Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

No Pathway Network information available for Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

#	Name	Source	Genes
1	Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling	WikiPathways	ABCC2 ABCC3 ABCC4 ABCC6 ABCG2 CES1 EPHX1 FOS GCLC GCLM GSTP1 HMOX1 JUN KEAP1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 NFE2L2 NQO1 NQO2 SRXN1 (see all 23) (see less)
2	Defective ABCC6 causes PXE	Reactome	ABCC6

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABCC6	ATP Binding Cassette Subfamily C Member 6	Protein Coding	2
2	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	1
3	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1
4	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	1
5	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
6	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
7	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
8	NQO2	N-Ribosyldihydronicotinamide:Quinone Dehydrogenase 2	Protein Coding	1
9	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
10	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
11	HMOX1	Heme Oxygenase 1	Protein Coding	1
12	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
13	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	1
14	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	1
15	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	EPHX1	Epoxide Hydrolase 1	Protein Coding	1
17	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
18	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
19	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
20	CES1	Carboxylesterase 1	Protein Coding	1
21	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
22	SRXN1	Sulfiredoxin 1	Protein Coding	1
23	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pseudoxanthoma elasticum	Direct
2	Cystic fibrosis	Enrichment	EPHX1, GCLC, HMOX1	4.69
3	Myocardial infarction	Enrichment	GCLC, GCLM	3.21
4	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.77
5	Arterial calcification, generalized, of infancy, 2	Enrichment	ABCC6	2.77
6	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.77
7	Pseudoxanthoma elasticum, forme fruste	Enrichment	ABCC6	2.77
8	Drug metabolism, altered, ces1-related	Enrichment	CES1	2.77
9	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.77
10	Blood group, junior system	Enrichment	ABCG2	2.77
11	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.77
12	Genetic lipodystrophy	Enrichment	EPHX1	2.77
13	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	KEAP1	2.47
14	Kala-azar 2	Enrichment	GSTP1	2.47
15	Arterial calcification of infancy	Enrichment	ABCC6	2.47
16	Dubin-johnson syndrome	Enrichment	ABCC2	2.29
17	Congenital generalized lipodystrophy	Enrichment	FOS	2.17
18	Breast cancer	Enrichment	JUN, NQO2	2.15
19	Histiocytoid hemangioma	Enrichment	FOS	2.07
20	Familial hypercholanemia	Enrichment	EPHX1	1.99
21	Cutis laxa	Enrichment	ABCC6	1.70
22	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.66
23	Lung cancer	Enrichment	NFE2L2	1.28
24	Eye disease	Enrichment	ABCC6	1.24
25	Optic atrophy plus syndrome	Enrichment	ABCC6	1.14
26	Hereditary breast carcinoma	Enrichment	NQO2	1.14
27	Colorectal cancer	Enrichment	NFE2L2	0.86
28	Hereditary retinal dystrophy	Enrichment	ABCC6	0.41
29	Fundus dystrophy	Enrichment	ABCC6	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling