PERK regulates gene expression

No Pathway Network information available for PERK regulates gene expression

Pathways in the PERK regulates gene expression SuperPath

#	Name	Source	Genes
1	PERK regulates gene expression	Reactome	ASNS ATF3 ATF4 ATF6 CCL2 CEBPB CEBPG CXCL8 DCP2 DDIT3 DIS3 EIF2AK3 EIF2S1 EIF2S2 EIF2S3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HERPUD1 HSPA5 IGFBP1 KHSRP NFYA NFYB NFYC PARN (see all 32) (see less)
2	ATF4 activates genes in response to endoplasmic reticulum stress	Reactome	ASNS ATF3 ATF4 ATF6 CCL2 CEBPB CEBPG CXCL8 DCP2 DDIT3 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HERPUD1 IGFBP1 KHSRP NFYA NFYB NFYC PARN (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	2
2	CEBPG	CCAAT Enhancer Binding Protein Gamma	Protein Coding	2
3	EXOSC8	Exosome Component 8	Protein Coding	2
4	EXOSC6	Exosome Component 6	Protein Coding	2
5	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	2
6	DCP2	Decapping MRNA 2	Protein Coding	2
7	DIS3	DIS3 Exosome Endoribonuclease And 3''''-5'''' Exoribonuclease	Protein Coding	2
8	ATF6	Activating Transcription Factor 6	Protein Coding	2
9	EXOSC7	Exosome Component 7	Protein Coding	2
10	EXOSC2	Exosome Component 2	Protein Coding	2
11	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	2
12	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	2
13	ASNS	Asparagine Synthetase (Glutamine-Hydrolyzing)	Protein Coding	2
14	ATF3	Activating Transcription Factor 3	Protein Coding	2
15	ATF4	Activating Transcription Factor 4	Protein Coding	2
16	NFYA	Nuclear Transcription Factor Y Subunit Alpha	Protein Coding	2
17	NFYB	Nuclear Transcription Factor Y Subunit Beta	Protein Coding	2
18	NFYC	Nuclear Transcription Factor Y Subunit Gamma	Protein Coding	2
19	PARN	Poly(A)-Specific Ribonuclease	Protein Coding	2
20	EXOSC3	Exosome Component 3	Protein Coding	2
21	EXOSC1	Exosome Component 1	Protein Coding	2
22	EXOSC9	Exosome Component 9	Protein Coding	2
23	EXOSC4	Exosome Component 4	Protein Coding	2
24	EXOSC5	Exosome Component 5	Protein Coding	2
25	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	2
26	KHSRP	KH-Type Splicing Regulatory Protein	Protein Coding	2
27	HERPUD1	Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1	Protein Coding	2
28	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
29	EIF2S3	Eukaryotic Translation Initiation Factor 2 Subunit Gamma	Protein Coding	1
30	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
31	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	1
32	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1

Disorders associated with PERK regulates gene expression SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pontocerebellar hypoplasia, type 1e	Enrichment	EXOSC3, EXOSC8, EXOSC9	6.85
2	Pontocerebellar hypoplasia	Enrichment	EXOSC3, EXOSC9	3.24
3	Dyskeratosis congenita, autosomal recessive 6	Enrichment	PARN	2.70
4	Pontocerebellar hypoplasia, type 1f	Enrichment	EXOSC1	2.70
5	Cerebellar ataxia, brain abnormalities, and cardiac conduction defects	Enrichment	EXOSC5	2.70
6	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4	Enrichment	PARN	2.70
7	Achromatopsia 7	Enrichment	ATF6	2.70
8	Pontocerebellar hypoplasia, type 1c	Enrichment	EXOSC8	2.70
9	Pontocerebellar hypoplasia, type 1d	Enrichment	EXOSC9	2.70
10	Short stature, hearing loss, retinitis pigmentosa, and distinctive facies	Enrichment	EXOSC2	2.70
11	Mehmo syndrome	Enrichment	EIF2S3	2.63
12	Congenital pontocerebellar hypoplasia type 1	Enrichment	EXOSC3	2.40
13	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	2.33
14	Pontocerebellar hypoplasia, type 1b	Enrichment	EXOSC3	2.22
15	Cerebellar disease	Enrichment	EXOSC3	2.22
16	Asparagine synthetase deficiency	Enrichment	ASNS	2.22
17	Myxoid liposarcoma	Enrichment	DDIT3	2.22
18	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	ASNS	2.22
19	Spinocerebellar ataxia, autosomal recessive 29	Enrichment	ASNS	2.22
20	Menkes disease	Enrichment	EIF2AK3	2.15
21	Pulmonary fibrosis	Enrichment	PARN	1.92
22	Hoyeraal-hreidarsson syndrome	Enrichment	PARN	1.92
23	Achromatopsia	Enrichment	ATF6	1.70
24	Interstitial lung disease 2	Enrichment	PARN	1.48
25	Human immunodeficiency virus type 1	Enrichment	CCL2	1.45
26	Congenital myopathy	Enrichment	EXOSC3	1.43
27	Dyskeratosis congenita	Enrichment	PARN	1.43
28	Lissencephaly	Enrichment	EXOSC3	1.39
29	Fetal akinesia deformation sequence 1	Enrichment	EXOSC3	1.15
30	Spastic ataxia	Enrichment	EXOSC8	1.00
31	Hereditary breast ovarian cancer syndrome	Enrichment	HERPUD1	0.98
32	Myeloma, multiple	Enrichment	DIS3	0.98
33	Cone-rod dystrophy 2	Enrichment	ATF6	0.90
34	Congenital nervous system abnormality	Enrichment	EXOSC3	0.72
35	Nervous system disease	Enrichment	EXOSC3	0.72
36	Microcephaly	Enrichment	EXOSC3	0.66
37	Hereditary retinal dystrophy	Enrichment	ATF6	0.35
38	Fundus dystrophy	Enrichment	ATF6	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PERK regulates gene expression

Pathway Network for PERK regulates gene expression

Member Pathways for PERK regulates gene expression

Pathways in the PERK regulates gene expression SuperPath

Associated Genes for PERK regulates gene expression

Associated Disorders for PERK regulates gene expression

Disorders associated with PERK regulates gene expression SuperPath

STRING Interaction Network for PERK regulates gene expression

Sources for PERK regulates gene expression