PAR1-mediated thrombin signaling events

No Pathway Network information available for PAR1-mediated thrombin signaling events

Pathways in the PAR1-mediated thrombin signaling events SuperPath

#	Name	Source	Genes
1	PAR1-mediated thrombin signaling events	PubChem	AKAP13 ARHGDIA ARHGEF1 ARRB1 DNM1 F2 F2R F2RL2 GNA12 GNA13 GNB1 GNG2 GRK3 MYL2 NOS3 PIK3CA PIK3R1 PKN1 PRKCA PRKCD RHOA ROCK1 SNX1 SNX2 TRPC6 VASP ZYX (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SNX2	Sorting Nexin 2	Protein Coding	1
2	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	1
3	SNX1	Sorting Nexin 1	Protein Coding	1
4	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	1
5	ZYX	Zyxin	Protein Coding	1
6	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1
7	MYL2	Myosin Light Chain 2	Protein Coding	1
8	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
9	PKN1	Protein Kinase N1	Protein Coding	1
10	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
11	PRKCD	Protein Kinase C Delta	Protein Coding	1
12	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
13	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
14	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
15	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	1
16	F2	Coagulation Factor II, Thrombin	Protein Coding	1
17	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
18	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
19	DNM1	Dynamin 1	Protein Coding	1
20	PRKCA	Protein Kinase C Alpha	Protein Coding	1
21	RHOA	Ras Homolog Family Member A	Protein Coding	1
22	GNB1	G Protein Subunit Beta 1	Protein Coding	1
23	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
24	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
25	ARRB1	Arrestin Beta 1	Protein Coding	1
26	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
27	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with PAR1-mediated thrombin signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.94
2	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.24
3	Stroke, ischemic	Enrichment	F2, NOS3	3.77
4	Macrodactyly	Enrichment	PIK3CA	2.70
5	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.70
6	Prothrombin deficiency, congenital	Enrichment	F2	2.70
7	Cowden syndrome 5	Enrichment	PIK3CA	2.70
8	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	2.70
9	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.70
10	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.70
11	Immunodeficiency 62	Enrichment	ARHGEF1	2.70
12	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.70
13	Short syndrome	Enrichment	PIK3R1	2.70
14	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.70
15	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.70
16	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.70
17	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.70
18	Pregnancy loss, recurrent 2	Enrichment	F2	2.70
19	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.70
20	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.70
21	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.70
22	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.70
23	Hypospadias	Enrichment	PIK3CA	2.70
24	Prothrombin deficiency	Enrichment	F2	2.70
25	Rare venous malformation	Enrichment	PIK3CA	2.70
26	Diaphragmatic eventration	Enrichment	PIK3CA	2.70
27	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.70
28	Rare combined vascular malformation	Enrichment	PIK3CA	2.70
29	Cavernous lymphangioma	Enrichment	PIK3CA	2.70
30	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.70
31	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.70
32	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.70
33	Macrodactyly of toe	Enrichment	PIK3CA	2.70
34	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA, TRPC6	2.69
35	Cerebral palsy	Enrichment	F2, GNB1	2.57
36	Keratosis, seborrheic	Enrichment	PIK3CA	2.40
37	Noonan syndrome 8	Enrichment	PIK3CA	2.40
38	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.40
39	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.40
40	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.40
41	Cerebral visual impairment	Enrichment	GNB1	2.40
42	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.22
43	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.22
44	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.22
45	Immunodeficiency 14	Enrichment	PIK3R1	2.22
46	Keratoacanthoma	Enrichment	PIK3CA	2.22
47	Cerebral sinovenous thrombosis	Enrichment	F2	2.22
48	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.10
49	Cerebrovascular disease	Enrichment	PIK3CA	2.10
50	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.10
51	Capillary malformations, congenital	Enrichment	PIK3CA	2.00
52	Alzheimer disease 2	Enrichment	NOS3	2.00
53	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	2.00
54	Pre-eclampsia	Enrichment	NOS3	2.00
55	Hemimegalencephaly	Enrichment	PIK3CA	2.00
56	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.92
57	Cowden syndrome 1	Enrichment	PIK3CA	1.92
58	Breast adenocarcinoma	Enrichment	PIK3CA	1.92
59	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.92
60	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.89
61	Nevus, epidermal	Enrichment	PIK3CA	1.86
62	Thrombophilia due to thrombin defect	Enrichment	F2	1.86
63	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.86
64	Gallbladder cancer	Enrichment	PIK3CA	1.86
65	Overgrowth syndrome	Enrichment	PIK3R1	1.86
66	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	1.86
67	Lennox-gastaut syndrome	Enrichment	DNM1	1.80
68	Hypothyroidism	Enrichment	GNB1	1.80
69	Arteriovenous malformation	Enrichment	PIK3CA	1.75
70	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.75
71	Cowden syndrome	Enrichment	PIK3CA	1.75
72	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.70
73	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.70
74	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.66
75	Myelodysplastic syndrome	Enrichment	GNB1	1.66
76	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.66
77	Meningioma	Enrichment	PIK3CA	1.63
78	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.63
79	Stereotypic movement disorder	Enrichment	DNM1	1.59
80	Heart disease	Enrichment	MYL2	1.56
81	Congenital myopathy 4a, autosomal dominant	Enrichment	MYL2	1.53
82	Lynch syndrome	Enrichment	PIK3CA	1.53
83	Alzheimer disease, familial, 1	Enrichment	NOS3	1.48
84	Hypertension, essential	Enrichment	NOS3	1.48
85	Cleft palate, isolated	Enrichment	GNB1	1.48
86	Cardiomyopathy, dilated, 1e	Enrichment	MYL2	1.48
87	Focal segmental glomerulosclerosis	Enrichment	TRPC6	1.41
88	Endometrial cancer	Enrichment	PIK3CA	1.39
89	Hepatocellular carcinoma	Enrichment	PIK3CA	1.37
90	Strabismus	Enrichment	GNB1	1.28
91	Bladder cancer	Enrichment	PIK3CA	1.25
92	Prostate cancer	Enrichment	PIK3CA	1.25
93	Lung cancer	Enrichment	PIK3CA	1.21
94	Familial hypertrophic cardiomyopathy	Enrichment	MYL2	1.20
95	Dystonia	Enrichment	GNB1	1.17
96	Gastric cancer	Enrichment	PIK3CA	1.08
97	Nephrotic syndrome	Enrichment	TRPC6	1.08
98	Hypertrophic cardiomyopathy	Enrichment	MYL2	1.08
99	West syndrome	Enrichment	DNM1	1.08
100	Hereditary breast carcinoma	Enrichment	PIK3CA	1.08
101	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.02
102	Hypertelorism	Enrichment	PIK3CA	1.01
103	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.98
104	Primary ovarian insufficiency	Enrichment	NOS3	0.95
105	Breast cancer	Enrichment	PIK3CA	0.86
106	Dilated cardiomyopathy	Enrichment	MYL2	0.83
107	Ovarian cancer	Enrichment	PIK3CA	0.74
108	Autism spectrum disorder	Enrichment	GNB1	0.71
109	Microcephaly	Enrichment	GNB1	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PAR1-mediated thrombin signaling events

Pathway Network for PAR1-mediated thrombin signaling events

Member Pathways for PAR1-mediated thrombin signaling events

Pathways in the PAR1-mediated thrombin signaling events SuperPath

Associated Genes for PAR1-mediated thrombin signaling events

Associated Disorders for PAR1-mediated thrombin signaling events

Disorders associated with PAR1-mediated thrombin signaling events SuperPath

STRING Interaction Network for PAR1-mediated thrombin signaling events

Sources for PAR1-mediated thrombin signaling events