Physiological and pathological hypertrophy of the heart

No Pathway Network information available for Physiological and pathological hypertrophy of the heart

Pathways in the Physiological and pathological hypertrophy of the heart SuperPath

#	Name	Source	Genes
1	Physiological and pathological hypertrophy of the heart	WikiPathways	AGT CAMK2D CTF1 EDN1 FOS GATA4 IL6ST JUN LIFR MAP2K3 MAPK1 MAPK11 MAPK14 MAPK8 MYEF2 NFATC4 PPP3CA PPP3CB PRKCB PRKCE RAC1 RHOA STAT3 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
2	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
3	RAC1	Rac Family Small GTPase 1	Protein Coding	1
4	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
5	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
6	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
7	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
8	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
9	PRKCB	Protein Kinase C Beta	Protein Coding	1
10	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
11	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
12	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
13	LIFR	LIF Receptor Subunit Alpha	Protein Coding	1
14	RHOA	Ras Homolog Family Member A	Protein Coding	1
15	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
17	GATA4	GATA Binding Protein 4	Protein Coding	1
18	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
19	EDN1	Endothelin 1	Protein Coding	1
20	AGT	Angiotensinogen	Protein Coding	1
21	CTF1	Cardiotrophin 1	Protein Coding	1
22	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
23	MYEF2	Myelin Expression Factor 2	Protein Coding	1

Disorders associated with Physiological and pathological hypertrophy of the heart SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Stuve-wiedemann syndrome 1	Enrichment	IL6ST, LIFR	5.08
2	Stüve-wiedemann syndrome	Enrichment	IL6ST, LIFR	5.08
3	Heart, malformation of	Enrichment	GATA4, MAPK1	3.38
4	Atrioventricular septal defect 4	Enrichment	GATA4	2.77
5	Auriculocondylar syndrome 3	Enrichment	EDN1	2.77
6	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.77
7	Noonan syndrome 13	Enrichment	MAPK1	2.77
8	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.77
9	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.77
10	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.77
11	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.77
12	Question mark ears, isolated	Enrichment	EDN1	2.77
13	Atrial septal defect 2	Enrichment	GATA4	2.77
14	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.77
15	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.77
16	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.77
17	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.77
18	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.77
19	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.77
20	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.77
21	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.77
22	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.77
23	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.77
24	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.77
25	Albinism, oculocutaneous, type vi	Enrichment	MYEF2	2.47
26	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.47
27	46,xy sex reversal 3	Enrichment	GATA4	2.47
28	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.29
29	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.29
30	Hyper ige syndrome	Enrichment	STAT3	2.29
31	Auriculocondylar syndrome 1	Enrichment	EDN1	2.17
32	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.17
33	Congenital generalized lipodystrophy	Enrichment	FOS	2.17
34	Transposition of the great arteries	Enrichment	GATA4	2.17
35	Ventricular septal defect 1	Enrichment	GATA4	2.07
36	Congenital heart defects, multiple types, 4	Enrichment	GATA4	2.07
37	Histiocytoid hemangioma	Enrichment	FOS	2.07
38	Hemihyperplasia, isolated	Enrichment	RHOA	1.99
39	Renal tubular dysgenesis	Enrichment	AGT	1.99
40	Oculocutaneous albinism	Enrichment	MYEF2	1.93
41	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.87
42	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.82
43	Specific learning disability	Enrichment	MAPK1	1.73
44	Acute promyelocytic leukemia	Enrichment	STAT3	1.66
45	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.63
46	Heart disease	Enrichment	GATA4	1.63
47	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.63
48	Hypertension, essential	Enrichment	AGT	1.55
49	Patent foramen ovale	Enrichment	GATA4	1.52
50	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.50
51	Familial atrial fibrillation	Enrichment	GATA4	1.40
52	Tetralogy of fallot	Enrichment	GATA4	1.36
53	Cakut	Enrichment	LIFR	1.25
54	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	1.09
55	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	1.04
56	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	1.04
57	Breast cancer	Enrichment	JUN	0.92
58	Microcephaly	Enrichment	MAPK1	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Physiological and pathological hypertrophy of the heart

Pathway Network for Physiological and pathological hypertrophy of the heart

Member Pathways for Physiological and pathological hypertrophy of the heart

Pathways in the Physiological and pathological hypertrophy of the heart SuperPath

Associated Genes for Physiological and pathological hypertrophy of the heart

Associated Disorders for Physiological and pathological hypertrophy of the heart

Disorders associated with Physiological and pathological hypertrophy of the heart SuperPath

STRING Interaction Network for Physiological and pathological hypertrophy of the heart

Sources for Physiological and pathological hypertrophy of the heart