PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

No Pathway Network information available for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Pathways in the PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer SuperPath

#	Name	Source	Genes
1	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer	WikiPathways	AKT1 ATG13 BAD CDKN1B EIF4EBP1 FOXO1 FOXO3 FOXO4 GRB10 GSK3B HRAS KRAS MAPKAP1 MLST8 MTOR NOS3 NRAS PDK1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PTEN RB1CC1 RHEB RICTOR RPTOR TFEB TSC2 ULK1 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	1
2	TFEB	Transcription Factor EB	Protein Coding	1
3	TSC2	TSC Complex Subunit 2	Protein Coding	1
4	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
5	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
6	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
7	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
8	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
9	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
10	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
11	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
12	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
13	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
14	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
15	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
16	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
17	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
18	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
19	FOXO3	Forkhead Box O3	Protein Coding	1
20	FOXO1	Forkhead Box O1	Protein Coding	1
21	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
22	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
23	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
24	ATG13	Autophagy Related 13	Protein Coding	1
25	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
26	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
27	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
28	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
29	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
30	FOXO4	Forkhead Box O4	Protein Coding	1
31	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
32	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1

Disorders associated with PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	MTOR, PIK3CA, PTEN, RHEB	9.81
2	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA, RB1CC1	9.39
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.04
4	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.08
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.32
6	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC2	7.32
7	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC2	7.32
8	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA, PTEN, RB1CC1	7.27
9	Ovarian cancer	Enrichment	AKT1, CDKN1B, KRAS, PIK3CA, PTEN, TSC2	6.94
10	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS, PTEN	6.38
11	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS, PTEN	6.38
12	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA, PTEN	6.24
13	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA, PTEN, RB1CC1	6.09
14	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	6.00
15	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	5.59
16	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	5.27
17	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.27
18	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.79
19	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.79
20	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	4.69
21	Rasopathy	Enrichment	HRAS, KRAS, NRAS	4.52
22	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.49
23	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.49
24	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.38
25	Colorectal cancer	Enrichment	AKT1, NRAS, PIK3CA, PIK3R1	4.31
26	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	4.09
27	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.09
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.95
29	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.95
30	Noonan syndrome 3	Enrichment	HRAS, KRAS	3.95
31	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.95
32	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.95
33	Gastric cancer	Enrichment	KRAS, PIK3CA, PTEN	3.86
34	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.82
35	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.72
36	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TSC2	3.72
37	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.62
38	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.46
39	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.46
40	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.26
41	Rhabdomyosarcoma	Enrichment	HRAS, PTEN	3.20
42	Diffuse large b-cell lymphoma	Enrichment	FOXO1, PTEN	3.05
43	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.96
44	Prostate cancer	Enrichment	PIK3CA, PTEN	2.68
45	Macrodactyly	Enrichment	PIK3CA	2.63
46	Proteus syndrome	Enrichment	AKT1	2.63
47	Oculoectodermal syndrome	Enrichment	KRAS	2.63
48	Vacterl association with hydrocephalus	Enrichment	PTEN	2.63
49	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.63
50	Cowden syndrome 5	Enrichment	PIK3CA	2.63
51	Melanosis, neurocutaneous	Enrichment	NRAS	2.63
52	Noonan syndrome 6	Enrichment	NRAS	2.63
53	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.63
54	Short syndrome	Enrichment	PIK3R1	2.63
55	Papillary tumor of the pineal region	Enrichment	PTEN	2.63
56	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.63
57	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.63
58	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.63
59	Neuroendocrine tumor	Enrichment	CDKN1B	2.63
60	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.63
61	Cowden syndrome 6	Enrichment	AKT1	2.63
62	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.63
63	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.63
64	Glioma susceptibility 2	Enrichment	PTEN	2.63
65	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.63
66	Hypospadias	Enrichment	PIK3CA	2.63
67	Congenital pulmonary airway malformation	Enrichment	KRAS	2.63
68	Rare venous malformation	Enrichment	PIK3CA	2.63
69	Diaphragmatic eventration	Enrichment	PIK3CA	2.63
70	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.63
71	Rare combined vascular malformation	Enrichment	PIK3CA	2.63
72	Cavernous lymphangioma	Enrichment	PIK3CA	2.63
73	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.63
74	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.63
75	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.63
76	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.63
77	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.63
78	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.63
79	Macrodactyly of toe	Enrichment	PIK3CA	2.63
80	Neurocutaneous melanocytosis	Enrichment	NRAS	2.63
81	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.62
82	Lung cancer	Enrichment	KRAS, PIK3CA	2.59
83	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, PTEN, TSC2	2.44
84	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.40
85	Costello syndrome	Enrichment	HRAS	2.33
86	Lymphangioleiomyomatosis	Enrichment	TSC2	2.33
87	Keratosis, seborrheic	Enrichment	PIK3CA	2.33
88	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.33
89	Noonan syndrome 8	Enrichment	PIK3CA	2.33
90	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.33
91	Cebalid syndrome	Enrichment	MTOR	2.33
92	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.33
93	Smith-kingsmore syndrome	Enrichment	MTOR	2.33
94	Vacterl with hydrocephalus	Enrichment	PTEN	2.33
95	Juvenile polyposis of infancy	Enrichment	PTEN	2.33
96	Wooly hair nevus	Enrichment	HRAS	2.33
97	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.15
98	Tuberous sclerosis 1	Enrichment	TSC2	2.15
99	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.15
100	Langerhans cell histiocytosis	Enrichment	NRAS	2.15
101	Tuberous sclerosis 2	Enrichment	TSC2	2.15
102	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.15
103	Hamartoma	Enrichment	TSC2	2.15
104	Xanthinuria, type ii	Enrichment	TSC2	2.15
105	Immunodeficiency 14	Enrichment	PIK3R1	2.15
106	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.15
107	Spermatocytoma	Enrichment	HRAS	2.15
108	Keratoacanthoma	Enrichment	PIK3CA	2.15
109	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, PTEN	2.13
110	Myeloma, multiple	Enrichment	KRAS, PIK3R2	2.12
111	Primary ovarian insufficiency	Enrichment	NOS3, RICTOR	2.07
112	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.03
113	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.03
114	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.03
115	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.03
116	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.03
117	Tuberous sclerosis	Enrichment	TSC2	2.03
118	Cerebrovascular disease	Enrichment	PIK3CA	2.03
119	Pilocytic astrocytoma	Enrichment	KRAS	2.03
120	Epidermolytic nevus	Enrichment	HRAS	2.03
121	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.03
122	Primary hyperparathyroidism	Enrichment	CDKN1B	2.03
123	Glioma	Enrichment	PTEN	2.03
124	Capillary malformations, congenital	Enrichment	PIK3CA	1.93
125	Alzheimer disease 2	Enrichment	NOS3	1.93
126	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.93
127	Macrocephaly/autism syndrome	Enrichment	PTEN	1.93
128	Pre-eclampsia	Enrichment	NOS3	1.93
129	Hemangioma	Enrichment	PTEN	1.93
130	Acute megakaryocytic leukemia	Enrichment	PTEN	1.93
131	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.85
132	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.85
133	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.79
134	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.79
135	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.79
136	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.79
137	Polycystic kidney disease 1	Enrichment	TSC2	1.79
138	Renal cell carcinoma with mit translocations	Enrichment	TFEB	1.79
139	Pilomyxoid astrocytoma	Enrichment	KRAS	1.79
140	Stroke, ischemic	Enrichment	NOS3	1.63
141	Melanoma	Enrichment	PTEN	1.63
142	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.63
143	Meningioma, familial	Enrichment	PTEN	1.59
144	Uterine corpus cancer	Enrichment	PTEN	1.59
145	Congenital nervous system abnormality	Enrichment	PTEN, TSC2	1.59
146	Nervous system disease	Enrichment	PTEN, TSC2	1.59
147	Autism spectrum disorder	Enrichment	PTEN, TSC2	1.57
148	Protein-deficiency anemia	Enrichment	NRAS	1.52
149	Nk-cell enteropathy	Enrichment	PIK3CB	1.52
150	Lung cancer susceptibility 3	Enrichment	KRAS	1.49
151	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.46
152	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.46
153	Rare genetic intellectual disability	Enrichment	MTOR	1.46
154	Alzheimer disease, familial, 1	Enrichment	NOS3	1.40
155	Hypertension, essential	Enrichment	NOS3	1.40
156	Arteriovenous malformations of the brain	Enrichment	KRAS	1.36
157	Hepatocellular carcinoma	Enrichment	PIK3CA	1.30
158	Pancreatic cancer	Enrichment	KRAS	1.24
159	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.22
160	West syndrome	Enrichment	TSC2	1.01
161	Hypertelorism	Enrichment	PIK3CA	0.94

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Pathway Network for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Member Pathways for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Pathways in the PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer SuperPath

Associated Genes for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Associated Disorders for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Disorders associated with PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer SuperPath

STRING Interaction Network for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer

Sources for PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer