Peroxisomal protein import

Pathway network for the Peroxisomal protein import SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Peroxisomal protein import SuperPath

#	Name	Source	Genes
1	Peroxisomal protein import	Reactome	ACAA1 ACOT2 ACOT4 ACOT8 ACOX1 ACOX2 ACOX3 AGPS AGXT AMACR BAAT CAT CRAT CROT DAO DDO DECR2 DHRS4 ECH1 ECI2 EHHADH EPHX2 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HSD17B4 IDE IDH1 LONP2 MLYCD MPV17 NOS2 NUDT19 NUDT7 PAOX PECR PEX1 PEX10 PEX12 PEX13 PEX14 PEX2 PEX26 PEX5 PEX6 PEX7 PHYH PIPOX RPS27A SCP2 SLC27A2 TYSND1 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 USP9X ZFAND6 (see all 63) (see less)
2	Protein localization	Reactome	ABCD1 ABCD2 ABCD3 ACAA1 ACBD5 ACO2 ACOT2 ACOT4 ACOT8 ACOX1 ACOX2 ACOX3 AGPS AGXT ALDH3A2 AMACR APP ATAD1 ATP5F1A ATP5F1B ATP5MC1 BAAT BAG6 BCS1L CAMLG CAT CHCHD10 CHCHD2 CHCHD3 CHCHD4 CHCHD5 CHCHD7 CMC2 CMC4 COA4 COA6 COQ2 COX17 COX19 CRAT CROT CS CYB5A CYC1 DAO DDO DECR2 DHRS4 DNAJC19 ECH1 ECI2 EHHADH EMD EPHX2 FIS1 FXN GDAP1 GET1 GET3 GET4 GFER GNPAT GRPEL1 GRPEL2 GSTK1 HACL1 HAO1 HAO2 HMGCL HMOX1 HSCB HSD17B4 HSPA9 HSPD1 IDE IDH1 IDH3G LDHD LONP2 MLYCD MPV17 MTX1 MTX2 NDUFB8 NOS2 NUDT19 NUDT7 OTC OTOF PAM16 PAOX PECR PEX1 PEX10 PEX11B PEX12 PEX13 PEX14 PEX16 PEX19 PEX2 PEX26 PEX3 PEX5 PEX6 PEX7 PHYH PIPOX PITRM1 PMPCA PMPCB PRNP PXMP2 PXMP4 RPS27A SAMM50 SCP2 SEC61B SEC61G SERP1 SGTA SLC25A12 SLC25A13 SLC25A17 SLC27A2 STX1A STX5 TAFAZZIN TIMM10 TIMM10B TIMM13 TIMM17A TIMM17B TIMM21 TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TYSND1 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBL4A USP9X VAMP2 VAPA VDAC1 ZFAND6 (see all 162) (see less)
3	Mitochondrial protein import	Reactome	ACO2 ATP5F1A ATP5F1B ATP5MC1 BCS1L CHCHD10 CHCHD2 CHCHD3 CHCHD4 CHCHD5 CHCHD7 CMC2 CMC4 COA4 COA6 COQ2 COX17 COX19 CS CYC1 DNAJC19 FXN GFER GRPEL1 GRPEL2 HSCB HSPA9 HSPD1 IDH3G LDHD MTX1 MTX2 NDUFB8 OTC PAM16 PITRM1 PMPCA PMPCB SAMM50 SLC25A12 SLC25A13 TAFAZZIN TIMM10 TIMM10B TIMM13 TIMM17A TIMM17B TIMM21 TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 VDAC1 (see all 63) (see less)
4	Peroxisomal lipid metabolism	Reactome	ABCD1 ACAA1 ACBD4 ACBD5 ACOT4 ACOT8 ACOX1 ACOX2 ACOX3 ACOXL ALDH3A2 AMACR CRAT CROT DECR2 ECI2 EHHADH HACL1 HAO2 HSD17B4 MLYCD NUDT19 NUDT7 PECR PHYH SCP2 SLC25A17 SLC27A2 (see all 28) (see less)
5	Class I peroxisomal membrane protein import	Reactome	ABCD1 ABCD2 ABCD3 ACBD5 ALDH3A2 ATAD1 FIS1 GDAP1 PEX11B PEX12 PEX13 PEX14 PEX16 PEX19 PEX2 PEX26 PEX3 PXMP2 PXMP4 SLC25A17 (see all 20) (see less)
6	Beta-oxidation of very long chain fatty acids	Reactome	ABCD1 ACAA1 ACOT4 ACOT8 ACOX1 DECR2 ECI2 EHHADH HSD17B4 MLYCD SLC27A2 (see all 11) (see less)
7	Beta-oxidation of pristanoyl-CoA	Reactome	ACOT8 ACOX2 ACOX3 ACOXL AMACR CRAT CROT HSD17B4 SCP2 (see all 9) (see less)
8	TYSND1 cleaves peroxisomal proteins	Reactome	ACAA1 ACOX1 AGPS HSD17B4 PHYH SCP2 TYSND1 (see all 7) (see less)
9	Alpha-oxidation of phytanate	Reactome	ALDH3A2 HACL1 PECR PHYH SLC25A17 SLC27A2 (see all 6) (see less)
10	Peroxisomal beta-oxidation of tetracosanoyl-CoA	WikiPathways	ACAA1 ACOX1 HSD17B4 SCP2
11	phytol degradation	PubChem	ALDH3A2 PECR

Gene overlap in member pathways for Peroxisomal protein import SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HSD17B4	Hydroxysteroid 17-Beta Dehydrogenase 4	Protein Coding	7
2	ACAA1	Acetyl-CoA Acyltransferase 1	Protein Coding	6
3	ACOX1	Acyl-CoA Oxidase 1	Protein Coding	6
4	SCP2	Sterol Carrier Protein 2	Protein Coding	6
5	ACOT8	Acyl-CoA Thioesterase 8	Protein Coding	5
6	SLC27A2	Solute Carrier Family 27 Member 2	Protein Coding	5
7	PHYH	Phytanoyl-CoA 2-Hydroxylase	Protein Coding	5
8	PECR	Peroxisomal Trans-2-Enoyl-CoA Reductase	Protein Coding	5
9	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	5
10	ECI2	Enoyl-CoA Delta Isomerase 2	Protein Coding	4
11	ACOT4	Acyl-CoA Thioesterase 4	Protein Coding	4
12	CRAT	Carnitine O-Acetyltransferase	Protein Coding	4
13	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	4
14	MLYCD	Malonyl-CoA Decarboxylase	Protein Coding	4
15	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	4
16	HACL1	2-Hydroxyacyl-CoA Lyase 1	Protein Coding	4
17	DECR2	2,4-Dienoyl-CoA Reductase 2	Protein Coding	4
18	CROT	Carnitine O-Octanoyltransferase	Protein Coding	4
19	ACOX2	Acyl-CoA Oxidase 2	Protein Coding	4
20	ACOX3	Acyl-CoA Oxidase 3, Pristanoyl	Protein Coding	4
21	SLC25A17	Solute Carrier Family 25 Member 17	Protein Coding	4
22	ABCD1	ATP Binding Cassette Subfamily D Member 1	Protein Coding	4
23	TYSND1	Trypsin Like Peroxisomal Matrix Peptidase 1	Protein Coding	3
24	NUDT7	Nudix Hydrolase 7	Protein Coding	3
25	NUDT19	Nudix Hydrolase 19	Protein Coding	3
26	HAO2	Hydroxyacid Oxidase 2	Protein Coding	3
27	PEX12	Peroxisomal Biogenesis Factor 12	Protein Coding	3
28	PEX13	Peroxisomal Biogenesis Factor 13	Protein Coding	3
29	PEX14	Peroxisomal Biogenesis Factor 14	Protein Coding	3
30	PEX26	Peroxisomal Biogenesis Factor 26	Protein Coding	3
31	PEX2	Peroxisomal Biogenesis Factor 2	Protein Coding	3
32	AGPS	Alkylglycerone Phosphate Synthase	Protein Coding	3
33	ACBD5	Acyl-CoA Binding Domain Containing 5	Protein Coding	3
34	DHRS4	Dehydrogenase/Reductase 4	Protein Coding	2
35	ACOT2	Acyl-CoA Thioesterase 2	Protein Coding	2
36	DAO	D-Amino Acid Oxidase	Protein Coding	2
37	AGXT	Alanine--Glyoxylate Aminotransferase	Protein Coding	2
38	ECH1	Enoyl-CoA Hydratase 1	Protein Coding	2
39	PAOX	Polyamine Oxidase	Protein Coding	2
40	EPHX2	Epoxide Hydrolase 2	Protein Coding	2
41	HMGCL	3-Hydroxy-3-Methylglutaryl-CoA Lyase	Protein Coding	2
42	IDE	Insulin Degrading Enzyme	Protein Coding	2
43	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	2
44	GSTK1	Glutathione S-Transferase Kappa 1	Protein Coding	2
45	MPV17	Mitochondrial Inner Membrane Protein MPV17	Protein Coding	2
46	NOS2	Nitric Oxide Synthase 2	Protein Coding	2
47	PIPOX	Pipecolic Acid And Sarcosine Oxidase	Protein Coding	2
48	PEX1	Peroxisomal Biogenesis Factor 1	Protein Coding	2
49	PEX6	Peroxisomal Biogenesis Factor 6	Protein Coding	2
50	PEX7	Peroxisomal Biogenesis Factor 7	Protein Coding	2
51	PEX10	Peroxisomal Biogenesis Factor 10	Protein Coding	2
52	HAO1	Hydroxyacid Oxidase 1	Protein Coding	2
53	ZFAND6	Zinc Finger AN1-Type Containing 6	Protein Coding	2
54	BAAT	Bile Acid-CoA:Amino Acid N-Acyltransferase	Protein Coding	2
55	PEX5	Peroxisomal Biogenesis Factor 5	Protein Coding	2
56	RPS27A	Ribosomal Protein S27a	Protein Coding	2
57	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
58	UBB	Ubiquitin B	Protein Coding	2
59	UBC	Ubiquitin C	Protein Coding	2
60	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
61	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
62	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	2
63	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	2
64	LONP2	Lon Peptidase 2, Peroxisomal	Protein Coding	2
65	GNPAT	Glyceronephosphate O-Acyltransferase	Protein Coding	2
66	CAT	Catalase	Protein Coding	2
67	DDO	D-Aspartate Oxidase	Protein Coding	2
68	TOMM6	Translocase Of Outer Mitochondrial Membrane 6	Protein Coding	2
69	CMC4	C-X9-C Motif Containing 4	Protein Coding	2
70	TIMM23	Translocase Of Inner Mitochondrial Membrane 23	Protein Coding	2
71	COX17	Cytochrome C Oxidase Copper Chaperone COX17	Protein Coding	2
72	SLC25A13	Solute Carrier Family 25 Member 13	Protein Coding	2
73	TIMM17B	Translocase Of Inner Mitochondrial Membrane 17B	Protein Coding	2
74	TIMM17A	Translocase Of Inner Mitochondrial Membrane 17A	Protein Coding	2
75	TOMM40	Translocase Of Outer Mitochondrial Membrane 40	Protein Coding	2
76	TIMM44	Translocase Of Inner Mitochondrial Membrane 44	Protein Coding	2
77	PITRM1	Pitrilysin Metallopeptidase 1	Protein Coding	2
78	MTX2	Metaxin 2	Protein Coding	2
79	PXMP4	Peroxisomal Membrane Protein 4	Protein Coding	2
80	DNAJC19	DnaJ Heat Shock Protein Family (Hsp40) Member C19	Protein Coding	2
81	CHCHD4	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4	Protein Coding	2
82	GRPEL2	GrpE Like 2, Mitochondrial	Protein Coding	2
83	CS	Citrate Synthase	Protein Coding	2
84	HSCB	HscB Mitochondrial Iron-Sulfur Cluster Cochaperone	Protein Coding	2
85	CYC1	Cytochrome C1	Protein Coding	2
86	TIMM8A	Translocase Of Inner Mitochondrial Membrane 8A	Protein Coding	2
87	LDHD	Lactate Dehydrogenase D	Protein Coding	2
88	ABCD2	ATP Binding Cassette Subfamily D Member 2	Protein Coding	2
89	PMPCA	Peptidase, Mitochondrial Processing Subunit Alpha	Protein Coding	2
90	FXN	Frataxin	Protein Coding	2
91	SAMM50	SAMM50 Sorting And Assembly Machinery Component	Protein Coding	2
92	TIMM10B	Translocase Of Inner Mitochondrial Membrane 10B	Protein Coding	2
93	TIMM13	Translocase Of Inner Mitochondrial Membrane 13	Protein Coding	2
94	TIMM10	Translocase Of Inner Mitochondrial Membrane 10	Protein Coding	2
95	TIMM9	Translocase Of Inner Mitochondrial Membrane 9	Protein Coding	2
96	TIMM8B	Translocase Of Inner Mitochondrial Membrane 8 Homolog B	Protein Coding	2
97	GFER	Growth Factor, Augmenter Of Liver Regeneration	Protein Coding	2
98	COQ2	Coenzyme Q2, Polyprenyltransferase	Protein Coding	2
99	TIMM21	Translocase Of Inner Mitochondrial Membrane 21	Protein Coding	2
100	TIMM22	Translocase Of Inner Mitochondrial Membrane 22	Protein Coding	2
101	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	2
102	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	2
103	IDH3G	Isocitrate Dehydrogenase (NAD(+)) 3 Non-Catalytic Subunit Gamma	Protein Coding	2
104	COA6	Cytochrome C Oxidase Assembly Factor 6	Protein Coding	2
105	CHCHD10	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10	Protein Coding	2
106	TOMM5	Translocase Of Outer Mitochondrial Membrane 5	Protein Coding	2
107	MTX1	Metaxin 1	Protein Coding	2
108	NDUFB8	NADH:Ubiquinone Oxidoreductase Subunit B8	Protein Coding	2
109	ATP5F1A	ATP Synthase F1 Subunit Alpha	Protein Coding	2
110	ACO2	Aconitase 2	Protein Coding	2
111	OTC	Ornithine Transcarbamylase	Protein Coding	2
112	ATP5F1B	ATP Synthase F1 Subunit Beta	Protein Coding	2
113	FIS1	Fission, Mitochondrial 1	Protein Coding	2
114	PAM16	Presequence Translocase Associated Motor 16	Protein Coding	2
115	CHCHD2	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2	Protein Coding	2
116	COA4	Cytochrome C Oxidase Assembly Factor 4 Homolog	Protein Coding	2
117	ATP5MC1	ATP Synthase Membrane Subunit C Locus 1	Protein Coding	2
118	GDAP1	Ganglioside Induced Differentiation Associated Protein 1	Protein Coding	2
119	TOMM7	Translocase Of Outer Mitochondrial Membrane 7	Protein Coding	2
120	CHCHD3	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3	Protein Coding	2
121	CMC2	C-X9-C Motif Containing 2	Protein Coding	2
122	TOMM22	Translocase Of Outer Mitochondrial Membrane 22	Protein Coding	2
123	PEX19	Peroxisomal Biogenesis Factor 19	Protein Coding	2
124	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	2
125	PXMP2	Peroxisomal Membrane Protein 2	Protein Coding	2
126	BCS1L	BCS1 Ubiquinol-Cytochrome C Reductase Complex Chaperone	Protein Coding	2
127	TAFAZZIN	Tafazzin, Phospholipid-Lysophospholipid Transacylase	Protein Coding	2
128	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	2
129	CHCHD7	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7	Protein Coding	2
130	GRPEL1	GrpE Like 1, Mitochondrial	Protein Coding	2
131	CHCHD5	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5	Protein Coding	2
132	ATAD1	ATPase Family AAA Domain Containing 1	Protein Coding	2
133	PEX3	Peroxisomal Biogenesis Factor 3	Protein Coding	2
134	SLC25A12	Solute Carrier Family 25 Member 12	Protein Coding	2
135	PEX11B	Peroxisomal Biogenesis Factor 11 Beta	Protein Coding	2
136	COX19	Cytochrome C Oxidase Assembly Factor COX19	Protein Coding	2
137	TIMM50	Translocase Of Inner Mitochondrial Membrane 50	Protein Coding	2
138	PEX16	Peroxisomal Biogenesis Factor 16	Protein Coding	2
139	PMPCB	Peptidase, Mitochondrial Processing Subunit Beta	Protein Coding	2
140	TOMM20	Translocase Of Outer Mitochondrial Membrane 20	Protein Coding	2
141	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	2
142	ACOXL	Acyl-CoA Oxidase Like	Protein Coding	2
143	SEC61B	SEC61 Translocon Subunit Beta	Protein Coding	1
144	UBE2J2	Ubiquitin Conjugating Enzyme E2 J2	Protein Coding	1
145	CYB5A	Cytochrome B5 Type A	Protein Coding	1
146	EMD	Emerin	Protein Coding	1
147	SEC61G	SEC61 Translocon Subunit Gamma	Protein Coding	1
148	SERP1	Stress Associated Endoplasmic Reticulum Protein 1	Protein Coding	1
149	HMOX1	Heme Oxygenase 1	Protein Coding	1
150	APP	Amyloid Beta Precursor Protein	Protein Coding	1
151	GET3	Guided Entry Of Tail-Anchored Proteins Factor 3, ATPase	Protein Coding	1
152	GET4	Guided Entry Of Tail-Anchored Proteins Factor 4	Protein Coding	1
153	PRNP	Prion Protein (Kanno Blood Group)	Protein Coding	1
154	SGTA	Small Glutamine Rich Tetratricopeptide Repeat Co-Chaperone Alpha	Protein Coding	1
155	STX1A	Syntaxin 1A	Protein Coding	1
156	STX5	Syntaxin 5	Protein Coding	1
157	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	1
158	GET1	Guided Entry Of Tail-Anchored Proteins Factor 1	Protein Coding	1
159	BAG6	BAG Cochaperone 6	Protein Coding	1
160	CAMLG	Calcium Modulating Ligand	Protein Coding	1
161	UBL4A	Ubiquitin Like 4A	Protein Coding	1
162	VAPA	VAMP Associated Protein A	Protein Coding	1
163	OTOF	Otoferlin	Protein Coding	1
164	ACBD4	Acyl-CoA Binding Domain Containing 4	Protein Coding	1

Disorders associated with Peroxisomal protein import SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neonatal adrenoleukodystrophy	Enrichment	PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3	11.32
2	Peroxisome biogenesis disorder 1b	Enrichment	PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3	10.94
3	Zellweger syndrome	Enrichment	PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3	10.94
4	Zellweger spectrum disorder	Enrichment	PEX1, PEX10, PEX19, PEX2, PEX5, PEX6	9.94
5	Rhizomelic chondrodysplasia punctata	Enrichment	AGPS, GNPAT, PEX5, PEX7	9.35
6	Peroxisome biogenesis disorder 1a	Enrichment	PEX1, PEX3, PEX5, PEX6	6.54
7	D-bifunctional protein deficiency	Enrichment	EHHADH, HSD17B4	5.75
8	Peroxisome biogenesis disorder 2b	Enrichment	PEX5, PEX6	4.67
9	Refsum disease, classic	Enrichment	PEX7, PHYH	4.20
10	Heimler syndrome 1	Enrichment	PEX1, PEX6	3.90
11	Sjogren-larsson syndrome	Enrichment	ALDH3A2	3.53
12	Peroxisomal acyl-coa oxidase deficiency	Enrichment	ACOX1	3.53
13	Mitchell syndrome	Enrichment	ACOX1	3.53
14	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	3.53
15	Rhizomelic chondrodysplasia punctata, type 3	Enrichment	AGPS	3.29
16	Carnitine acetyltransferase deficiency	Enrichment	CRAT	3.18
17	Bile acid synthesis defect, congenital, 6	Enrichment	ACOX2	3.18
18	Neurodegeneration with brain iron accumulation 8	Enrichment	CRAT	3.18
19	Hypoadrenocorticism, familial	Enrichment	ABCD1	3.09
20	Fanconi renotubular syndrome 3	Enrichment	EHHADH	3.09
21	Encephalitis	Enrichment	ABCD1	3.09
22	X-linked cerebral adrenoleukodystrophy	Enrichment	ABCD1	3.09
23	Adrenomyeloneuropathy	Enrichment	ABCD1	3.09
24	Chronic primary adrenal insufficiency	Enrichment	ABCD1	3.09
25	Isolated complex iii deficiency	Enrichment	BCS1L, CYC1	2.94
26	Bile acid synthesis defect, congenital, 4	Enrichment	AMACR	2.88
27	Alpha-methylacyl-coa racemase deficiency	Enrichment	AMACR	2.88
28	Peroxisome biogenesis disorder 3b	Enrichment	PEX12	2.83
29	Peroxisome biogenesis disorder 10a	Enrichment	PEX3	2.83
30	Peroxisome biogenesis disorder 3a	Enrichment	PEX12	2.83
31	Peroxisome biogenesis disorder 8a	Enrichment	PEX16	2.83
32	Peroxisome biogenesis disorder 12a	Enrichment	PEX19	2.83
33	Peroxisome biogenesis disorder 14b	Enrichment	PEX11B	2.83
34	Retinal dystrophy with leukodystrophy	Enrichment	ACBD5	2.83
35	Peroxisome biogenesis disorder 10b	Enrichment	PEX3	2.83
36	Peroxisome biogenesis disorder 8b	Enrichment	PEX16	2.83
37	Bile acid synthesis defect, congenital, 5	Enrichment	ABCD3	2.83
38	Hyperekplexia 4	Enrichment	ATAD1	2.83
39	Autosomal recessive ataxia due to pex16 deficiency	Enrichment	PEX16	2.83
40	Autosomal recessive ataxia due to pex2 deficiency	Enrichment	PEX2	2.83
41	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	ABCD1	2.79
42	Adrenoleukodystrophy	Enrichment	ABCD1	2.79
43	Cadds	Enrichment	ABCD1	2.79
44	Perrault syndrome	Enrichment	HSD17B4	2.63
45	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	ABCD1	2.61
46	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	ABCD1	2.61
47	Perrault syndrome 2	Enrichment	HSD17B4	2.58
48	Early-onset autosomal dominant alzheimer disease	Enrichment	APP, TOMM40	2.54
49	Charcot-marie-tooth disease, demyelinating, type 4a	Enrichment	GDAP1	2.53
50	Charcot-marie-tooth disease, axonal, with vocal cord paresis, autosomal recessive	Enrichment	GDAP1	2.53
51	Charcot-marie-tooth disease, recessive intermediate a	Enrichment	GDAP1	2.53
52	Peroxisome biogenesis disorder 11a	Enrichment	PEX13	2.53
53	Peroxisome biogenesis disorder 13a	Enrichment	PEX14	2.53
54	Peroxisome biogenesis disorder 11b	Enrichment	PEX13	2.53
55	Charcot-marie-tooth disease, axonal, type 2h	Enrichment	GDAP1	2.53
56	Peroxisome biogenesis disorder 7a	Enrichment	PEX26	2.53
57	Axonal neuropathy	Enrichment	GDAP1	2.53
58	Peroxisome biogenesis disorder 7b	Enrichment	PEX26	2.53
59	Charcot-marie-tooth disease type 4a	Enrichment	GDAP1	2.53
60	Congenital nervous system abnormality	Enrichment	ABCD1, HSD17B4	2.50
61	Nervous system disease	Enrichment	ABCD1, HSD17B4	2.50
62	Malonyl-coa decarboxylase deficiency	Enrichment	MLYCD	2.49
63	Primary fanconi renotubular syndrome	Enrichment	EHHADH	2.49
64	Orofacial cleft 1	Enrichment	PHYH	2.40
65	Peroxisome biogenesis disorder 5b	Enrichment	PEX2	2.35
66	Charcot-marie-tooth disease, axonal, type 2k	Enrichment	GDAP1	2.35
67	Peroxisome biogenesis disorder 5a	Enrichment	PEX2	2.35
68	Rhizomelic chondrodysplasia punctata, type 2	Enrichment	GNPAT	2.33
69	Peroxisome biogenesis disorder 2a	Enrichment	PEX5	2.33
70	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	2.33
71	Rhizomelic chondrodysplasia punctata, type 1	Enrichment	PEX7	2.33
72	3-hydroxy-3-methylglutaryl-coa lyase deficiency	Enrichment	HMGCL	2.33
73	Hyperoxaluria, primary, type i	Enrichment	AGXT	2.33
74	Peroxisome biogenesis disorder 4a	Enrichment	PEX6	2.33
75	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	2.33
76	Acatalasemia	Enrichment	CAT	2.33
77	Peroxisome biogenesis disorder 9b	Enrichment	PEX7	2.33
78	Peroxisome biogenesis disorder 6a	Enrichment	PEX10	2.33
79	Peroxisome biogenesis disorder 6b	Enrichment	PEX10	2.33
80	Metaphyseal enchondromatosis with d-2-hydroxyglutaric aciduria	Enrichment	IDH1	2.33
81	Heimler syndrome 2	Enrichment	PEX6	2.33
82	Hypercholanemia, familial 3	Enrichment	BAAT	2.33
83	Rhizomelic chondrodysplasia punctata, type 5	Enrichment	PEX5	2.33
84	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	2.33
85	Peroxisomal disease	Enrichment	PEX1	2.33
86	Autosomal recessive ataxia due to pex10 deficiency	Enrichment	PEX10	2.33
87	D-lactic aciduria with gout	Enrichment	LDHD	2.33
88	Retinitis pigmentosa 99	Enrichment	IDH3G	2.33
89	Mohr-tranebjaerg syndrome	Enrichment	TIMM8A	2.33
90	Developmental and epileptic encephalopathy 39 with leukodystrophy	Enrichment	SLC25A12	2.33
91	3-methylglutaconic aciduria, type v	Enrichment	DNAJC19	2.33
92	Mitochondrial complex iii deficiency, nuclear type 6	Enrichment	CYC1	2.33
93	Even-plus syndrome	Enrichment	HSPA9	2.33
94	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.33
95	Spinal muscular atrophy, jokela type	Enrichment	CHCHD10	2.33
96	Bjornstad syndrome	Enrichment	BCS1L	2.33
97	Myopathy, isolated mitochondrial, autosomal dominant	Enrichment	CHCHD10	2.33
98	Mandibuloacral dysplasia progeroid syndrome	Enrichment	MTX2	2.33
99	Ornithine transcarbamylase deficiency, hyperammonemia due to	Enrichment	OTC	2.33
100	Mitochondrial complex v deficiency, nuclear type 4b	Enrichment	ATP5F1A	2.33
101	Gracile syndrome	Enrichment	BCS1L	2.33
102	Mitochondrial complex iv deficiency, nuclear type 13	Enrichment	COA6	2.33
103	Spastic paraplegia 13, autosomal dominant	Enrichment	HSPD1	2.33
104	Combined oxidative phosphorylation deficiency 22	Enrichment	ATP5F1A	2.33
105	Parkinson disease 22, autosomal dominant	Enrichment	CHCHD2	2.33
106	Spinocerebellar ataxia, autosomal recessive 30	Enrichment	PITRM1	2.33
107	3-methylglutaconic aciduria, type ix	Enrichment	TIMM50	2.33
108	Mitochondrial complex i deficiency, nuclear type 32	Enrichment	NDUFB8	2.33
109	Mitochondrial complex v deficiency, nuclear type 4a	Enrichment	ATP5F1A	2.33
110	Combined oxidative phosphorylation deficiency 43	Enrichment	TIMM22	2.33
111	Developmental and epileptic encephalopathy 39	Enrichment	SLC25A12	2.33
112	Garg-mishra progeroid syndrome	Enrichment	TOMM7	2.33
113	Anemia, sideroblastic, 5	Enrichment	HSCB	2.33
114	Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2	Enrichment	ATP5F1B	2.33
115	Lower motor neuron syndrome with late-adult onset	Enrichment	CHCHD10	2.33
116	Renal tubulopathy-encephalopathy-liver failure syndrome	Enrichment	BCS1L	2.33
117	Disorder of ornithine metabolism	Enrichment	OTC	2.33
118	Multiple system atrophy, parkinsonian type	Enrichment	COQ2	2.33
119	Pigmentation anomaly of the skin	Enrichment	MTX2	2.33
120	Citrullinemia type ii	Enrichment	SLC25A13	2.33
121	Perrault syndrome 1	Enrichment	HSD17B4	2.33
122	Cerebral palsy	Enrichment	ALDH3A2	2.24
123	Myocarditis	Enrichment	ABCD1	2.19
124	Neurodegeneration with brain iron accumulation	Enrichment	CRAT	2.18
125	Hyperekplexia	Enrichment	ATAD1	2.13
126	Polyneuropathy	Enrichment	GDAP1	2.13
127	Sensory peripheral neuropathy	Enrichment	GDAP1	2.13
128	Peroxisome biogenesis disorder 4b	Enrichment	PEX6	2.03
129	Mitochondrial dna depletion syndrome 15	Enrichment	MPV17	2.03
130	Buratti-harel syndrome	Enrichment	LONP2	2.03
131	Primary hyperoxaluria	Enrichment	AGXT	2.03
132	Submucosal cleft palate	Enrichment	UBB	2.03
133	Cleft hard palate	Enrichment	UBB	2.03
134	Multiple system atrophy 1	Enrichment	COQ2	2.03
135	Citrullinemia, classic	Enrichment	SLC25A13	2.03
136	Hydrocephalus, normal-pressure, 1	Enrichment	PMPCA	2.03
137	Leukodystrophy, hypomyelinating, 4	Enrichment	HSPD1	2.03
138	Porphyria, acute intermittent	Enrichment	ACO2	2.03
139	Citrin deficiency, neonatal or infantile onset	Enrichment	SLC25A13	2.03
140	Myopathy, mitochondrial progressive, with congenital cataract and developmental delay	Enrichment	GFER	2.03
141	Spondylometaphyseal dysplasia, megarbane-dagher-melki type	Enrichment	PAM16	2.03
142	Frontotemporal dementia and/or amyotrophic lateral sclerosis 2	Enrichment	CHCHD10	2.03
143	Agammaglobulinemia, x-linked	Enrichment	TIMM8A	2.03
144	Multiple mitochondrial dysfunctions syndrome 6	Enrichment	PMPCB	2.03
145	Isolated mitochondrial myopathy	Enrichment	CHCHD10	2.03
146	Spondylometaphyseal dysplasia megarbane-dagher-melike type	Enrichment	PAM16	2.03
147	Acute porphyria	Enrichment	ACO2	2.03
148	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.03
149	Citrullinemia	Enrichment	SLC25A13	2.03
150	Normal pressure hydrocephalus	Enrichment	PMPCA	2.03
151	Multiple system atrophy	Enrichment	COQ2	2.03
152	Multiple system atrophy, cerebellar type	Enrichment	COQ2	2.03
153	Oculopharyngodistal myopathy 1	Enrichment	ABCD3	1.99
154	Fatal familial insomnia	Enrichment	PRNP	1.92
155	Gerstmann-straussler disease	Enrichment	PRNP	1.92
156	Kuru	Enrichment	PRNP	1.92
157	Cardiomyopathy, dilated, 2h	Enrichment	GET3	1.92
158	Congenital disorder of glycosylation, type iiz	Enrichment	CAMLG	1.92
159	Spongiform encephalopathy with neuropsychiatric features	Enrichment	PRNP	1.92
160	Huntington disease-like 1	Enrichment	PRNP	1.92
161	Arthrogryposis and ectodermal dysplasia	Enrichment	OTOF	1.92
162	Cerebral amyloid angiopathy, app-related	Enrichment	APP	1.92
163	Congenital disorder of glycosylation, type iiaa	Enrichment	STX5	1.92
164	Familial alzheimer-like prion disease	Enrichment	PRNP	1.92
165	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	1.92
166	Heme oxygenase 1 deficiency	Enrichment	HMOX1	1.92
167	Prion disease	Enrichment	PRNP	1.92
168	Congenital disorder of glycosylation, type iiy	Enrichment	GET4	1.92
169	Prp systemic amyloidosis	Enrichment	PRNP	1.92
170	Inherited human prion disease	Enrichment	PRNP	1.92
171	Inherited creutzfeldt-jakob disease	Enrichment	PRNP	1.92
172	Uvula, bifid	Enrichment	UBB	1.86
173	Cleft soft palate	Enrichment	UBB	1.86
174	Long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HMGCL	1.86
175	Brown-vialetto-van laere syndrome 2	Enrichment	PEX6	1.86
176	Enchondromatosis	Enrichment	IDH1	1.86
177	Mpv17-related mitochondrial dna maintenance defect	Enrichment	MPV17	1.86
178	Hyperpigmentation of the skin	Enrichment	USP9X	1.86
179	Mitochondrial complex iii deficiency, nuclear type 1	Enrichment	BCS1L	1.86
180	Mitochondrial complex iv deficiency, nuclear type 5	Enrichment	ATP5F1A	1.86
181	Friedreich ataxia	Enrichment	FXN	1.86
182	Spinocerebellar ataxia, autosomal recessive 2	Enrichment	PMPCA	1.86
183	Citrin deficiency, adolescent or adult onset	Enrichment	SLC25A13	1.86
184	Barth syndrome	Enrichment	TAFAZZIN	1.86
185	Mitochondrial dna depletion syndrome 7	Enrichment	PITRM1	1.86
186	Coenzyme q10 deficiency, primary, 1	Enrichment	COQ2	1.86
187	Infantile cerebellar-retinal degeneration	Enrichment	ACO2	1.86
188	Optic atrophy 9	Enrichment	ACO2	1.86
189	Optic atrophy plus syndrome	Enrichment	ACO2, PEX1, PMPCA	1.81
190	Mitochondrial dna depletion syndrome 6	Enrichment	MPV17	1.73
191	Charcot-marie-tooth disease, axonal, type 2ee	Enrichment	MPV17	1.73
192	Autosomal recessive isolated optic atrophy	Enrichment	ACO2	1.73
193	Enchondromatosis, multiple, ollier type	Enrichment	IDH1	1.64
194	Paroxysmal extreme pain disorder	Enrichment	IDH1	1.64
195	Cox deficiency, infantile mitochondrial myopathy	Enrichment	COA6	1.64
196	Rare genetic deafness	Enrichment	HSD17B4	1.64
197	Hirschsprung disease 1	Enrichment	ABCD1	1.63
198	Creatine phosphokinase, elevated serum	Enrichment	GDAP1	1.63
199	Isolated elevated serum creatine phosphokinase levels	Enrichment	GDAP1	1.63
200	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.62
201	Methemoglobinemia and ambiguous genitalia	Enrichment	CYB5A	1.62
202	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.62
203	Creutzfeldt-jakob disease	Enrichment	PRNP	1.62
204	Hereditary methemoglobinemia	Enrichment	CYB5A	1.62
205	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.62
206	Mitochondrial dna depletion syndrome	Enrichment	MPV17	1.56
207	Familial hypercholanemia	Enrichment	BAAT	1.56
208	Multiple enchondromatosis, maffucci type	Enrichment	IDH1	1.49
209	Paroxysmal dystonia	Enrichment	PEX6	1.49
210	Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency	Enrichment	CYB5A	1.45
211	Deafness, autosomal recessive 3	Enrichment	OTOF	1.45
212	Glioma susceptibility 1	Enrichment	IDH1	1.44
213	Isolated atp synthase deficiency	Enrichment	ATP5F1A	1.44
214	Auditory neuropathy	Enrichment	OTOF, TIMM8A	1.42
215	Nephrocalcinosis	Enrichment	AGXT	1.34
216	Nephrolithiasis	Enrichment	AGXT	1.34
217	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	CHCHD10	1.34
218	Peripheral nervous system disease	Enrichment	GDAP1	1.34
219	Neuropathy	Enrichment	GDAP1	1.34
220	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD	1.33
221	Frontotemporal dementia 2	Enrichment	PRNP	1.33
222	Emery-dreifuss muscular dystrophy	Enrichment	EMD	1.33
223	Movement disease	Enrichment	BCS1L	1.30
224	Lactic acidosis	Enrichment	ATP5F1A	1.26
225	Cystic fibrosis	Enrichment	HMOX1, STX1A	1.25
226	Deafness, autosomal recessive 9	Enrichment	OTOF	1.23
227	Otof-related hearing loss	Enrichment	OTOF	1.23
228	Hypercholesterolemia, familial, 1	Enrichment	EPHX2	1.23
229	Premature menopause	Enrichment	PEX6	1.23
230	Charcot-marie-tooth disease	Enrichment	GDAP1	1.23
231	Mitochondrial disease	Enrichment	GFER, TIMM50	1.21
232	Isolated macular dystrophy	Enrichment	ACO2	1.20
233	Familial hypercholesterolemia	Enrichment	EPHX2	1.17
234	Gliosarcoma	Enrichment	IDH1	1.14
235	Hypertension	Enrichment	MTX2	1.14
236	Giant cell glioblastoma	Enrichment	IDH1	1.12
237	Alzheimer's disease 1	Enrichment	APP	1.09
238	Leukodystrophy	Enrichment	HSPD1	1.05
239	Focal segmental glomerulosclerosis	Enrichment	COQ2	1.05
240	Retinitis pigmentosa	Enrichment	PHYH	1.04
241	Nephrotic syndrome	Enrichment	AGXT, COQ2	1.03
242	Malaria	Enrichment	NOS2	0.99
243	Developmental and epileptic encephalopathy 1	Enrichment	SLC25A12	0.96
244	Hereditary retinal dystrophy	Enrichment	PHYH	0.91
245	Fundus dystrophy	Enrichment	PHYH	0.91
246	Familial isolated dilated cardiomyopathy	Enrichment	GET3, TAFAZZIN	0.88
247	Connective tissue disease	Enrichment	PEX7	0.86
248	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	0.84
249	Alzheimer's disease	Enrichment	APP	0.84
250	Left ventricular noncompaction	Enrichment	TAFAZZIN	0.82
251	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHCHD10, DAO	0.82
252	Non-syndromic x-linked intellectual disability	Enrichment	USP9X	0.81
253	Leukemia, acute myeloid	Enrichment	IDH1	0.77
254	Hypertrophic cardiomyopathy	Enrichment	PMPCA	0.74
255	Alzheimer disease, familial, 1	Enrichment	APP	0.73
256	West syndrome	Enrichment	SLC25A12	0.73
257	Neuromuscular disease	Enrichment	EMD	0.71
258	Sensorineural hearing loss	Enrichment	PEX6	0.70
259	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD	0.69
260	Williams-beuren syndrome	Enrichment	STX1A	0.67
261	Spastic ataxia	Enrichment	PEX10	0.66
262	Primary ovarian insufficiency	Enrichment	PEX6	0.62
263	Dilated cardiomyopathy	Enrichment	EMD, TAFAZZIN	0.61
264	Ear malformation	Enrichment	OTOF	0.60
265	Leigh syndrome, nuclear	Enrichment	BCS1L	0.56
266	Leigh disease	Enrichment	BCS1L	0.52
267	Non-syndromic genetic deafness	Enrichment	OTOF	0.45
268	Myopathy	Enrichment	EMD	0.42
269	Nonsyndromic hearing loss	Enrichment	OTOF	0.40
270	Microcephaly	Enrichment	BCS1L	0.36
271	Deafness, autosomal recessive	Enrichment	OTOF	0.27
272	Autosomal recessive nonsyndromic deafness	Enrichment	OTOF	0.27
273	Autism	Enrichment	STX1A	0.24
274	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	OTOF	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Peroxisomal protein import

Pathway Network for Peroxisomal protein import

Pathway network for the Peroxisomal protein import SuperPath

Member Pathways for Peroxisomal protein import

Pathways in the Peroxisomal protein import SuperPath

Gene overlap in member pathways for Peroxisomal protein import SuperPath

Associated Genes for Peroxisomal protein import

Associated Disorders for Peroxisomal protein import

Disorders associated with Peroxisomal protein import SuperPath

STRING Interaction Network for Peroxisomal protein import

Sources for Peroxisomal protein import