Phenytoin Pathway, Pharmacokinetics

Pathway network for the Phenytoin Pathway, Pharmacokinetics SuperPath

Sources:

PharmGKB
WikiPathways
Reactome

Pathways in the Phenytoin Pathway, Pharmacokinetics SuperPath

#	Name	Source	Genes
1	Phenytoin Pathway, Pharmacokinetics	PharmGKB	ALPL COMT CYP1A2 CYP2A6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 CYP3A5 CYP3A7 EPHX1 NQO1 PTGIS TBXAS1 UGT1A1 UGT1A4 UGT1A6 UGT1A9 UGT2B15 (see all 21) (see less)
2	Tamoxifen metabolism	WikiPathways	CYP1A1 CYP1A2 CYP1B1 CYP2A6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 CYP3A5 FMO1 FMO3 SULT1A1 SULT1E1 SULT2A1 UGT1A10 UGT1A4 UGT1A8 UGT2B15 UGT2B7 (see all 21) (see less)
3	Metronidazole Pathway, Pharmacokinetics	PharmGKB	CYP2A6 CYP2E1 CYP3A4 CYP3A5 CYP3A7 UGT1A1 (see all 6) (see less)
4	Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CYP3A4 CYP3A5 UGT1A1
5	Defective UGT1A1 causes hyperbilirubinemia	Reactome	UGT1A1

Gene overlap in member pathways for Phenytoin Pathway, Pharmacokinetics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	4
2	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	4
3	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	4
4	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	3
5	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	3
6	UGT2B15	UDP Glucuronosyltransferase Family 2 Member B15	Protein Coding	2
7	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	2
8	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	2
9	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	2
10	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	2
11	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	2
12	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	2
13	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	2
14	PTGIS	Prostaglandin I2 Synthase	Protein Coding	1
15	TBXAS1	Thromboxane A Synthase 1	Protein Coding	1
16	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	1
17	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	1
18	EPHX1	Epoxide Hydrolase 1	Protein Coding	1
19	ALPL	Alkaline Phosphatase, Biomineralization Associated	Protein Coding	1
20	COMT	Catechol-O-Methyltransferase	Protein Coding	1
21	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
22	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
23	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	1
24	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
25	SULT1E1	Sulfotransferase Family 1E Member 1	Protein Coding	1
26	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	1
27	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	1
28	FMO3	Flavin Containing Dimethylaniline Monoxygenase 3	Protein Coding	1
29	FMO1	Flavin Containing Dimethylaniline Monoxygenase 1	Protein Coding	1
30	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	1
31	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1

Disorders associated with Phenytoin Pathway, Pharmacokinetics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bilirubin metabolic disorder	Direct
2	Gilbert syndrome	Direct
3	Crigler-najjar syndrome, type i	Direct
4	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	9.05
5	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	9.05
6	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	9.05
7	Coumarin resistance	Enrichment	CYP2A6, CYP2C9	5.16
8	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.66
9	Hypertension, essential	Enrichment	CYP3A5, PTGIS	3.51
10	Letrozole toxicity	Enrichment	CYP2A6	3.35
11	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.81
12	Hypophosphatasia, adult	Enrichment	ALPL	2.81
13	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	2.81
14	Hypophosphatasia, childhood	Enrichment	ALPL	2.81
15	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	2.81
16	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.81
17	Prenatal benign hypophosphatasia	Enrichment	ALPL	2.81
18	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	2.81
19	Genetic lipodystrophy	Enrichment	EPHX1	2.81
20	Severe primary trimethylaminuria	Enrichment	FMO3	2.81
21	Tobacco addiction	Enrichment	CYP2A6	2.75
22	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	2.51
23	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ALPL	2.51
24	Hypophosphatasia	Enrichment	ALPL	2.51
25	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ALPL	2.51
26	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.51
27	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.51
28	Trimethylaminuria	Enrichment	FMO3	2.51
29	Primary trimethylaminuria	Enrichment	FMO3	2.51
30	Primary congenital glaucoma	Enrichment	CYP1B1	2.51
31	Hypophosphatasia, infantile	Enrichment	ALPL	2.33
32	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	2.21
33	Juvenile glaucoma	Enrichment	CYP1B1	2.11
34	Familial hypercholanemia	Enrichment	EPHX1	2.03
35	Glaucoma, primary open angle	Enrichment	CYP1B1	2.03
36	Anterior segment dysgenesis 5	Enrichment	CYP1B1	2.03
37	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	1.97
38	Lung cancer	Enrichment	CYP2A6	1.85
39	Peters-plus syndrome	Enrichment	CYP1B1	1.81
40	Digeorge syndrome	Enrichment	COMT	1.73
41	Anterior segment dysgenesis	Enrichment	CYP1B1	1.64
42	Brittle bone disorder	Enrichment	ALPL	1.46
43	Cystic fibrosis	Enrichment	EPHX1	1.31
44	Bardet-biedl syndrome	Enrichment	COMT	1.20
45	Schizophrenia	Enrichment	COMT	1.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Phenytoin Pathway, Pharmacokinetics

Pathway Network for Phenytoin Pathway, Pharmacokinetics

Pathway network for the Phenytoin Pathway, Pharmacokinetics SuperPath

Member Pathways for Phenytoin Pathway, Pharmacokinetics

Pathways in the Phenytoin Pathway, Pharmacokinetics SuperPath

Gene overlap in member pathways for Phenytoin Pathway, Pharmacokinetics SuperPath

Associated Genes for Phenytoin Pathway, Pharmacokinetics

Associated Disorders for Phenytoin Pathway, Pharmacokinetics

Disorders associated with Phenytoin Pathway, Pharmacokinetics SuperPath

STRING Interaction Network for Phenytoin Pathway, Pharmacokinetics

Sources for Phenytoin Pathway, Pharmacokinetics