Phosphorylation of CD3 and TCR zeta chains

Pathway network for the Phosphorylation of CD3 and TCR zeta chains SuperPath

Sources:

Reactome

Pathways in the Phosphorylation of CD3 and TCR zeta chains SuperPath

#	Name	Source	Genes
1	Phosphorylation of CD3 and TCR zeta chains	Reactome	CD247 CD3D CD3E CD3G CD4 CSK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LCK PAG1 PTPN22 PTPRC PTPRJ (see all 22) (see less)
2	Generation of second messenger molecules	Reactome	CD101 CD247 CD3D CD3E CD3G CD4 ENAH EVL FYB1 GRAP2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ITK LAT LCK LCP2 NCK1 PAK1 PAK2 PAK3 PLCG1 PLCG2 VASP WAS ZAP70 (see all 34) (see less)
3	Co-inhibition by PD-1	Reactome	CD247 CD274 CD3D CD3E CD3G CD4 CSK HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LCK PDCD1 PDCD1LG2 PTPN11 PTPN6 (see all 23) (see less)

Gene overlap in member pathways for Phosphorylation of CD3 and TCR zeta chains SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	3
2	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	3
3	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	3
4	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	3
5	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	3
6	HLA-DQB2	Major Histocompatibility Complex, Class II, DQ Beta 2	Protein Coding	3
7	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	3
8	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	3
9	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	3
10	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	3
11	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	3
12	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
13	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	3
14	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	3
15	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	3
16	CD247	CD247 Molecule	Protein Coding	3
17	CD4	CD4 Molecule	Protein Coding	3
18	CSK	C-Terminal Src Kinase	Protein Coding	2
19	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	1
20	PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Protein Coding	1
21	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
22	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	1
23	FYB1	FYN Binding Protein 1	Protein Coding	1
24	LAT	Linker For Activation Of T Cells	Protein Coding	1
25	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
26	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
27	NCK1	NCK Adaptor Protein 1	Protein Coding	1
28	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
29	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
30	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
31	EVL	Enah/Vasp-Like	Protein Coding	1
32	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
33	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
34	ENAH	ENAH Actin Regulator	Protein Coding	1
35	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
36	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
37	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
38	CD101	CD101 Molecule	Protein Coding	1
39	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	1
40	CD274	CD274 Molecule	Protein Coding	1
41	PDCD1	Programmed Cell Death 1	Protein Coding	1
42	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
43	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
44	PDCD1LG2	Programmed Cell Death 1 Ligand 2	Protein Coding	1

Disorders associated with Phosphorylation of CD3 and TCR zeta chains SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, LCK, PTPRC	10.44
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	8.43
3	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1, HLA-DPB1, PTPN22	7.13
4	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	5.60
5	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	5.60
6	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	5.60
7	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1, PTPN22	5.12
8	Temporal arteritis	Enrichment	HLA-DRB1, PTPN22	4.82
9	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	4.82
10	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	4.60
11	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, PTPN22	4.28
12	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, PTPN22	4.28
13	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	4.16
14	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	3.65
15	Okt4 epitope deficiency	Enrichment	CD4	2.79
16	Immunodeficiency 18	Enrichment	CD3E	2.79
17	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.79
18	Immunodeficiency 25	Enrichment	CD247	2.79
19	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.79
20	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.79
21	Immunodeficiency 22	Enrichment	LCK	2.79
22	Berylliosis	Enrichment	HLA-DPB1	2.79
23	Immunodeficiency 79	Enrichment	CD4	2.79
24	Cd45 deficiency	Enrichment	PTPRC	2.79
25	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.79
26	Thrombocytopenia 10	Enrichment	PTPRJ	2.79
27	Immunodeficiency 19	Enrichment	CD3D	2.79
28	Metachondromatosis	Enrichment	PTPN11	2.77
29	Leopard syndrome 1	Enrichment	PTPN11	2.77
30	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	2.77
31	Systemic lupus erythematosus 2	Enrichment	PDCD1	2.77
32	Autoimmune disease, multisystem, infantile-onset, 5	Enrichment	CD274	2.77
33	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.77
34	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.77
35	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.77
36	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.77
37	Malignant astrocytoma	Enrichment	PTPN11	2.77
38	Systemic lupus erythematosus	Enrichment	HLA-DRB1, PTPN22	2.75
39	Thrombocytopenia 1	Enrichment	WAS	2.60
40	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.60
41	Immunodeficiency 81	Enrichment	LCP2	2.60
42	Knobloch syndrome 2	Enrichment	PAK2	2.60
43	Immunodeficiency 48	Enrichment	ZAP70	2.60
44	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.60
45	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.60
46	Thrombocytopenia 3	Enrichment	FYB1	2.60
47	Lymphoproliferative syndrome 1	Enrichment	ITK	2.60
48	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.60
49	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.60
50	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.60
51	Was-related disorders	Enrichment	WAS	2.60
52	Congenital autosomal recessive small-platelet thrombocytopenia	Enrichment	FYB1	2.60
53	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.60
54	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	2.49
55	Sarcoidosis 1	Enrichment	HLA-DRB1	2.49
56	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.49
57	Immunodeficiency 17	Enrichment	CD3G	2.49
58	Werner syndrome	Enrichment	PTPN11	2.47
59	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	2.31
60	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.30
61	Wiskott-aldrich syndrome	Enrichment	WAS	2.30
62	Lymphoproliferative syndrome	Enrichment	ITK	2.30
63	Immunodeficiency 52	Enrichment	LAT	2.30
64	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.29
65	Tricuspid valve insufficiency	Enrichment	PTPN11	2.29
66	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	2.19
67	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.17
68	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.17
69	Follicular lymphoma	Enrichment	HLA-DRB1	2.09
70	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	2.09
71	Lymphoma	Enrichment	PTPN11	2.07
72	Limited scleroderma	Enrichment	HLA-DRB1	2.01
73	Knobloch syndrome	Enrichment	PAK2	2.00
74	Patent ductus arteriosus	Enrichment	PTPN11	1.99
75	Noonan syndrome 3	Enrichment	PTPN11	1.93
76	Knobloch syndrome 1	Enrichment	PAK2	1.90
77	Pectus excavatum	Enrichment	PTPN11	1.73
78	Specific learning disability	Enrichment	PTPN11	1.73
79	Epicanthus	Enrichment	PTPN11	1.70
80	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.70
81	Congenital long qt syndrome	Enrichment	PTPN11	1.70
82	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.60
83	Combined immunodeficiency	Enrichment	ZAP70	1.56
84	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.56
85	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.56
86	Patent foramen ovale	Enrichment	PTPN11	1.52
87	Noonan syndrome 1	Enrichment	PTPN11	1.42
88	Scoliosis	Enrichment	PTPN11	1.40
89	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.36
90	Rasopathy	Enrichment	PTPN11	1.36
91	Strabismus	Enrichment	PTPN11	1.35
92	Severe covid-19	Enrichment	HLA-DQB1	1.34
93	Long qt syndrome 1	Enrichment	PTPN11	1.30
94	Non-immune hydrops fetalis	Enrichment	PTPN11	1.29
95	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.15
96	Thrombocytopenia	Enrichment	PTPN11	1.11
97	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.04
98	Colorectal cancer	Enrichment	PTPRJ	0.88
99	Autism spectrum disorder	Enrichment	PTPN11	0.77
100	Microcephaly	Enrichment	PTPN11	0.72
101	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.70
102	Complex neurodevelopmental disorder	Enrichment	PAK3	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Phosphorylation of CD3 and TCR zeta chains

Pathway Network for Phosphorylation of CD3 and TCR zeta chains

Pathway network for the Phosphorylation of CD3 and TCR zeta chains SuperPath

Member Pathways for Phosphorylation of CD3 and TCR zeta chains

Pathways in the Phosphorylation of CD3 and TCR zeta chains SuperPath

Gene overlap in member pathways for Phosphorylation of CD3 and TCR zeta chains SuperPath

Associated Genes for Phosphorylation of CD3 and TCR zeta chains

Associated Disorders for Phosphorylation of CD3 and TCR zeta chains

Disorders associated with Phosphorylation of CD3 and TCR zeta chains SuperPath

STRING Interaction Network for Phosphorylation of CD3 and TCR zeta chains

Sources for Phosphorylation of CD3 and TCR zeta chains