2.53
81	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.52
82	Intellectual developmental disorder, autosomal recessive 44	Enrichment	METTL23	2.51
83	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.51
84	Gliosarcoma	Enrichment	ATM, TP53	2.49
85	Myeloma, multiple	Enrichment	CREBBP, H2AC16, H2AC17	2.44
86	Rhabdomyosarcoma 2	Enrichment	TP53	2.43
87	Lymphoma	Enrichment	TP53	2.43
88	Acute megakaryocytic leukemia	Enrichment	TP53	2.43
89	Giant cell glioblastoma	Enrichment	ATM, TP53	2.43
90	Tumor predisposition syndrome 3	Enrichment	POT1	2.42
91	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8	Enrichment	POT1	2.42
92	High-grade astrocytoma with piloid features	Enrichment	POT1	2.42
93	Cerebroretinal microangiopathy with calcifications and cysts 3	Enrichment	POT1	2.42
94	Li-fraumeni syndrome	Enrichment	TP53	2.35
95	Adrenocortical carcinoma	Enrichment	TP53	2.35
96	Breast adenocarcinoma	Enrichment	TP53	2.35
97	Melanoma, uveal 1	Enrichment	MBD4	2.35
98	Familial adenomatous polyposis 3	Enrichment	NTHL1	2.35
99	Tumor predisposition syndrome 2	Enrichment	MBD4	2.35
100	Diffuse large b-cell lymphoma	Enrichment	NBN, TP53	2.34
101	Intellectual disability-hypotonic facies syndrome, x-linked, 1	Enrichment	ATRX	2.31
102	Gastric neuroendocrine neoplasm	Enrichment	ATRX	2.31
103	Esophageal cancer	Enrichment	TP53	2.29
104	Silver-russell syndrome 1	Enrichment	HMGA2	2.29
105	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.29
106	Essential thrombocythemia	Enrichment	TP53	2.29
107	Gallbladder cancer	Enrichment	TP53	2.29
108	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.29
109	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.27
110	Neuroendocrine tumor	Enrichment	CDKN1B	2.27
111	Endometrial serous adenocarcinoma	Enrichment	ATM	2.27
112	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.27
113	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.27
114	Microcephaly 4, primary, autosomal recessive	Enrichment	KNL1	2.27
115	Short stature and microcephaly with genital anomalies	Enrichment	CENPT	2.27
116	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.27
117	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.27
118	Buschke-ollendorff syndrome	Enrichment	LEMD3	2.26
119	Hypothyroidism, central, with testicular enlargement	Enrichment	IGSF1	2.26
120	Shprintzen-goldberg craniosynostosis syndrome	Enrichment	SKI	2.26
121	Radioulnar synostosis with amegakaryocytic thrombocytopenia 2	Enrichment	MECOM	2.26
122	Ovary adenocarcinoma	Enrichment	INHBA	2.26
123	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.26
124	Colorectal cancer 3	Enrichment	SMAD7	2.26
125	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.26
126	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	2.26
127	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.26
128	Heritable thoracic aortic disease	Enrichment	SMAD4	2.26
129	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.26
130	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.26
131	Foxg1 syndrome due to intragenic alteration	Enrichment	FOXG1	2.26
132	Foxg1 syndrome due to 14q12 microdeletion	Enrichment	FOXG1	2.26
133	Menke-hennekam syndrome	Enrichment	CREBBP	2.26
134	Isolated osteopoikilosis	Enrichment	LEMD3	2.26
135	Glioma susceptibility 1	Enrichment	TP53	2.23
136	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.23
137	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9	2.18
138	Adult hepatocellular carcinoma	Enrichment	TP53	2.18
139	Primary hyperaldosteronism	Enrichment	TP53	2.18
140	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.18
141	Colorectal cancer 10	Enrichment	POLD1	2.18
142	Ataxia-oculomotor apraxia 4	Enrichment	PNKP	2.18
143	Colorectal cancer 12	Enrichment	POLE	2.18
144	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.18
145	Immunodeficiency 120	Enrichment	POLD1	2.18
146	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.18
147	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.18
148	Immunodeficiency 96	Enrichment	LIG1	2.18
149	Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures	Enrichment	ADPRS	2.18
150	Spinocerebellar ataxia, autosomal recessive 26	Enrichment	XRCC1	2.18
151	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.18
152	Immunodeficiency 122	Enrichment	POLD3	2.18
153	Familial colorectal cancer	Enrichment	TP53	2.13
154	Revesz syndrome	Enrichment	TINF2	2.12
155	Dyskeratosis congenita, autosomal dominant 3	Enrichment	TINF2	2.12
156	Oligodendroglioma	Enrichment	POT1	2.12
157	Anaplastic oligodendroglioma	Enrichment	POT1	2.12
158	Myelodysplastic syndrome	Enrichment	TP53	2.09
159	Familial adenomatous polyposis 2	Enrichment	MUTYH	2.09
160	Digeorge syndrome	Enrichment	HIRA	2.05
161	Congenital disorder of deglycosylation 2	Enrichment	NEIL1	2.05
162	Immunodeficiency with hyper-igm, type 5	Enrichment	UNG	2.05
163	Alpha-thalassemia myelodysplasia syndrome	Enrichment	ATRX	2.01
164	Waardenburg syndrome, type 4c	Enrichment	POLR2F	2.01
165	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ATRX	2.01
166	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	2.01
167	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ATRX	2.01
168	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.97
169	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.97
170	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.97
171	High grade glioma	Enrichment	ATM	1.97
172	T-cell prolymphocytic leukemia	Enrichment	ATM	1.97
173	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	1.97
174	Body mass index quantitative trait locus 19	Enrichment	CENPO	1.97
175	Degenerative disc disease	Enrichment	CENPP	1.97
176	Methylmalonic aciduria and homocystinuria, cbll type	Enrichment	CENPT	1.97
177	Acute myeloid leukemia without maturation	Enrichment	NPM1	1.97
178	Lymphomatoid papulosis	Enrichment	NPM1	1.97
179	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	1.97
180	Myhre syndrome	Enrichment	SMAD4	1.96
181	Thumb deformity	Enrichment	CREBBP	1.96
182	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.96
183	Heterotaxy, visceral, 4, autosomal	Enrichment	ACVR2B	1.96
184	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.96
185	Menke-hennekam syndrome 2	Enrichment	EP300	1.96
186	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.96
187	Osteopoikilosis	Enrichment	LEMD3	1.96
188	Witteveen-kolk syndrome	Enrichment	SIN3A	1.96
189	Radioulnar synostosis	Enrichment	MECOM	1.96
190	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	MECOM	1.96
191	Submucosal cleft palate	Enrichment	UBB	1.96
192	Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome	Enrichment	MECOM	1.96
193	Cleft hard palate	Enrichment	UBB	1.96
194	Dyskeratosis congenita, autosomal dominant 6	Enrichment	ACD	1.95
195	Rhabdomyosarcoma	Enrichment	TP53	1.93
196	Spastic paraplegia 7, autosomal recessive	Enrichment	MUTYH	1.92
197	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	1.88
198	Charcot-marie-tooth disease, axonal, type 2b2	Enrichment	PNKP	1.88
199	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	1.88
200	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	1.88
201	Charcot-marie-tooth disease type 2b2	Enrichment	PNKP	1.88
202	Microcephaly, seizures, and developmental delay	Enrichment	PNKP	1.88
203	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	1.88
204	Mitochondrial dna depletion syndrome 20	Enrichment	LIG3	1.88
205	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.83
206	Alpha thalassemia-intellectual disability syndrome type 1	Enrichment	ATRX	1.83
207	Hepatoblastoma	Enrichment	TP53	1.81
208	Ataxia-telangiectasia	Enrichment	ATM	1.79
209	Nijmegen breakage syndrome	Enrichment	NBN	1.79
210	Polycythemia vera	Enrichment	ATM	1.79
211	Koolen-de vries syndrome	Enrichment	ATM	1.79
212	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	CENPT	1.79
213	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	1.79
214	Pilomatrixoma	Enrichment	MUTYH	1.79
215	Juvenile polyposis syndrome	Enrichment	SMAD4	1.78
216	Uvula, bifid	Enrichment	UBB	1.78
217	Transposition of the great arteries, dextro-looped	Enrichment	ACVR1B	1.78
218	Cleft soft palate	Enrichment	UBB	1.78
219	Tethered spinal cord syndrome	Enrichment	CREBBP	1.78
220	Loeys-dietz syndrome 1	Enrichment	SMAD2	1.78
221	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.78
222	Diamond-blackfan anemia 1	Enrichment	TP53	1.77
223	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.71
224	Childhood apraxia of speech	Enrichment	RFC3	1.70
225	Colorectal cancer	Enrichment	MUTYH, POLD1, POLE	1.70
226	Familial adenomatous polyposis 1	Enrichment	MUTYH	1.70
227	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.67
228	Mantle cell lymphoma	Enrichment	ATM	1.67
229	Primary hyperparathyroidism	Enrichment	CDKN1B	1.67
230	Oculomotor apraxia	Enrichment	ATM	1.67
231	Orofacial cleft	Enrichment	FST	1.66
232	Aortic aneurysm	Enrichment	SMAD3	1.66
233	Orofacial clefting syndrome	Enrichment	FST	1.66
234	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TINF2	1.65
235	Non-immune hydrops fetalis	Enrichment	UBN1	1.65
236	Clear cell renal cell carcinoma	Enrichment	OGG1	1.62
237	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.61
238	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TINF2	1.58
239	Diamond-blackfan anemia	Enrichment	TP53	1.58
240	Developmental and epileptic encephalopathy 12	Enrichment	PNKP	1.58
241	Glioblastoma	Enrichment	ATM	1.57
242	Acute myeloid leukemia with maturation	Enrichment	NPM1	1.57
243	Goldberg-shprintzen syndrome	Enrichment	SKI	1.56
244	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.56
245	2q23.1 microduplication syndrome	Enrichment	ACVR2A	1.56
246	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.56
247	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.56
248	Hereditary clear cell renal cell carcinoma	Enrichment	OGG1	1.55
249	Thrombocytopenia	Enrichment	MECOM, SMAD4	1.54
250	Leukemia, acute myeloid	Enrichment	TP53	1.54
251	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.53
252	Waardenburg syndrome	Enrichment	POLR2F	1.53
253	Type 2 diabetes mellitus	Enrichment	HMGA1	1.52
254	Hypertrichosis	Enrichment	CREBBP	1.49
255	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.47
256	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.47
257	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.43
258	Rett syndrome	Enrichment	FOXG1	1.42
259	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.42
260	Ewing sarcoma	Enrichment	SMARCA5	1.37
261	Rett syndrome, congenital variant	Enrichment	FOXG1	1.36
262	Charge syndrome	Enrichment	EP300	1.31
263	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.31
264	Lynch syndrome 1	Enrichment	ATM	1.28
265	Aplastic anemia	Enrichment	NBN	1.28
266	Optic nerve disease	Enrichment	FOXG1	1.27
267	Immune deficiency disease	Enrichment	ATM	1.24
268	Leukemia, acute lymphoblastic	Enrichment	NBN	1.24
269	Uterine corpus cancer	Enrichment	ATM	1.24
270	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	LIG3	1.24
271	Renal cell carcinoma, nonpapillary	Enrichment	OGG1	1.23
272	Premature menopause	Enrichment	NBN	1.17
273	Acute promyelocytic leukemia	Enrichment	NPM1	1.17
274	Chromosome 1p36 deletion syndrome	Enrichment	SKI	1.16
275	Stereotypic movement disorder	Enrichment	FOXG1	1.16
276	Combined immunodeficiency	Enrichment	POLD1	1.15
277	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.15
278	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.15
279	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.13
280	Heart disease	Enrichment	CREBBP	1.13
281	Polydactyly, postaxial, type a1	Enrichment	EP300	1.10
282	Corpus callosum, agenesis of	Enrichment	CREBBP	1.10
283	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.10
284	Septopreoptic holoprosencephaly	Enrichment	FOXH1	1.10
285	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.10
286	Midline interhemispheric variant of holoprosencephaly	Enrichment	FOXH1	1.10
287	Endometrial cancer	Enrichment	MUTYH	1.09
288	Isolated congenital microcephaly	Enrichment	FOXG1	1.07
289	Microform holoprosencephaly	Enrichment	FOXH1	1.07
290	Lobar holoprosencephaly	Enrichment	FOXH1	1.07
291	Polycystic liver disease	Enrichment	RUVBL1	1.06
292	Autosomal dominant polycystic liver disease	Enrichment	RUVBL1	1.06
293	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	1.05
294	Alobar holoprosencephaly	Enrichment	FOXH1	1.05
295	Semilobar holoprosencephaly	Enrichment	FOXH1	1.02
296	Arteriovenous malformations of the brain	Enrichment	LEMD3	1.00
297	Ehlers-danlos syndrome	Enrichment	SMAD3	1.00
298	Lissencephaly	Enrichment	NBN	0.97
299	Kallmann syndrome	Enrichment	POLR2F	0.97
300	Early infantile developmental and epileptic encephalopathy	Enrichment	PNKP	0.95
301	Visceral heterotaxy	Enrichment	ACVR2B	0.94
302	Congenital nervous system abnormality	Enrichment	CREBBP, FOXG1	0.93
303	Nervous system disease	Enrichment	CREBBP, FOXG1	0.93
304	Parkinson's disease	Enrichment	RFC1	0.92
305	Scoliosis	Enrichment	CREBBP	0.90
306	Williams-beuren syndrome	Enrichment	RFC2	0.90
307	Hirschsprung disease 1	Enrichment	POLR2F	0.87
308	Strabismus	Enrichment	FOXG1	0.86
309	Parkinson disease, late-onset	Enrichment	RFC1	0.83
310	Primary autosomal recessive microcephaly	Enrichment	KNL1	0.80
311	Connective tissue disease	Enrichment	SMAD3	0.79
312	Autosomal recessive non-syndromic intellectual disability	Enrichment	METTL23	0.78
313	Body mass index quantitative trait locus 11	Enrichment	CENPO	0.63
314	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	ATRX	0.62
315	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	CENPP	0.61
316	Undetermined early-onset epileptic encephalopathy	Enrichment	FOXG1	0.57
317	Primary ovarian insufficiency	Enrichment	NBN	0.56
318	Rare genetic deafness	Enrichment	POLR2F	0.49
319	Autism	Enrichment	CREBBP	0.48
320	Microcephaly	Enrichment	ATRX	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Packaging Of Telomere Ends

Pathway Network for Packaging Of Telomere Ends

Pathway network for the Packaging Of Telomere Ends SuperPath

Member Pathways for Packaging Of Telomere Ends

Pathways in the Packaging Of Telomere Ends SuperPath

Gene overlap in member pathways for Packaging Of Telomere Ends SuperPath

Associated Genes for Packaging Of Telomere Ends

Associated Disorders for Packaging Of Telomere Ends

Disorders associated with Packaging Of Telomere Ends SuperPath

STRING Interaction Network for Packaging Of Telomere Ends

Sources for Packaging Of Telomere Ends