Phase I biotransformations, non P450
Pathways in the Phase I biotransformations, non P450 SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Phase I biotransformations, non P450 | WikiPathways |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | CES2 | Carboxylesterase 2 | Protein Coding | 1 |
| 2 | PON3 | Paraoxonase 3 | Protein Coding | 1 |
| 3 | PON2 | Paraoxonase 2 | Protein Coding | 1 |
| 4 | PON1 | Paraoxonase 1 | Protein Coding | 1 |
| 5 | LIPA | Lipase A, Lysosomal Acid Type | Protein Coding | 1 |
| 6 | ESD | Esterase D | Protein Coding | 1 |
| 7 | CES1 | Carboxylesterase 1 | Protein Coding | 1 |
| 8 | CES5A | Carboxylesterase 5A | Protein Coding | 1 |
Disorders associated with Phase I biotransformations, non P450 SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 | Enrichment | PON1, PON2, PON3 | 5.39 |
| 2 | Drug metabolism, altered, ces1-related | Enrichment | CES1 | 3.23 |
| 3 | Cholesteryl ester storage disease | Enrichment | LIPA | 3.23 |
| 4 | Wolman disease | Enrichment | LIPA | 3.23 |
| 5 | Lysosomal acid lipase deficiency | Enrichment | LIPA | 3.23 |
| 6 | Microvascular complications of diabetes 5 | Enrichment | PON1 | 2.93 |
