Phase 0 - rapid depolarisation

No Pathway Network information available for Phase 0 - rapid depolarisation

Pathways in the Phase 0 - rapid depolarisation SuperPath

#	Name	Source	Genes
1	Phase 0 - rapid depolarisation	Reactome	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G FGF11 FGF12 FGF13 FGF14 RANGRF SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	1
2	FGF11	Fibroblast Growth Factor 11	Protein Coding	1
3	FGF12	Fibroblast Growth Factor 12	Protein Coding	1
4	FGF13	Fibroblast Growth Factor 13	Protein Coding	1
5	FGF14	Fibroblast Growth Factor 14	Protein Coding	1
6	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	1
7	RANGRF	RAN Guanine Nucleotide Release Factor	Protein Coding	1
8	SCN3B	Sodium Voltage-Gated Channel Beta Subunit 3	Protein Coding	1
9	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	1
10	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	1
11	CACNG6	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 6	Protein Coding	1
12	SCN1A	Sodium Voltage-Gated Channel Alpha Subunit 1	Protein Coding	1
13	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	1
14	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	1
15	SCN2B	Sodium Voltage-Gated Channel Beta Subunit 2	Protein Coding	1
16	SCN3A	Sodium Voltage-Gated Channel Alpha Subunit 3	Protein Coding	1
17	SCN4A	Sodium Voltage-Gated Channel Alpha Subunit 4	Protein Coding	1
18	SCN4B	Sodium Voltage-Gated Channel Beta Subunit 4	Protein Coding	1
19	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	1
20	SCN7A	Sodium Voltage-Gated Channel Alpha Subunit 7	Protein Coding	1
21	SCN8A	Sodium Voltage-Gated Channel Alpha Subunit 8	Protein Coding	1
22	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	1
23	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	1
24	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
25	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	1
26	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	1
27	CALM1	Calmodulin 1	Protein Coding	1
28	CALM2	Calmodulin 2	Protein Coding	1
29	CALM3	Calmodulin 3	Protein Coding	1
30	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
31	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
32	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
33	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
34	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	1

Disorders associated with Phase 0 - rapid depolarisation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Brugada syndrome	Enrichment	CACNA1C, CACNB2, RANGRF, SCN10A, SCN1B, SCN2B, SCN3B, SCN5A	16.00
2	Long qt syndrome 1	Enrichment	CACNA1C, CALM1, CALM2, CALM3, SCN10A, SCN4B, SCN5A	11.32
3	Generalized epilepsy with febrile seizures plus	Enrichment	FGF13, SCN1A, SCN1B, SCN2A, SCN9A	9.83
4	Familial atrial fibrillation	Enrichment	SCN1B, SCN2B, SCN3B, SCN4B, SCN5A	8.52
5	Dravet syndrome	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	8.17
6	Hereditary sodium channelopathy-related small fibers neuropathy	Enrichment	SCN10A, SCN11A, SCN9A	7.84
7	Developmental and epileptic encephalopathy	Enrichment	CACNA2D2, SCN1A, SCN2A, SCN3A, SCN8A	7.59
8	Erythermalgia, primary	Enrichment	SCN10A, SCN11A, SCN9A	7.24
9	Paroxysmal extreme pain disorder	Enrichment	SCN10A, SCN11A, SCN9A	6.84
10	Undetermined early-onset epileptic encephalopathy	Enrichment	FGF12, SCN1A, SCN1B, SCN3A, SCN8A	6.60
11	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	SCN10A, SCN11A, SCN9A	6.30
12	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.10
13	Long qt syndrome	Enrichment	CACNA1C, CALM1, CALM2, SCN5A	6.01
14	Epilepsy	Enrichment	SCN1A, SCN2A, SCN3A, SCN8A	5.55
15	Cardiac conduction defect	Enrichment	CACNA1C, SCN1B, SCN5A	5.51
16	Benign epilepsy with centrotemporal spikes	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	5.51
17	Centralopathic epilepsy	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	5.42
18	Sudden infant death syndrome	Enrichment	CALM2, SCN1A, SCN5A	5.02
19	Generalized epilepsy with febrile seizures plus, type 1	Enrichment	SCN1A, SCN1B	4.74
20	Autism	Enrichment	CAMK2G, SCN1A, SCN2A, SCN8A	4.52
21	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C, SCN5A	4.44
22	Hereditary progressive cardiac conduction defect	Enrichment	SCN1B, SCN5A	4.44
23	Heart conduction disease	Enrichment	CACNA1C, SCN5A	4.22
24	Self-limited infantile epilepsy	Enrichment	SCN2A, SCN8A	4.22
25	Fetal akinesia deformation sequence 1	Enrichment	SCN4A, SCN5A, SCN8A	3.98
26	Brugada syndrome 1	Enrichment	SCN10A, SCN5A	3.90
27	Focal epilepsy	Enrichment	SCN2A, SCN8A	3.90
28	Distal arthrogryposis	Enrichment	SCN4A, SCN5A, SCN8A	3.81
29	West syndrome	Enrichment	SCN1A, SCN2A, SCN8A	3.75
30	Developmental and epileptic encephalopathy 14	Enrichment	SCN1A, SCN2A	3.66
31	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, SCN8A	3.58
32	Early infantile developmental and epileptic encephalopathy	Enrichment	SCN1B, SCN2A	3.04
33	Developmental and epileptic encephalopathy 1	Enrichment	SCN1A, SCN8A	2.75
34	Spinocerebellar ataxia 27a	Enrichment	FGF14	2.60
35	Brugada syndrome 4	Enrichment	CACNB2	2.60
36	Brugada syndrome 5	Enrichment	SCN1B	2.60
37	Long qt syndrome 10	Enrichment	SCN4B	2.60
38	Episodic pain syndrome, familial, 3	Enrichment	SCN11A	2.60
39	Developmental and epileptic encephalopathy 11	Enrichment	SCN2A	2.60
40	Neuropathy, hereditary sensory and autonomic, type vii	Enrichment	SCN11A	2.60
41	Atrial fibrillation, familial, 14	Enrichment	SCN2B	2.60
42	Intellectual developmental disorder, x-linked 110	Enrichment	FGF13	2.60
43	Spinocerebellar ataxia 27b, late-onset	Enrichment	FGF14	2.60
44	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.60
45	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.60
46	Myoclonus, familial, 2	Enrichment	SCN8A	2.60
47	Developmental and epileptic encephalopathy 62	Enrichment	SCN3A	2.60
48	Developmental and epileptic encephalopathy 90	Enrichment	FGF13	2.60
49	Atrial fibrillation, familial, 13	Enrichment	SCN1B	2.60
50	Brugada syndrome 3	Enrichment	CACNA1C	2.60
51	Episodic ataxia, type 9	Enrichment	SCN2A	2.60
52	Episodic pain syndrome, familial, 2	Enrichment	SCN10A	2.60
53	Long qt syndrome 16	Enrichment	CALM3	2.60
54	Benign familial infantile epilepsy	Enrichment	SCN2A	2.60
55	Brugada syndrome 7	Enrichment	SCN3B	2.60
56	Epilepsy, familial focal, with variable foci 4	Enrichment	SCN3A	2.60
57	Developmental and epileptic encephalopathy 47	Enrichment	FGF12	2.60
58	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.60
59	Muscular channelopathy	Enrichment	SCN4A	2.60
60	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.60
61	Long qt syndrome 15	Enrichment	CALM2	2.60
62	Spinocerebellar ataxia type 27b	Enrichment	FGF14	2.60
63	Atypical timothy syndrome	Enrichment	CACNA1C	2.60
64	Timothy syndrome type 2	Enrichment	CACNA1C	2.60
65	Timothy syndrome type 1	Enrichment	CACNA1C	2.60
66	Cacna1c-related disorders	Enrichment	CACNA1C	2.60
67	Complex neurodevelopmental disorder	Enrichment	CACNA1C, SCN2A, SCN8A	2.44
68	Atrial standstill 1	Enrichment	SCN5A	2.30
69	Progressive familial heart block, type ia	Enrichment	SCN5A	2.30
70	Paramyotonia congenita	Enrichment	SCN4A	2.30
71	Batten-turner congenital myopathy	Enrichment	SCN4A	2.30
72	Indifference to pain, congenital, autosomal recessive	Enrichment	SCN9A	2.30
73	Timothy syndrome	Enrichment	CACNA1C	2.30
74	Seizures, benign familial infantile, 3	Enrichment	SCN2A	2.30
75	Sick sinus syndrome 1	Enrichment	SCN5A	2.30
76	Myotonia, potassium-aggravated	Enrichment	SCN4A	2.30
77	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.30
78	Atrial fibrillation, familial, 10	Enrichment	SCN5A	2.30
79	Migraine, familial hemiplegic, 3	Enrichment	SCN1A	2.30
80	Cognitive impairment with or without cerebellar ataxia	Enrichment	SCN8A	2.30
81	Long qt syndrome 14	Enrichment	CALM1	2.30
82	Long qt syndrome 3	Enrichment	SCN5A	2.30
83	Long qt syndrome 8	Enrichment	CACNA1C	2.30
84	Developmental and epileptic encephalopathy 6b	Enrichment	SCN1A	2.30
85	Sinoatrial node disease	Enrichment	SCN5A	2.30
86	Congenital myopathy 22a, classic	Enrichment	SCN4A	2.30
87	Congenital myopathy 22b, severe fetal	Enrichment	SCN4A	2.30
88	Myasthenic syndrome, congenital, 16	Enrichment	SCN4A	2.30
89	Benign familial neonatal epilepsy	Enrichment	SCN2A	2.30
90	Developmental and epileptic encephalopathy 30	Enrichment	SCN2A	2.30
91	Hypokalemic periodic paralysis, type 2	Enrichment	SCN4A	2.30
92	Scn1a seizure disorders	Enrichment	SCN1A	2.30
93	Seizures, benign familial infantile, 5	Enrichment	SCN8A	2.30
94	Malignant migrating partial seizures of infancy	Enrichment	SCN2A	2.30
95	Developmental and epileptic encephalopathy 76	Enrichment	SCN1A	2.30
96	Small fiber neuropathy	Enrichment	SCN9A	2.30
97	Benign neonatal seizures	Enrichment	SCN2A	2.30
98	Isolated atrial standstill	Enrichment	SCN5A	2.30
99	Dystonia 12	Enrichment	SCN2A	2.12
100	Generalized epilepsy with febrile seizures plus, type 2	Enrichment	SCN1A	2.12
101	Developmental and epileptic encephalopathy 13	Enrichment	SCN8A	2.12
102	Generalized epilepsy with febrile seizures plus, type 7	Enrichment	SCN9A	2.12
103	Tremor, hereditary essential, 6	Enrichment	SCN4A	2.12
104	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1C	2.12
105	Hereditary episodic ataxia	Enrichment	SCN2A	2.12
106	Neuropathy, hereditary sensory and autonomic, type iia	Enrichment	SCN9A	2.00
107	Long qt syndrome 2	Enrichment	SCN5A	2.00
108	Hyperkalemic periodic paralysis	Enrichment	SCN4A	2.00
109	Developmental and epileptic encephalopathy 12	Enrichment	SCN2A	2.00
110	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	2.00
111	Hereditary sensory and autonomic neuropathy type 2	Enrichment	SCN9A	2.00
112	Developmental and epileptic encephalopathy 52	Enrichment	SCN1B	2.00
113	Atrial fibrillation	Enrichment	SCN5A	2.00
114	Sotos syndrome 1	Enrichment	SCN4A	2.00
115	Episodic ataxia	Enrichment	SCN2A	2.00
116	Familial or sporadic hemiplegic migraine	Enrichment	SCN1A	2.00
117	Sick sinus syndrome	Enrichment	SCN5A	2.00
118	Paroxysmal familial ventricular fibrillation	Enrichment	SCN5A	2.00
119	Familial sick sinus syndrome	Enrichment	SCN5A	2.00
120	Sotos syndrome	Enrichment	SCN4A	1.90
121	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	SCN8A	1.90
122	Cardiac arrest	Enrichment	SCN5A	1.90
123	Sensory peripheral neuropathy	Enrichment	SCN11A	1.90
124	Hypokalemic periodic paralysis, type 1	Enrichment	SCN4A	1.83
125	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.83
126	Pain disorder	Enrichment	SCN4A	1.83
127	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	SCN3A	1.76
128	Lennox-gastaut syndrome	Enrichment	SCN1A	1.70
129	Alternating hemiplegia of childhood	Enrichment	SCN2A	1.70
130	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.70
131	Myoclonic-atonic epilepsy	Enrichment	SCN1A	1.65
132	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.65
133	Bilateral perisylvian polymicrogyria	Enrichment	SCN3A	1.65
134	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	SCN5A	1.65
135	Polymicrogyria	Enrichment	SCN3A	1.61
136	Movement disease	Enrichment	SCN2A	1.56
137	Congenital long qt syndrome	Enrichment	SCN5A	1.53
138	Postsynaptic congenital myasthenic syndromes	Enrichment	SCN4A	1.53
139	Microcephaly	Enrichment	CAMK2B, SCN1A	1.42
140	Wolff-parkinson-white syndrome	Enrichment	SCN5A	1.40
141	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	SCN5A	1.40
142	Cardiomyopathy, dilated, 1e	Enrichment	SCN5A	1.38
143	Congenital myopathy	Enrichment	SCN4A	1.33
144	Malaria	Enrichment	SCN8A	1.25
145	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	1.23
146	Left ventricular noncompaction	Enrichment	SCN5A	1.07
147	Dystonia	Enrichment	CAMK2B	1.07
148	Cerebral palsy	Enrichment	CACNA1C	1.03
149	Myopathy	Enrichment	SCN4A	1.02
150	Body mass index quantitative trait locus 11	Enrichment	SCN1A	0.93
151	Spastic ataxia	Enrichment	SCN2A	0.90
152	Familial isolated dilated cardiomyopathy	Enrichment	SCN5A	0.90
153	Dilated cardiomyopathy	Enrichment	SCN5A	0.74
154	Congenital nervous system abnormality	Enrichment	CAMK2B	0.63
155	Nervous system disease	Enrichment	CAMK2B	0.63
156	Autism spectrum disorder	Enrichment	SCN2A	0.62

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¹¹ MalaCards

Phase 0 - rapid depolarisation

Pathway Network for Phase 0 - rapid depolarisation

Member Pathways for Phase 0 - rapid depolarisation

Pathways in the Phase 0 - rapid depolarisation SuperPath

Associated Genes for Phase 0 - rapid depolarisation

Associated Disorders for Phase 0 - rapid depolarisation

Disorders associated with Phase 0 - rapid depolarisation SuperPath

STRING Interaction Network for Phase 0 - rapid depolarisation

Sources for Phase 0 - rapid depolarisation