Pathogenesis of ALS

No Pathway Network information available for Pathogenesis of ALS

Pathways in the Pathogenesis of ALS SuperPath

#	Name	Source	Genes
1	Pathogenesis of ALS	QIAGEN	BAD BAX BCL2 BCL2L1 CASP1 CASP3 CASP9 CYCS GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GRINA SLC1A1 SLC1A2 SLC1A3 SOD1 TP53 (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
2	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
3	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
4	BCL2L1	BCL2 Like 1	Protein Coding	1
5	CASP1	Caspase 1	Protein Coding	1
6	CASP3	Caspase 3	Protein Coding	1
7	CASP9	Caspase 9	Protein Coding	1
8	CYCS	Cytochrome C, Somatic	Protein Coding	1
9	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	1
10	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
11	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
12	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
13	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
14	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
15	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
16	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1
17	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
18	GRIN3A	Glutamate Ionotropic Receptor NMDA Type Subunit 3A	Protein Coding	1
19	GRIN3B	Glutamate Ionotropic Receptor NMDA Type Subunit 3B	Protein Coding	1
20	GRINA	Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1	Protein Coding	1
21	SLC1A1	Solute Carrier Family 1 Member 1	Protein Coding	1
22	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	1
23	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	1
24	SOD1	Superoxide Dismutase 1	Protein Coding	1
25	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with Pathogenesis of ALS SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	West syndrome	Enrichment	GRIA3, GRIN1, GRIN2B	4.16
2	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1, GRIN2B	3.99
3	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.73
4	Dicarboxylic aminoaciduria	Enrichment	SLC1A1	2.73
5	Episodic ataxia, type 6	Enrichment	SLC1A3	2.73
6	Developmental and epileptic encephalopathy 41	Enrichment	SLC1A2	2.73
7	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.73
8	Schizophrenia 18	Enrichment	SLC1A1	2.73
9	Bone marrow failure syndrome 5	Enrichment	TP53	2.73
10	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.73
11	Papilloma of choroid plexus	Enrichment	TP53	2.73
12	Basal cell carcinoma 7	Enrichment	TP53	2.73
13	Anaplastic thyroid carcinoma	Enrichment	TP53	2.73
14	Thrombocytopenia 4	Enrichment	CYCS	2.73
15	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.73
16	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.73
17	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.73
18	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.73
19	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.73
20	Ductal carcinoma in situ	Enrichment	TP53	2.73
21	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.73
22	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.73
23	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.73
24	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.73
25	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.73
26	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.73
27	Hot water epilepsy	Enrichment	SLC1A1	2.73
28	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.73
29	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.73
30	Landau-kleffner syndrome	Enrichment	GRIN2A	2.73
31	Choroid plexus cancer	Enrichment	TP53	2.73
32	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.73
33	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.73
34	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.73
35	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.73
36	Grin2a-related disorders	Enrichment	GRIN2A	2.73
37	Epilepsy	Enrichment	GRIN2A, GRIN2B	2.61
38	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	2.59
39	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	2.55
40	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.43
41	Cervical cancer	Enrichment	TP53	2.43
42	Lymphoma, hodgkin, classic	Enrichment	TP53	2.43
43	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.43
44	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.43
45	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.43
46	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.43
47	Congenital fibrosarcoma	Enrichment	TP53	2.43
48	Li-fraumeni syndrome 1	Enrichment	TP53	2.43
49	Sarcoma	Enrichment	TP53	2.43
50	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.43
51	Cervix carcinoma	Enrichment	TP53	2.43
52	Hodgkin's lymphoma	Enrichment	TP53	2.43
53	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.43
54	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.43
55	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.43
56	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D, SLC1A2	2.33
57	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	2.30
58	Osteogenic sarcoma	Enrichment	TP53	2.26
59	Nasopharyngeal carcinoma	Enrichment	TP53	2.26
60	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	2.26
61	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.26
62	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.26
63	Anaplastic astrocytoma	Enrichment	TP53	2.26
64	Squamous cell carcinoma	Enrichment	TP53	2.26
65	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.26
66	Adenocarcinoma	Enrichment	TP53	2.26
67	Bone osteosarcoma	Enrichment	TP53	2.26
68	Small cell cancer of the lung	Enrichment	TP53	2.13
69	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.13
70	Astigmatism	Enrichment	GRIN2B	2.13
71	Lung sarcomatoid carcinoma	Enrichment	TP53	2.13
72	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.13
73	Rhabdomyosarcoma 2	Enrichment	TP53	2.04
74	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	2.04
75	Follicular lymphoma	Enrichment	BCL2	2.04
76	Lymphoma	Enrichment	TP53	2.04
77	Acute megakaryocytic leukemia	Enrichment	TP53	2.04
78	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	2.04
79	Sleep disorder	Enrichment	GRIN2B	2.04
80	Li-fraumeni syndrome	Enrichment	TP53	1.96
81	Adrenocortical carcinoma	Enrichment	TP53	1.96
82	Breast adenocarcinoma	Enrichment	TP53	1.96
83	Colorectal cancer	Enrichment	BAX, TP53	1.96
84	Esophageal cancer	Enrichment	TP53	1.89
85	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.89
86	Essential thrombocythemia	Enrichment	TP53	1.89
87	Motor neuron disease	Enrichment	SOD1	1.89
88	Gallbladder cancer	Enrichment	TP53	1.89
89	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.89
90	Glioma susceptibility 1	Enrichment	TP53	1.83
91	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.83
92	Alternating hemiplegia of childhood	Enrichment	SLC1A3	1.83
93	Adult hepatocellular carcinoma	Enrichment	TP53	1.78
94	Primary hyperaldosteronism	Enrichment	TP53	1.78
95	Autism spectrum disorder	Enrichment	GRIA1, GRIN2B	1.77
96	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.74
97	Leukemia, chronic lymphocytic	Enrichment	TP53	1.74
98	Familial colorectal cancer	Enrichment	TP53	1.74
99	Myelodysplastic syndrome	Enrichment	TP53	1.70
100	Complex neurodevelopmental disorder	Enrichment	GRIA4, GRIN2B	1.66
101	Lip and oral cavity carcinoma	Enrichment	TP53	1.66
102	Lung cancer susceptibility 3	Enrichment	TP53	1.59
103	Rhabdomyosarcoma	Enrichment	TP53	1.54
104	Gliosarcoma	Enrichment	TP53	1.54
105	Giant cell glioblastoma	Enrichment	TP53	1.51
106	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.49
107	Diffuse large b-cell lymphoma	Enrichment	TP53	1.46
108	Craniosynostosis	Enrichment	GRIN2B	1.44
109	Hepatoblastoma	Enrichment	TP53	1.42
110	Hepatocellular carcinoma	Enrichment	TP53	1.40
111	Diamond-blackfan anemia 1	Enrichment	TP53	1.38
112	Scoliosis	Enrichment	GRIN2B	1.36
113	Pancreatic cancer	Enrichment	TP53	1.35
114	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.35
115	Bladder cancer	Enrichment	TP53	1.28
116	Prostate cancer	Enrichment	TP53	1.28
117	Dystonia	Enrichment	GRIA3	1.20
118	Developmental and epileptic encephalopathy	Enrichment	GRIA3	1.19
119	Diamond-blackfan anemia	Enrichment	TP53	1.19
120	Cerebral palsy	Enrichment	GRIN2B	1.16
121	Leukemia, acute myeloid	Enrichment	TP53	1.15
122	Gastric cancer	Enrichment	TP53	1.12
123	Hereditary breast carcinoma	Enrichment	TP53	1.11
124	Thrombocytopenia	Enrichment	CYCS	1.07
125	Body mass index quantitative trait locus 11	Enrichment	GRIA4	1.05
126	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.01
127	Myeloma, multiple	Enrichment	TP53	1.01
128	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.99
129	Breast cancer	Enrichment	TP53	0.89
130	Ovarian cancer	Enrichment	TP53	0.77
131	Microcephaly	Enrichment	GRIN2B	0.69
132	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathogenesis of ALS

Pathway Network for Pathogenesis of ALS

Member Pathways for Pathogenesis of ALS

Pathways in the Pathogenesis of ALS SuperPath

Associated Genes for Pathogenesis of ALS

Associated Disorders for Pathogenesis of ALS

Disorders associated with Pathogenesis of ALS SuperPath

STRING Interaction Network for Pathogenesis of ALS

Sources for Pathogenesis of ALS