Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Pathway network for the Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

Sources:

PharmGKB
PubChem

Pathways in the Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics	PharmGKB	G6PD GPI HK1 PGD PGLS SLC2A1 (see all 6) (see less)
2	pentose phosphate pathway (oxidative branch) I	PubChem	G6PD H6PD PGD PGLS
3	pentose phosphate pathway (oxidative branch)	PubChem	G6PD PGD PGLS
4	GDP-mannose biosynthesis	PubChem	GPI

Gene overlap in member pathways for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PGLS	6-Phosphogluconolactonase	Protein Coding	3
2	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	3
3	PGD	Phosphogluconate Dehydrogenase	Protein Coding	3
4	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	2
5	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
6	HK1	Hexokinase 1	Protein Coding	1
7	H6PD	Hexose-6-Phosphate Dehydrogenase/Glucose 1-Dehydrogenase	Protein Coding	1

Disorders associated with Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	4.13
2	Congenital nonspherocytic hemolytic anemia	Enrichment	G6PD	3.66
3	Cortisone reductase deficiency 1	Enrichment	H6PD	3.53
4	Congenital hemolytic anemia	Enrichment	G6PD	3.35
5	Glucosephosphate dehydrogenase deficiency	Enrichment	G6PD	3.35
6	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	3.35
7	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	3.35
8	Retinitis pigmentosa 79	Enrichment	HK1	3.35
9	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	3.35
10	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	3.35
11	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	3.35
12	Epilepsy with myoclonic absences	Enrichment	SLC2A1	3.35
13	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	3.35
14	Hereditary spherocytosis	Enrichment	GPI	3.35
15	Hemolytic anemia	Enrichment	GPI	3.29
16	Cortisone reductase deficiency	Enrichment	H6PD	3.23
17	Dystonia 9	Enrichment	SLC2A1	3.05
18	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	3.05
19	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	3.05
20	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	G6PD	2.96
21	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.88
22	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.88
23	Coronary heart disease 5	Enrichment	G6PD	2.70
24	Paroxysmal dystonia	Enrichment	SLC2A1	2.51
25	Alternating hemiplegia of childhood	Enrichment	SLC2A1	2.45
26	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	2.40
27	Malaria	Enrichment	G6PD	2.29
28	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.96
29	Strabismus	Enrichment	SLC2A1	1.92
30	Epilepsy	Enrichment	SLC2A1	1.76
31	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	1.74
32	Centralopathic epilepsy	Enrichment	SLC2A1	1.72
33	West syndrome	Enrichment	SLC2A1	1.71
34	Autism spectrum disorder	Enrichment	HK1	1.33
35	Microcephaly	Enrichment	SLC2A1	1.27
36	Retinitis pigmentosa	Enrichment	HK1	1.04
37	Hereditary retinal dystrophy	Enrichment	HK1	0.91
38	Fundus dystrophy	Enrichment	HK1	0.91

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Pathway Network for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Pathway network for the Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

Member Pathways for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Pathways in the Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

Gene overlap in member pathways for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

Associated Genes for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Associated Disorders for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Disorders associated with Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics SuperPath

STRING Interaction Network for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics

Sources for Pentose Phosphate Pathway (Erythrocyte), Pharmacodynamics