Pathways of nucleic acid metabolism and innate immune sensing

No Pathway Network information available for Pathways of nucleic acid metabolism and innate immune sensing

Pathways in the Pathways of nucleic acid metabolism and innate immune sensing SuperPath

#	Name	Source	Genes
1	Pathways of nucleic acid metabolism and innate immune sensing	WikiPathways	ADAR CGAS IFIH1 IFNB1 IRF3 MAVS OAS1 RIGI RNASEH2A RNASEH2B RNASEH2C RNASEL RNASET2 SAMHD1 STING1 TREX1 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RNASEH2C	Ribonuclease H2 Subunit C	Protein Coding	1
2	RNASET2	Ribonuclease T2	Protein Coding	1
3	RNASEH2B	Ribonuclease H2 Subunit B	Protein Coding	1
4	RNASEH2A	Ribonuclease H2 Subunit A	Protein Coding	1
5	RNASEL	Ribonuclease L	Protein Coding	1
6	CGAS	Cyclic GMP-AMP Synthase	Protein Coding	1
7	TREX1	Three Prime Repair Exonuclease 1	Protein Coding	1
8	SAMHD1	SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1	Protein Coding	1
9	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	1
10	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
11	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
12	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
13	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	1
14	IFNB1	Interferon Beta 1	Protein Coding	1
15	STING1	Stimulator Of Interferon Response CGAMP Interactor 1	Protein Coding	1
16	RIGI	RNA Sensor RIG-I	Protein Coding	1

Disorders associated with Pathways of nucleic acid metabolism and innate immune sensing SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Aicardi-goutieres syndrome	Enrichment	ADAR, IFIH1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, TREX1	10.65
2	Aicardi-goutiares syndrome	Enrichment	ADAR, IFIH1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, TREX1	10.46
3	Familial chilblain lupus	Enrichment	SAMHD1, STING1, TREX1	8.87
4	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	5.88
5	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, IFNB1, IRF3	5.69
6	Cerebral palsy	Enrichment	RNASEH2B, SAMHD1	3.03
7	Prostate cancer, hereditary, 1	Enrichment	RNASEL	2.93
8	Chilblain lupus 2	Enrichment	SAMHD1	2.93
9	Sting-associated vasculopathy, infantile-onset	Enrichment	STING1	2.93
10	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.93
11	Singleton-merten syndrome 1	Enrichment	IFIH1	2.93
12	Immunodeficiency 95	Enrichment	IFIH1	2.93
13	Type 1 diabetes mellitus 19	Enrichment	IFIH1	2.93
14	Aicardi-goutieres syndrome 5	Enrichment	SAMHD1	2.93
15	Sting-associated vasculopathy with onset in infancy	Enrichment	STING1	2.93
16	Aicardi-goutieres syndrome 3	Enrichment	RNASEH2C	2.93
17	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	2.93
18	Singleton-merten syndrome 2	Enrichment	RIGI	2.93
19	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	2.93
20	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	2.93
21	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	2.93
22	Aicardi-goutieres syndrome 4	Enrichment	RNASEH2A	2.63
23	Leukoencephalopathy, cystic, without megalencephaly	Enrichment	RNASET2	2.63
24	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	2.63
25	Aicardi-goutieres syndrome 6	Enrichment	ADAR	2.63
26	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	RNASEH2C	2.63
27	Basal ganglia disease	Enrichment	IFIH1	2.63
28	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	2.63
29	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	TREX1	2.45
30	Chilblain lupus 1	Enrichment	TREX1	2.45
31	Aicardi-goutieres syndrome 2	Enrichment	RNASEH2B	2.45
32	Chilblain lupus	Enrichment	TREX1	2.45
33	Aicardi-goutieres syndrome 1	Enrichment	TREX1	2.33
34	Thrombotic microangiopathy	Enrichment	TREX1	2.33
35	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	2.33
36	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	TREX1	2.23
37	Spastic diplegia	Enrichment	IFIH1	2.23
38	Vascular dementia	Enrichment	TREX1	2.23
39	Congenital nervous system abnormality	Enrichment	RNASEH2B, RNASEH2C	2.17
40	Nervous system disease	Enrichment	RNASEH2B, RNASEH2C	2.17
41	Prostate cancer	Enrichment	RNASEL	1.47
42	Systemic lupus erythematosus	Enrichment	TREX1	1.35
43	Myeloma, multiple	Enrichment	SAMHD1	1.19
44	Colorectal cancer	Enrichment	ADAR	1.01
45	Ovarian cancer	Enrichment	RNASEL	0.95
46	Autism spectrum disorder	Enrichment	RNASEH2B	0.92
47	Hereditary retinal dystrophy	Enrichment	TREX1	0.53
48	Fundus dystrophy	Enrichment	TREX1	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathways of nucleic acid metabolism and innate immune sensing

Pathway Network for Pathways of nucleic acid metabolism and innate immune sensing

Member Pathways for Pathways of nucleic acid metabolism and innate immune sensing

Pathways in the Pathways of nucleic acid metabolism and innate immune sensing SuperPath

Associated Genes for Pathways of nucleic acid metabolism and innate immune sensing

Associated Disorders for Pathways of nucleic acid metabolism and innate immune sensing

Disorders associated with Pathways of nucleic acid metabolism and innate immune sensing SuperPath

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