Paracetamol ADME

Pathway network for the Paracetamol ADME SuperPath

Sources:

Reactome
PharmGKB

Pathways in the Paracetamol ADME SuperPath

#	Name	Source	Genes
1	Paracetamol ADME	Reactome	ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCG2 ACY1 CNDP2 CYP2E1 GGT1 GGT5 GGT6 GGT7 GSTM1 GSTP1 GSTT1 NAT1 NAT2 SULT1A1 SULT1A3 SULT1A4 SULT1C4 SULT1E1 SULT2A1 UGT1A1 UGT1A10 UGT1A6 UGT1A9 UGT2B15 (see all 29) (see less)
2	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics	PharmGKB	ABCC2 ABCC3 ABCC4 ABCG2 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP3A4 GSTM1 GSTP1 GSTT1 SULT1A1 SULT1A3 SULT1A4 SULT1E1 SULT2A1 UGT1A1 UGT1A6 UGT1A9 UGT2B15 (see all 21) (see less)
3	Acetaminophen Pathway (toxic doses), Pharmacokinetics	PharmGKB	ABCC2 ABCC3 ABCC4 ABCG2 CYP1A2 CYP2A6 CYP2D6 CYP2E1 GSTM1 GSTP1 GSTT1 SULT1A1 SULT1A3 SULT1A4 SULT1E1 SULT2A1 UGT1A1 UGT1A6 UGT1A9 UGT2B15 (see all 20) (see less)
4	Isoniazid Pathway, Pharmacokinetics	PharmGKB	CYP2E1 GSTM1 GSTT1 NAT2
5	Sulfasalazine, Mesalazine and Sulfapyridine Pathway, Pharmacokinetics	PharmGKB	ABCG2 NAT1 NAT2

Gene overlap in member pathways for Paracetamol ADME SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	4
2	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	4
3	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	4
4	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	4
5	NAT2	N-Acetyltransferase 2	Protein Coding	3
6	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	3
7	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	3
8	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	3
9	SULT1A4	Sulfotransferase Family 1A Member 4	Protein Coding	3
10	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	3
11	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	3
12	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	3
13	SULT1E1	Sulfotransferase Family 1E Member 1	Protein Coding	3
14	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	3
15	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	3
16	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	3
17	UGT2B15	UDP Glucuronosyltransferase Family 2 Member B15	Protein Coding	3
18	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	3
19	NAT1	N-Acetyltransferase 1	Protein Coding	2
20	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	2
21	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	2
22	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	2
23	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	1
24	GGT6	Gamma-Glutamyltransferase 6	Protein Coding	1
25	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	1
26	GGT7	Gamma-Glutamyltransferase 7	Protein Coding	1
27	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	1
28	SULT1C4	Sulfotransferase Family 1C Member 4	Protein Coding	1
29	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
30	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	1
31	CNDP2	Carnosine Dipeptidase 2	Protein Coding	1
32	ACY1	Aminoacylase 1	Protein Coding	1
33	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1

Disorders associated with Paracetamol ADME SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A9	8.46
2	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A9	8.46
3	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A9	8.46
4	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A9	8.46
5	Gilbert syndrome	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A9	8.26
6	Bilirubin metabolic disorder	Enrichment	UGT1A1, UGT1A10, UGT1A6, UGT1A9	8.26
7	Acetylation, slow	Enrichment	NAT2	3.66
8	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.66
9	Blood group, junior system	Enrichment	ABCG2	3.66
10	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.83
11	Letrozole toxicity	Enrichment	CYP2A6	2.83
12	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.81
13	Glutathionuria	Enrichment	GGT1	2.67
14	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.67
15	Kala-azar 2	Enrichment	GSTP1	2.53
16	Dubin-johnson syndrome	Enrichment	ABCC2	2.35
17	Coumarin resistance	Enrichment	CYP2A6	2.35
18	Tobacco addiction	Enrichment	CYP2A6	2.23
19	Aminoacylase 1 deficiency	Enrichment	ACY1	2.07
20	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.05
21	Lung cancer	Enrichment	CYP2A6	1.34
22	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Paracetamol ADME

Pathway network for the Paracetamol ADME SuperPath

Member Pathways for Paracetamol ADME

Pathways in the Paracetamol ADME SuperPath

Gene overlap in member pathways for Paracetamol ADME SuperPath

Associated Genes for Paracetamol ADME

Associated Disorders for Paracetamol ADME

Disorders associated with Paracetamol ADME SuperPath

STRING Interaction Network for Paracetamol ADME

Sources for Paracetamol ADME