PDGFR-alpha signaling pathway

No Pathway Network information available for PDGFR-alpha signaling pathway

Pathways in the PDGFR-alpha signaling pathway SuperPath

#	Name	Source	Genes
1	PDGFR-alpha signaling pathway	PubChem	CAV1 CAV3 CRK CRKL CSNK2A1 ELK1 FOS GRB2 ITGAV JAK1 JUN PDGFRA PIK3CA PIK3R1 PLCG1 PRRT2 RAPGEF1 SHB SHC1 SHF SOS1 SRF (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SHF	Src Homology 2 Domain Containing F	Protein Coding	1
2	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
3	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
4	CAV3	Caveolin 3	Protein Coding	1
5	SRF	Serum Response Factor	Protein Coding	1
6	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
7	SHB	SH2 Domain Containing Adaptor Protein B	Protein Coding	1
8	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
9	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
10	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
11	CAV1	Caveolin 1	Protein Coding	1
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
13	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
14	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
15	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
16	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
17	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
18	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
19	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
20	SHC1	SHC Adaptor Protein 1	Protein Coding	1
21	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
22	JAK1	Janus Kinase 1	Protein Coding	1

Disorders associated with PDGFR-alpha signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.12
2	Breast cancer	Enrichment	JUN, PIK3CA, SHC1	3.63
3	Macrodactyly	Enrichment	PIK3CA	2.79
4	Noonan syndrome 4	Enrichment	SOS1	2.79
5	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.79
6	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.79
7	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.79
8	Cowden syndrome 5	Enrichment	PIK3CA	2.79
9	Gist-plus syndrome	Enrichment	PDGFRA	2.79
10	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.79
11	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.79
12	Short syndrome	Enrichment	PIK3R1	2.79
13	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.79
14	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.79
15	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.79
16	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.79
17	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.79
18	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.79
19	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.79
20	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.79
21	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.79
22	Hypospadias	Enrichment	PIK3CA	2.79
23	Rare venous malformation	Enrichment	PIK3CA	2.79
24	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.79
25	Diaphragmatic eventration	Enrichment	PIK3CA	2.79
26	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.79
27	Rare combined vascular malformation	Enrichment	PIK3CA	2.79
28	Cavernous lymphangioma	Enrichment	PIK3CA	2.79
29	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.79
30	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.79
31	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.79
32	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.79
33	Macrodactyly of toe	Enrichment	PIK3CA	2.79
34	Fibromatosis, gingival, 1	Enrichment	SOS1	2.49
35	Pulmonic stenosis	Enrichment	SOS1	2.49
36	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.49
37	Keratosis, seborrheic	Enrichment	PIK3CA	2.49
38	Noonan syndrome 8	Enrichment	PIK3CA	2.49
39	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.49
40	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.49
41	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.49
42	Qualitative or quantitative defects of caveolin-3	Enrichment	CAV3	2.49
43	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.49
44	Prrt2-related disorder	Enrichment	PRRT2	2.49
45	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.31
46	Nuchal bleb, familial	Enrichment	SOS1	2.31
47	Rippling muscle disease 2	Enrichment	CAV3	2.31
48	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.31
49	Long qt syndrome 9	Enrichment	CAV3	2.31
50	Myopathy, distal, tateyama type	Enrichment	CAV3	2.31
51	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.31
52	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1	2.31
53	Immunodeficiency 14	Enrichment	PIK3R1	2.31
54	Keratoacanthoma	Enrichment	PIK3CA	2.31
55	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.19
56	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.19
57	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.19
58	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.19
59	Congenital generalized lipodystrophy	Enrichment	FOS	2.19
60	Cerebrovascular disease	Enrichment	PIK3CA	2.19
61	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.19
62	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.19
63	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.19
64	Gingival fibromatosis	Enrichment	SOS1	2.19
65	Capillary malformations, congenital	Enrichment	PIK3CA	2.09
66	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	2.09
67	Histiocytoid hemangioma	Enrichment	FOS	2.09
68	Hemimegalencephaly	Enrichment	PIK3CA	2.09
69	Self-limited infantile epilepsy	Enrichment	PRRT2	2.09
70	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	2.09
71	Primary hypereosinophilic syndrome	Enrichment	PDGFRA	2.09
72	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.06
73	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.01
74	Cowden syndrome 1	Enrichment	PIK3CA	2.01
75	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.01
76	Limited scleroderma	Enrichment	CAV1	2.01
77	Breast adenocarcinoma	Enrichment	PIK3CA	2.01
78	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.01
79	Nevus, epidermal	Enrichment	PIK3CA	1.95
80	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.95
81	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.95
82	Noonan syndrome 3	Enrichment	SOS1	1.95
83	Gallbladder cancer	Enrichment	PIK3CA	1.95
84	Overgrowth syndrome	Enrichment	PIK3R1	1.95
85	Ovarian cancer	Enrichment	PDGFRA, PIK3CA	1.94
86	Myopathy, tubular aggregate, 1	Enrichment	CAV3	1.89
87	Arteriovenous malformation	Enrichment	PIK3CA	1.84
88	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.84
89	Cowden syndrome	Enrichment	PIK3CA	1.84
90	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.79
91	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.79
92	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.75
93	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.75
94	Meningioma	Enrichment	PIK3CA	1.71
95	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.71
96	Aortic valve disease 1	Enrichment	SOS1	1.68
97	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.65
98	Cleft lip/palate	Enrichment	PDGFRA	1.65
99	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.65
100	Lynch syndrome	Enrichment	PIK3CA	1.62
101	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.62
102	Creatine phosphokinase, elevated serum	Enrichment	CAV3	1.59
103	Isolated elevated serum creatine phosphokinase levels	Enrichment	CAV3	1.59
104	Sudden infant death syndrome	Enrichment	CAV3	1.56
105	Endometrial cancer	Enrichment	PIK3CA	1.47
106	Hepatocellular carcinoma	Enrichment	PIK3CA	1.45
107	Noonan syndrome 1	Enrichment	SOS1	1.44
108	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CAV3	1.42
109	Rasopathy	Enrichment	SOS1	1.38
110	Bladder cancer	Enrichment	PIK3CA	1.34
111	Prostate cancer	Enrichment	PIK3CA	1.34
112	Severe covid-19	Enrichment	ITGAV	1.34
113	Long qt syndrome 1	Enrichment	CAV3	1.32
114	Long qt syndrome	Enrichment	CAV3	1.31
115	Lung cancer	Enrichment	PIK3CA	1.30
116	Familial hypertrophic cardiomyopathy	Enrichment	CAV3	1.28
117	Gastric cancer	Enrichment	PIK3CA	1.17
118	Hereditary breast carcinoma	Enrichment	PIK3CA	1.16
119	Hypertelorism	Enrichment	PIK3CA	1.09
120	Autism spectrum disorder	Enrichment	CSNK2A1	0.79
121	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.74
122	Inherited cancer-predisposing syndrome	Enrichment	PDGFRA	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PDGFR-alpha signaling pathway

Pathway Network for PDGFR-alpha signaling pathway

Member Pathways for PDGFR-alpha signaling pathway

Pathways in the PDGFR-alpha signaling pathway SuperPath

Associated Genes for PDGFR-alpha signaling pathway

Associated Disorders for PDGFR-alpha signaling pathway

Disorders associated with PDGFR-alpha signaling pathway SuperPath

STRING Interaction Network for PDGFR-alpha signaling pathway

Sources for PDGFR-alpha signaling pathway