Phosphodiesterases in neuronal function

No Pathway Network information available for Phosphodiesterases in neuronal function

Pathways in the Phosphodiesterases in neuronal function SuperPath

#	Name	Source	Genes
1	Phosphodiesterases in neuronal function	WikiPathways	ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA2A CAMK2A CHRNA7 CREB1 DRD1 DRD2 GRIA1 GRIN1 GRIN2D GUCY1A1 GUCY1A2 GUCY1B1 GUCY1B2 LINC00473 NOS1 PDE11A PDE12 PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE6A PDE6B PDE6C PDE6D PDE6G PDE6H PDE7A PDE7B PDE8A PDE8B PDE9A PPP1R1B PRKACA PRKG1 (see all 52) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PDE9A	Phosphodiesterase 9A	Protein Coding	1
2	PDE8A	Phosphodiesterase 8A	Protein Coding	1
3	PDE7A	Phosphodiesterase 7A	Protein Coding	1
4	PDE4C	Phosphodiesterase 4C	Protein Coding	1
5	PDE1A	Phosphodiesterase 1A	Protein Coding	1
6	PDE7B	Phosphodiesterase 7B	Protein Coding	1
7	PDE5A	Phosphodiesterase 5A	Protein Coding	1
8	PDE8B	Phosphodiesterase 8B	Protein Coding	1
9	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	1
10	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
11	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
12	ADCY10	Adenylate Cyclase 10	Protein Coding	1
13	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
14	PDE6B	Phosphodiesterase 6B	Protein Coding	1
15	PDE1B	Phosphodiesterase 1B	Protein Coding	1
16	PDE6H	Phosphodiesterase 6H	Protein Coding	1
17	PDE6G	Phosphodiesterase 6G	Protein Coding	1
18	PDE6C	Phosphodiesterase 6C	Protein Coding	1
19	PDE6A	Phosphodiesterase 6A	Protein Coding	1
20	PDE4D	Phosphodiesterase 4D	Protein Coding	1
21	PDE4B	Phosphodiesterase 4B	Protein Coding	1
22	PDE4A	Phosphodiesterase 4A	Protein Coding	1
23	PDE3B	Phosphodiesterase 3B	Protein Coding	1
24	PDE3A	Phosphodiesterase 3A	Protein Coding	1
25	PDE2A	Phosphodiesterase 2A	Protein Coding	1
26	PDE1C	Phosphodiesterase 1C	Protein Coding	1
27	PDE11A	Phosphodiesterase 11A	Protein Coding	1
28	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
29	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
30	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
31	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
32	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
33	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	1
34	PDE12	Phosphodiesterase 12	Protein Coding	1
35	DRD2	Dopamine Receptor D2	Protein Coding	1
36	DRD1	Dopamine Receptor D1	Protein Coding	1
37	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
38	ADORA2A	Adenosine A2a Receptor	Protein Coding	1
39	ADCY8	Adenylate Cyclase 8	Protein Coding	1
40	CHRNA7	Cholinergic Receptor Nicotinic Alpha 7 Subunit	Protein Coding	1
41	ADCY7	Adenylate Cyclase 7	Protein Coding	1
42	ADCY6	Adenylate Cyclase 6	Protein Coding	1
43	ADCY5	Adenylate Cyclase 5	Protein Coding	1
44	ADCY3	Adenylate Cyclase 3	Protein Coding	1
45	ADCY2	Adenylate Cyclase 2	Protein Coding	1
46	ADCY1	Adenylate Cyclase 1	Protein Coding	1
47	ADCY4	Adenylate Cyclase 4	Protein Coding	1
48	LINC00473	Long Intergenic Non-Protein Coding RNA 473	RNA Gene	1
49	ADCY9	Adenylate Cyclase 9	Protein Coding	1
50	PDE6D	Phosphodiesterase 6D	Protein Coding	1
51	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
52	GUCY1B2	Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)	Pseudogene	1

Disorders associated with Phosphodiesterases in neuronal function SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Isolated micronodular adrenocortical disease	Enrichment	PDE11A, PDE8B	4.84
2	Achromatopsia	Enrichment	PDE6C, PDE6H	3.20
3	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, GRIA1, GRIN1	3.04
4	Cone-rod dystrophy 6	Enrichment	PDE6B, PDE6C	2.89
5	Hypertension and brachydactyly syndrome	Enrichment	PDE3A	2.42
6	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.42
7	Striatal degeneration, autosomal dominant 1	Enrichment	PDE8B	2.42
8	Achromatopsia 6	Enrichment	PDE6H	2.42
9	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.42
10	Retinitis pigmentosa 57	Enrichment	PDE6G	2.42
11	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.42
12	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.42
13	Joubert syndrome 22	Enrichment	PDE6D	2.42
14	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.42
15	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.42
16	Intellectual developmental disorder with paroxysmal dyskinesia or seizures	Enrichment	PDE2A	2.42
17	Retinal cone dystrophy 3a	Enrichment	PDE6H	2.42
18	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.42
19	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.42
20	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.42
21	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	2.42
22	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.42
23	Cone dystrophy 4	Enrichment	PDE6C	2.42
24	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.42
25	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.42
26	Retinitis pigmentosa 43	Enrichment	PDE6A	2.42
27	Pigmented nodular adrenocortical disease, primary, 3	Enrichment	PDE8B	2.42
28	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.42
29	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.42
30	Deafness, autosomal dominant 74	Enrichment	PDE1C	2.42
31	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.42
32	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.42
33	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.42
34	Striatal degeneration, autosomal dominant	Enrichment	PDE8B	2.42
35	Idiopathic hypercalciuria	Enrichment	ADCY10	2.42
36	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	2.42
37	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.42
38	Hereditary retinal dystrophy	Enrichment	PDE6A, PDE6B, PDE6C, PDE6G, PDE6H	2.31
39	Fundus dystrophy	Enrichment	PDE6A, PDE6B, PDE6C, PDE6G, PDE6H	2.31
40	Hypercalciuria, absorptive, 2	Enrichment	ADCY10	2.12
41	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	2.12
42	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.12
43	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.12
44	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	2.12
45	Pigmented nodular adrenocortical disease, primary, 2	Enrichment	PDE11A	2.12
46	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.12
47	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.12
48	Acrodysostosis	Enrichment	PDE4D	2.12
49	Chromosome 15q13.3 deletion syndrome	Enrichment	CHRNA7	2.12
50	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.12
51	Fibrolamellar carcinoma	Enrichment	PRKACA	2.12
52	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PDE11A	2.12
53	Night blindness, congenital stationary, autosomal dominant 2	Enrichment	PDE6B	1.94
54	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	1.94
55	Retinitis pigmentosa 40	Enrichment	PDE6B	1.94
56	Melanoma of soft tissue	Enrichment	CREB1	1.94
57	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.94
58	Chorea, benign hereditary	Enrichment	ADCY5	1.82
59	Carney complex variant	Enrichment	PDE11A	1.82
60	Idiopathic achalasia	Enrichment	NOS1	1.82
61	Albinism, oculocutaneous, type ii	Enrichment	PDE6B	1.72
62	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PDE2A	1.72
63	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	1.68
64	Dystonia 11, myoclonic	Enrichment	DRD2	1.64
65	Moyamoya disease 1	Enrichment	GUCY1A1	1.64
66	Paroxysmal dystonia	Enrichment	PDE2A	1.58
67	Choreatic disease	Enrichment	PDE2A	1.52
68	Ellis-van creveld syndrome	Enrichment	PRKACA	1.47
69	Orofaciodigital syndrome vi	Enrichment	PDE6D	1.38
70	Retinitis pigmentosa	Enrichment	PDE6A, PDE6B, PDE6G	1.32
71	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	1.31
72	Leber plus disease	Enrichment	PDE6A, PDE6B	1.29
73	Isolated macular dystrophy	Enrichment	PDE6C	1.28
74	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.17
75	Myocardial infarction	Enrichment	GUCY1A1	1.09
76	Congenital stationary night blindness	Enrichment	PDE6B	1.07
77	Cone dystrophy	Enrichment	PDE6C	1.05
78	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.04
79	Isolated joubert syndrome	Enrichment	PDE6D	0.96
80	Eye disease	Enrichment	PDE6C	0.90
81	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1	0.84
82	Centralopathic epilepsy	Enrichment	GRIN1	0.82
83	West syndrome	Enrichment	GRIN1	0.81
84	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	0.81
85	Body mass index quantitative trait locus 11	Enrichment	ADCY3	0.76
86	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	PDE1C	0.74
87	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	0.71
88	Schizophrenia	Enrichment	PDE11A	0.69
89	Cone-rod dystrophy 2	Enrichment	PDE6B	0.64
90	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.54
91	Autism spectrum disorder	Enrichment	GRIA1	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Phosphodiesterases in neuronal function

Pathway Network for Phosphodiesterases in neuronal function

Member Pathways for Phosphodiesterases in neuronal function

Pathways in the Phosphodiesterases in neuronal function SuperPath

Associated Genes for Phosphodiesterases in neuronal function

Associated Disorders for Phosphodiesterases in neuronal function

Disorders associated with Phosphodiesterases in neuronal function SuperPath

STRING Interaction Network for Phosphodiesterases in neuronal function

Sources for Phosphodiesterases in neuronal function