Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins

No Pathway Network information available for Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins

#	Name	Source	Genes
1	Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins	WikiPathways	AKT1 AKT1S1 APOB ATG2B ATG4A EIF4B LAMP2 LAMTOR1 LARP1 NBR1 PPP1R9A RB1CC1 RPS6KB1 TMEM59 VAMP8 VPS18 VPS33A VPS39 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
2	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	1
3	VAMP8	Vesicle Associated Membrane Protein 8	Protein Coding	1
4	AKT1S1	AKT1 Substrate 1	Protein Coding	1
5	VPS33A	VPS33A Core Subunit Of CORVET And HOPS Complexes	Protein Coding	1
6	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
7	ATG2B	Autophagy Related 2B	Protein Coding	1
8	LAMP2	Lysosomal Associated Membrane Protein 2	Protein Coding	1
9	APOB	Apolipoprotein B	Protein Coding	1
10	VPS39	VPS39 Subunit Of HOPS Complex	Protein Coding	1
11	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
12	TMEM59	Transmembrane Protein 59	Protein Coding	1
13	ATG4A	Autophagy Related 4A Cysteine Peptidase	Protein Coding	1
14	VPS18	VPS18 Core Subunit Of CORVET And HOPS Complexes	Protein Coding	1
15	PPP1R9A	Protein Phosphatase 1 Regulatory Subunit 9A	Protein Coding	1
16	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
17	NBR1	NBR1 Autophagy Cargo Receptor	Protein Coding	1
18	LARP1	La Ribonucleoprotein 1, Translational Regulator	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast adenocarcinoma	Enrichment	AKT1, RB1CC1	4.60
2	Proteus syndrome	Enrichment	AKT1	2.88
3	Danon disease	Enrichment	LAMP2	2.88
4	Cowden syndrome 6	Enrichment	AKT1	2.88
5	Hereditary breast carcinoma	Enrichment	AKT1, RB1CC1	2.82
6	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.58
7	Hypobetalipoproteinemia	Enrichment	APOB	2.58
8	Hypercholesterolemia, familial, 2	Enrichment	APOB	2.40
9	Estrogen resistance	Enrichment	TMEM59	2.40
10	Mucopolysaccharidosis-plus syndrome	Enrichment	VPS33A	2.40
11	Breast cancer	Enrichment	AKT1, RB1CC1	2.36
12	Hyperlipidemia, familial combined, 3	Enrichment	APOB	2.18
13	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.98
14	Coronary heart disease 5	Enrichment	APOB	1.93
15	Cowden syndrome	Enrichment	AKT1	1.93
16	Meningioma	Enrichment	AKT1	1.80
17	Hypercholesterolemia, familial, 1	Enrichment	APOB	1.77
18	Familial hypercholesterolemia	Enrichment	APOB	1.70
19	Familial hypertrophic cardiomyopathy	Enrichment	LAMP2	1.37
20	Left ventricular noncompaction	Enrichment	LAMP2	1.34
21	Hypertrophic cardiomyopathy	Enrichment	LAMP2	1.26
22	Dilated cardiomyopathy	Enrichment	LAMP2	1.00
23	Colorectal cancer	Enrichment	AKT1	0.96
24	Ovarian cancer	Enrichment	AKT1	0.90

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins