Parkinson's disease pathway

No Pathway Network information available for Parkinson's disease pathway

Pathways in the Parkinson's disease pathway SuperPath

#	Name	Source	Genes
1	Parkinson's disease pathway	WikiPathways	APAF1 ATXN2 CASP2 CASP3 CASP6 CASP7 CASP9 CCNE1 CCNE2 CYCS DDC EPRS1 GPR37 HTRA2 LRRK2 MAPK11 MAPK12 MAPK13 MAPK14 PARK7 PINK1 PRKN SEPTIN5 SLC6A3 SNCA SNCAIP SYT11 TH UBA1 UBA7 UBB UBE2G1 UBE2G2 UBE2J1 UBE2J2 UBE2L3 UBE2L6 UCHL1 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SNCAIP	Synuclein Alpha Interacting Protein	Protein Coding	1
2	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	1
3	CCNE2	Cyclin E2	Protein Coding	1
4	CCNE1	Cyclin E1	Protein Coding	1
5	CASP9	Caspase 9	Protein Coding	1
6	CASP7	Caspase 7	Protein Coding	1
7	CASP3	Caspase 3	Protein Coding	1
8	CASP2	Caspase 2	Protein Coding	1
9	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	1
10	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	1
11	UBA7	Ubiquitin Like Modifier Activating Enzyme 7	Protein Coding	1
12	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	1
13	UBB	Ubiquitin B	Protein Coding	1
14	TH	Tyrosine Hydroxylase	Protein Coding	1
15	SNCA	Synuclein Alpha	Protein Coding	1
16	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	1
17	PINK1	PTEN Induced Kinase 1	Protein Coding	1
18	ATXN2	Ataxin 2	Protein Coding	1
19	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
20	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
21	CYCS	Cytochrome C, Somatic	Protein Coding	1
22	SEPTIN5	Septin 5	Protein Coding	1
23	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
24	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
25	GPR37	G Protein-Coupled Receptor 37	Protein Coding	1
26	HTRA2	HtrA Serine Peptidase 2	Protein Coding	1
27	DDC	Dopa Decarboxylase	Protein Coding	1
28	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
29	LRRK2	Leucine Rich Repeat Kinase 2	Protein Coding	1
30	PARK7	Parkinsonism Associated Deglycase	Protein Coding	1
31	CASP6	Caspase 6	Protein Coding	1
32	UBE2J2	Ubiquitin Conjugating Enzyme E2 J2	Protein Coding	1
33	UBE2G2	Ubiquitin Conjugating Enzyme E2 G2	Protein Coding	1
34	UBE2G1	Ubiquitin Conjugating Enzyme E2 G1	Protein Coding	1
35	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
36	UBE2J1	Ubiquitin Conjugating Enzyme E2 J1	Protein Coding	1
37	SYT11	Synaptotagmin 11	Protein Coding	1
38	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	1

Disorders associated with Parkinson's disease pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Early-onset parkinson's disease	Enrichment	HTRA2, LRRK2, PARK7, PINK1, PRKN, SNCA, UCHL1	10.88
2	Parkinson disease, late-onset	Enrichment	ATXN2, LRRK2, PRKN, SNCA	6.27
3	Parkinson's disease	Enrichment	ATXN2, LRRK2, PRKN	4.72
4	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PARK7, PINK1	3.94
5	Parkinson disease 1, autosomal dominant	Enrichment	SNCA	2.55
6	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.55
7	Parkinson disease 4, autosomal dominant	Enrichment	SNCA	2.55
8	Leprosy 2	Enrichment	PRKN	2.55
9	Thrombocytopenia 4	Enrichment	CYCS	2.55
10	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	2.55
11	Parkinson disease 7, autosomal recessive early-onset	Enrichment	PARK7	2.55
12	Parkinson disease 5, autosomal dominant	Enrichment	UCHL1	2.55
13	Leukodystrophy, hypomyelinating, 15	Enrichment	EPRS1	2.55
14	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	2.55
15	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.55
16	Amyotrophic lateral sclerosis type 13	Enrichment	ATXN2	2.55
17	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	2.55
18	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	PARK7	2.25
19	Parkinson disease 12	Enrichment	PRKN	2.25
20	Vexas syndrome	Enrichment	UBA1	2.25
21	Parkinson disease 8, autosomal dominant	Enrichment	LRRK2	2.25
22	Segawa syndrome, autosomal recessive	Enrichment	TH	2.25
23	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.25
24	Spinocerebellar ataxia 2	Enrichment	ATXN2	2.25
25	Spastic paraplegia 79b, autosomal recessive	Enrichment	UCHL1	2.25
26	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	2.25
27	Parkinson disease 15, autosomal recessive early-onset	Enrichment	SNCA	2.25
28	Hereditary spastic paraplegia 79a	Enrichment	UCHL1	2.25
29	Spastic paraplegia 79a, autosomal dominant, with ataxia	Enrichment	UCHL1	2.25
30	Submucosal cleft palate	Enrichment	UBB	2.25
31	Cleft hard palate	Enrichment	UBB	2.25
32	Dystonia, dopa-responsive	Enrichment	TH	2.08
33	Klippel-feil syndrome 1, autosomal dominant	Enrichment	LRRK2	2.08
34	Uvula, bifid	Enrichment	UBB	2.08
35	Cleft soft palate	Enrichment	UBB	2.08
36	Tobacco addiction	Enrichment	SLC6A3	1.95
37	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	1.95
38	Complex hereditary spastic paraplegia	Enrichment	PRKN	1.95
39	Dementia, lewy body	Enrichment	SNCA	1.86
40	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.86
41	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.86
42	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.86
43	Machado-joseph disease	Enrichment	LRRK2	1.78
44	Autosomal dominant cerebellar ataxia	Enrichment	LRRK2	1.60
45	Lung cancer susceptibility 3	Enrichment	PRKN	1.41
46	Rasopathy	Enrichment	DDC	1.15
47	Lung cancer	Enrichment	PRKN	1.07
48	Dystonia	Enrichment	TH	1.03
49	Systemic lupus erythematosus	Enrichment	UBE2L3	0.98
50	Thrombocytopenia	Enrichment	CYCS	0.90
51	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ATXN2	0.82
52	Schizophrenia	Enrichment	PRKN	0.82
53	Autism	Enrichment	PRKN	0.74
54	Ovarian cancer	Enrichment	PRKN	0.61
55	Autism spectrum disorder	Enrichment	PRKN	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Parkinson's disease pathway

Pathway Network for Parkinson's disease pathway

Member Pathways for Parkinson's disease pathway

Pathways in the Parkinson's disease pathway SuperPath

Associated Genes for Parkinson's disease pathway

Associated Disorders for Parkinson's disease pathway

Disorders associated with Parkinson's disease pathway SuperPath

STRING Interaction Network for Parkinson's disease pathway

Sources for Parkinson's disease pathway