Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

No Pathway Network information available for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Pathways in the Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes SuperPath

#	Name	Source	Genes
1	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Reactome	BHLHE40 BMAL1 CIPC CLOCK CREB1 CREBBP CREM CRTC1 CRY1 CRY2 DBP KMT2A LOC102724428 NPAS2 NR1D1 PER1 PER2 PER3 RBM4 RORA RORC SIK1 TFEB (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LOC102724428	Salt Inducible Kinase 1B (Putative)	Protein Coding	1
2	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
3	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
4	CREM	CAMP Responsive Element Modulator	Protein Coding	1
5	CRY1	Cryptochrome Circadian Regulator 1	Protein Coding	1
6	CRY2	Cryptochrome Circadian Regulator 2	Protein Coding	1
7	SIK1	Salt Inducible Kinase 1	Protein Coding	1
8	DBP	D-Box Binding PAR BZIP Transcription Factor	Protein Coding	1
9	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	1
10	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	1
11	KMT2A	Lysine Methyltransferase 2A	Protein Coding	1
12	NPAS2	Neuronal PAS Domain Protein 2	Protein Coding	1
13	PER1	Period Circadian Regulator 1	Protein Coding	1
14	RBM4	RNA Binding Motif Protein 4	Protein Coding	1
15	RORA	RAR Related Orphan Receptor A	Protein Coding	1
16	RORC	RAR Related Orphan Receptor C	Protein Coding	1
17	TFEB	Transcription Factor EB	Protein Coding	1
18	CIPC	CLOCK Interacting Pacemaker	Protein Coding	1
19	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
20	PER3	Period Circadian Regulator 3	Protein Coding	1
21	PER2	Period Circadian Regulator 2	Protein Coding	1
22	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	1
23	CLOCK	Clock Circadian Regulator	Protein Coding	1

Disorders associated with Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Advanced sleep phase syndrome	Enrichment	PER2, PER3	5.08
2	Rare genetic intellectual disability	Enrichment	CREBBP, KMT2A	3.55
3	Advanced sleep phase syndrome, familial, 1	Enrichment	PER2	2.77
4	Advanced sleep phase syndrome, familial, 3	Enrichment	PER3	2.77
5	Immunodeficiency 42	Enrichment	RORC	2.77
6	Delayed sleep phase disorder	Enrichment	CRY1	2.77
7	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.77
8	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	2.77
9	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.77
10	Menke-hennekam syndrome	Enrichment	CREBBP	2.77
11	Language disorder	Enrichment	SIK1	2.77
12	Thumb deformity	Enrichment	CREBBP	2.47
13	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.47
14	Homocystinuria-megaloblastic anemia, cble type	Enrichment	PER3	2.47
15	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1	2.47
16	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.47
17	Developmental and epileptic encephalopathy 30	Enrichment	SIK1	2.47
18	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Enrichment	RORA	2.47
19	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	2.47
20	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	2.47
21	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	2.47
22	Tethered spinal cord syndrome	Enrichment	CREBBP	2.29
23	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.29
24	Melanoma of soft tissue	Enrichment	CREB1	2.29
25	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	2.29
26	Acute megakaryocytic leukemia	Enrichment	KMT2A	2.07
27	Kabuki syndrome 1	Enrichment	KMT2A	1.99
28	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.99
29	Wiedemann-steiner syndrome	Enrichment	KMT2A	1.99
30	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.99
31	Hypertrichosis	Enrichment	CREBBP	1.99
32	Renal cell carcinoma with mit translocations	Enrichment	TFEB	1.93
33	Cornelia de lange syndrome 1	Enrichment	KMT2A	1.82
34	Cornelia de lange syndrome	Enrichment	KMT2A	1.82
35	Heart disease	Enrichment	CREBBP	1.63
36	Corpus callosum, agenesis of	Enrichment	CREBBP	1.60
37	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.60
38	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.60
39	Early infantile developmental and epileptic encephalopathy	Enrichment	SIK1	1.52
40	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.50
41	Scoliosis	Enrichment	CREBBP	1.40
42	Leukemia, acute myeloid	Enrichment	KMT2A	1.18
43	Benign epilepsy with centrotemporal spikes	Enrichment	LOC102724428	1.17
44	Centralopathic epilepsy	Enrichment	LOC102724428	1.15
45	West syndrome	Enrichment	SIK1	1.14
46	Myeloma, multiple	Enrichment	CREBBP	1.04
47	Autism	Enrichment	CREBBP	0.94
48	Congenital nervous system abnormality	Enrichment	CREBBP	0.78
49	Nervous system disease	Enrichment	CREBBP	0.78
50	Autism spectrum disorder	Enrichment	KMT2A	0.77
51	Microcephaly	Enrichment	KMT2A	0.72
52	Complex neurodevelopmental disorder	Enrichment	RORA	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Pathway Network for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Member Pathways for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Pathways in the Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes SuperPath

Associated Genes for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Associated Disorders for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Disorders associated with Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes SuperPath

STRING Interaction Network for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Sources for Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes