Phenobarbital Pathway, Pharmacokinetics/Pharmacodynamics
No Pathway Network information available for Phenobarbital Pathway, Pharmacokinetics/Pharmacodynamics
Pathways in the Phenobarbital Pathway, Pharmacokinetics/Pharmacodynamics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Phenobarbital Pathway, Pharmacokinetics/Pharmacodynamics | PharmGKB | |
| 2 | Siponimod Pathway, Pharmacokinetics/Pharmacodynamics | PharmGKB |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | CYP2B6 | Cytochrome P450 Family 2 Subfamily B Member 6 | Protein Coding | 2 |
| 2 | CYP2C19 | Cytochrome P450 Family 2 Subfamily C Member 19 | Protein Coding | 2 |
| 3 | CYP2C9 | Cytochrome P450 Family 2 Subfamily C Member 9 | Protein Coding | 2 |
| 4 | CYP3A4 | Cytochrome P450 Family 3 Subfamily A Member 4 | Protein Coding | 2 |
| 5 | UGT1A1 | UDP Glucuronosyltransferase Family 1 Member A1 | Protein Coding | 1 |
| 6 | NR1I2 | Nuclear Receptor Subfamily 1 Group I Member 2 | Protein Coding | 1 |
| 7 | CYP2E1 | Cytochrome P450 Family 2 Subfamily E Member 1 | Protein Coding | 1 |
| 8 | NR1I3 | Nuclear Receptor Subfamily 1 Group I Member 3 | Protein Coding | 1 |
| 9 | CYP2C8 | Cytochrome P450 Family 2 Subfamily C Member 8 | Protein Coding | 1 |
| 10 | S1PR1 | Sphingosine-1-Phosphate Receptor 1 | Protein Coding | 1 |
| 11 | S1PR3 | Sphingosine-1-Phosphate Receptor 3 | Protein Coding | 1 |
| 12 | S1PR5 | Sphingosine-1-Phosphate Receptor 5 | Protein Coding | 1 |
Disorders associated with Phenobarbital Pathway, Pharmacokinetics/Pharmacodynamics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Drug metabolism, poor, cyp2c19-related | Enrichment | CYP2C19 | 3.23 |
| 2 | Efavirenz, poor metabolism of | Enrichment | CYP2B6 | 3.23 |
| 3 | Vitamin d-dependent rickets, type 3 | Enrichment | CYP3A4 | 3.23 |
| 4 | Drug metabolism, altered, cyp2c8-related | Enrichment | CYP2C8 | 3.23 |
| 5 | Coumarin resistance | Enrichment | CYP2C9 | 2.75 |
| 6 | Crigler-najjar syndrome, type i | Enrichment | UGT1A1 | 2.23 |
| 7 | Hyperbilirubinemia, transient familial neonatal | Enrichment | UGT1A1 | 2.23 |
| 8 | Bilirubin, serum level of, quantitative trait locus 1 | Enrichment | UGT1A1 | 2.23 |
| 9 | Crigler-najjar syndrome, type ii | Enrichment | UGT1A1 | 2.23 |
| 10 | Gilbert syndrome | Enrichment | UGT1A1 | 2.19 |
| 11 | Bilirubin metabolic disorder | Enrichment | UGT1A1 | 2.19 |
